S. Wigneshweraraj

发表

Nitrogen stress response and stringent response are coupled in Escherichia coli

Geraint Barton, Martin Buck, Sivaramesh Wigneshweraraj, 2014, Nature Communications.

Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC

S. Wigneshweraraj, E. James, A. Edwards, 2013, FEMS microbiology letters.

The Adaptive Response to Long-Term Nitrogen Starvation in Escherichia coli Requires the Breakdown of Allantoin

S. Wigneshweraraj, L. Burchell, Amy Switzer, 2020, bioRxiv.

The Adaptive Response to Long-Term Nitrogen Starvation in Escherichia coli Requires the Breakdown of Allantoin

S. Wigneshweraraj, L. Burchell, Amy Switzer, 2020, Journal of Bacteriology.

A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation.

L. D. de Carvalho, Daniel R Brown, S. Wigneshweraraj, 2018, Microbiology.

New insights into the adaptive transcriptional response to nitrogen starvation in Escherichia coli

Daniel R Brown, S. Wigneshweraraj, Amy Switzer, 2018, Biochemical Society transactions.

Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG

Sivaramesh Wigneshweraraj, Daniel R Brown, Zhensheng Pan, 2015, Scientific Reports.

Interplay between the β′ Clamp and the β′ Jaw Domains during DNA Opening by the Bacterial RNA Polymerase at σ54-dependent Promoters

K. Severinov, M. Buck, S. Wigneshweraraj, 2006 .

A second paradigm for gene activation in bacteria.

D. Bose, M. Buck, J. Schumacher, 2006, Biochemical Society transactions.

Communication between Eσ54, promoter DNA and the conserved threonine residue in the GAFTGA motif of the PspF σ54‐dependent activator during transcription activation

E. Morett, M. Buck, S. Wigneshweraraj, 2004, Molecular microbiology.

Regulated communication between the upstream face of RNA polymerase and the β′ subunit jaw domain

S. Nechaev, K. Severinov, N. Zenkin, 2004, The EMBO journal.

Nucleotide-dependent Triggering of RNA Polymerase-DNA Interactions by an AAA Regulator of Transcription*

M. Buck, S. Wigneshweraraj, W. Cannon, 2003, Journal of Biological Chemistry.

The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: Identifying a surface that binds σ54

M. Buck, J. Schumacher, S. Wigneshweraraj, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Mechanochemical ATPases and transcriptional activation

M. Buck, J. Schumacher, S. Wigneshweraraj, 2002, Molecular microbiology.

Correlating protein footprinting with mutational analysis in the bacterial transcription factor σ54 (σN)

M. Buck, S. Wigneshweraraj, P. Casaz, 2002 .

Regulatory sequences in sigma 54 localise near the start of DNA melting.

A. Ishihama, M. Buck, S. Wigneshweraraj, 2001, Journal of molecular biology.

Redox Regulation of the Quorum-sensing Transcription Factor AgrA by Coenzyme A

I. Gout, V. Filonenko, S. Wigneshweraraj, 2021, Antioxidants.

What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

S. Wigneshweraraj, A. Edwards, Kimberley L. Painter, 2014, Trends in microbiology.

Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein

M. Buck, S. Wigneshweraraj, N. Joly, 2007, Molecular microbiology.

Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility

S. Wigneshweraraj, A. Edwards, S. Peacock, 2018, Microbiology.

Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage

K. Severinov, S. Wigneshweraraj, Dhruti Savalia, 2013, Microbiology.

Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1

S. Darst, E. Campbell, Daniel R Brown, 2013, Proceedings of the National Academy of Sciences.

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids

Thomas B. Clarke, S. Wigneshweraraj, A. Edwards, 2016, Nature Microbiology.

Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes

Nicole C. Robb, A. Kapanidis, Kristofer Gryte, 2017, Nucleic acids research.

Sensor I Threonine of the AAA+ ATPase Transcriptional Activator PspF Is Involved in Coupling Nucleotide Triphosphate Hydrolysis to the Restructuring of σ54-RNA Polymerase*

M. Buck, J. Schumacher, S. Wigneshweraraj, 2007, Journal of Biological Chemistry.

The Agr Quorum-Sensing System Regulates Fibronectin Binding but Not Hemolysis in the Absence of a Functional Electron Transport Chain

S. Wigneshweraraj, E. James, A. Edwards, 2014, Infection and Immunity.

Interplay between the beta' clamp and the beta' jaw domains during DNA opening by the bacterial RNA polymerase at sigma54-dependent promoters.

K. Severinov, M. Buck, S. Wigneshweraraj, 2006, Journal of molecular biology.

Visualizing the organization and reorganization of transcription complexes for gene expression.

P. Stockley, D. Bose, M. Buck, 2008, Biochemical Society transactions.

The association between Hfq and RNase E in long‐term nitrogen‐starved Escherichia coli

S. Wigneshweraraj, A. J. Carpousis, Josh McQuail, 2021, Molecular microbiology.

The association between Hfq and RNase E in long-term nitrogen starved Escherichia coli

S. Wigneshweraraj, A. J. Carpousis, Josh McQuail, 2021, bioRxiv.

Structural Insights into the Activity of Enhancer-Binding Proteins

C. Robinson, M. Buck, J. Schumacher, 2005, Science.

Activity Map of the Escherichia coli RNA Polymerase Bridge Helix*

Simone C. Wiesler, D. Bose, R. Weinzierl, 2011, The Journal of Biological Chemistry.

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies

R. Tuma, P. Stockley, M. Buck, 2014, Nucleic acids research.

Low Resolution Structure of the ς54 Transcription Factor Revealed by X-ray Solution Scattering*

D. Svergun, M. Malfois, M. Koch, 2000, The Journal of Biological Chemistry.

Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation.

Emily F. Ruff, M. Record, I. Artsimovitch, 2012, Biochemistry.

Opening and Closing of the Bacterial RNA Polymerase Clamp

Shimon Weiss, Jennifer L. Knight, Rolf Jansen, 2012, Science.

Organization of an Activator-Bound RNA Polymerase Holoenzyme

T. Pape, D. Bose, M. Buck, 2008, Molecular cell.

Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2

Minhao Liu, E. Cota, K. Severinov, 2012, Molecular cell.

Reprint of: inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

Minhao Liu, E. Cota, K. Severinov, 2011, Journal of molecular biology.

Inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2.

Minhao Liu, E. Cota, K. Severinov, 2011, Journal of molecular biology.

Stable DNA Opening within Open Promoter Complexes Is Mediated by the RNA Polymerase β′-Jaw Domain*

K. Severinov, M. Buck, S. Wigneshweraraj, 2005, Journal of Biological Chemistry.

The second paradigm for activation of transcription.

R. Finn, M. Buck, J. Schumacher, 2005, Progress in nucleic acid research and molecular biology.

Reorganisation of an RNA polymerase–promoter DNA complex for DNA melting

Konstantin Severinov, Martin Buck, K. Severinov, 2004, The EMBO journal.

β subunit residues 186-433 and 436-445 are commonly used by Eσ54 and Eσ70 RNA polymerase for open promoter complex formation

S. Nechaev, K. Severinov, M. Buck, 2002 .

Conservation of sigma–core RNA polymerase proximity relationships between the enhancer‐independent and enhancer‐dependent sigma classes

N. Fujita, A. Ishihama, M. Buck, 2000, The EMBO journal.

The prevalence and implications of single nucleotide polymorphisms in genes encoding the RNA polymerase of clinical isolates of Staphylococcus aureus

S. Wigneshweraraj, S. Peacock, Bing Liu, 2020, MicrobiologyOpen.

Xenogeneic Regulation of the Bacterial Transcription Machinery.

K. Severinov, S. Wigneshweraraj, S. Matthews, 2019, Journal of molecular biology.

T7 phage factor required for managing RpoS in Escherichia coli

S. Wigneshweraraj, L. Burchell, Bing Liu, 2018, Proceedings of the National Academy of Sciences.

A T7 phage factor required for managing RpoS in Escherichia coli

S. Wigneshweraraj, L. Burchell, Bing Liu, 2018, bioRxiv.

The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism

S. Wigneshweraraj, L. Burchell, S. Matthews, 2016, Journal of molecular biology.

The sabotage of the bacterial transcription machinery by a small bacteriophage protein

K. Severinov, S. Wigneshweraraj, V. Mekler, 2014, Bacteriophage.

Modus operandi of the bacterial RNA polymerase containing the σ54 promoter‐specificity factor

Nicolas Joly, Konstantin Severinov, Mathieu Rappas, 2008, Molecular microbiology.

Protein-DNA interactions that govern AAA+ activator-dependent bacterial transcription initiation.

M. Buck, S. Wigneshweraraj, P. Burrows, 2008, Journal of molecular biology.

Mapping σ54-RNA Polymerase Interactions at the –24 Consensus Promoter Element*

A. Ishihama, K. Severinov, M. Buck, 2003, Journal of Biological Chemistry.

Multiple roles of the RNA polymerase beta subunit flap domain in sigma 54-dependent transcription.

K. Severinov, M. Buck, S. Wigneshweraraj, 2003, The Journal of biological chemistry.

Enhancer-Dependent Transcription by Bacterial RNA Polymerase: The β Subunit Downstream Lobe Is Used by σ54 During Open Promoter Complex Formation

Susan Jones, S. Nechaev, K. Severinov, 2003 .

Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein

K. Severinov, S. Wigneshweraraj, L. Burchell, 2017, Nucleic acids research.

Regulation of virulence gene expression

S. Wigneshweraraj, Mark Thomas, 2014, Virulence.

Sigma54-dependent transcription activator phage shock protein F of Escherichia coli: a fragmentation approach to identify sequences that contribute to self-association.

M. Buck, S. Wigneshweraraj, Xiaodong Zhang, 2004, The Biochemical journal.

Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action.

S. Elderkin, E. Morett, M. Buck, 2001, Genes & development.

A Role for the RNA Polymerase Gene Specificity Factor σ54 in the Uniform Colony Growth of Uropathogenic Escherichia coli

S. Wigneshweraraj, L. Burchell, Teresa L. M. Thurston, 2022, Journal of bacteriology.

The RNA polymerase gene specificity factor σ54 is required for homogeneous non-planktonic growth of uropathogenic Escherichia coli

S. Wigneshweraraj, L. Burchell, Amy Switzer, 2022, bioRxiv.

The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starved Escherichia coli

S. Wigneshweraraj, L. Burchell, Amy Switzer, 2020, The Journal of Biological Chemistry.

Sensing DNA opening in transcription using quenchable Förster resonance energy transfer.

Yusdi Santoso, Kristofer Gryte, Thorben Cordes, 2010, Biochemistry.

Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo

Mauricio Barahona, M. Stumpf, M. Bennett, 2013, mBio.

Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein

K. Turgay, S. Wigneshweraraj, L. Burchell, 2019, The Journal of Biological Chemistry.

A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism

S. Matthews, K. Severinov, G. Barton, 2013, RNA biology.

The Rsb Phosphoregulatory Network Controls Availability of the Primary Sigma Factor in Chlamydia trachomatis and Influences the Kinetics of Growth and Development

S. Wigneshweraraj, M. Mcclure, D. Fisher, 2015, PLoS pathogens.

Molecular insights into the control of transcription initiation at the Staphylococcus aureus agr operon.

S. Wigneshweraraj, J. Reynolds, 2011, Journal of molecular biology.

Mapping sigma 54-RNA polymerase interactions at the -24 consensus promoter element.

Akira Ishihama, Konstantin Severinov, Martin Buck, 2003, The Journal of biological chemistry.

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli

J. Pogliano, S. Wigneshweraraj, Christin Peters, 2017, bioRxiv.

The role of the conserved phenylalanine in the σ54-interacting GAFTGA motif of bacterial enhancer binding proteins

Nan Zhang, M. Buck, M. Jovanovic, 2009, Nucleic acids research.

Coupling sigma factor conformation to RNA polymerase reorganisation for DNA melting.

M. Buck, S. Wigneshweraraj, B. T. Nixon, 2009, Journal of molecular biology.

RNA Management During T7 Infection.

S. Wigneshweraraj, Aline Tabib-Salazar, 2022, PHAGE.

Molecular mechanism of transcription inhibition by phage T7 gp2 protein.

K. Severinov, S. Wigneshweraraj, V. Mekler, 2011, Journal of molecular biology.

T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

Minhao Liu, E. Cota, K. Severinov, 2010, Proceedings of the National Academy of Sciences.

Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised

K. Severinov, S. Wigneshweraraj, S. Matthews, 2012, Microbiology.

Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species

I. Gout, V. Filonenko, P. Setlow, 2020, FEMS microbiology letters.

Microsoft Word-fnaa174.docx

I. Gout, V. Filonenko, P. Setlow, 2020 .

Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.

A. Christoffels, S. Wigneshweraraj, R. Warren, 2017, Tuberculosis.

Mapping ATP-dependent Activation at a σ54 Promoter*

P. Stockley, M. Buck, S. Wigneshweraraj, 2006, Journal of Biological Chemistry.

Enhancing the antibacterial function of probiotic Escherichia coli Nissle: when less is more

S. Wigneshweraraj, P. Gabant, Emma Bartram, 2023, bioRxiv.

Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA

R. Weinzierl, S. Wigneshweraraj, E. James, 2014, Nucleic acids research.

Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.

Kaiming Zhang, S. Wigneshweraraj, Hang Yang, 2022, Cell Reports.

A Bacteriophage DNA Mimic Protein Employs a Non-specific Strategy to Inhibit the Bacterial RNA Polymerase

S. Wigneshweraraj, Bing Liu, Zhihao Wang, 2021, Frontiers in Microbiology.

A Role for the Conserved GAFTGA Motif of AAA+ Transcription Activators in Sensing Promoter DNA Conformation*

E. Morett, M. Buck, S. Wigneshweraraj, 2007, Journal of Biological Chemistry.

In vitro roles of invariant helix-turn-helix motif residue R383 in sigma(54) (sigma(N)).

A. Ishihama, M. Buck, S. Wigneshweraraj, 2001, Nucleic acids research.

Construction and functional analyses of a comprehensive σ54 site-directed mutant library using alanine–cysteine mutagenesis

R. Weinzierl, M. Buck, S. Wigneshweraraj, 2009, Nucleic acids research.

Interactions of regulated and deregulated forms of the sigma54 holoenzyme with heteroduplex promoter DNA.

Martin Buck, M. Buck, S. Wigneshweraraj, 2002, Nucleic acids research.

Reorganisation of an RNA polymerase–promoter DNA complex for DNA melting

S. Wigneshweraraj, P. Burrows, Martin Buck, 2004, The EMBO journal.

A bacteriophage transcription regulator inhibits bacterial transcription initiation by σ-factor displacement

K. Severinov, S. Wigneshweraraj, V. Mekler, 2014, Nucleic acids research.

Global Hfq-mediated RNA interactome of nitrogen starved Escherichia coli uncovers a conserved post-transcriptional regulatory axis required for optimal growth recovery

S. Wigneshweraraj, T. Bischler, P. Haberkant, 2023, Nucleic Acids Research.