J. Sysol

发表

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.

J. Garcia, R. Machado, M. Bonini, 2015, American journal of physiology. Lung cellular and molecular physiology.

Classification and pathophysiology of pulmonary hypertension

R. Machado, J. Sysol, R. Machado, 2018, Continuing Cardiology Education.

Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models

Ashutosh Kumar Singh, S. Setty, R. Machado, 2018, Translational research : the journal of laboratory and clinical medicine.

Regulation of Cell Signaling Pathways PDGF induces SphK 1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation

R. Machado, V. Natarajan, J. Sysol, 2016 .

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension

R. Dweik, D. Valdez-Jasso, S. Ye, 2017, Circulation.

Loss of lung WWOX expression causes neutrophilic inflammation.

R. Machado, Jiwang Chen, J. Sysol, 2017, American journal of physiology. Lung cellular and molecular physiology.

Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death

R. Machado, Jiwang Chen, J. Sysol, 2017, American journal of respiratory cell and molecular biology.

The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.

J. Garcia, R. Machado, J. Yuan, 2014, American journal of respiratory and critical care medicine.

Sickle Cell Disease and Acute Chest Syndrome: Epidemiology, Diagnosis, Management, Outcomes

R. Machado, J. Sysol, 2016, Hematologic Abnormalities and Acute Lung Syndromes.

Cortactin Loss Protects Against Hemin-Induced Acute Lung Injury in Sickle Cell Disease.

G. Sandusky, S. Dudek, V. Natarajan, 2022, American journal of physiology. Lung cellular and molecular physiology.

smooth muscle cells endothelin-A receptor expression in lung artery Fibroblast growth factor mediates hypoxia-induced

S. Oparil, S. Wedgwood, M. Bonini, 2015 .

Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia

S. Dimauro, A. Elkahloun, P. Houillier, 2013, Proceedings of the National Academy of Sciences.

Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling

D. Valdez-Jasso, Ming Tang, V. Natarajan, 2022, International journal of molecular sciences.

Gene therapy in a murine model of Methylmalonic Acidemia (MMA) using rAAV9 mediated gene delivery

R. Chandler, C. Venditti, J. Sysol, 2011, Gene Therapy.

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.

S. Comhair, V. Natarajan, Jiwang Chen, 2018, American journal of physiology. Lung cellular and molecular physiology.

Exome sequencing identifies ACSF3 as the cause of Combined Malonic and Methylmalonic Aciduria

Leslie G. Biesecker, Marjan Huizing, William L. Nyhan, 2011, Nature genetics.

Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease

Amit R. Patel, R. Lang, R. Machado, 2016, PloS one.

FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.

S. Dimauro, A. Elkahloun, D. Kleiner, 2018, JCI insight.

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

S. Kasif, Manway Liu, M. Patti, 2016, Molecular metabolism.

PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation.

R. Machado, V. Natarajan, J. Sysol, 2016, American journal of physiology. Cell physiology.

Overexpression of miR-1 in human PASMCs inhibits basal and hypoxia-induced proliferation

S. Comhair, R. Machado, V. Natarajan, 2017 .

Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation

C. Venditti, I. Manoli, J. Sysol, 2024, JCI insight.