O. Perisic

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Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Phillip T. Hawkins, Roger L. Williams, P. Hawkins, 2000, Cell.

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.

P. Hawkins, L. Stephens, R. Williams, 2000, Cell.

Structural Mapping of the Catalytic Mechanism for a Mammalian Phosphoinositide-specific Phospholipase C †, ‡

R. Williams, O. Perisic, M. Roberts, 1996 .

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

Yuval Inbar, Haim J. Wolfson, Dina Schneidman-Duhovny, 2007, Science.

Cooperative binding of drosophila heat shock factor to arrays of a conserved 5 bp unit

Hua Xiao, John T. Lis, J. Lis, 1991, Cell.

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Michael I. Wilson, Roger L. Williams, P. Hawkins, 2004, Advances in enzyme regulation.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

D. Sabatini, Balaji Santhanam, Roger L. Williams, 2019, Science.

Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane.

Roger L. Williams, R. Williams, H. Paterson, 1995, The Biochemical journal.

Activation of GCN2 by the ribosomal P-stalk

Roger L. Williams, R. Hegde, O. Perisic, 2019, Proceedings of the National Academy of Sciences.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Roger L. Williams, A. Bresnick, J. Backer, 2013, Proceedings of the National Academy of Sciences.

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Roger L. Williams, J. Burke, O. Perisic, 2011, Structure.

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

Roger L. Williams, J. Burke, O. Perisic, 2011, Structure.

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

Roger L. Williams, J. Burke, O. Perisic, 2015, The Biochemical journal.

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

B. Kuster, Roger L. Williams, G. Médard, 2022, Nature Chemical Biology.

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Roger L. Williams, P. Hawkins, L. Stephens, 2001, Molecular cell.

Finding a fitting shoe for Cinderella

Roger L. Williams, O. Perisic, Simon Miller, 2010 .

Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.

Roger L. Williams, O. Perisic, Simon Miller, 2010, Autophagy.

The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain

M. Bycroft, Roger L. Williams, K. Hofmann, 2012, Structure.

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Roger L. Williams, P. Hawkins, L. Stephens, 2000, Molecular cell.

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA)

Glenn R Masson, John E Burke, Oscar Vadas, 2012, Proceedings of the National Academy of Sciences.

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Roger L. Williams, O. Perisic, L. Essen, 1996, Nature.

Protease-activated kinase II as the potential mediator of insulin-stimulated phosphorylation of ribosomal protein S6.

O. Perisic, J. Traugh, 1983, The Journal of biological chemistry.

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.

Michael I. Wilson, Roger L. Williams, O. Perisic, 2003, Molecular cell.

Binding of the PX domain of p47phox to phosphatidylinositol 3,4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction

Jerónimo Bravo, Wonhwa Cho, Roger L. Williams, 2002, The EMBO journal.

The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.

Roger L. Williams, R. Williams, O. Perisic, 1995, Journal of molecular biology.

Structural insights into phosphoinositide 3-kinase catalysis and signalling

Christian Ried, Roger L. Williams, L. Stephens, 1999, Nature.

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Nada Jabado, James Curtis, Sergey Nejentsev, 2013, Science.

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

J. Lis, O. Perisic, Hua Xiao, 1989, Cell.

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

Roger L. Williams, C. Sachse, J. Burke, 2016, Autophagy.

ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes

M. Lamers, Roger L. Williams, O. Perisic, 2012, Proceedings of the National Academy of Sciences.

ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.

B. González, Roger L. Williams, O. Perisic, 2004, Developmental cell.

Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2 *

Roger L. Williams, H. Paterson, O. Perisic, 1999, The Journal of Biological Chemistry.

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Roger L. Williams, P. Hawkins, L. Stephens, 2000, Cell.

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

Roger L. Williams, G. Murshudov, S. Freund, 2021, bioRxiv.

The structure and regulatory function(s) of cortisol receptor--1: Extragenosomic effects dependent on the cortisol receptor activation.

O. Perisic, N. Ribarac-Stepić, M. Katan, 1979, Journal of steroid biochemistry.

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Roger L. Williams, P. Hawkins, L. Stephens, 2011, Molecular cell.

Structure of Lipid Kinase p110b/p85b Elucidates anUnusualSH2-Domain-MediatedInhibitoryMechanism

Roger L. Williams, P. Hawkins, L. Stephens, 2022 .

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012, Science Signaling.

Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012 .

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors

Roger L. Williams, J. Downward, P. Hawkins, 2018, Proceedings of the National Academy of Sciences.

A tobacco DNA binding protein that interacts with a light-responsive box II element.

E. Lam, O. Perisic, 1992, The Plant cell.

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

S. Emr, Roger L. Williams, O. Perisic, 2007, Nature.

Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

S. Munro, Roger L. Williams, D. Veprintsev, 2003, Molecular cell.

Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling*

Roger L. Williams, J. Bravo, A. Paul, 2001, The Journal of Biological Chemistry.

17 Modular Units of Heat Shock Regulatory Regions: Structure and Function

J. Lis, O. Perisic, Hua Xiao, 1990 .

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically*

Roger L. Williams, B. Davletov, O. Perisic, 1998, The Journal of Biological Chemistry.

Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology.

Jan Löwe, J. Löwe, O. Perisic, 2005, Progress in biophysics and molecular biology.

Crystal structure of a diabody, a bivalent antibody fragment.

R. Williams, G. Winter, O. Perisic, 1994, Structure.

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors

Kevan M. Shokat, John E. Burke, K. Shokat, 2014, Science.

The 1.9 A crystal structure of a nucleoside diphosphate kinase complex with adenosine 3',5'-cyclic monophosphate: evidence for competitive inhibition.

R. Williams, O. Perisic, S. Strelkov, 1995, Journal of molecular biology.

A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.

Roger L. Williams, R. Williams, O. Perisic, 1997, Biochemistry.

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2*

M. Bycroft, Roger L. Williams, O. Perisic, 1998, The Journal of Biological Chemistry.

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

S. Emr, Roger L. Williams, D. Veprintsev, 2006, Cell.

Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.

C. Byus, O. Perisic, J. Trevillyan, 1985, The Journal of biological chemistry.

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

K. Shokat, Roger L. Williams, O. Perisic, 2010, Science.

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

S. Munro, J. Briggs, Roger L. Williams, 2021, Nature communications.

Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC)

Roger L. Williams, C. Downes, O. Perisic, 1998, The Journal of Biological Chemistry.

Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation.

R. Williams, O. Perisic, M. Roberts, 1997, Biochemistry.

Structural insight into the ESCRT‐I/‐II link and its role in MVB trafficking

S. Emr, Roger L. Williams, D. Veprintsev, 2007, The EMBO journal.

Protease‐activated kinase II as the mediator of epidermal growth factor‐stimulated phosphorylation of ribosomal protein S6

O. Perisic, J. Traugh, Olga Perisic, 1985, FEBS letters.

Evolution and assembly of ESCRTs.

Roger L. Williams, S. Bell, A. Pobbati, 2009, Biochemical Society transactions.

Identification of two types of immature antigenic molecules on chicken red cells.

O. Perisic, T. Greenland, J. Blanchet, 1982, Experimental Cell Research.

Normal or retrovirus-infected cultured chicken embryo cells express the 48,000 D age-related antigen characteristic of embryonic chicken erythrocytes.

O. Perisic, T. Greenland, J. Blanchet, 1981, Differentiation; research in biological diversity.

Allosteric activation of PI3Kα by oncogenic mutations

Roger L. Williams, J. Burke, O. Perisic, 2013, Oncotarget.

Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

S. Emr, Roger L. Williams, D. Veprintsev, 2007, Biochemical Society symposium.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Roger L. Williams, A. Bresnick, J. Backer, 2013, Proceedings of the National Academy of Sciences.

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress

O. Perisic, Roger L. Williams, Anna C. Howes, 2023, Science Advances.

Evolution and assembly of ESCRTs.

Roger L. Williams, S. Bell, A. Pobbati, 2009, Biochemical Society transactions.