Y. Lao

发表

Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway

Dongsheng Cao, Jingqing Yang, Xi-sha Chen, 2018, Acta Pharmacologica Sinica.

Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage

F. Murad, Y. Lao, Hong-Xi Xu, 2015, Mediators of inflammation.

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

Wei Xu, W. Xie, Yaou Zhang, 2014, Autophagy.

DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells.

Yaou Zhang, N. Xu, Y. Lao, 2015, Biochemical and biophysical research communications.

The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2

N. Xu, Y. Lao, Hongxi Xu, 2019, Cell Death & Disease.

The natural compound from Garcinia bracteata mainly induces GSDME-mediated pyroptosis in esophageal cancer cells.

Y. Lao, H. Xu, Man Wu, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Hypersubones A and B, new polycyclic acylphloroglucinols with intriguing adamantane type cores from Hypericum subsessile.

Y. Lao, Xiao-nian Li, Hong-Xi Xu, 2015, Organic letters.

The natural compound neobractatin inhibits cell proliferation mainly by regulating the RNA binding protein CELF6.

Y. Lao, Hongxi Xu, Wen-wei Fu, 2022, Food & function.

Autophagy in Cancer Chemoprevention: Identification of Novel Autophagy Modulators with Anticancer Potential.

N. Xu, Y. Lao, 2016, Methods in molecular biology.

Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue

Y. Lao, Shuang-yue Li, Q. Ding, 2018, EBioMedicine.

Screening of the active fractions from the Coreopsis tinctoria Nutt. Flower on diabetic endothelial protection and determination of the underlying mechanism.

Y. Lao, Hong Zhang, Hongxi Xu, 2020, Journal of ethnopharmacology.

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

Y. Lao, Han-Ming Shen, Liming Wang, 2020, Acta Pharmacologica Sinica.

Development of a lytic peptide derived from BH3-only proteins

D. Wang, Q. Liu, Y. Lao, 2016, Cell Death Discovery.

Two new lignans from Gymnotheca chinensis Decne

Y. Lao, Hong-Xi Xu, L. Ding, 2014 .

Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways

Y. Lao, Hongxi Xu, C. Liang, 2018, Cell Death & Disease.

A nucleic acid biosensor for gene expression analysis in nanograms of mRNA.

H. Xie, Zhiqiang Gao, Y. Yu, 2004, Analytical chemistry.

Genetically encoded fluorescence screening probe for MgrA, a global regulator in Staphylococcus aureus

Y. Lao, Qingzhou Zhang, Hong Zhang, 2015 .

Interactions between traditional chinese medicine and anticancer drugs in chemotherapy

Y. Lao, Danqing Xu, Hongxi Xu, 2017 .

Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death.

N. Xu, Y. Lao, Hongxi Xu, 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

Yuanzhi Lao, Yaou Zhang, D. Gillespie, 2012, Journal of oncology.

Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of α-hemolysin.

Y. Lao, Hong-Xi Xu, Hong Zhang, 2019, Pharmacological research.

Identification and Characterization of Anticancer Compounds Targeting Apoptosis and Autophagy from Chinese Native Garcinia Species

Peng Cao, Yuanzhi Lao, Danqing Xu, 2014, Planta Medica.

The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro

Y. Lao, Cheng Guo, Danqing Xu, 2020, Frontiers in Pharmacology.

Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury

Y. Lao, Hong Zhang, Jinling Yang, 2020, Frontiers in Pharmacology.

Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STAT/JAK Signaling Pathway

Y. Lao, Yingjia Zhang, Yanhui Zhao, 2015, BioMed research international.

Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells

Ling Yang, Y. Lao, P. Cao, 2015, Molecules.

Bioassay-guided isolation of prenylated xanthones and polycyclic acylphloroglucinols from the leaves of Garcinia nujiangensis.

Y. Lao, Shi-lin Chen, Hong-Xi Xu, 2012, Journal of Natural Products.

Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.

Ling Yang, Y. Lao, Hong-Xi Xu, 2014, Journal of natural products.

Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies.

Yuanzhi Lao, N. Xu, Y. Lao, 2014, Journal of ethnopharmacology.

Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro

Y. Lao, Hui Li, Hong-Xi Xu, 2016, Acta Pharmacologica Sinica.

UPLC-PDA-QTOFMS-guided isolation of prenylated xanthones and benzoylphloroglucinols from the leaves of Garcinia oblongifolia and their migration-inhibitory activity

Y. Lao, Hong-Xi Xu, Hong Zhang, 2016, Scientific Reports.

Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus

Y. Lao, H. Qin, Ping K. Ruan, 2013, Virology Journal.

The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation

Y. Lao, Hong Zhang, H. Tan, 2015, BMC Cancer.

Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus

Y. Lao, H. Qin, Ping K. Ruan, 2013, Virology Journal.

Mobilization of Ca2+ from endoplasmic reticulum to mitochondria plays a positive role in the early stage of UV- or TNFalpha-induced apoptosis.

D. Chang, Y. Lao, 2008, Biochemical and biophysical research communications.

Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway

Dongsheng Cao, Xi-sha Chen, Yi-di Guan, 2018, Acta Pharmacologica Sinica.

MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability

L. Liu, W. Xie, Yaou Zhang, 2017, Oncogene.

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway

Wei Xu, W. Xie, Yaou Zhang, 2014, Autophagy.

Prenylated benzoylphloroglucinols and biphenyl derivatives from the leaves of Garcinia multiflora Champ

Y. Lao, Liping Wang, H. Tan, 2015 .

Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins

Menghong Sun, N. Xu, Y. Lao, 2015, Scientific Reports.

The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2

N. Xu, Y. Lao, Man Wu, 2019, Cell Death & Disease.

Calcium and Apoptosis

D. Chang, Y. Lao, J. Guo, 2009 .

Calcium signaling in apoptotic mammalian cells

Y. Lao, 2008 .

MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis

Xuan Luo, W. Xie, Yaou Zhang, 2016, Oncotarget.

In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum

Chengjie Sun, Feng Yin, Zigang Li, 2018, Theranostics.

Study of the functional role of Bcl-2 family proteins in regulating Ca(2+) signals in apoptotic cells.

D. Chang, Y. Lao, 2007, Biochemical Society transactions.

Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation

Y. Lao, J. Holst, Hongxi Xu, 2016, Cell Death and Disease.

Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth

N. Xu, Y. Lao, Qianjun Zhou, 2018, Cell Death & Disease.

Garciyunnanimines A–C, novel cytotoxic polycyclic polyprenylated acylphloroglucinol imines from Garcinia yunnanensis

Y. Lao, Lianbo Xiao, Danqing Xu, 2017 .

Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.

Y. Lao, Liping Wang, Rong Wu, 2016, Bioorganic & medicinal chemistry.

Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways

Y. Lao, Hong Zhang, Jing Wang, 2019, Acta Pharmacologica Sinica.

Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways

Y. Lao, C. Liang, H. Tan, 2018, Cell Death & Disease.

Nujiangexathone A, a novel compound from Garcinia nujiangensis, suppresses cervical cancer growth by targeting hnRNPK.

Y. Lao, H. Tan, Man Wu, 2016, Cancer letters.

The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α

N. Xu, Y. Lao, Man Wu, 2019, Front. Oncol..

Bis(7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels

Y. Pang, Wenming Li, Yifan Han, 2006, Journal of neurochemistry.

Crosslinked Aspartic Acids as Helix-Nucleating Templates.

F. Jiang, H Zhao, Yundong Wu, 2016, Angewandte Chemie.

Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica.

Y. Lao, Hong-Xi Xu, Rong Wu, 2019, Organic letters.

SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC

Y. Lao, Hua Zhou, Man Wu, 2019, Front. Oncol..

p32, a novel binding partner of Mcl-1, positively regulates mitochondrial Ca(2+) uptake and apoptosis.

D. Chang, Y. Lao, K. Xiao, 2014, Biochemical and biophysical research communications.

Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi

Y. Lao, Hong-Xi Xu, H. Tan, 2018, Tetrahedron Letters.

Nujiangexathone A, a Novel Compound Derived from Garcinia nujiangensis, Induces Caspase-Dependent Apoptosis in Cervical Cancer through the ROS/JNK Pathway

Y. Lao, Hong-Xi Xu, H. Tan, 2016, Molecules.

Autophagy Regulators in Cancer

Y. Lao, Yan-Fang Xian, Man Wu, 2023, International journal of molecular sciences.

Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi

Y. Lao, Hong-Xi Xu, Gang Xu, 2020, Natural Products and Bioprospecting.

Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.

Hua Yu, Y. Pang, Wenming Li, 2007, Journal of proteome research.

Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth

N. Xu, Y. Lao, Qianjun Zhou, 2018, Cell Death & Disease.

In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell

Chengjie Sun, Feng Yin, Zigang Li, 2017, Theranostics.

Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death.

N. Xu, Y. Lao, Zhixiu Lin, 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Breast cancer susceptibility gene mRNAs quantified by microarrays with electrochemical detection.

Yuan Hong Yu, H. Xie, Zhiqiang Gao, 2004, Clinical chemistry.

Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation

Y. Lao, Han-Ming Shen, Guang Lu, 2018, Acta Pharmacologica Sinica.