M. Geng

发表

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

Cheng Luo, Bairong Shen, Zhongjie Liang, 2015, Scientific Reports.

Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.

Youhong Hu, M. Geng, Dong Lu, 2017, ACS medicinal chemistry letters.

Molecularly targeted cancer therapy: some lessons from the past decade.

Min Huang, Jian Ding, M. Geng, 2014, Trends in pharmacological sciences.

Emerging cancer therapeutic opportunities target DNA-repair systems.

Ling-hua Meng, Z. Miao, Jian Ding, 2006, Trends in pharmacological sciences.

Determination of the accessibility of acidic oligosaccharide sugar chain to blood-brain barrier using surface plasmon resonance.

M. Geng, Meiyu Geng, Li Gan, 2006, Biological & pharmaceutical bulletin.

One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates.

Wei Huang, Yang Yang, Min Huang, 2016, Organic & biomolecular chemistry.

D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting topoisomerase IIα

Qin Chen, Min Huang, Jian Ding, 2011, Investigational New Drugs.

Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.

M. Geng, Yingxia Li, Hongchun Liu, 2013, European journal of medicinal chemistry.

Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.

Jian Ding, Lin-jiang Tong, M. Geng, 2008, Journal of medicinal chemistry.

Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities.

Sheng Yao, M. Geng, C. Ke, 2022, Journal of agricultural and food chemistry.

Correction to "Discovery and Optimization of 4,5-Diarylisoxazoles as Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and Heat Shock Protein 90".

Min Huang, M. Geng, M. Huang, 2014, Journal of medicinal chemistry.

Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.

Min Huang, M. Geng, Jing-kang Shen, 2014, Journal of medicinal chemistry.

Modified Release and Improved Stability of Unstable BCS II Drug by Using Cyclodextrin Complex as Carrier To Remotely Load Drug into Niosomes.

M. Geng, Hongchun Liu, Min-min Zhang, 2016, Molecular pharmaceutics.

Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis.

Youhong Hu, M. Geng, Dong Lu, 2015, European journal of medicinal chemistry.

Sulfated polymannuroguluronate, a novel anti‐acquired immune deficiency syndrome drug candidate, blocks neuroinflammatory signalling by targeting the transactivator of transcription (Tat) protein

M. Geng, W. Xia, Limei Wang, 2006, Journal of neurochemistry.

Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China

Zhenqing Zhang, M. Geng, Y. Weng, 2021, Journal of pharmaceutical analysis.

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.

Hong Liu, M. Zheng, M. Geng, 2017, Journal of medicinal chemistry.

CTC clusters induced by heparanase enhance breast cancer metastasis

Jian Ding, M. Geng, Han Yang, 2018, Acta Pharmacologica Sinica.

Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis.

Yi Chen, Haiying Liu, Jian Ding, 2006, Cancer research.

FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2015, Oncoscience.

FS-93 , an Hsp 90 inhibitor , induces G 2 / M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2015 .

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaymé reaction and their Hsp90 inhibitory activity.

J. Li, Min Yang, M. Geng, 2015, Organic & biomolecular chemistry.

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Yechun Xu, Min Huang, M. Geng, 2014, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.

M. Geng, Ruimin Huang, L. Xing, 2018, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold.

Wei Zhang, M. Geng, Yingxia Li, 2016, Bioorganic & medicinal chemistry letters.

Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.

M. Geng, Jian-Ping Lin, Yong Wang, 2013, Organic & biomolecular chemistry.

Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors.

Youhong Hu, M. Geng, Dong Lu, 2016, European journal of medicinal chemistry.

Discovery of novel type II c-Met inhibitors based on BMS-777607.

Wei Zhang, M. Geng, Yingxia Li, 2014, European journal of medicinal chemistry.

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression

Zhuqing Zhang, M. Geng, Juan Yan, 2018, Acta Pharmacologica Sinica.

Identification of AOSC-binding proteins in neurons

Ming Liu, M. Geng, X. Xin, 2008 .

Sulfated Polymannuroguluronate, a Novel Anti-AIDS Drug Candidate, Inhibits T Cell Apoptosis by Combating Oxidative Damage of Mitochondria

Xueyan Fu, B. Miao, M. Geng, 2005, Molecular Pharmacology.

Discovery of 4-chloro-3-(5-(pyridin-3-yl)-1,2,4-oxadiazole-3-yl)benzamides as novel RET kinase inhibitors.

Youhong Hu, M. Geng, R. Sheng, 2016, Bioorganic & medicinal chemistry letters.

Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors

Jian Ding, Lin-jiang Tong, M. Geng, 2011, Acta Pharmacologica Sinica.

Structure-based Discovery of a Series of NSD2-PWWP1 Inhibitor

M. Geng, Jian Li, B. Xiong, 2021 .

N-acetylglucosaminyltransferase V Modifies TrKA Protein, Regulates the Receptor Function

M. Geng, Jing Li, Xiaoyun Yang, 2008, Cellular and Molecular Neurobiology.

Oligomannurarate sulfate, a novel antimitotic agent, exerts anti-cancer activity by binding to tubulin on novel site

Xueyan Fu, B. Miao, M. Geng, 2010, Cancer biology & therapy.

A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia

Wei Chen, Kewei Chen, Y. Guan, 2020, Alzheimer's research & therapy.

An In Vitro Study of the Structure-Activity Relationships of Sulfated Polysaccharide from Brown Algae to its Antioxidant Effect

M. Geng, Jinfeng Hu, Jun Tian Zhang, 2001, Journal of Asian natural products research.

Sulfated polymannuroguluronate inhibits Tat-induced SLK cell adhesion via a novel binding site, a KKR spatial triad

M. Geng, Yan-lin Wu, B. Xiong, 2011, Acta Pharmacologica Sinica.

Sanofi-Cell Research outstanding paper award of 2017

Min Huang, Jian Ding, M. Geng, 2018, Cell Research.

p53 β-hydroxybutyrylation attenuates p53 activity

W. Gu, Yingming Zhao, T. Tong, 2019, Cell Death & Disease.

EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells

Min Huang, Jian Ding, M. Geng, 2019, Acta Pharmacologica Sinica.

Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models

Yi Chen, Jian Ding, M. Geng, 2019, Journal of Experimental & Clinical Cancer Research.

MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

Yi Chen, Hong Zhu, Z. Miao, 2007, Molecular Cancer Therapeutics.

Immunogenic comparison of two coupling methods of marine polysaccharide to bovine serum albumin.

Jian Ding, M. Geng, X. Xin, 2004, Biological & pharmaceutical bulletin.

Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.

Bing Zhou, Yan Zhang, M. Geng, 2022, European journal of medicinal chemistry.

G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin

Yi Chen, Jian Ding, M. Geng, 2017, Nature Communications.

Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold.

M. Geng, Hongchun Liu, Ai-jun Shen, 2022, European journal of medicinal chemistry.

Effects of vitamin B6 and its related compounds on survival of cultured brain neurons

H. Saito, M. Geng, H. Katsuki, 1995, Neuroscience Research.

Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.

M. Geng, Hongchun Liu, Min-min Zhang, 2018, European journal of medicinal chemistry.

Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors.

M. Geng, Hongchun Liu, Min-min Zhang, 2017, European journal of medicinal chemistry.

Ectopic Expression of a Combination of 5 Genes Detects High Risk Forms of Adult T-cell Acute Lymphoblastic Leukemia

Yuan-fang Liu, M. Geng, Florent Chuffart, 2021 .

T-cell receptor (TCR)/CD3 is involved in sulfated polymannuroguluronate (SPMG)-induced T lymphocyte activation.

Xueyan Fu, B. Miao, Jian Ding, 2005, International immunopharmacology.

Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation

M. Geng, Zuoquan Xie, Yiping Zou, 2022, Cancer science.

A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis

Jian Ding, Jian-Ping Zuo, M. Geng, 2021, Acta Pharmacologica Sinica.

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

M. Huang, Min Huang, M. Geng, 2019, European journal of medicinal chemistry.

Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction between Kinase Insert Domain-Containing Receptor (KDR) and αvβ3 Integrin via Binding to the Extracellular Domain of KDR

Jian Ding, M. Geng, Li-ping Lin, 2007, Molecular Pharmacology.

Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction between KDR and αvβ3 Integrin via Binding to the Extracellular Domain of KDR

Jian Ding, M. Geng, Li-ping Lin, 2007 .

Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis

M. Geng, Zuoquan Xie, Xingkun Chu, 2022, Kidney Diseases.

A new marine-derived sulfated polysaccharide from brown alga suppresses tumor metastasis both in vitro and in vivo

M. Geng, X. Xin, Jing Li, 2006, Cancer Biology & Therapy.

Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

Ying Zhang, M. Geng, Hong Yang, 2022, European journal of medicinal chemistry.

Inhibitory effect of heparin-derived oligosaccharides on secretion of interleukin-4 and interleukin-5 from human peripheral blood T lymphocytes.

M. Geng, H. Guan, Y. Chi, 2004, World journal of gastroenterology.

SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

Yi Chen, Ling-hua Meng, Jian Ding, 2021, Acta Pharmacologica Sinica.

HER2/PD1 bispecific antibody in IgG4 subclass with superior anti‐tumour activities

M. Geng, N. Xia, Wen-xin Luo, 2022, Clinical and translational medicine.

Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats

Jingwei Tian, M. Geng, Wang-lin Jiang, 2005, Neuroscience Letters.

R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II

M. Huang, Min Huang, Yi Chen, 2007, Molecular Cancer Therapeutics.

GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms

Jian Ding, Lin-jiang Tong, M. Geng, 2009, Acta Pharmacologica Sinica.

Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents

Min Huang, Jian Ding, Junyan Lu, 2015, Oncotarget.

Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability.

M. Geng, Xin Qi, Jing Li, 2011, Glycobiology.

Penibruguieramine A, a novel pyrrolizidine alkaloid from the endophytic fungus Penicillium sp. GD6 associated with Chinese mangrove Bruguiera gymnorrhiza.

Bo-ping Ye, M. Geng, A. Mándi, 2014, Organic letters.

Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.

Zhuqing Zhang, M. Geng, B. Xiong, 2021, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy.

M. Huang, Min Huang, Yi Chen, 2018, European journal of medicinal chemistry.

Synthesis and evaluation of novel non-covalent binding quinazoline glycoside derivatives targeting the L858R and T790M variants of EGFR

M. Geng, Renshuai Zhang, Tao Jiang, 2016 .

The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc

Qin Chen, Jian Ding, Lin-jiang Tong, 2011, Journal of Molecular Medicine.

Cell surface sialic acid inhibits Cx43 gap junction functions in constructed Hela cancer cells involving in sialylated N-cadherin

M. Geng, Hong-chun Liu, Li-juan Wang, 2010, Molecular and Cellular Biochemistry.

Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells.

M. Geng, Xin Qi, X. Xin, 2007, Biochemical pharmacology.

MS80, a novel sulfated polysaccharide, inhibits CD40-NF-κB pathway via targeting RIP2

M. Geng, Hongchun Liu, X. Xin, 2010, Molecular and Cellular Biochemistry.

Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

Yi Chen, Jian Ding, Lin-jiang Tong, 2018, Acta Pharmacologica Sinica.

Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells

Yuan-ming Luo, K. Fan, M. Geng, 2012, The Journal of Antibiotics.

Synthesis and antitumor activity of 10-arylcamptothecin derivatives.

M. Geng, Hongchun Liu, Yu Jiao, 2011, Bioorganic & medicinal chemistry letters.

Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay.

Kaixian Chen, Hualiang Jiang, Hong Liu, 2012, Organic & biomolecular chemistry.

Antitumor pharmacological research in the era of personalized medicine

Min Huang, M. Geng, Jianqin Ding, 2022, Acta Pharmacologica Sinica.

Effects of dermatan sulfate derivatives on platelet surface P-selectin expression and protein C activity in blood of inflammatory bowel disease patients.

M. Geng, H. Guan, Y. Chi, 2004, World journal of gastroenterology.

Sulfated polymannuroguluronate, a novel anti‐acquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus tat protein through attenuating calcium overload

M. Geng, Bin Hui, Jing Li, 2008, Journal of neuroscience research.

Novel Conjugates of Aspirin with Phenolic Acid as Anti‐inflammatory Agents Having Significantly Reduced Gastrointestinal Toxicity

Wei Zhang, Shan Jiang, M. Geng, 2010, Archiv der Pharmazie.

Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes.

B. Miao, Jian Ding, Huashi Guan, 2004, Biochemical pharmacology.

LncRNA MEG3 inhibits the growth, invasion and migration of Wilms' tumor via Wnt/β-catenin pathway.

M. Geng, Y. Wang, G. Teng, 2020, European review for medical and pharmacological sciences.

Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.

Yi Chen, M. Geng, Gang Liu, 2011, Journal of medicinal chemistry.

Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.

Hualiang Jiang, Hong Liu, Zhongjie Liang, 2012, Bioorganic & medicinal chemistry.

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.

M. Geng, Gang Liu, Yuanxiang Wang, 2011, Organic & biomolecular chemistry.

Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors.

Min Huang, Yi Chen, Jian Ding, 2017, Bioorganic & medicinal chemistry letters.

Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3

Shi-feng Yun, M. Geng, T. Fang, 2018, Acta Pharmacologica Sinica.

Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity

Min Huang, Jian Ding, M. Geng, 2017, Oncogene.

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Jian Ding, M. Geng, Tao Wang, 2019, Cell Research.

Alzheimer’s disease hypothesis and related therapies

M. Geng, Xiaoguang Du, Xinyi Wang, 2018, Translational Neurodegeneration.

The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent Fibroblast Growth Factor Receptor (FGFR) Inhibitors by Rational Drug Design.

Hualiang Jiang, Yechun Xu, Hong Liu, 2019, Journal of medicinal chemistry.

Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase.

Youhong Hu, M. Geng, Dong Lu, 2016, European journal of medicinal chemistry.

Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C.

Shujuan Yu, M. Geng, G. Liang, 2018, Organic & biomolecular chemistry.

Penibruguieramine A, a novel pyrrolizidine alkaloid from the endophytic fungus Penicillium sp. GD6 associated with Chinese mangrove Bruguiera gymnorrhiza.

Bo-ping Ye, M. Geng, A. Mándi, 2014, Organic letters.

Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.

C. Luo, M. Geng, Bin Zhao, 2016, ACS medicinal chemistry letters.

Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors.

Yechun Xu, M. Geng, Qiu-feng Liu, 2012, Bioorganic & medicinal chemistry letters.

Design and Synthesis of a Series of Novel Bisquinazoline Glycosides as Epidermal Growth Factor Receptor Inhibitors

M. Geng, Junlei Wang, Tao Jiang, 2011, Chemical biology & drug design.

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.

Yi Chen, M. Geng, Yuanxiang Wang, 2011, Bioorganic & medicinal chemistry.

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor.

Yechun Xu, M. Geng, Qiu-feng Liu, 2016, European journal of medicinal chemistry.

Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors.

M. Geng, Hongchun Liu, Yin-chun Ji, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.

Cheng Luo, Ying Wang, Zhongjie Liang, 2013, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Ke Ding, Zhang Zhang, Yong Xu, 2012, Journal of medicinal chemistry.

Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

Jian Ding, M. Geng, B. Xiong, 2015, Journal of medicinal chemistry.

Dicarabrones A and B, a pair of new epimers dimerized from sesquiterpene lactones via a [3 + 2] cycloaddition from Carpesium abrotanoides.

M. Geng, Chunping Tang, Y. Ye, 2015, Organic letters.

Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors.

F. Nan, M. Geng, Lin-qian Yu, 2014, Organic & biomolecular chemistry.

Two New Citrinin Dimers from a Volcano Ash‐Derived Fungus, Penicillium citrinum HGY1‐5

M. Geng, T. Zhu, L. Du, 2010 .

Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor.

M. Geng, T. Zhu, Dehai Li, 2014, The Journal of organic chemistry.

Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation.

M. Geng, Yin-chun Ji, Zilan Song, 2018, European journal of medicinal chemistry.

Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.

C. Luo, M. Geng, Fanwang Meng, 2016, Journal of medicinal chemistry.

Sesquiterpenes and dimeric sesquiterpenoids from Sarcandra glabra.

M. Geng, J. Yue, Xiu-Feng He, 2010, Journal of natural products.

Pseudolarix Acid B, a New Tubulin-Binding Agent, Inhibits Angiogenesis by Interacting with a Novel Binding Site on Tubulin

Jian Ding, Lin-jiang Tong, M. Geng, 2006, Molecular Pharmacology.

A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines

Wei Zhang, S. Ley, M. Geng, 2015 .

AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR

Yi Chen, Jian Ding, Lin-jiang Tong, 2012, Journal of cellular and molecular medicine.

Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.

Yi Chen, M. Geng, Yin-chun Ji, 2014, ACS medicinal chemistry letters.

Aspergiolides C and D: spirocyclic aromatic polyketides with potent protein kinase c-Met inhibitory effects.

G. Bringmann, M. Geng, Ying Wang, 2011, Chemistry.

Sesquiterpenes from Dysoxylum oliganthum and Dysoxylum excelsum

M. Geng, J. Yue, S. Dong, 2012, Journal of Asian natural products research.

Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

M. Geng, Ai-jun Shen, Hui Zhang, 2015, Acta pharmaceutica Sinica. B.

Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.

Jian Ding, M. Geng, J. Yue, 2012, Journal of medicinal chemistry.

Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.

S. Zhang, M. Geng, J. Yue, 2010, Journal of natural products.

Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.

M. Geng, J. Yue, Hua-dong Chen, 2010, Organic letters.

Trigochilides A and B, two highly modified daphnane-type diterpenoids from Trigonostemon chinensis.

M. Geng, J. Yue, Hua-dong Chen, 2009, Organic letters.

Trigochilides A and B, two highly modified daphnane-type diterpenoids from Trigonostemon chinensis.

M. Geng, J. Yue, Hua-dong Chen, 2009, Organic letters.

Cytotoxic sesquiterpenoids from Sarcandra glabra

M. Geng, J. Yue, Gang Ni, 2013 .

Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma

Min Huang, Yi Chen, Jian Ding, 2017, Hepatology.

Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase IIα inhibitor.

Wei-Chang Fu, M. Geng, T. Zhu, 2011, Journal of medicinal chemistry.

Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation

Min Huang, Jian Ding, M. Geng, 2017, Cell Research.

Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor.

M. Geng, T. Zhu, Dehai Li, 2014, The Journal of organic chemistry.

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Min Huang, C. Luo, M. Geng, 2017, Journal of medicinal chemistry.

Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.

Hualiang Jiang, Hong Liu, M. Zheng, 2013, ACS medicinal chemistry letters.

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Zhuqing Zhang, Jian Ding, M. Geng, 2019, Journal of medicinal chemistry.

Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models

Yi Chen, Jian Ding, M. Geng, 2019, Journal of experimental & clinical cancer research : CR.

The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors

Yi Chen, Jian Ding, M. Geng, 2018, Molecular Cancer Therapeutics.

c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors

Min Huang, Yi Chen, Jian Ding, 2016, Clinical Cancer Research.

Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.

Yu Zhang, Chen Yan, Haiyang Liu, 2014, Bioorganic & medicinal chemistry letters.

Oligomannurarate sulfate blocks tumor growth by inhibiting NF-κB activation

Yi Chen, Jian Ding, M. Geng, 2010, Acta Pharmacologica Sinica.

Multiple and multivalent interactions of novel anti-AIDS drug candidates, sulfated polymannuronate (SPMG)-derived oligosaccharides, with gp120 and their anti-HIV activities.

Jing Li, Haiying Liu, Zhenqing Zhang, 2005, Glycobiology.

Potentiation of T cell function by a marine algae-derived sulfated polymannuroguluronate: in vitro analysis of novel mechanisms.

Jing Li, Wei Xia, Jian Ding, 2005, Journal of pharmacological sciences.

Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF‐κB via targeting of Mre11

Yi Chen, Jian Ding, M. Geng, 2012, International journal of cancer.

Targeting sphingosine-1-phosphate signaling for cancer therapy

Hong Liu, M. Geng, Hong Liu, 2017, Science China Life Sciences.

Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.

Jian Ding, M. Geng, Hongchun Liu, 2016, Journal of medicinal chemistry.

A novel long non-coding RNA-ARA: adriamycin resistance-associated.

M. Geng, Hongchun Liu, Ai-jun Shen, 2014, Biochemical pharmacology.

Luminal Breast Cancer Cell Lines Overexpressing ZNF703 Are Resistant to Tamoxifen through Activation of Akt/mTOR Signaling

M. Geng, K. Shen, Zuoquan Xie, 2013, PloS one.

Immunocytochemical localization of secretory component in Paneth cell secretory granules-rat Paneth cells participate in acquired immunity

C. Jiang, M. Geng, Kai-Zhong Tao, 2005, Journal of Molecular Histology.

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Min Huang, M. Geng, Feifei Liu, 2018, Acta pharmaceutica Sinica. B.

Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors

Dong-mei Zhao, M. Geng, B. Xiong, 2016, Acta Pharmacologica Sinica.

Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

Min Huang, Jian Ding, M. Geng, 2018, Bioorganic & Medicinal Chemistry Letters.

Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

Min Huang, Jian Ding, M. Geng, 2017, Bioorganic & medicinal chemistry letters.

Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9

M. Geng, Hongchun Liu, Ai-jun Shen, 2013, Molecules.

Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases.

Jian Ding, M. Geng, Zilan Song, 2015, Journal of medicinal chemistry.

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

Min Huang, Yi Chen, Jian Ding, 2018, Cell.

JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin

Min Huang, Yi Chen, Jian Ding, 2014, Oncotarget.

Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition.

Min Huang, Jian Ding, M. Geng, 2017, Cancer letters.

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo

K. Yu, Yi Chen, Jian Ding, 2023, Journal of Cancer.

Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

Jian Ding, M. Geng, B. Xiong, 2016, Acta Pharmacologica Sinica.

SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo.

Min Huang, Jian Ding, M. Geng, 2014, Cancer letters.

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Min Huang, Jian Ding, Hanlin Zeng, 2019, Nature Communications.

SOMG-833, a Novel Selective c-MET Inhibitor, Blocks c-MET–Dependent Neoplastic Effects and Exerts Antitumor Activity

Min Huang, Yi Chen, Jian Ding, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold.

M. Geng, Yin-chun Ji, Qizheng Yao, 2015, Bioorganic & medicinal chemistry.

Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.

Min Huang, M. Geng, Hong Liu, 2019, Journal of medicinal chemistry.

Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study

M. Geng, B. Xiong, Jing-kang Shen, 2018, Acta pharmaceutica Sinica. B.

Undecylprodigiosin Induced Apoptosis in P388 Cancer Cells Is Associated with Its Binding to Ribosome

Ping Liu, M. Geng, Q. Gu, 2013, PloS one.

Featured Article: Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells

M. Geng, Hongchun Liu, Q. Zhi, 2015, Experimental biology and medicine.

Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration

M. Geng, Yu-Chih Liu, Min-min Zhang, 2017, Acta Pharmacologica Sinica.

c-Myc alterations confer therapeutic response and acquired resistance to c-Met inhibitors in MET-addicted cancers.

Min Huang, Yi Chen, Jian Ding, 2015, Cancer research.

Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer.

Min Huang, Yi Chen, Jian Ding, 2016, Cancer cell.

Lactate Dehydrogenase B Is Associated with the Response to Neoadjuvant Chemotherapy in Oral Squamous Cell Carcinoma

Min Huang, M. Geng, Wenyi Sun, 2015, PloS one.

Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro

Yi Chen, Jian Ding, M. Geng, 2013, Acta Pharmacologica Sinica.

Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Zhuqing Zhang, Jian Ding, M. Geng, 2018, Cancer letters.

An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core.

M. Geng, Yin-chun Ji, L. Xing, 2016, European journal of medicinal chemistry.

Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: design, synthesis, and structure-activity relationship study.

Jian Ding, M. Geng, L. Xing, 2015, European journal of medicinal chemistry.

Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.

Jian Ding, M. Geng, Yin-chun Ji, 2014, European journal of medicinal chemistry.

Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors.

Xutong Li, M. Geng, Hong Liu, 2023, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Hualiang Jiang, Hong Liu, M. Zheng, 2020, Acta pharmaceutica Sinica. B.

Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity.

Yechun Xu, M. Geng, Qiu-feng Liu, 2014, ACS medicinal chemistry letters.

Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors.

Youhong Hu, M. Geng, Dong Lu, 2017, European journal of medicinal chemistry.

A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

Li-Jun Jiang, M. Cantillon, Wei Chen, 2021, Alzheimer's research & therapy.

A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

Li-Jun Jiang, M. Cantillon, Wei Chen, 2020, Alzheimer's Research & Therapy.

C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant

Lei-Ping Yu, Jian Ding, Lin-jiang Tong, 2015 .

A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma

Jian Ding, M. Geng, Hongchun Liu, 2018, Theranostics.

Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

M. Geng, B. Xiong, Jing-kang Shen, 2020, Acta Pharmacologica Sinica.

CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression

Zhuqing Zhang, M. Geng, Juan Yan, 2018, Acta Pharmacologica Sinica.

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells

Min Huang, Jian Ding, M. Geng, 2017, The Journal of cell biology.

Effects of the novel vascular targeting agent MDS-11P on tumor vascularity and its antitumor activity.

M. Geng, Xin Qi, Peng Wang, 2011, Biochemical pharmacology.

Role of cell surface oligosaccharides of mouse mammary tumor cell lines in cancer metastasis.

Y. Xing, M. Geng, Jing Li, 2007, Indian journal of biochemistry & biophysics.

The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of β-1,6-GlcNAc branching on HUVEC conformation

M. Geng, Jing Li, Yun-li Peng, 2010, Molecular and Cellular Biochemistry.

N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway

Y. Xing, M. Geng, X. Xin, 2008, Molecular and Cellular Biochemistry.

Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration

Min Huang, M. Geng, Hongwei Li, 2017, Journal of Cancer.

Identification and Therapeutic Intervention of Co-activated ALK , FGFR 2 and EphA 5 Kinases in Hepatocellular Carcinoma

Jian Ding, M. Geng, Hongchun Liu, 2018 .

The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma

Min Huang, Yi Chen, H. Xu, 2011, Journal of the National Cancer Institute.

Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation.

M. Geng, Yin-chun Ji, W. Duan, 2021, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.

Zhuqing Zhang, M. Geng, Hong Yang, 2019, European journal of medicinal chemistry.

Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage.

M. Geng, L. Xing, Bo Liu, 2021, Journal of medicinal chemistry.

Studies of marine sulfated polymannuroguluronate on endothelial cell proliferation and endothelial immunity and related mechanisms.

Jing Li, Huashi Guan, Jian Ding, 2003, Journal of pharmacological sciences.

AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo

Yang Yang, Mingyue Zheng, Hua Xie, 2011, PloS one.

Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients

M. Geng, He-ming Wu, Zuoquan Xie, 2014, PloS one.

Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket

Bing Xiong, Jian Ding, M. Geng, 2006, Molecular Pharmacology.

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.

Weiliang Zhu, Hualiang Jiang, Hong Liu, 2013, Bioorganic & medicinal chemistry letters.

Primary study of structure-activity relationship of transport of marine-derived sugar chains across blood-brain barrier by 3-phenylphenol colorimetry

M. Geng, Xiu-li Guo, Qin Nie, 2004 .

Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core.

M. Geng, Yin-chun Ji, L. Xing, 2016, Bioorganic & medicinal chemistry letters.

Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease

M. Geng, Qin Nie, Xiao-guang Du, 2011, Acta Pharmacologica Sinica.

SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

Ling-hua Meng, Jian Ding, M. Geng, 2021, Acta Pharmacologica Sinica.

Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms

Jian Ding, M. Geng, X. Xin, 2005, Neuroscience Letters.

Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase

M. Zheng, Min Huang, Jian Ding, 2017, Clinical Cancer Research.

Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type‐A Receptor 5 Kinases in Hepatocellular Carcinoma

Jian Ding, M. Geng, Hongchun Liu, 2018, Hepatology.

Structure−Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists

M. Geng, Jing Ma, Zuoquan Xie, 2022, European Journal of Medicinal Chemistry.

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors.

Jingwei Shao, M. Geng, Chen Wang, 2016, Bioorganic & medicinal chemistry letters.

Glucose transporter 1, distribution in the brain and in neural disorders: its relationship with transport of neuroactive drugs through the blood-brain barrier.

M. Geng, Xiu-li Guo, G. Du, 2005, Biochemical genetics.

PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.

Q. Zhan, Jian Ding, M. Geng, 2019, Cancer letters.

p53 β-hydroxybutyrylation attenuates p53 activity

W. Gu, Yingming Zhao, T. Tong, 2019, Cell Death & Disease.

Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer

Yi Chen, Jian Ding, M. Geng, 2017, Theranostics.

Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer

Yi Chen, Jian Ding, M. Geng, 2017, Acta Pharmacologica Sinica.

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Huibin Zhang, Jinpei Zhou, Xuekui Yu, 2022, Cell discovery.

Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration

M. Geng, Yu-Chih Liu, Hongchun Liu, 2017, Acta Pharmacologica Sinica.

Exploiting histone deacetylases for cancer therapy: from hematological malignancies to solid tumors

Min Huang, M. Geng, 2016, Science China Life Sciences.

Sesquiterpene lactones from Inula cappa

Sheng Yao, M. Geng, Chunping Tang, 2012 .

WITHDRAWN: Acidic oligosaccharide sugar chain (AOSC) transport through the blood–brain barrier in glucose transporter 1 (GLUT-1)-dependent pathway

M. Geng, W. Xia, Xiu-li Guo, 2006 .

Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein.

Jing Li, Jian Ding, M. Geng, 2004, Journal of pharmacological sciences.

Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

Cheng Luo, Min Huang, Zhongjie Liang, 2012, PloS one.

Expression of Polymeric Immunoglobulin Receptor mRNA and Protein in Human Paneth Cells: Paneth Cells Participate in Acquired Immunity

C. Jiang, M. Geng, Li-mei Wang, 2006, The American Journal of Gastroenterology.

LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo

Kai Yu, Yi Chen, Jian Ding, 2021, Cancer science.

Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis.

Yu Zhou, Min Huang, M. Geng, 2022, Journal of medicinal chemistry.

Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity.

O. Zetterqvist, M. Geng, Jin-ping Li, 2005, Biochemical and biophysical research communications.

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors.

Jian Li, Tongchao Liu, M. Geng, 2021, Journal of medicinal chemistry.

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

Bingbing Sun, Yu Jiang, M. Geng, 2023, Research.

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities

Jian Ding, M. Geng, Wei-ren Liu, 2016, Oncotarget.

Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.

M. Geng, Y. Long, Yingming Yao, 2015, Bioorganic & medicinal chemistry letters.

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification.

Hualiang Jiang, Zhixiang Wu, Min Huang, 2015, Cancer research.

The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo

Jingui Ma, Linjiang Tong, Jian Ding, 2008, PloS one.

Effects of Ginkgo Biloba Extract EGb761 on Human Colon Adenocarcinoma Cells

Yan-tao Han, M. Geng, Y. Miao, 2011, Cellular Physiology and Biochemistry.

Measures of bioavailable serum sex hormone levels in aging Chinese by protein chip

M. Geng, G. Du, Juntian Zhang, 2006, Science in China Series C.

Development and validation of LC-MS/MS method for quantitation of sodium oligomannate in human plasma, urine and feces.

Zhenqing Zhang, M. Geng, Xing Yang, 2023, Bioanalysis.

neoplastic effects and exerts antitumor activity

Yi Chen, Jian Ding, M. Geng, 2014 .

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

Min Huang, Jian Ding, Hanlin Zeng, 2019, Nature Communications.

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.

Yechun Xu, M. Geng, Jian Li, 2014, Bioorganic & medicinal chemistry letters.

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Yi Chen, Jian Ding, M. Geng, 2015, Oncotarget.

O‐Linked Triazolotriazines: Potent and Selective c‐Met Inhibitors

Zhongjie Liang, C. Luo, M. Geng, 2012, ChemMedChem.

Discovery of 3H‐Imidazo[4,5‐b]pyridines as Potent c‐Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation

Yi Chen, M. Geng, B. Xiong, 2012, ChemMedChem.

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

M. Geng, Xuchao Zhang, Zuoquan Xie, 2023, Signal transduction and targeted therapy.

Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models

Yi Chen, Jian Ding, M. Geng, 2017, Molecular Cancer Therapeutics.

Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition

Yi Chen, M. Geng, Zhaobing Gao, 2012 .

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.

China's reform of the regulatory system for medical products and its impact

M. Geng, Hualiang Jiang, Ruiling Song, 2019, National science review.

Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors.

Yu Zhou, Min Huang, M. Geng, 2021, Journal of medicinal chemistry.

Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma.

M. Geng, B. Xiong, Yuchen Jiang, 2019, European journal of medicinal chemistry.

Yhhu3813 is a novel selective inhibitor of c-Met Kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells

Min Huang, Yi Chen, Jian Ding, 2013, Acta Pharmacologica Sinica.

Targeting sphingosine-1-phosphate signaling for cancer therapy

Hong Liu, M. Geng, Zuoquan Xie, 2017, Science China Life Sciences.

O-GlcNAcylation of Cofilin Promotes Breast Cancer Cell Invasion*

Min Huang, Jian Ding, M. Geng, 2013, The Journal of Biological Chemistry.

A Triad of Lys12, Lys41, Arg78 Spatial Domain, a Novel Identified Heparin Binding Site on Tat Protein, Facilitates Tat-Driven Cell Adhesion

Hualiang Jiang, M. Zheng, M. Geng, 2008, PloS one.

α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells

Jian Ding, M. Geng, J. Qian, 2009, Acta Pharmacologica Sinica.

CTC clusters induced by heparanase enhance breast cancer metastasis

Jian Ding, M. Geng, Xun Huang, 2018, Acta Pharmacologica Sinica.

Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides.

Wei Zhang, M. Geng, Gaopeng Song, 2010, Bioorganic & medicinal chemistry.

SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors

Jian Ding, Yan-fen Fang, M. Geng, 2020, Acta pharmacologica Sinica.

SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors

Jian Ding, Yan-fen Fang, M. Geng, 2020, Acta Pharmacologica Sinica.

Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth

M. Geng, Zhiai Xu, Liufu Deng, 2023, Chemical science.

Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists.

M. Geng, Zuoquan Xie, Han Li, 2021, Journal of medicinal chemistry.

Acidic oligosaccharide sugar chain, a marine-derived oligosaccharide, activates human glial cell line-derived neurotrophic factor signaling

M. Geng, Limei Wang, Xue-hong Chen, 2007, Neuroscience Letters.

A marine-derived acidic oligosaccharide sugar chain specifically inhibits neuronal cell injury mediated by β-amyloid-induced astrocyte activation in vitro

M. Geng, W. Xia, Jing Li, 2007, Neurological Research.

Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.

Qingsong Liu, Jian Ding, Lin-jiang Tong, 2018, Journal of medicinal chemistry.

Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.

Kaixian Chen, Hualiang Jiang, Hong Liu, 2011, Bioorganic & medicinal chemistry letters.

Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

Yi Chen, Jian Ding, Lin-jiang Tong, 2018, Acta Pharmacologica Sinica.

Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease

M. Geng, Ding-yu Hu, Xin Wang, 2013, Acta Pharmacologica Sinica.

5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.

M. Geng, Hong Liu, Chunpu Li, 2021, European journal of medicinal chemistry.

Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

Min Huang, Jian Ding, M. Geng, 2017, Front. Pharmacol..

Protective effect of ifenprodil against glucose deprivation-induced damage in cultured rat hippocampal neurons.

N. Nishiyama, H. Saito, M. Geng, 1997, Japanese journal of pharmacology.

Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

Wei Zhang, M. Geng, Yin-chun Ji, 2014, Molecules.

DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

Yi Chen, Jian Ding, Lin-jiang Tong, 2016, Acta Pharmacologica Sinica.

Characterization of conformational epitope of alginate-derived polymannuronates by surface plasmon resonance.

Jing Li, Jian Ding, M. Geng, 2005, Biochimie.

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

M. Geng, W. Duan, Jun Fan, 2018, Journal of medicinal chemistry.

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.

Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors.

Jian Ding, M. Geng, Hua Xie, 2020, European journal of medicinal chemistry.

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors

Tongchao Liu, M. Geng, B. Xiong, 2022, Journal of Medicinal Chemistry.

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities

Jian Ding, M. Geng, Yin-chun Ji, 2016, Oncotarget.

Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells

Qin Chen, Haiying Liu, Jian Ding, 2009, Acta Pharmacologica Sinica.

Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors.

X. Chen, Hong Liu, M. Geng, 2015, ACS medicinal chemistry letters.

Alzheimer’s disease hypothesis and related therapies

M. Geng, Xiaoguang Du, Xinyi Wang, 2018, Translational Neurodegeneration.

Causal communication between gut microbiota dysbiosis and neuroinflammation in Alzheimer’s disease and therapeutic intervention by oligomannate

M. Geng, 2020, Alzheimer's & Dementia.

Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2).

Min Huang, Jian Ding, M. Geng, 2016, Bioorganic & medicinal chemistry letters.

Molecularly targeted cancer therapy: some lessons from the past decade.

Min Huang, Jian Ding, M. Geng, 2014, Trends in pharmacological sciences.

Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors

M. Geng, B. Xiong, Dongmei Zhao, 2016, Molecules.

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

M. Geng, B. Xiong, Hongchun Liu, 2016, Acta pharmaceutica Sinica. B.

Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia

Yuan-fang Liu, M. Geng, Florent Chuffart, 2022, BMC Genomics.

Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase

M. Zheng, Min Huang, Jian Ding, 2017, Clinical Cancer Research.

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.

M. Geng, Gang Liu, Yuanxiang Wang, 2011, Organic & biomolecular chemistry.

The effects of thiamine and oxythiamine on the survival of cultured brain neurons.

H. Saito, M. Geng, H. Katsuki, 1995, Japanese Journal of Pharmacology.

Effects of Ginkgo Biloba Extract EGb761 on Human Colon Adenocarcinoma Cells

Yan-tao Han, M. Geng, Y. Miao, 2011, Cellular Physiology and Biochemistry.

Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3

Shi-feng Yun, M. Geng, T. Fang, 2018, Acta Pharmacologica Sinica.

Sesquiterpenes and dimeric sesquiterpenoids from Sarcandra glabra.

M. Geng, J. Yue, Xiu-Feng He, 2010, Journal of natural products.

c-Myc alterations confer therapeutic response and acquired resistance to c-Met inhibitors in MET-addicted cancers.

Min Huang, Yi Chen, Jian Ding, 2015, Cancer research.

Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations

Bing Xiong, Xin Wang, Jing Ai, 2013, Acta Pharmacologica Sinica.

Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.

M. Geng, Hongchun Liu, Qingchao Liu, 2013, European journal of medicinal chemistry.

Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.

Kaixian Chen, Hualiang Jiang, Hong Liu, 2011, Bioorganic & medicinal chemistry letters.

ASK120067 (limertinib) exerts pre-clinical anti-tumor activity by inhibiting EGFR exon20 insertion

Yi Chen, Jian Ding, Lin-jiang Tong, 2022, Frontiers in Drug Discovery.

Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.

Wei Zhang, M. Geng, S. Ren, 2015, Organic & biomolecular chemistry.

Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.

Jian Ding, M. Geng, Hongchun Liu, 2016, Journal of medicinal chemistry.

Geng et al. reply

Jian Ding, M. Geng, Tao Wang, 2020, Cell Research.