R. Sordella

发表

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

Daniel A. Haber, D. Haber, J. Settleman, 2004, Science.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Patricia L. Harris, D. Louis, D. Christiani, 2004, The New England journal of medicine.

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

A. Iafrate, Xiao-Jun Ma, M. Erlander, 2007, Proceedings of the National Academy of Sciences.

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

Johannes Zuber, Lukas E. Dow, Gregory J. Hannon, 2011, Cell.

Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.

Barry Fine, Le Zhang, Yoshihiko Yamada, 2002, Developmental cell.

Modulation of Rho GTPase Signaling Regulates a Switch between Adipogenesis and Myogenesis

J. Settleman, Guang-Chao Chen, Wei Jiang, 2003, Cell.

Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms

D. Haber, J. Settleman, D. Bell, 2008, Clinical Cancer Research.

Raffaella Sordella Anti-Apoptotic Pathways Mutations in Lung Cancer Activate EGFR Gefitinib-Sensitizing

D. Haber, J. Settleman, D. Bell, 2011 .

Protein interaction mapping in C. elegans using proteins involved in vulval development.

M. Vidal, J. Hartley, G. Temple, 2000, Science.

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Michael C Schatz, Kenneth Chang, Jude Kendall, 2017, eLife.

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.

Patricia L. Harris, Allan Wissner, Thomas J Lynch, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Towards patient-based cancer therapeutics

Benito Munoz, Michelle Palmer, Paul A Clemons, 2010, Nature Biotechnology.

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization

J. Kinney, Alexander Vaughan, D. Tuveson, 2017, Nature Communications.

DOCK4, a GTPase Activator, Is Disrupted during Tumorigenesis

D. Haber, J. Settleman, D. Bell, 2003, Cell.

The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

Martha E. Zeeman, S. Powers, C. Cordon-Cardo, 2017, The Journal of cell biology.

p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

J. Settleman, P. Comoglio, S. Corso, 2005, Journal of Cell Science.

SHP-2 Positively Regulates Myogenesis by Coupling to the Rho GTPase Signaling Pathway

J. Settleman, M. Fornaro, A. Bennett, 2004, Molecular and Cellular Biology.

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

M. Ladanyi, S. Lowe, Edward R. Kastenhuber, 2016, eLife.

Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas

S. Powers, R. Sordella, Jinyu Li, 2016, Scientific Reports.

TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

N. Altorki, L. Kenner, R. Sordella, 2010, Proceedings of the National Academy of Sciences.

Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

Gayatry Mohapatra, D. Sgroi, D. Haber, 2006, Proceedings of the National Academy of Sciences of the United States of America.

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.

A. Krasnitz, M. Wigler, R. Lucito, 2008, Genes & development.

Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

M. Ladanyi, S. Lowe, Edward R. Kastenhuber, 2017, eLife.

A rapid and tunable method to temporally control Cas9 expression enables the identification of essential genes and the interrogation of functional gene interactions in vitro and in vivo

Adam Kepecs, Alexander Vaughan, D. Tuveson, 2015, bioRxiv.

TAp73 is essential for germ cell adhesion and maturation in testis

U. Moll, M. Dobbelstein, D. Kramer, 2014, The Journal of cell biology.

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

Gayatry Mohapatra, D. Haber, Sreenath V. Sharma, 2005, Nature Genetics.

MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.

C. Cordon-Cardo, Christof Fellmann, M. Castillo-Martin, 2015, Cancer discovery.

Myc drives Pten / p 53-deficient proliferation and metastasis due to Il 6-secretion and Akt-suppression via Phlpp 2 RUNNING TITLE : Il 6 drives Myc in Pten-mutant prostate metastasis

C. Cordon-Cardo, Christof Fellmann, M. Castillo-Martin, 2015 .

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.

D. Haber, J. Settleman, K. Anderson, 2007, Cancer research.

The Evolution of TP53 Mutations: From Loss-of-Function to Separation-of-Function Mutants.

R. Sordella, Debjani Pal, Nitin H. Shirole, 2016, Journal of cancer biology & research.

Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance

Ken Chen, Chris Sander, Olivier Gevaert, 2016, Molecular Cancer Research.

A Novel Platform for Proteomic Analysis of Proximal Source Pulmonary Venous Blood Identifies Potential Biomarkers for Non-Small Cell Lung Cancer (NSCLC)

N. Altorki, J. Port, R. Sordella, 2014 .

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma

S. Lyons, Sania Jevtic, R. Sordella, 2021, Laboratory Investigation.

Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor

O. Elemento, N. Altorki, R. Mohney, 2013, Molecular Cancer Research.

Distinct but Overlapping Functions for the Closely Related p190 RhoGAPs in Neural Development

J. Settleman, R. Sordella, J. Vanderheide, 2006, Developmental Neuroscience.

TGF-b reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD 44 + / CD 24 � cancer cells

Tyler H. Garvin, M. Schatz, J. Kendall, 2017 .

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

Adrian Krainer, Scott W. Lowe, Matthew J. Lazzara, 2014, Proceedings of the National Academy of Sciences.

Driving Actin Dynamics under the Influence of Alcohol

R. Sordella, L. Aelst, Raffaella Sordella, 2006, Cell.

Genetic Analysis of Rho Protein Function in Mice

J. Settleman, R. Sordella, Raffaella Sordella, 2005 .

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

G. Hannon, R. Sordella, Debjani Pal, 2021, eLife.

Dialogue between RhoA/ROCK and members of the Par complex in cell polarity.

L. Van Aelst, R. Sordella, Raffaella Sordella, 2008, Developmental cell.

An FF domain-dependent protein interaction mediates a signaling pathway for growth factor-induced gene expression.

J. Settleman, Guang-Chao Chen, Wei Jiang, 2005, Molecular cell.

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression

Vilma Jimenez Sabinina, G. Hannon, V. J. Sabinina, 2021, bioRxiv.