T. Churchill

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Mesenchymal stem cell therapy inhibited inflammatory and profibrotic pathways induced by partial bladder outlet obstruction and prevented high-pressure urine storage.

B. Wiafe, A. Adesida, T. Churchill, 2019, Journal of pediatric urology.

Surface Expression of Toll-Like Receptor 9 Is Upregulated on Intestinal Epithelial Cells in Response to Pathogenic Bacterial DNA

F. Obermeier, T. Churchill, K. Madsen, 2007, Infection and Immunity.

Glutaraldehyde-Fixed Bioprosthetic Heart Valve Conduits Calcify and Fail From Xenograft Rejection

G. Korbutt, R. Rajotte, T. Churchill, 2006, Circulation.

IFN‐γ is an Absolute Requirement for Spontaneous Acceptance of Liver Allografts

N. Kneteman, P. Halloran, T. Churchill, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Hepatitis C virus replication in mice with chimeric human livers

D. Tyrrell, J. Lakey, N. Kneteman, 2001, Nature Medicine.

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.

T. Churchill, K. Madsen, L. Jewell, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Avoiding initial hypothermia does not improve liver graft quality in a porcine donation after circulatory death (DCD) model of normothermic perfusion

Sunita Ghosh, A. M. Shapiro, T. Churchill, 2019, PloS one.

Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

D. Tyrrell, N. Kneteman, D. Douglas, 2010 .

Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

D. Tyrrell, N. Kneteman, D. Douglas, 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Hatchling turtles survive freezing during winter hibernation.

K. Storey, T. Churchill, R. Brooks, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Intermediary Energy Metabolism during Dormancy and Anoxia in the Land Snail Otala lactea

K. Storey, T. Churchill, 1989, Physiological Zoology.

NOVEL APPROACHES TOWARD EARLY DIAGNOSIS OF ISLET ALLOGRAFT REJECTION1

J. Lakey, A. M. Shapiro, N. Kneteman, 2001, Transplantation.

Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis

T. Churchill, K. Madsen, J. Ewaschuk, 2007, Hepatology.

Reduction of Colitis by Prebiotics in HLA‐B27 Transgenic Rats Is Associated with Microflora Changes and Immunomodulation

H. Harmsen, T. Churchill, F. Hoentjen, 2005, Inflammatory bowel diseases.

Sirolimus drug-eluting, hydrogel-impregnated polypropylene mesh reduces intra-abdominal adhesion formation in a mouse model.

A M James Shapiro, A. M. Shapiro, T. Churchill, 2011, Surgery.

Creatine-loading preserves intestinal barrier function during organ preservation.

T. Churchill, K. Madsen, A. Thiesen, 2018, Cryobiology.

Redefining the properties of an osmotic agent in an intestinal-specific preservation solution.

T. Churchill, A. Thiesen, J. Carter, 2010, World journal of gastroenterology.

Comparing the effects of Dextran 70 and Hydroxyethyl starch in an intestinal storage solution.

T. Churchill, A. Thiesen, J. Carter, 2010, Cryobiology.

Optimizing the concentration of hydroxyethylstarch in a novel intestinal-specific preservation solution.

T. Churchill, A. Thiesen, J. Carter, 2010, Cryobiology.

T. Churchill, L. Jewell, Lin-Fu Zhu, 2005, Transplantation.

Human small bowel storage: the role for luminal preservation solutions

T. Churchill, K. Madsen, D. Bigam, 2003, Transplantation.

A NOVEL TECHNIQUE OF HYPOTHERMIC LUMINAL PERFUSION FOR SMALL BOWEL PRESERVATION

J. Lakey, T. Churchill, J. Avila, 2003, Transplantation.

Defining the Role of a Tailored Luminal Solution for Small Bowel Preservation

N. Kneteman, T. Churchill, K. Madsen, 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

POTENTIATING THE BENEFIT OF VASCULAR-SUPPLIED GLUTAMINE DURING SMALL BOWEL STORAGE: Importance of Buffering Agent1

N. Kneteman, T. Churchill, K. Madsen, 2002, Transplantation.

Energy metabolism following prolonged hepatic cold preservation: benefits of interrupted hypoxia on the adenine nucleotide pool in rat liver.

T. Churchill, B. Fuller, S. Mitchell, 1999, Cryobiology.

Investigation of a primary requirement of organ preservation solutions: supplemental buffering agents improve hepatic energy production during cold storage.

N. Kneteman, T. Churchill, 1998, Transplantation.

Protective properties of amino acids in liver preservation: effects of glycine and a combination of amino acids on anaerobic metabolism and energetics.

T. Churchill, C. Green, B. Fuller, 1995, Journal of hepatology.

Thigh Ultrasound Used to Identify Frail Elderly Patients with Sarcopenia Undergoing Surgery: A Pilot Study.

V. Baracos, T. Churchill, P. Tandon, 2020, The Journal of surgical research.

Analysis of postdischarge costs following emergent general surgery in elderly patients.

T. Churchill, F. Clement, Jenelle L Pederson, 2018, Canadian journal of surgery. Journal canadien de chirurgie.

Dehydration tolerance in wood frogs: a new perspective on development of amphibian freeze tolerance.

K. Storey, T. Churchill, Kenneth B. Storey, 1993, The American journal of physiology.

Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury

T. Churchill, K. Madsen, S. Salim, 2017, PloS one.

Decellularization reduces the immune response to aortic valve allografts in the rat.

R. Rajotte, T. Churchill, J. Lakey, 2005, The Journal of thoracic and cardiovascular surgery.

5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

T. Churchill, K. Madsen, H. Jijon, 2005, The Biochemical journal.

Human islet mass, morphology, and survival after cryopreservation using the Edmonton protocol

V. Mohan, R. Anjana, A. Shapiro, 2013, Islets.

Alleviating Intestinal Ischemia-Reperfusion Injury in an In Vivo Large Animal Model: Developing an Organ-Specific Preservation Solution

T. Churchill, K. Madsen, D. Bigam, 2008, Transplantation.

Urine intestinal fatty acid-binding protein predicts acute mesenteric ischemia in patients.

T. Churchill, S. Salim, P. Y. Young, 2017, The Journal of surgical research.

Intravenous Injection of Endogenous Microbial Components Abrogates DSS-Induced Colitis

T. Churchill, R. Fedorak, Beate C. Sydora, 2012, Digestive Diseases and Sciences.

Ameliorating Injury during Preservation and Isolation of Human Islets Using the Two-Layer Method with Perfluorocarbon and UW Solution

J. Lakey, A. M. Shapiro, T. Churchill, 2006, Cell transplantation.

Critical role of natural killer cells in the rejection of human hepatocytes after xenotransplantation into immunodeficient mice

D. Tyrrell, N. Kneteman, D. Douglas, 2010, Transplant international : official journal of the European Society for Organ Transplantation.

Improved Outcomes in Islet Isolation and Transplantation by the Use of a Novel Hemoglobin‐based O2 Carrier

L. Philipson, J. Lakey, T. Churchill, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

I-FABP as Biomarker for the Early Diagnosis of Acute Mesenteric Ischemia and Resultant Lung Injury

C. Streutker, Haibo Zhang, T. Churchill, 2014, PloS one.

Effect of preoperative long-term opioid therapy on patient outcomes after total knee arthroplasty: an analysis of multicentre population-based administrative data

C. A. Jones, D. Voaklander, L. Beaupre, 2021, Canadian journal of surgery. Journal canadien de chirurgie.

Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study

J. Holroyd-Leduc, T. Churchill, R. Padwal, 2018, Canadian Medical Association Journal.

Metabolomic Profiles Are Gender, Disease and Time Specific in the Interleukin-10 Gene-Deficient Mouse Model of Inflammatory Bowel Disease

C. Slupsky, T. Churchill, R. Fedorak, 2013, PloS one.

Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice.

T. Churchill, A. Borowiec, L. Guan, 2012, The Journal of surgical research.

Naturally Occurring Glycoalkaloids in Potatoes Aggravate Intestinal Inflammation in Two Mouse Models of Inflammatory Bowel Disease

T. Churchill, R. Fedorak, J. Meddings, 2010, Digestive Diseases and Sciences.

Glycogen phosphorylase activity during the cold storage of liver: A limiting effect on glycolytic flux and energy production.

T. Churchill, B. Fuller, 1996, Transplantation.

Intraosseous infusion into the skull: potential application for the management of hydrocephalus.

T. Churchill, J. Pugh, K. Aronyk, 2007, Journal of neurosurgery.

Comparison of aortic valve allograft decellularization techniques in the rat.

T. Churchill, J. Lakey, D. Ross, 2006, Journal of biomedical materials research. Part A.

Incidence and predictors of postoperative delirium in the older acute care surgery population: a prospective study

T. Churchill, Diana Rucker, L. Warkentin, 2019, Canadian journal of surgery. Journal canadien de chirurgie.

Hypoxia-increased expression of genes involved in inflammation, dedifferentiation, pro-fibrosis, and extracellular matrix remodeling of human bladder smooth muscle cells

B. Wiafe, A. Adesida, T. Churchill, 2016, In Vitro Cellular & Developmental Biology - Animal.

Short-Term Storage of the Ischemically Damaged Human Pancreas by the Two-Layer Method Prior to Islet Isolation

A. Shapiro, J. Lakey, T. Churchill, 2004, Cell transplantation.

Improvement of Pancreatic Islet Isolation Outcomes Using Glutamine Perfusion during Isolation Procedure

J. Lakey, A. M. Shapiro, T. Churchill, 2003, Cell transplantation.

expedited article Inhibition of poly(ADP-ribose) polymerase attenuates inﬂammation in a model of chronic colitis

T. Churchill, K. Madsen, L. Jewell, 2000 .

Preserving the mucosal barrier during small bowel storage1

J. Lakey, T. Churchill, J. Avila, 2003, Transplantation.

Mesenchymal stem cells inhibit hypoxia-induced inflammatory and fibrotic pathways in bladder smooth muscle cells

B. Wiafe, A. Adesida, T. Churchill, 2018, World Journal of Urology.

Epithelial barrier disruption allows nondisease‐causing bacteria to initiate and sustain IBD in the IL‐10 gene‐deficient mouse

T. Churchill, R. Fedorak, Beate C. Sydora, 2007, Inflammatory bowel diseases.

The influence of short-term fasting on the quality of small bowel graft preservation.

T. Churchill, P. Salehi, 2005, Cryobiology.

Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets.

G. Korbutt, T. Churchill, H. Idikio, 2008, European journal of pharmacology.

The Importance of Impermeant Support in Small Bowel Preservation: A Morphologic, Metabolic and Functional study

N. Kneteman, T. Churchill, K. Madsen, 2001, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Human cytomegalovirus infection in humanized liver chimeric mice

A. Humar, N. Kneteman, D. Douglas, 2013, Hepatology research : the official journal of the Japan Society of Hepatology.

Beneficial effects of supplemental buffer and substrate on energy metabolism during small bowel storage.

T. Churchill, J. Spratlin, P. Salehi, 2004, Cryobiology.

An underlying mechanism for improved liver preservation with a combined histidine-lactobionate-raffinose flush solution

T. Churchill, B. Davidson, C. Green, 1995, Transplant international : official journal of the European Society for Organ Transplantation.

Restoration of hepatic metabolism by cold reperfusion.

T. Churchill, B. Fuller, S. Mitchell, 1995, Biochemical Society Transactions.

Organ-Specific Solutions and Strategies for the Intestinal Preservation

T. Churchill, M. Oltean, 2014, International reviews of immunology.

An underlying mechanism for improved liver preservation with a combined histidine‐lactobionate‐raffinose flush solution

T. Churchill, B. Davidson, C. Green, 1995 .

Effects of different cold preservation solutions on restoration of hepatic energy metabolism during cold reperfusion.

T. Churchill, B. Fuller, S. Mitchell, 1996, Cryobiology.

The role of protein kinase A in anaerobic energy production during liver storage.

N. Kneteman, T. Churchill, D. Mercer, 2000, Journal of hepatology.

Metabolic adaptations of a lower vertebrate to long-term hypothermic hypoxia provide clues to successful clinical liver preservation.

N. Kneteman, T. Churchill, C. Fedorow, 1998, Cryobiology.

Glycolysis and energy metabolism in rat liver during warm and cold ischemia: evidence of an activation of the regulatory enzyme phosphofructokinase.

T. Churchill, B. Fuller, K. Cheetham, 1994, Cryobiology.

Liver metabolism in cold hypoxia: a comparison of energy metabolism and glycolysis in cold-sensitive and cold-resistant mammals

T. Churchill, C. Green, B. Fuller, 1994, Journal of Comparative Physiology B.

Acidosis and lipopolysaccharide from Escherichia coli B:055 cause hyperpermeability of rumen and colon tissues.

T. Churchill, K. Madsen, S. M. Dunn, 2007, Journal of dairy science.

Freeze tolerance in hermit flower beetle (Osmoderma eremicola) larvae

K. Storey, D. Joanisse, T. Churchill, 1993 .

Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion.

T. Churchill, K. Madsen, M. Kulka, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Metabolic effects of dehydration on an aquatic frog, Rana pipiens.

K. Storey, T. Churchill, Kenneth B. Storey, 1995, The Journal of experimental biology.

Responses to freezing exposure of hatchling turtles Trachemys scripta elegans: factors influencing the development of freeze tolerance by reptiles.

K. Storey, T. Churchill, 1992, The Journal of experimental biology.

Natural freezing survival by painted turtles Chrysemys picta marginata and C. picta bellii.

K. Storey, T. Churchill, 1992, The American journal of physiology.

Metabolic responses to freezing by organs of hatchling painted turtles Chrysemys picta marginata and C.p. bellii

K. Storey, T. Churchill, 1991 .

Freezing Survival and Metabolism of Box Turtles

K. Storey, T. Churchill, J. M. Storey, 1993 .

Freezing and anoxia tolerance of slugs: a metabolic perspective

K. Storey, T. Churchill, J. M. Storey, 2007, Journal of Comparative Physiology B.

Freezing Survival and Metabolism of Box Turtles, Terrapene carolina

K. Storey, T. Churchill, J. M. Storey, 1993 .

Metabolic effects of cold storage on livers from euthermic and hibernating Columbian ground squirrels.

S. Williams, T. Churchill, A. Busza, 1996, Cryobiology.

Evidence for a Monophyletic Gobiinae

T. Churchill, J. Passonneau, S. Brooks, 1993 .

Metabolic consequences of rapid cycles of temperature change for freeze-avoiding vs freeze-tolerant insects

K. Storey, T. Churchill, 1989 .

Effects of hypothermic hypoxia on anaerobic energy metabolism in isolated anuran livers

N. Kneteman, T. Churchill, C. Fedorow, 1998, Journal of Comparative Physiology B.

Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches.

T. Churchill, D. Ross, L. Mcgann, 2011, The Journal of thoracic and cardiovascular surgery.

RESUSCITATION WITH 21% OR 100% OXYGEN IS EQUALLY EFFECTIVE IN RESTORING PERFUSION AND OXYGEN METABOLISM IN THE LIVER OF HYPOXIC NEWBORN PIGLETS

T. Churchill, D. Bigam, P. Cheung, 2007, Shock.

Preoperative opioid use is associated with worse patient outcomes after Total joint arthroplasty: a systematic review and meta-analysis

C. A. Jones, D. Voaklander, L. Beaupre, 2019, BMC Musculoskeletal Disorders.

Pharmacokinetic Characterization of Intravenous Cyclosporine Treatment for Cardioprotection During Resuscitation of Asphyxiated Newborn Piglets

R. Gill, D. Brocks, T. Churchill, 2013, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Alleviating Ischemia‐Reperfusion Injury in Small Bowel

J. Lakey, T. Churchill, K. Madsen, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Ameliorating Small Bowel Injury Using a Cavitary Two‐Layer Preservation Method with Perfluorocarbon and a Nutrient‐Rich Solution

J. Lakey, T. Churchill, K. Madsen, 2004 .

Intestinal decontamination using povidone-iodine compromises small bowel storage quality

T. Churchill, K. Madsen, D. Bigam, 2003, Transplantation.

Cyclosporine treatment improves mesenteric perfusion and attenuates necrotizing enterocolitis (NEC)-like intestinal injury in asphyxiated newborn piglets during reoxygenation

R. Gill, T. Churchill, W. Cho, 2012, Intensive Care Medicine.

Proton nuclear magnetic resonance spectroscopy of lactate production in isolated rat liver during cold preservation.

S. Williams, T. Churchill, A. Busza, 1996, Cryobiology.

Metabolic responses to freezing and anoxia by the periwinkle Littorina littorea

Kenneth B. Storey, K. Storey, T. Churchill, 1996 .

cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation

T. Churchill, K. Madsen, A. Thiesen, 2010, PloS one.

Cyclosporine treatment improves cardiac function and systemic hemodynamics during resuscitation in a newborn piglet model of asphyxia: A dose–response study

R. Gill, T. Churchill, W. Cho, 2012, Critical care medicine.

Metabolic responses to anoxia and freezing by the freeze tolerant marine mussel Geukensia demissus

K. Storey, T. Churchill, 1995 .

Relationship between energetic stress and pro-apoptotic/cytoprotective kinase mechanisms in intestinal preservation.

T. Churchill, B. Christensen, K. Madsen, 2007, Surgery.

The importance of calcium-related effects on energetics at hypothermia: effects of membrane-channel antagonists on energy metabolism of rat liver.

T. Churchill, C. Green, B. Fuller, 1995, Cryobiology.

A Metabolic Mechanism for the Detrimental Effect of Exogenous Glucose During Cardiac Storage

N. Kneteman, T. Churchill, Jay Z. J. Zhu, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Conservation of phosphorylation state of cardiac phosphofructokinase during in vitro hypothermic hypoxia.

N. Kneteman, T. Churchill, B. M. Wu, 2000, American journal of physiology. Heart and circulatory physiology.

VSL#3 probiotics provide protection against acute intestinal ischaemia/reperfusion injury.

T. Churchill, K. Madsen, B. Sis, 2013, Beneficial microbes.

Metabolic correlates to glycerol biosynthesis in a freeze-avoiding insect,Epiblema scudderiana

K. Storey, T. Churchill, 1989, Journal of Comparative Physiology B.

Organ Metabolism and Cryoprotectant Synthesis during Freezing in Spring Peepers Pseudacris crucifer

K. Storey, T. Churchill, 1996 .

Oncostatin M Plays a Critical Role in Survival after Acute Intestinal Ischemia: Reperfusion Injury.

T. Mueller, T. Churchill, B. Sis, 2020, Surgical infections.

Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD

T. Churchill, R. Fedorak, Beate C. Sydora, 2010, Digestive Diseases and Sciences.

Freezing survival of the garter snake Thamnophis sirtalis parietalis

K. Storey, T. Churchill, 1992 .

Resuscitation of the ischemically damaged human pancreas by the two-layer method prior to islet isolation.

J. Lakey, A. M. Shapiro, T. Churchill, 2003, Transplantation proceedings.

Metabolic responses to dehydration by liver of the wood frog, Rana sylvatica

K. Storey, T. Churchill, 1994 .

Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine

T. Churchill, D. Bigam, M. Vento, 2012, Pediatric Research.

Control of oxidative stress in small bowel: relevance to organ preservation.

T. Churchill, K. Madsen, P. Salehi, 2006, Surgery.

Ameliorating small bowel injury using a cavitary two-layer preservation method with perfluorocarbon and a nutrient-rich solution.

J. Lakey, T. Churchill, K. Madsen, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Oncostatin M Receptor Type II Knockout Mitigates Inflammation and Improves Survival from Sepsis in Mice

T. Mueller, T. Churchill, S. Salim, 2023, Biomedicines.

Effects of dehydration on organ metabolism in the frogPseudacris crucifer: hyperglycemic responses to dehydration mimic freezing-induced cryoprotectant production

K. Storey, T. Churchill, 2004, Journal of Comparative Physiology B.

A comparison of combination dopamine and epinephrine treatment with high-dose dopamine alone in asphyxiated newborn piglets after resuscitation

T. Churchill, D. Bigam, P. Cheung, 2013, Pediatric Research.