S. Higuchi

发表

Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect

T. Akagi, K. Ushinohama, Shoko Ikesue, 2004, Journal of Pharmacology and Experimental Therapeutics.

Changing the dosing schedule minimizes the disruptive effects of interferon on clock function

H. Aramaki, S. Higuchi, S. Ohdo, 2001, Nature Medicine.

Influence of dosing schedules on toxicity and antitumour effects of combined cisplatin and docetaxel treatment in mice

T. Kinoshita, S. Higuchi, H. To, 2009, The Journal of pharmacy and pharmacology.

Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats.

H. Sasaki, S. Higuchi, Kanoko Egashira, 2012, Drug metabolism and pharmacokinetics.

Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway

Y. Sasaguri, H. Izumi, K. Kohno, 2010, PloS one.

Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model.

Y. Sawada, H. Takanaga, S. Higuchi, 2000, British journal of clinical pharmacology.

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy

S. Higuchi, H. Takane, I. Ieiri, 2006, Expert opinion on drug metabolism & toxicology.

SLCO1B1 (OATP1B1, an Uptake Transporter) and ABCG2 (BCRP, an Efflux Transporter) Variant Alleles and Pharmacokinetics of Pitavastatin in Healthy Volunteers

K. Maeda, H. Kusuhara, Y. Sugiyama, 2007, Clinical pharmacology and therapeutics.

CYP2C19 polymorphism effect on phenobarbitone

E. Yukawa, S. Higuchi, N. Tashiro, 2000, European Journal of Clinical Pharmacology.

Pharmacokineties in Japanese patients with epilepsy: analysis by population pharmacokinetics

E. Yukawa, S. Higuchi, N. Tashiro, 2000 .

Life-threatening toxicities in a patient with UGT1A1*6/*28 and SLCO1B1*15/*15 genotypes after irinotecan-based chemotherapy

S. Higuchi, H. Takane, I. Ieiri, 2009, Cancer Chemotherapy and Pharmacology.

CPT‐11: Population Pharmacokinetic Model and Estimation of Pharmacokinetics Using the Bayesian Method in Patients with Lung Cancer

K. Eguchi, N. Saijo, Y. Ohe, 1994, Japanese journal of cancer research : Gann.

Evaluation of Wagner's method in phenytoin dosage adjustments.

E. Yukawa, S. Higuchi, Y. Nakao, 1987 .

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

E. Yukawa, S. Higuchi, S. Ohdo, 2003, Journal of Pharmacology and Experimental Therapeutics.

Influence of Feeding Schedule on 24-h Rhythm of Hepatotoxicity Induced by Acetaminophen in Mice

S. Higuchi, S. Ohdo, H. Terazono, 2004, Journal of Pharmacology and Experimental Therapeutics.

Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis.

S. Higuchi, N. Tashiro, I. Ieiri, 2000, Therapeutic drug monitoring.

Influence of dosing schedules on toxicity and antitumour effects of combined cisplatin and docetaxel treatment in mice

T. Kinoshita, S. Higuchi, H. To, 2009 .

Current Status of Population Pharmacokinetics and Pharmacokinetic

S. Higuchi, Misato Nakanishi, S. Nakade, 2003 .

Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor.

S. Higuchi, S. Ohdo, M. Iida, 2003, Metabolism: clinical and experimental.

Transforming Growth Factor-β1 Upregulates the Tight Junction and P-glycoprotein of Brain Microvascular Endothelial Cells

T. Tsuruo, Y. Sawada, M. Naito, 2004, Cellular and Molecular Neurobiology.

In vitro activity of lauric acid or myristylamine in combination with six antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA).

H. Sasaki, S. Kamihira, S. Higuchi, 2006, International journal of antimicrobial agents.

Contribution of Angiotensin Converting Enzyme Gene Polymorphism to the Action of Angiotensin II Receptor Antagonist (CS-866)

T. Ogihara, S. Higuchi, M. Okada, 2002 .

Doxorubicin Chronotherapy in Japanese Outpatients with Breast Cancer

Tsuyoshi Saito, A. Fujimura, S. Higuchi, 2005, Drugs in R&D.

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism

H. Kusuhara, Y. Sugiyama, S. Higuchi, 2008, Journal of Human Genetics.

Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells.

T. Tsuruo, Y. Sawada, M. Naito, 2004, Cellular and molecular neurobiology.

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

J. Kigawa, Y. Kanamori, Masakuni Takahashi, 2001, The Journal of pharmacology and experimental therapeutics.

SNP Communication Novel Large-scale Deletion ( whole Exon 7 ) in the ABCC 2 Gene in a Patient with the Dubin-Johnson Syndrome

M. Mori, K. Kashiwabara, Y. Yata, 2009 .

Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome.

M. Mori, K. Kashiwabara, Y. Yata, 2009, Drug metabolism and pharmacokinetics.

Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.

Y. Sugiyama, S. Higuchi, H. Takane, 2004, Hepatology research : the official journal of the Japan Society of Hepatology.

Pharmacokinetics of nicardipine enantiomers in healthy young volunteers

S. Higuchi, M. Nakano, T. Teramura, 1997, European Journal of Clinical Pharmacology.

Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach.

S. Higuchi, R. Heinig, Takahiko Tanigawa, 2006, Drug metabolism and pharmacokinetics.

Predictive performance of equations to estimate creatinine clearance from serum creatinine in Japanese patients with congestive heart failure.

E. Yukawa, S. Higuchi, T. Aoyama, 1999, American journal of therapeutics.

Methotrexate Chronotherapy is Effective Against Rheumatoid Arthritis

H. Sasaki, K. Eguchi, S. Higuchi, 2011, Chronobiology international.

Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice.

H. Aramaki, S. Higuchi, S. Ohdo, 2006, Biochemical pharmacology.

Dosing time dependency of doxorubicin‐induced cardiotoxicity and bone marrow toxicity in rats

E. Kobayashi, A. Fujimura, E. Yukawa, 2003, The Journal of pharmacy and pharmacology.

Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment.

S. Higuchi, S. Ohdo, H. Hattori, 2008, Atherosclerosis.

Dosing time-dependency of the arthritis-inhibiting effect of tacrolimus in mice.

S. Higuchi, H. To, I. Ieiri, 2011, Journal of pharmacological sciences.

Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells.

E. Yukawa, S. Higuchi, S. Ohdo, 2001, Life sciences.

Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats

S. Higuchi, K. Kawai, K. Arimori, 2008, The Journal of pharmacy and pharmacology.

Digoxin Population Pharmacokinetics from Routine Clinical Data: Role of Patient Characteristics for Estimating Dosing Regimens

E. Yukawa, S. Higuchi, T. Aoyama, 1992, The Journal of pharmacy and pharmacology.

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, CYP2C19m1 in exon 5 and CYP2C19m2 in exon 4, in Japanese subjects

S. Higuchi, I. Ieiri, A. Urae, 1996 .

Patients G-CSF Receptor on Neutrophils in Cancer Colony-Stimulating Factor ( G-CSF ) and Recombinant Human Granulocyte Close Association between Clearance of

S. Higuchi, S. Ohdo, M. Fukuda, 1998 .

Basis for Dosing Time-Dependent Changes in the Antiviral Activity of Interferon-α in Mice

H. Aramaki, E. Yukawa, S. Higuchi, 2000 .

Influences of Artificial Heart-Lung Machine Operation on the Binding Sites of Albumin: Possibility of an Effective Administration Plan

S. Higuchi, I. Ieiri, K. Kawai, 2014, International Journal of Artificial Organs.

Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

T. Kubota, S. Higuchi, K. Chiba, 2000, European Journal of Clinical Pharmacology.

Detection of a drug–drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling

E. Yukawa, S. Higuchi, S. Ohdo, 1998, European Journal of Clinical Pharmacology.

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

S. Higuchi, I. Ieiri, A. Suzuki, 2001, Pharmacogenetics.

Gastric pH profiles of beagle dogs and their use as an alternative to human testing.

S. Higuchi, M. Akimoto, A. Furuya, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.

E. Shimizu, A. Yamasaki, S. Higuchi, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.

S. Higuchi, I. Ieiri, Daisuke Kobayashi, 2011, Drug metabolism and pharmacokinetics.

Resistance of Human Cancer Cell Lines Activating Transcription Factor 4 Increases the Cisplatin

K. Yasumoto, H. Izumi, K. Kohno, 2003 .

Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines.

K. Yasumoto, H. Izumi, K. Kohno, 2003, Cancer research.

Population pharmacokinetics of pranlukast hydrate dry syrup in children with bronchial asthma

E. Yukawa, S. Higuchi, N. Kondo, 2003 .

Secretory PLA2 inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFα‐stimulated human endothelial cells

S. Higuchi, S. Ohdo, M. Iida, 2008, British journal of pharmacology.

Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus.

S. Higuchi, S. Ohdo, M. Iida, 2009, Diabetes research and clinical practice.

Ocular pharmacokinetic/pharmacodynamic modeling for timolol in rabbits using a telemetry system.

H. Sasaki, S. Higuchi, T. Kitahara, 2008, Biological & pharmaceutical bulletin.

Pre-administration of docetaxel protects against adriamycin-induced cardiotoxicity

H. Sasaki, S. Higuchi, S. Ohdo, 2008, Breast Cancer Research and Treatment.

Determination of (+)- and (-)-nicardipine concentrations in human serum and their correlation with the antihypertensive effect after oral administration of racemic nicardipine

S. Higuchi, M. Nakano, T. Umeda, 2004, European Journal of Clinical Pharmacology.

Glucocorticoid Hormone Regulates the Circadian Coordination of (cid:1) -Opioid Receptor Expression in Mouse Brainstem □ S

S. Higuchi, S. Ohdo, Miyako Yoshida, 2005 .

Uptake and Efflux of Quinacrine, a Candidate for the Treatment of Prion Diseases, at the Blood-Brain Barrier

T. Tsuruo, Y. Sawada, M. Naito, 2004, Cellular and Molecular Neurobiology.

Population Pharmacokinetics of Ramatroban in Healthy Volunteers and Patients with Bronchial Asthma/Perennial Allergic Rhinitis

E. Yukawa, S. Higuchi, Takahiko Tanigawa, 1997 .

Influence of Dosing Schedule on Toxicity and Antitumor Effects of a Combination of Adriamycin and Docetaxel in Mice

S. Higuchi, S. Ohdo, H. To, 2004, Clinical Cancer Research.

Chronopharmacological Study of Interferon-α in Mice

E. Yukawa, S. Higuchi, S. Ohdo, 1997 .

P-Hydroxylation of Phenobarbital: Relationship to (s)-Mephenytoin Hydroxylation (CYP2C19) Polymorphism

S. Higuchi, N. Tashiro, I. Ieiri, 2001, Therapeutic drug monitoring.

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics.

E. Yukawa, S. Higuchi, N. Tashiro, 2000, European journal of clinical pharmacology.

Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.

E. Yukawa, S. Higuchi, S. Ueda, 2006, Drug metabolism and pharmacokinetics.

Pharmacokinetic and pharmacodynamic analysis of TS‐943, a selective non‐peptide platelet glycoprotein‐IIb/IIIa (GPIIb/IIIa) receptor antagonist, using a nonlinear mixed effect model in dogs

S. Higuchi, M. Akimoto, S. Jingu, 2002, The Journal of pharmacy and pharmacology.

Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice.

S. Higuchi, S. Ohdo, H. To, 2005, Cancer research.

Chronopharmacology of granulocyte colony-stimulating factor in mice.

E. Yukawa, S. Higuchi, N. Ogawa, 1998, The Journal of pharmacology and experimental therapeutics.

Cell-cycle-dependent pharmacology of methotrexate in HL-60.

H. Aramaki, T. Fukagawa, S. Higuchi, 2005, Journal of pharmacological sciences.

Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in mice.

J. Viyoch, E. Yukawa, S. Higuchi, 2001, The Journal of pharmacology and experimental therapeutics.

Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.

S. Higuchi, I. Ieiri, A. Urae, 1998, Therapeutic drug monitoring.

Aplastic anaemia induced by intravenous phenytoin and lidocaine administration

S. Higuchi, K. Ueda, T. Kurokawa, 1985, European Journal of Pediatrics.

Sensitive and real-time method for evaluating corneal barrier considering tear flow.

Takashi Kitahara, Hitoshi Sasaki, Shun Higuchi, 2010, Biological & pharmaceutical bulletin.

Influence of food on serum ambenonium concentration in patients with myasthenia gravis

S. Higuchi, K. Ohtsubo, N. Fujii, 1992, European Journal of Clinical Pharmacology.

Sensitive determination of ambenonium chloride in serum from patients with myasthenia gravis using ion-exchange resin extraction and reversed-phase ion-pair chromatography.

S. Higuchi, K. Ohtsubo, N. Fujii, 1989, Journal of chromatography.

Phenytoin intoxication induced by fluvoxamine.

E. Yukawa, S. Higuchi, N. Tashiro, 2001, Therapeutic drug monitoring.

Population pharmacokinetic analysis of meropenem in Japanese adult patients

S. Higuchi, S. Takemoto, T. Sasaki, 2011, Journal of clinical pharmacy and therapeutics.

Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells.

S. Higuchi, S. Ohdo, M. Iida, 2003, European journal of pharmacology.

Glucocorticoid Hormone Regulates the Circadian Coordination of μ-Opioid Receptor Expression in Mouse Brainstem

S. Higuchi, S. Ohdo, Miyako Yoshida, 2005, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Recombinant Human Granulocyte Colony Stimulating Factor (Lenograstim) Administration

S. Higuchi, N Hayashi, H Kinoshita, 1999, Journal of clinical pharmacology.

Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects

Y. Sawada, H. Takanaga, S. Higuchi, 2000, Clinical pharmacology and therapeutics.

Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice.

T Ishizaki, E. Yukawa, S. Higuchi, 1997, The Journal of pharmacology and experimental therapeutics.

Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese Patients

S. Higuchi, H. Takane, I. Ieiri, 2011, Antimicrobial Agents and Chemotherapy.

Effect of Dosing Schedule on Pharmacokinetics of Alpha Interferon and Anti-Alpha Interferon Neutralizing Antibody in Mice

H. Aramaki, E. Yukawa, S. Higuchi, 2001, Antimicrobial Agents and Chemotherapy.

ANALYSIS OF THE FACTORS INFLUENCING ANTI‐EPILEPTIC DRUG CONCENTRATIONS‐VALPROIC ACID

S. Higuchi, I. Ieiri, T. Aoyama, 1990, Journal of clinical pharmacy and therapeutics.

Pharmacoepidemiologic detection of calcium channel blocker‐induced change on digoxin clearance using multiple trough screen analysis

E. Yukawa, S. Higuchi, S. Ohdo, 2002, Biopharmaceutics & drug disposition.

Population Pharmacokinetics of Digoxin in Japanese Patients

S. Higuchi, T. Aoyama, M. Yukawa, 2001, Clinical pharmacokinetics.

Pharmacokinetic analysis of subcutaneous erythropoietin administration with nonlinear mixed effect model including endogenous production.

E. Yukawa, S. Higuchi, H. Kinoshita, 1998, British journal of clinical pharmacology.

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

M. Oshimura, E. Nanba, S. Higuchi, 2004, Human molecular genetics.

Influence of age and co‐medication on steady‐state phenobarbital serum level—dose ratios in Japanese paediatric patients

E. Yukawa, S. Higuchi, T. Aoyama, 1992, Journal of clinical pharmacy and therapeutics.

Influence of age and co‐medication on steady‐state carbamazepine serum level—dose ratios in Japanese paediatric patients

E. Yukawa, S. Higuchi, T. Aoyama, 1992, Journal of clinical pharmacy and therapeutics.

INFLUENCE OF AGE AND CONCURRENT MEDICATION ON STEADY‐STATE VALPROIC ACID SERUM LEVEL‐DOSE RATIOS IN JAPANESE PAEDIATRIC PATIENTS

E. Yukawa, S. Higuchi, T. Aoyama, 1991, Journal of clinical pharmacy and therapeutics.

Pharmacokinetic Study of Zonisamide in Patients Undergoing Brain Surgery

T. Morioka, S. Nishio, M. Fukui, 1996, The Journal of pharmacy and pharmacology.

Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans

Yuichi Sugiyama, Miyuki Kimura, Hiroyuki Kusuhara, 2008, Clinical pharmacology and therapeutics.

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

Miyuki Kimura, Kenji Otsubo, Shun Higuchi, 2002, Clinical pharmacology and therapeutics.

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

Y. Sugiyama, S. Higuchi, I. Ieiri, 2009, Expert opinion on drug metabolism & toxicology.

Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Yuichi Sugiyama, Miyuki Kimura, Kenji Otsubo, 2003, Clinical pharmacology and therapeutics.

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

Keizo Sugimachi, Kenji Otsubo, Atsushi Yamauchi, 2002, Transplantation.

Possibility of Using Saliva Samples for Therapeutic Drug Monitoring (TDM) of Theophylline

S. Higuchi, K. Ushijima, Kenichi Toraishi, 2006 .

Population‐Based Investigation of Valproic Acid Relative Clearance Using Nonlinear Mixed Effects Modeling: Influence of Drug‐Drug Interaction and Patient Characteristics

S. Higuchi, S. Ohdo, E Yukawa, 1997, Journal of clinical pharmacology.

Pharmacoepidemiologic investigation of a clonazepam‐valproic acid interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients

E. Yukawa, S. Higuchi, T. Nonaka, 2003, Journal of clinical pharmacy and therapeutics.

Pharmacoepidemiologic Investigation of Clonazepam Relative Clearance by Mixed‐Effect Modeling Using Routine Clinical Pharmacokinetic Data in Japanese Patients

E. Yukawa, S. Higuchi, S. Ohdo, 2002, Journal of clinical pharmacology.

Pharmacoepidemiologic Investigation of a Clonazepam-Carbamazepine Interaction by Mixed Effect Modeling Using Routine Clinical Pharmacokinetic Data in Japanese Patients

E. Yukawa, S. Higuchi, S. Ohdo, 2001, Journal of clinical psychopharmacology.

Detection of Carbamazepine‐induced Changes in Valproic Acid Relative Clearance in Man by Simple Pharmacokinetic Screening

S. Higuchi, S. Ohdo, T. Aoyama, 1997, The Journal of pharmacy and pharmacology.

Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified Wagner-Nelson method with a nonlinear elimination model.

E. Yukawa, S. Higuchi, S. Ohdo, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Population‐Based Investigation of Relative Clearance of Digoxin in Japanese Patients by Multiple Trough Screen Analysis: An Update

S. Higuchi, S. Ohdo, T. Aoyama, 1997, Journal of clinical pharmacology.

The Effects of Genetic Polymorphisms of CYP2C9 and CYP2C 19 on Phenytoin Metabolism in Japanese Adult Patients with Epilepsy: Studies in Stereoselective Hydroxylation and Population Pharmacokinetics

E. Yukawa, S. Higuchi, N. Tashiro, 1998, Epilepsia.

Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.

S. Higuchi, N. Tashiro, I. Ieiri, 1997, British journal of clinical pharmacology.

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.

S. Higuchi, S. Ohdo, T. Jodoi, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Chronopharmacology of antitumor effect induced by interferon-beta in tumor-bearing mice.

E. Yukawa, S. Higuchi, S. Ohdo, 2000, The Journal of pharmacology and experimental therapeutics.

Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time.

T. Akagi, K. Ushinohama, E. Yukawa, 2003, Life Science.

Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride.

T. Ikemura, H. Iba, H. Aramaki, 2009, Journal of pharmacological sciences.

Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study

S. Higuchi, I. Ieiri, K. Ohtsubo, 1995, European Journal of Clinical Pharmacology.

THE EFFECT OF CONCURRENT ADMINISTRATION OF SODIUM VALPROATE ON SERUM LEVELS OF PRIMIDONE AND ITS METABOLITE PHENOBARBITAL

E. Yukawa, S. Higuchi, T. Aoyama, 1989, Journal of clinical pharmacy and therapeutics.

Pharmacoepidemiological study on adverse reactions of antiepileptic drugs.

S. Higuchi, I. Ieiri, T. Aoyama, 1992, Chemical & pharmaceutical bulletin.

Predicting serum lithium concentration using Bayesian method: a comparison with other methods.

S. Higuchi, S Higuchi, T Aoyama, 1988, Journal of pharmacobio-dynamics.

Chronotoxicity of methotrexate in mice and its relation to circadian rhythm of DNA synthesis and pharmacokinetics.

E. Yukawa, S. Higuchi, K. Inoue, 1997, Japanese journal of pharmacology.

Population pharmacokinetics of phenytoin from routine clinical data in Japan: an update.

E. Yukawa, S. Higuchi, E Yukawa, 1990, Chemical & pharmaceutical bulletin.

One‐point Feedback Control Method for Phenytoin Dosage Adjustment

S. Higuchi, E Yukawa, S Higuchi, 1991, The Journal of pharmacy and pharmacology.

Clinical utility of a new and simple technique for individualizing phenytoin dosage.

E. Yukawa, S. Higuchi, E Yukawa, 1989, Journal of pharmacobio-dynamics.

COMPARISON OF SINGLE‐POINT PHENYTOIN DOSAGE PREDICTION TECHNIQUES

E. Yukawa, S. Higuchi, K. Ohtsubo, 1988, Journal of clinical pharmacy and therapeutics.

Chronopharmacological study of KE-SI-TO in mice.

S. Higuchi, N. Ogawa, S. Ohdo, 1997, Life Science.

Chronopharmacological study of KE-SI-TO components in mice.

S. Higuchi, N. Ogawa, S. Ohdo, 1998, Life sciences.

Influence of dosing time on pharmacological action of G-CSF in mice.

E. Yukawa, S. Higuchi, N. Ogawa, 1998, Life sciences.

Circadian rhythm of fever induced by interferon- α in mice

E. Yukawa, S. Higuchi, S. Ohdo, 1997 .

Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice.

S. Higuchi, N. Ogawa, S. Ohdo, 1996, The Journal of pharmacology and experimental therapeutics.

Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy.

S. Higuchi, I. Ieiri, A. Urae, 1999, British journal of clinical pharmacology.

Genetic polymorphisms and functional characterization of the 5′‐flanking region of the human CYP2C9 gene: In vitro and in vivo studies

S. Higuchi, N. Tashiro, I. Ieiri, 2001, Clinical pharmacology and therapeutics.

Relationship Between 24-Hour Rhythm in Antiviral Effect of Interferon-β and Interferon-α/β Receptor Expression in Mice

E. Yukawa, S. Higuchi, S. Ohdo, 2002 .

Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder.

S. Higuchi, A. Sarashina, I. Ieiri, 2010, British journal of clinical pharmacology.

Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication.

S. Higuchi, N. Tashiro, I. Ieiri, 2000, Therapeutic drug monitoring.

Relationship between 24-hour rhythm in antiviral effect of interferon-beta and interferon-alpha/beta receptor expression in mice.

E. Yukawa, S. Higuchi, S. Ohdo, 2002, Japanese Journal of Pharmacology.

Quantitative Population Pharmacokinetic Analysis of Pravastatin Using an Enterohepatic Circulation Model Combined With Pharmacogenomic Information on SLCO1B1 and ABCC2 Polymorphisms

Kazuya Maeda, Yuichi Sugiyama, Shun Higuchi, 2009, Journal of clinical pharmacology.

POPULATION PHARMACOKINETICS OF PHENYTOIN FROM ROUTINE CLINICAL DATA IN JAPAN

E. Yukawa, S. Higuchi, E Yukawa, 1989, Journal of clinical pharmacy and therapeutics.

Predictive Performance of Bayesian Method in a Simulation Work: One-Compartment Open Linear Model Containing an Oral Route

Toshinobu Aoyama, Shun Higuchi, Ichiro Ieiri, 1988 .

PEDA: a microcomputer program for parameter estimation and dosage adjustment in clinical practice.

S. Higuchi, S Higuchi, T Aoyama, 1987, Journal of pharmacobio-dynamics.

Chronopharmacological study of interferon-alpha in mice.

E. Yukawa, S. Higuchi, S. Ohdo, 1997, The Journal of pharmacology and experimental therapeutics.

The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress

S. Higuchi, H. To, K. Mine, 2006, European Neuropsychopharmacology.

Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.

E. Nanba, S. Higuchi, Y. Fukumaki, 2000, Pharmacogenetics.

Ocular pharmacokinetic/pharmacodynamic modeling for multiple anti-glaucoma drugs.

H. Sasaki, S. Higuchi, T. Kitahara, 2008, Biological & pharmaceutical bulletin.

Glycoxidized low-density lipoprotein enhances monocyte chemoattractant protein-1 mRNA expression in human umbilical vein endothelial cells: relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor.

S. Higuchi, S. Ohdo, M. Iida, 2002, Metabolism: Clinical and Experimental.

Interindividual variation of serum haloperidol concentrations in Japanese patients – clinical considerations on steady‐state serum level–dose ratios

E. Yukawa, S. Higuchi, T. Maki, 2003, Journal of clinical pharmacy and therapeutics.

Population Pharmacokinetics of Haloperidol Using Routine Clinical Pharmacokinetic Data in Japanese Patients

E. Yukawa, S. Higuchi, S. Ohdo, 2002, Clinical pharmacokinetics.

Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in Japanese patients.

E. Yukawa, S. Higuchi, S. Ohdo, 2000, Journal of clinical psychopharmacology.

Influence of Additional Therapy with Zonisamide (Excegran) on Protein Binding and Metabolism of Carbamazepine

S. Higuchi, I. Ieiri, K. Ohtsubo, 1994, Epilepsia.

Warfarin-dosing algorithm based on a population pharmacokinetic/pharmacodynamic model combined with Bayesian forecasting.

Shun Higuchi, Hiroko Tabuchi, Ichiro Ieiri, 2009, Pharmacogenomics.

Phenobarbitone Population Pharmacokinetics from Routine Clinical Data: Role of Patient Characteristics for Estimating Dosing Regimens

E. Yukawa, S. Higuchi, T. Aoyama, 1992, The Journal of pharmacy and pharmacology.

Population analysis for the optimization of digoxin treatment in Japanese paediatric patients

E. Yukawa, S. Higuchi, M. Minemoto, 1999, Journal of Clinical Pharmacy and Therapeutics.

Polymorphism in human organic cation transporters and metformin action.

S. Higuchi, H. Takane, I. Ieiri, 2008, Pharmacogenomics.

24-Hour Oscillation of Mouse Methionine Aminopeptidase2, a Regulator of Tumor Progression, Is Regulated by Clock Gene Proteins

S. Higuchi, S. Ohdo, S. Koyanagi, 2004, Cancer Research.

Basis for dosing time-dependent changes in the antiviral activity of interferon-alpha in mice.

H. Aramaki, E. Yukawa, S. Higuchi, 2000, The Journal of pharmacology and experimental therapeutics.

Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms.

S. Higuchi, H. Takane, I. Ieiri, 2008, Current drug metabolism.

Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.

S. Higuchi, S. Ohdo, H. Takane, 2006, Endocrinology.

Pharmacokinetics of omeprazole (a substrate of CYP2C19) and comparison with two mutant alleles, C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4, in Japanese subjects.

S. Higuchi, I. Ieiri, A. Urae, 1996, Clinical pharmacology and therapeutics.

A CYP2D6 phenotype-genotype mismatch in Japanese psychiatric patients.

S. Higuchi, N. Tashiro, I. Ieiri, 2004, Pharmacopsychiatry.

Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice

S. Higuchi, S. Ohdo, H. To, 2005, Journal of Pharmacology and Experimental Therapeutics.

Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats

S. Higuchi, S. Ohdo, H. To, 2006, Behavioural Brain Research.

Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine.

S. Higuchi, S. Ohdo, Miyako Yoshida, 2006, Journal of pharmacological sciences.

Drug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein binding

S. Higuchi, I. Ieiri, K. Ohtsubo, 1995, Brain and Development.

Close Association between Clearance of Recombinant Human Granulocyte Colony-Stimulating Factor (G-CSF) and G-CSF Receptor on Neutrophils in Cancer Patients

S. Higuchi, S. Ohdo, M. Fukuda, 1999, Antimicrobial Agents and Chemotherapy.

Efficacy of emetic and United State pharmacopoeia ipecac syrup in prevention of drug absorption.

S. Higuchi, K. Otsubo, T. Aoyama, 1990, Chemical & pharmaceutical bulletin.

Statistical evaluation of clinical trial design for a population pharmacokinetic study--a case study.

S. Higuchi, H. Okamoto, S. Nakade, 2004, Drug metabolism and pharmacokinetics.

Effect of Haloperidol on mPer1 Gene Expression in Mouse Suprachiasmatic Nuclei*

J. Viyoch, S. Higuchi, S. Ohdo, 2005, Journal of Biological Chemistry.

Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans

H. Kusuhara, Y. Sugiyama, J. Ware, 2008, Clinical pharmacology and therapeutics.

Influence of age and comedication on steady‐state clonazepam serum level–dose ratios in Japanese epileptic patients

E. Yukawa, S. Higuchi, S. Ohdo, 2001, Journal of Clinical Pharmacy and Therapeutics.

Evaluation of single-point phenytoin dosage prediction methods in pediatric patients.

E. Yukawa, S. Higuchi, T. Aoyama, 1988, Journal of pharmacobio-dynamics.

Clinical management of boric acid ingestion: pharmacokinetic assessment of efficacy of hemodialysis for treatment of acute boric acid poisoning.

S. Higuchi, K. Futagami, J. Yoshitake, 1992, Journal of pharmacobio-dynamics.

Lithium Population Pharmacokinetics from Routine Clinical Data: Role of Patient Characteristics for Estimating Dosing Regimens

E. Yukawa, S. Higuchi, T. Aoyama, 1993, Therapeutic drug monitoring.

Association of polymorphisms in the cytochrome P450 (CYP) 2C19 and 2C18 genes in Japanese epileptic patients.

S. Higuchi, Y. Fukumaki, N. Tashiro, 1998, Pharmacogenetics.

Time‐dependent Nephrotoxicity Associated with Daily Administration of Cisplatin in Mice

A. Fujimura, S. Higuchi, H. To, 2000, The Journal of pharmacy and pharmacology.

Effects of Dosing Time and Schedule on Cisplatin‐Induced Nephrotoxicity in Rats

A. Fujimura, S. Higuchi, Y. Hakamata, 2000, The Journal of pharmacy and pharmacology.