C. Vlahos

发表

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

K Y Hui, C. Vlahos, W. Matter, 1994, The Journal of biological chemistry.

Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity.

B. Blazer-Yost, C. Vlahos, M. Esterman, 2003, American journal of physiology. Cell physiology.

Inhibition of MG‐63 cell proliferation and PDGF‐stimulated cellular processes by inhibitors of phosphatidylinositol 3‐kinase

G. Bokoch, James E. Thomas, Y. Wang, 1997, Journal of cellular biochemistry.

The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase.

C. Vlahos, E. E. Dekker, 1988, The Journal of biological chemistry.

Calmodulin Activates Phosphatidylinositol 3-Kinase*

M. White, D. Burks, C. Vlahos, 1997, The Journal of Biological Chemistry.

Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA*

R. Campbell, Xiaohong Yu, C. Vlahos, 2005, Journal of Biological Chemistry.

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

C. Vlahos, J. Parkinson, B. Grinnell, 1990, The Journal of biological chemistry.

Inhibitors of Cellular Signaling Targets

C. Vlahos, L. Stancato, 2004 .

Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart.

G. Sandusky, C. Vlahos, M. Esterman, 2001, Journal of molecular and cellular cardiology.

Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells.

B. Blazer-Yost, C. Vlahos, R. Record, 1998, American journal of physiology. Endocrinology and metabolism.

Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells.

B. Blazer-Yost, C. Vlahos, R. Record, 1998, American journal of physiology. Endocrinology and metabolism.

Inhibition of neutrophil oxidative burst and granule secretion by Wortmannin: Potential role of MAP kinase and renaturable kinases

S. Grinstein, G. Downey, C. Vlahos, 1997, Journal of cellular physiology.

An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.

C. Vlahos, W. Duan, W. F. Wong, 2005, International immunopharmacology.

Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption.

B. Blazer-Yost, T. Paunescu, C. Vlahos, 1999, The American journal of physiology.

Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption.

B. Blazer-Yost, T. Paunescu, C. Vlahos, 1999, American journal of physiology. Cell physiology.

Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

A. Toker, J. Hartwig, L. Cantley, 1995, The Journal of Biological Chemistry.

Protein kinase C βII activation induces angiotensin converting enzyme expression in neonatal rat cardiomyocytes

P. Iversen, C. Vlahos, Lan Yu, 2003 .

Signaling pathways mediated by the beta(2)-adrenergic receptor in the fibroblast: a novel role for PI 3-kinase.

C. Vlahos, 2001, Journal of molecular and cellular cardiology.

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.

G. King, F. Schoen, K. Suzuma, 2002, Diabetes.

The purification and characterization of recombinant human renin expressed in the human kidney cell line 293.

C. Vlahos, D. T. Berg, J. Walls, 1990, Biochemical and biophysical research communications.

Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.

J. Dixon, C. Vlahos, W. Matter, 2001, Biochemical and biophysical research communications.

Platelet derived growth factor (PDGF), androgens and inflammation: possible etiologic factors in the development of prostatic hyperplasia.

J. Eble, C. Vlahos, W. Lamph, 1993, The Journal of urology.

Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation.

M. Rekhter, C. Vlahos, R. Gilmour, 2008, Biochemical and biophysical research communications.

Protein Kinase C- α and - ϵ Modulate Connexin-43 Phosphorylation in Human Heart

G. Sandusky, P. Allen, C. Vlahos, 2001 .

Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart.

G. Sandusky, P. Allen, C. Vlahos, 2001, Journal of molecular and cellular cardiology.

Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition.

C. Christoffersen, C. Vlahos, R. Joshi, 1998, Biochemical and biophysical research communications.

Selective activation of PI3Kα/Akt/GSK‐3β signalling and cardiac compensatory hypertrophy during recovery from heart failure

C. Vlahos, R. Gill, Qingyu Wu, 2009, European journal of heart failure.

Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes

C. Vlahos, J. Falck, C. W. Garner, 1995, Molecular and Cellular Endocrinology.

LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins.

P. Dawson, C. Vlahos, W. Matter, 1996, Journal of lipid research.

Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.

V. Sánchez-Margalet, C. Vlahos, I. Goldfine, 1994, Biochemical and biophysical research communications.

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.

P. Silver, P. Cohen, B. Perry, 2007, Blood.

angiogenesis a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling ) , is Solenopsis invicta Solenopsin , the alkaloidal component of the fire ant

P. Silver, P. Cohen, B. Perry, 2006 .

Increased Protein Kinase C Activity and Expression of Ca 2 (cid:49) -Sensitive Isoforms in the Failing Human Heart

G. King, R. Walsh, G. Sandusky, 1999 .

Possible Involvement of Phosphatidylinositol 3‐Kinase in Regulated Exocytosis: Studies in Chromaffin Cells with Inhibitor LY294002

D. Aunis, S. Chasserot-Golaz, S. Dirrig, 1998, Journal of neurochemistry.

Synthetic studies on the furan ring of wortmannin

B. Norman, C. Vlahos, J. Paschal, 1995 .

Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase.

J. A. Badwey, C. Vlahos, J. Giner, 2006, Bioorganic & medicinal chemistry letters.

Inhibitors of cellular signaling targets: designs and limitations.

C. Vlahos, L. Stancato, 2004, Methods in molecular biology.

Synthesis and in vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3‐Kinase.

R. Schultz, C. Vlahos, H. Kirst, 1997 .

Anticancer drugs and signalling targets : principles and examples

G. Powis, R. Abraham, C. Vlahos, 1995 .

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

E. Prossnitz, C. Vlahos, W. Matter, 1995, Journal of immunology.

Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats.

C. Vlahos, H. Bryant, M. Cohen, 1997, The Journal of pharmacology and experimental therapeutics.

LY-294002-inhibitable PI 3-kinase and regulation of baseline rates of Na(+) transport in A6 epithelia.

B. Blazer-Yost, T. Paunescu, C. Vlahos, 2000, American journal of physiology. Cell physiology.

Anti-inflammatory effects of LY294002, a PI3K inhibitor, in a mouse model of asthma

C. Vlahos, W. Duan, W. Wong, 2004 .

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

J. Blenis, C. Kahn, B. Cheatham, 1994, Molecular and cellular biology.

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP

J. Blenis, K. P. Lemon, J. Chung, 1995, Molecular and cellular biology.

17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase

J. Dodge, B. Norman, C. Vlahos, 1995 .

Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474.

C. Vlahos, J. Parkinson, B. Grinnell, 1993, The Biochemical journal.

Kinases as therapeutic targets for heart failure

A. Clerk, C. Vlahos, S. McDowell, 2003, Nature Reviews Drug Discovery.

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs.

C. Vlahos, W. Matter, R. F. Brown, 1992, Biochemical and Biophysical Research Communications - BBRC.

Synthesis and in vitro evaluation of new wortmannin esters: potent inhibitors of phosphatidylinositol 3-kinase.

R. Schultz, C. Vlahos, H. Kirst, 1996, Journal of medicinal chemistry.

Signal transduction in neutrophil activation Phosphatidylinositol 3‐kinase is stimulated without tyrosine phosphorylation

C. Vlahos, W. Matter, 1992, FEBS Letters.

A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy.

D. M. Olive, C. Vlahos, W. Matter, 2005, Analytical biochemistry.

Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes.

C. Vlahos, W. Matter, S. McDowell, 2004, American journal of physiology. Heart and circulatory physiology.

Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs.

J. Dodge, R. Schultz, C. Shih, 1996, Journal of medicinal chemistry.

Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States: A Possible Explanation for Impaired Collateral Formation in Cardiac Tissue

L. Aiello, G. King, K. Suzuma, 2002, Circulation.

Characterization of a modified human tissue plasminogen activator comprising a kringle-2 and a protease domain.

C. Vlahos, D. Mcclure, M. Warrick, 1990, The Journal of biological chemistry.

Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.

M. Lai, C. Vlahos, M. Zinda, 2001, Biochemical and biophysical research communications.

Functional properties of the recombinant kringle-2 domain of tissue plasminogen activator produced in Escherichia coli.

C. Vlahos, O. Wilhelm, S. Jaskunas, 1990, The Journal of biological chemistry.

Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling

C. Vlahos, W. Matter, Wei Zeng, 2004, Critical care medicine.

Design and implementation of a particle concentration fluorescence method for the detection of HIV-1 protease inhibitors.

C. Vlahos, J. Manetta, W. Heath, 1992, Analytical biochemistry.

Substitutions at the P2' site of gag p17-p24 affect cleavage efficiency by HIV-1 protease.

C. Vlahos, W. Heath, M. Lai, 1990, Biochemical and biophysical research communications.

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.

G. King, R. Walsh, G. Sandusky, 1999, Circulation.

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase.

G. Bokoch, Y. Wang, U. Knaus, 1996, The Biochemical journal.

Purification of recombinant HIV-1 protease.

C. Vlahos, M. Lai, A. Dee, 1991, Preparative biochemistry.

Effects of wortmannin analogs on bone in vitro and in vivo.

J. Dodge, C. Vlahos, W. Matter, 1996, The Journal of pharmacology and experimental therapeutics.

Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells.

B. Blazer-Yost, C. Vlahos, R. Record, 1998, American Journal of Physiology.

Platelet‐derived growth factor induces proliferation of hyperplastic human prostatic stromal cells

Jeffrey A. Jones, J. Eble, C. Vlahos, 1993, Journal of cellular biochemistry.

Evidence for an essential arginine residue in the active site of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Modification with 1,2-cyclohexanedione.

C. Vlahos, E. E. Dekker, M. A. Ghalambor, 1985, Journal of Biological Chemistry.

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

J. Dodge, G. Powis, R. Abraham, 1994, Cancer research.

Amino acid sequence of the pyruvate and the glyoxylate active-site lysine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase.

C. Vlahos, E. E. Dekker, 1986, The Journal of biological chemistry.

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

H. Wakasaki, C. Vlahos, K. Way, 2002 .