P. Santofimia-Castaño

发表

Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells.

J. Bolaños, M. Fernández-Bermejo, G. Salido, 2015, Free radical biology & medicine.

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2020, JCI insight.

Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib

J. Iovanna, N. Dusetti, P. Santofimia-Castaño, 2020, Clinical Cancer Research.

α‐lipoic acid reduces postreperfusion syndrome in human liver transplantation ‐ a pilot study

J. Iovanna, P. Santofimia-Castaño, A. Gadano, 2018, Transplant international : official journal of the European Society for Organ Transplantation.

Iron-Sensitive Prodrugs That Trigger Active Ferroptosis in Drug-Tolerant Pancreatic Cancer Cells.

A. Puisieux, J. Iovanna, N. Dusetti, 2022, Journal of the American Chemical Society.

Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma

J. Iovanna, P. Santofimia-Castaño, Wenjun Lan, 2019, Cancers.

Melatonin induces calcium mobilization and influences cell proliferation independently of MT1/MT2 receptor activation in rat pancreatic stellate cells

M. Fernández-Bermejo, G. Salido, A. González, 2015, Cell Biology and Toxicology.

Culture of pancreatic AR42J cell for use as a model for acinar cell function

G. Salido, P. Santofimia-Castaño, Antonio González, 2011 .

Modulation of copper accumulation and copper-induced toxicity by antioxidants and copper chelators in cultured primary brain astrocytes.

P. Santofimia-Castaño, R. Dringen, Felix Bulcke, 2015, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Cinnamtannin B-1, a natural antioxidant that reduces the effects of H2O2 on CCK-8-evoked responses in mouse pancreatic acinar cells

G. Salido, A. González, P. Santofimia-Castaño, 2011, Journal of Physiology and Biochemistry.

Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia.

J. Iovanna, M. Estaras, A. González, 2022, Biochemical pharmacology.

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Cells.

Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes.

G. Salido, A. González, P. Santofimia-Castaño, 2016, Toxicology.

Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells

J. Iovanna, M. Estaras, M. Fernández-Bermejo, 2022, Journal of Physiology and Biochemistry.

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

J. Pouysségur, J. Iovanna, J. Neira, 2021, Cell death discovery.

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Molecular & cellular oncology.

NUPR1 protects against hyperPARylation-dependent cell death

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2022, Communications Biology.

Interferences of resveratrol with fura-2-derived fluorescence in intracellular free-Ca2+ concentration determinations

G. Salido, P. Santofimia-Castaño, Antonio González, 2016, Cytotechnology.

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

Á. Almeida, J. Bolaños, P. Santofimia-Castaño, 2015, Cell Death and Differentiation.

The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells.

M. Fernández-Bermejo, G. Salido, P. Santofimia-Castaño, 2014, Toxicology letters.

Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells

M. Fernández-Bermejo, G. Salido, P. Santofimia-Castaño, 2014, Molecular and Cellular Biochemistry.

Melatonin modulates Ca2+ mobilization and amylase release in response to cholecystokinin octapeptide in mouse pancreatic acinar cells

G. Salido, P. Santofimia-Castaño, Antonio González, 2013, Journal of Physiology and Biochemistry.

Ebselen alters mitochondrial physiology and reduces viability of rat hippocampal astrocytes.

G. Salido, P. Santofimia-Castaño, Antonio González, 2013, DNA and cell biology.

Cinnamtannin B-1, a natural antioxidant that reduces the effects of H2O2 on CCK-8-evoked responses in mouse pancreatic acinar cells

G. Salido, P. Santofimia-Castaño, Ramón Rivera-Barreno, 2012, Journal of Physiology and Biochemistry.

Ethanol reduces kainate-evoked glutamate secretion in rat hippocampal astrocytes

G. Salido, P. Santofimia-Castaño, Antonio González, 2011, Brain Research.

Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells

D. López-Guerra, G. Blanco-Fernández, M. Estaras, 2020, Scientific Reports.

Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

J. Iovanna, P. Santofimia-Castaño, Can Huang, 2021, International journal of molecular sciences.

Stroma-targeting strategies in pancreatic cancer: a double-edged sword

J. Iovanna, P. Santofimia-Castaño, Xi Liu, 2022, Journal of Physiology and Biochemistry.

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

J. Iovanna, N. Dusetti, P. Santofimia-Castaño, 2018, Scientific Reports.

Melatonin modulates Ca2+ mobilization and amylase release in response to cholecystokinin octapeptide in mouse pancreatic acinar cells

G. Salido, P. Santofimia-Castaño, Antonio González, 2013, Journal of Physiology and Biochemistry.

Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells

J. Iovanna, M. Estaras, V. Roncero, 2019, Journal of Physiology and Biochemistry.

Melatonin induces calcium mobilization and influences cell proliferation independently of MT1/MT2 receptor activation in rat pancreatic stellate cells

G. Salido, P. Santofimia-Castaño, B. Sánchez-Correa, 2015, Cell Biology and Toxicology.

Combating pancreatic cancer chemoresistance by triggering multiple cell death pathways.

J. Iovanna, P. Santofimia-Castaño, 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Dendrimers as competitors of protein-protein interactions of the intrinsically disordered nuclear chromatin protein NUPR1.

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Biomacromolecules.

Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2020, International journal of biological macromolecules.

NUPR1: A Critical Regulator of the Antioxidant System

J. Iovanna, P. Santofimia-Castaño, Can Huang, 2021, Cancers.

NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue

J. Iovanna, P. Santofimia-Castaño, P. Soubeyran, 2021, The FEBS journal.

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2α

J. Iovanna, P. Santofimia-Castaño, P. Soubeyran, 2020, bioRxiv.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

A. Carrier, J. Iovanna, J. Neira, 2018, Scientific Reports.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, The Journal of clinical investigation.

Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells

G. Salido, P. Santofimia-Castaño, J. A. Tapia, 2012, Molecular and Cellular Biochemistry.

Change in the Characteristics of Ca 2+ Signaling in Pancreatic Acinar Cells in Culture

G. Salido, P. Santofimia-Castaño, A. Schmid, 2014 .

Intrinsically disordered chromatin protein NUPR1 binds to the enzyme PADI4.

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2023, Journal of molecular biology.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

A. Carrier, J. Iovanna, J. Neira, 2018, bioRxiv.

Targeting intrinsically disordered proteins involved in cancer

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Cellular and Molecular Life Sciences.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2018, Biochimica et biophysica acta. General subjects.

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B

M. Vidal, J. Iovanna, J. Neira, 2017, Proceedings of the National Academy of Sciences.

Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells

G. Salido, P. Santofimia-Castaño, J. A. Tapia, 2012, Molecular and Cellular Biochemistry.

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2021, Biomolecules.

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma.

J. Iovanna, P. Santofimia-Castaño, Ling Peng, 2020, Cancer letters.

Inducing ferroptosis by the NUPR1 inhibitor ZZW115 to kill pancreatic cancer cells

J. Iovanna, P. Santofimia-Castaño, N. Fraunhoffer, 2020 .

Ebselen impairs cellular oxidative state and induces endoplasmic reticulum stress and activation of crucial mitogen‐activated protein kinases in pancreatic tumour AR42J cells

G. Salido, P. Santofimia-Castaño, A. Martínez-Ruíz, 2018, Journal of cellular biochemistry.

Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells

G. Salido, P. Santofimia-Castaño, Antonio González, 2014, Molecular and Cellular Biochemistry.

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors

P. Santofimia-Castaño, G. Lomberk, P. Soubeyran, 2024, EMBO molecular medicine.

Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells

D. López-Guerra, G. Blanco-Fernández, V. Roncero, 2020, Scientific Reports.

Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells

J. Iovanna, V. Roncero, G. Blanco, 2019, Journal of Physiology and Biochemistry.