C. Rudd

C. Rudd, Hongyan Wang, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY

C. Rudd, L. Geng, 2002, British journal of haematology.

C. Rudd, K. Prasad, 1992 .

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

C. Rudd, J. Trevillyan, S. Schlossman, 1988, Proceedings of the National Academy of Sciences of the United States of America.

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

S. Shoelson, H. Schneider, C. Rudd, 1995, The Journal of experimental medicine.

The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76

H. Schneider, C. Rudd, Karsten Köhler, 2013, Science Signaling.

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

Omer Dushek, P. A. van der Merwe, C. Rudd, 2015, The Journal of Immunology.

CD28 co-signaling in the adaptive immune response.

C. Rudd, P. Říha, 2010, Self/nonself.

Distinct NF-κB activation pathways engaged by T-cell receptor and co-receptor CD 28 on T-cells

C. Rudd, Y. R. Thaker, 2015 .

Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells

C. Rudd, Y. R. Thaker, 2015 .

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

C. Rudd, 2021, Frontiers in Cell and Developmental Biology.

Isoelectric focusing of bovine major histocompatibility complex class II molecules

D. Watkins, N. Letvin, H. Lewin, 1989, European journal of immunology.

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

K. Strebhardt, C. Rudd, K. Strebhardt, 2019, Scientific Reports.

CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation.

C. Rudd, M. Raab, S. Pfister, 2001, Immunity.

CD28 and Lipid Rafts Coordinate Recruitment of Lck to the Immunological Synapse of Human T Lymphocytes1

B. Marinari, L. Tuosto, A. Viola, 2004, The Journal of Immunology.

Disabled receptor signaling and new primary immunodeficiency disorders.

C. Rudd, 2006, The New England journal of medicine.

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

K. Maclennan, G. Cook, C. Rudd, 2021, iScience.

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras

S. Shoelson, H. Schneider, C. Rudd, 1995, European journal of immunology.

The reverse stop-signal model for CTLA4 function

C. Rudd, 2008, Nature Reviews Immunology.

Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1

R. Lechler, A. Sharpe, H. Schneider, 2002, The Journal of Immunology.

Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion

C. Rudd, Hongyan Wang, B. Wei, 2007, Molecular and Cellular Biology.

Membrane Rafts Play a Crucial Role in Receptor Activator of Nuclear Factor κB Signaling and Osteoclast Function*

Hong-Hee Kim, Z. Lee, H. Kwak, 2003, The Journal of Biological Chemistry.

Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function

H. Schneider, C. Rudd, A. Azouz, 2001, The Journal of experimental medicine.

T-cell signaling and immunopathologies

C. Rudd, 2010, Seminars in Immunopathology.

TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.

N. Hogg, H. Schneider, C. Rudd, 2008, Immunology letters.

Co-Receptors in the Positive and Negative Regulation of T-Cell Immunity

H. Schneider, C. Rudd, 2008 .

CTLA-4 trafficking and surface expression.

H. Schneider, E. Valk, C. Rudd, 2008, Trends in immunology.

SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering

M. Purbhoo, C. Rudd, D. Davis, 2010, Proceedings of the National Academy of Sciences.

Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1

C. Rudd, Yuning Lu, D. Lim, 2016, Immunology letters.

ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation

C. Rudd, Hongyan Wang, F. McCann, 2004, The Journal of experimental medicine.

SKAP-55 regulates integrin adhesion and formation of T cell–APC conjugates

N. Hogg, H. Schneider, C. Rudd, 2003, Nature Immunology.

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Hidde L. Ploegh, Andre Franke, Yasuyuki Kondo, 2014, Nature.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

G. Petsko, M. Ostrowski, H. Ploegh, 2016, Nature.

Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment.

C. Rudd, L. Busque, J. Hébert, 2022, Blood reviews.

The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling*

M. Jücker, C. Rudd, R. Feldman, 1997, The Journal of Biological Chemistry.

Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity

C. Rudd, M. Issa, Mark E Issa, 2021, Journal of cellular immunology.

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

C. Rudd, Alison Taylor, 2019, BMC Research Notes.

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility andinteractions with antigen presenting cells

C. Rudd, Alison Taylor, 2020 .

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

C. Rudd, M. Brunner‐Weinzierl, 2018, Front. Immunol..

Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells.

C. Rudd, Janna Krueger, 2017, Immunity.

CD28 family of receptors inter-connect in the regulation of T-cells

S. Rieder, C. Rudd, Janna Krueger, 2017, Receptors & clinical investigation.

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor.

C. Rudd, 1990, Immunology today.

YopH dephosphorylates Cas and Fyn-binding protein in macrophages.

C. Rudd, A. Gustavsson, K. Andersson, 1999, Microbial pathogenesis.

Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells

N. Câmara, R. Lechler, H. Schneider, 2006, Journal of leukocyte biology.

Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.

H. Schneider, C. Rudd, Yuning Lu, 2012, Blood.

Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

C. Rudd, A. Kazanova, 2021, PLoS biology.

The CD4/CD8:p56lck complex in T lymphocytes: a potential mechanism to regulate T-cell growth.

C. Rudd, S. Schlossman, E. Barber, 1989, Biochemistry and cell biology = Biochimie et biologie cellulaire.

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

L. Cantley, S. Shoelson, C. Rudd, 1994, Proceedings of the National Academy of Sciences of the United States of America.

S. Lehar, H. Schneider, C. Rudd, 2000, Immunity.

T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.

H. Kang, H. Schneider, E. Valk, 2006, Immunity.

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

K. Strebhardt, C. Rudd, Y. R. Thaker, 2019, Nature Communications.

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

C. Rudd, J. Trevillyan, S. Schlossman, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

C. Rudd, M. Yamamoto, M. Raab, 1994, Molecular and cellular biology.

Functional expression of HLA-DP genes transfected into mouse fibroblasts

W. Bodmer, J. Trowsdale, J. Lamb, 1985, Nature.

Molecular analysis of the interaction of p56lck with the CD4 and CD8 antigens.

C. Rudd, J. Hahn, M. Sy, 1991, Advances in experimental medicine and biology.

The Expression of HLA-DR, DQ and DP Antigens on the Surface of Lymphocytes as Assessed by 2-D Polyacrylamide Gel Analysis of Immunoprecipitates

J. Bodmer, W. Bodmer, M. Crumpton, 1984 .

Function of the LFA‐1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes

J. Ritz, C. Rudd, R. Schmidt, 1986, European journal of immunology.

CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.

H. Schneider, C. Rudd, H. Kang, 1998, Journal of immunology.

Regulation and Function of SKAP-55 Non-canonical Motif Binding to the SH3c Domain of Adhesion and Degranulation-promoting Adaptor Protein*

H. Kang, C. Rudd, J. Duke-Cohan, 2006, Journal of Biological Chemistry.

1F7, a novel cell surface molecule, involved in helper function of CD4 cells.

N. Letvin, G. Levinson, C. Morimoto, 1989, Journal of Immunology.

Cutting Edge: Regulator of G Protein Signaling-1 Selectively Regulates Gut T Cell Trafficking and Colitic Potential

A. Hayday, C. Rudd, T. Raine, 2011, The Journal of Immunology.

Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.

P. Schwartzberg, H. Schneider, C. Rudd, 1998, Biochemical and biophysical research communications.

A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade

C. Rudd, 2020, Science Immunology.

Decreased CD8‐p561ck Activity in Peripheral Blood T‐Lymphocytes from Patients with Hereditary Haemochromatosis

C. Rudd, G. Porto, M. Sousa, 1994, Scandinavian journal of immunology.

Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells

C. Rudd, Yulan Yi, Hebin Liu, 2019, The Journal of Immunology.

Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain.

C. Rudd, M. Raab, 1996, Biochemical and biophysical research communications.

TcR and TcR-CD28 Engagement of Protein Kinase B (PKB/AKT) and Glycogen Synthase Kinase-3 (GSK-3) Operates Independently of Guanine Nucleotide Exchange Factor VAV-1*

H. Schneider, C. Rudd, Joanne E Wood, 2006, Journal of Biological Chemistry.

Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells*

H. Schneider, C. Rudd, B. Guérette, 2000, The Journal of Biological Chemistry.

Signaling scaffolds in immune cells.

C. Rudd, J. Kennedy, M. Raab, 1999, Cell calcium.

SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages

B. Neel, B. Schraven, J. Timms, 1999, Current Biology.

Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition.

H. Schneider, C. Rudd, 2000, Biochemical and biophysical research communications.

CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86.

C. Rudd, D. Céfai, H. Hu, 1996, International immunology.

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation*

J. Ladbury, H. Schneider, C. Rudd, 2013, The Journal of Biological Chemistry.

Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.

C. Rudd, L. Geng, M. Raab, 1999, Journal of immunology.

SLP-76 Binding to FYB at Tyr TCR-Driven IL-2 Transcription Requires FYB / FYN-T in the Up-Regulation of Cutting Edge : SLP-76 Cooperativity with

C. Rudd, L. Geng, M. Raab, 1999 .

Lymphocyte signaling: Adapting new adaptors

C. Rudd, 1998, Current Biology.

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

C. Rudd, S. Bunnell, L. Berg, 1995, Proceedings of the National Academy of Sciences of the United States of America.

SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.

C. Rudd, Hongyan Wang, 2008, Trends in cell biology.

Association of T cell antigen CD7 with type II phosphatidylinositol‐4 kinase, a key component in pathways of inositol phosphate turnover

H. Schneider, C. Rudd, G. Subrahmanyam, 2003, European journal of immunology.

Advances in T-cell co-receptor biology and cancer immunotherapy.

C. Rudd, 2019, Seminars in immunology.

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

C. Rudd, J. Trevillyan, S. Schlossman, 1989, Proceedings of the National Academy of Sciences of the United States of America.

CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.

H. Schneider, E. Valk, C. Rudd, 2006, Advances in experimental medicine and biology.

CTLA-4 Negative Signaling via Lipid Rafts: A New Perspective

H. Schneider, C. Rudd, Margarita Martín, 2002, Science's STKE.

C. Rudd, K. Prasad, 1992, Molecular and cellular biology.

C. Rudd, K. Prasad, 2022 .

Small Molecule Inhibitors as an Alternative to Antibody Blockade in Immunotherapy

C. Rudd, Alison Taylor, 2019 .

CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.

H. Schneider, C. Rudd, 2008, Biochemical and biophysical research communications.

Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).

L. Cantley, O. Janssen, C. Rudd, 1993, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen

C. Rudd, S. Schlossman, Tsutomu Takeuchi, 1987, European journal of immunology.

Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA‐4 to a positive signaling receptor

L. Yin, H. Schneider, C. Rudd, 2003, Journal of leukocyte biology.

Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.

T. Kirchhausen, H. Schneider, C. Rudd, 1999, Journal of immunology.

HLA-D region antigen-associated invariant polypeptides as revealed by two-dimensional gel analysis. Glycosylation and structural inter-relationships.

J. Bodmer, W. Bodmer, M. Crumpton, 1985, The Journal of biological chemistry.

Isolation and characterization of a human T lymphocyte-associated glycoprotein (gp40).

M. Greaves, C. Rudd, D. Sutherland, 1984, Journal of immunology.

Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

C. Rudd, F. Santinon, Bennani Fatima Ezzahra, 2022, Scientific Reports.

Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases

C. Rudd, E. Affar, E. Milot, 2022, The Journal of biological chemistry.

Characterisation of the HLA-D Region DQw3 Specificity Using the Monoclonal Antibodies 2HB6 and IVD12

J. Bodmer, W. Bodmer, M. Crumpton, 1984 .

Physiological and aberrant regulation of memory T cell trafficking by the co- stimulatory molecule CD28. Running title: Regulation of memory T cell trafficking by CD28

K. Okkenhaug, C. Rudd, D. Scott, 2006 .

A role for adhesion and degranulation‐promoting adapter protein in collagen‐induced platelet activation mediated via integrin α2β1

S. Watson, C. Rudd, C. Hughes, 2012, Journal of thrombosis and haemostasis : JTH.

Structural characterization of CD6: properties of two distinct epitopes involved in T cell activation.

C. Morimoto, C. Rudd, S. Schlossman, 1989, Molecular immunology.

The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens

C. Morimoto, C. Rudd, Chika Morimoto, 1987, The Journal of experimental medicine.

SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells

C. Rudd, U. Diekmann, M. Sauer, 2016, Molecular and Cellular Biology.

A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells

N. Letvin, C. Morimoto, C. Rudd, 1987, Nature.

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

K. Strebhardt, C. Rudd, Y. Matthess, 2011, The Journal of Biological Chemistry.

Functional Defects of SKAP-55-Deﬁcient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion (cid:1)

C. Rudd, B. Wei, Hebin Liu, 2007 .

T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice

C. Rudd, Alison Taylor, X. Smith, 2016, Immunology letters.

CTLA‐4 co‐receptor impacts on the function of Treg and CD8+ T‐cell subsets

C. Rudd, 2009, European journal of immunology.

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

C. Rudd, Hongyan Wang, Eun-Kyeong Jo, 2005, The Journal of experimental medicine.

Ganglioside-induced CD4 endocytosis occurs independent of serine phosphorylation and is accompanied by dissociation of P56lck.

H. Scholz, W. Haseltine, F. Hucho, 1992, Journal of immunology.

FcγRIIIA-mediated signaling involves src-family lck in human natural killer cells

C. Pignata, J. Ritz, C. Rudd, 1993 .

Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.

C. Pignata, J. Ritz, C. Rudd, 1993, Journal of immunology.

Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines

C. Rudd, F. Bennani, K. Karrouchi, 2022, Heliyon.

Adaptor ADAP (adhesion- and degranulation-promoting adaptor protein) regulates beta1 integrin clustering on mast cells.

C. Rudd, L. Geng, 2001, Biochemical and biophysical research communications.

Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system

C. Rudd, D. Rothstein, S. Schlossman, 1989, European journal of immunology.

Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen.

C. Morimoto, C. Rudd, T. Tedder, 1989, Cellular immunology.

Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.

C. Rudd, Alison Taylor, Kittiphat Chanthong, 2020, Cell reports.

Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report

C. Rudd, 2020, Frontiers in Pharmacology.

A regulatory role for cytoplasmic YVKM motif in CTLA‐4 inhibition of TCR signaling

H. Schneider, C. Rudd, Hui Hu, 2001, European journal of immunology.

Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells.

H. Schneider, C. Rudd, H. Hu, 2001, Biochemical and biophysical research communications.

In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics

M. Scrima, C. Rudd, L. Rastrelli, 2022, Current issues in molecular biology.

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

K. Strebhardt, C. Rudd, X. Smith, 2017, Nature Communications.

Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells.

C. Pignata, J. Ritz, M. Hallek, 1995, Cellular immunology.

The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells.

N. Letvin, C. Morimoto, C. Rudd, 1986, Journal of immunology.

Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study

C. Rudd, K. Karrouchi, M. Faouzi, 2022, Journal of biomolecular structure & dynamics.

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

J. Ladbury, K. Strebhardt, C. Rudd, 2010, Immunity.

A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes.

C. Rudd, J. C. Telfer, 1991, Science.

ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy

C. Rudd, B. Wei, Chi Zhang, 2015, EMBO molecular medicine.

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

C. Rudd, R. Kremer, B. Larrivée, 2021, PloS one.

Hydroxychloroquine (HCQ) reverses anti-PD-1 immune murine checkpoint blockade: TCF1 as a marker in humans for COVID-19 and HCQ therapy

C. Rudd, B. Larrivée, M. Issa, 2020, medRxiv.

Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56lck Complex in Human T‐Cell Activation

P. Anderson, C. Morimoto, C. Rudd, 1989, Immunological reviews.

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

C. Rudd, H. Saragovi, S. D. del Rincón, 2020, Frontiers in Immunology.

T-cell signalling and immune system disorders

C. Rudd, J. Downey, B. Wilkinson, 2005, Expert Reviews in Molecular Medicine.

Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications.

C. Rudd, Alison Taylor, Janna Krueger, 2019, Seminars in immunology.

Reversal of the TCR Stop Signal by CTLA-4

Paul Garside, James M. Brewer, Christopher E. Rudd, 2006, Science.

O. Janssen, C. Rudd, M. Yamamoto, 1993, Biochimica et biophysica acta.

Association of a 70‐kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cells

P. Anderson, C. Rudd, É. Vivier, 1993 .

Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: Differential involvement of the FYB SH3 domain

C. Rudd, S. Kraeft, L. Geng, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Immunopathologies linked to integrin signalling

C. Rudd, Hongyan Wang, D. Lim, 2010, Seminars in Immunopathology.

Positive and negative adaptors in T‐cell signalling

C. Rudd, Hongyan Wang, B. Wilkinson, 2004, Immunology.

Protein tyrosine phosphorylation in T cell signaling.

A. Alonso, T. Mustelin, J. Merlo, 2002, Frontiers in bioscience : a journal and virtual library.

SH3 domain recognition of a proline‐independent tyrosine‐based RKxxYxxY motif in immune cell adaptor SKAP55

G. Wagner, A. Musacchio, C. Rudd, 2000, The EMBO journal.

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells*

C. Rudd, A. D. da Silva, Hyun Kang, 1999, The Journal of Biological Chemistry.

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.

C. Rudd, H. Kang, S. Kraeft, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

Z. Li, C. Rudd, C E Rudd, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells.

C. Rudd, H. Hirai, A. Bouton, 1997, Journal of immunology.

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates anti-tumor immune responses.

N. Sonenberg, W. Miller, Jie Su, 2021, The Journal of clinical investigation.

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

M. Cybulsky, J. Penninger, I. Kozieradzki, 2001, Science.

SKAP1 is dispensable for chemokine-induced migration of primary T-cells

C. Rudd, Hongyan Wang, Yuning Lu, 2010, Immunology letters.

Novel Isoform of Lymphoid Adaptor FYN-T-binding Protein (FYB-130) Interacts with SLP-76 and Up-regulates Interleukin 2 Production*

S. Weremowicz, C. Morton, C. Rudd, 1999, The Journal of Biological Chemistry.

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation.

H. Schneider, C. Rudd, C E Rudd, 1995, Immunity.

Mechanisms of CD28 signalling.

H. Schneider, C. Rudd, D. Céfai, 1995, Research in immunology.

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

L. Cantley, O. Janssen, C. Rudd, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A functional dichotomy in CD4+ T lymphocytes.

C. Rudd, 1988, Immunology today.

Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases.

O. Janssen, C. Rudd, A. D. da Silva, 1994, Immunology today.

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

L. Cantley, O. Janssen, C. Rudd, 1993, Molecular and cellular biology.

T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)

O. Janssen, C. Rudd, A. D. da Silva, 1993, The Journal of experimental medicine.

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

L. Cantley, B. Schaffhausen, O. Janssen, 1994, The Journal of biological chemistry.

Diverse Mechanisms Regulate the Surface Expression of Immunotherapeutic Target CTLA-4

H. Schneider, C. Rudd, 2014, Front. Immunol..

CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase1

C. Rudd, Hongyan Wang, B. Wei, 2007, The Journal of Immunology.

and Myosin Light Chain Kinase Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, Rapid T Cell Polarization That Depends on CTL-Associated Antigen-4 Ligation Induces

C. Rudd, B. Wei, Hongyan Wang, 2007 .

Independent CD28 signaling via VAV and SLP‐76: a model for in trans costimulation

C. Rudd, Monika Raab, Christopher E. Rudd, 2003, Immunological reviews.

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.

C. Rudd, A. D. da Silva, P. Findell, 1997, Immunity.

The molecular mechanisms of regulatoryT cell immunosuppression

Kendall A. Smith, P. Pandiyan, H. Waldmann, 2011 .

Effective chimeric antigen receptor T cells against SARS-CoV-2

C. Rudd, H. Saragovi, Stephanie Thurmond, 2021, iScience.

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

H. Schneider, C. Rudd, 2003, Nature Reviews Immunology.

Microtubules, colchicine, and lymphocyte blastogenesis.

C. Rudd, K. Rogers, D. Brown, 1979, Canadian Journal of Biochemistry.

Biochemistry of Class II Antigens: Workshop Report

J. Bodmer, W. Bodmer, M. Crumpton, 1984 .

CD45 ligation expands Tregs by promoting interactions with DCs.

Y. Wan, R. Flavell, C. Rudd, 2014, The Journal of clinical investigation.

Upstream-downstream: CD28 cosignaling pathways and T cell function.

C. Rudd, 1996, Immunity.

Thymidine transport in human lymphocytes stimulated with concanavalin A: effect of colchicine.

C. Rudd, J. Kaplan, 1981, Journal of immunology.

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

C. Rudd, E. Zúñiga, P. Stevenson, 2016, Immunity.

2H1--a novel antigen involved in T lymphocyte triggering.

N. Letvin, C. Morimoto, C. Rudd, 1988, Journal of immunology.

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines

C. Rudd, N. Fernández, Y. R. Thaker, 2017, The Journal of Biological Chemistry.

Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy.

C. Rudd, Alison Taylor, 2019, Advances in experimental medicine and biology.

Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy.

C. Rudd, D. Rothstein, Alison Taylor, 2018, Cancer research.

Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8+ Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy

C. Rudd, Alison Taylor, 2017, Front. Immunol..

CTLA‐4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization

G. Bismuth, H. Schneider, C. Rudd, 2008, European journal of immunology.

Phosphatidylinositol 3-Kinase p85 Adaptor Function in T-cells

H. Kang, H. Schneider, C. Rudd, 2002, The Journal of Biological Chemistry.

CTLA-4 blockade of antigen-induced cell death.

C. Rudd, S. da Rocha Dias, S. Dias, 2001, Blood.

CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

C. Rudd, M. Yamamoto, K. Prasad, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy

C. Rudd, Alison Taylor, 2019, Journal of immunological sciences.

Lymphocyte signaling: Cbl sets the threshold for autoimmunity

Christopher E. Rudd, H. Schneider, C. Rudd, 2000, Current Biology.

Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells

K. Strebhardt, H. Schneider, E. Valk, 2008, PloS one.

Two-step TCR /CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains,

O. Janssen, C. Rudd, Yun-Cai Cai, 1994 .

MAPK p38: alternative and nonstressful in T cells

C. Rudd, 2005, Nature Immunology.

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling*

Mary J. Tharayil, Hong-Hee Kim, C. Rudd, 1998, The Journal of Biological Chemistry.

Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis

C. Rudd, 2001, Science's STKE.

B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

S. Rieder, C. Rudd, J. Karnell, 2020, Cellular & Molecular Immunology.

LYMPHOKINE REGULATION OF CD 45 R EXPRESSION ON HUMAN T CELL CLONES

D. Hafler, C. Rudd, S. Brod, 2003 .

Lymphokine regulation of CD45R expression on human T cell clones

D. Hafler, C. Rudd, S. Brod, 1989, The Journal of experimental medicine.

Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression

K. Inder, H. Schneider, E. Valk, 2014, Molecular and Cellular Biology.

Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function.

H. Schneider, C. Rudd, A. Azouz, 2001, The Journal of experimental medicine.

SLP-76 sterile alpha motif (SAM) and individual H5 alpha helix mediates oligomer formation for microclusters and T-cell activation

H. Schneider, C. Rudd, Loren J. Stagg, 2013 .

Association of a 70-kDa tyrosine phosphoprotein with the CD16: zeta: gamma complex expressed in human natural killer cells.

P. Anderson, C. Rudd, É. Vivier, 1993, European journal of immunology.

Cell cycle 'check points' T cell anergy

C. Rudd, 2006, Nature Immunology.

TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB.

C. Rudd, A. D. da Silva, M. Raab, 1997, Biochemical Society transactions.

GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

C. Rudd, 2020, Frontiers in Immunology.

Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors

C. Rudd, B. Wei, C. Jolly, 2013, Retrovirology.

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

K. Strebhardt, C. Rudd, M. Raab, 2019, Scientific Reports.

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region

K. Strebhardt, C. Rudd, M. Raab, 2018, BMC Research Notes.

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells

H. Schneider, C. Rudd, M. Goldberg, 2015, Molecular cell.

Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

C. Rudd, M. Raab, Y. Gui, 2023, Frontiers in Immunology.

CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells

C. Rudd, H. Dai, Fadi G Lakkis, 2016, The Journal of Immunology.

Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule.

J. Mier, C. Rudd, S. R. Hull, 1991, The Journal of biological chemistry.

2D-QSAR study and design of novel pyrazole derivatives as an anticancer lead compound against A-549, MCF-7, HeLa, HepG-2, PaCa-2, DLD-1

C. Rudd, K. Karrouchi, M. Faouzi, 2023, Computational Toxicology.

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region

K. Strebhardt, C. Rudd, M. Raab, 2018, BMC Research Notes.

A 72-kilodalton fyn-related polypeptide (p72fyn-R) binds to the antigen-receptor/CD3 (TcR/CD3) complex.

C. Rudd, A. D. da Silva, 1993, Journal of Biological Chemistry.

The HIV‐1 Surface Protein gp120 Has No Effect on Transmembrane Signal Transduction in T Cells

F. Hucho, C. Rudd, K. Buchner, 1992, Journal of acquired immune deficiency syndromes.

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.

J. Ladbury, K. Strebhardt, C. Rudd, 2010, Immunity.

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

C. Rudd, Hongyan Wang, E. Jo, 2005, The Journal of experimental medicine.