E. Mackow

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Role of vascular and lymphatic endothelial cells in hantavirus pulmonary syndrome suggests targeted therapeutic approaches.

E. Mackow, E. Gorbunova, Nadine A. Dalrymple, 2013, Lymphatic research and biology.

Antigenicity, immunogenicity and passive protection induced by immunization of mice with baculovirus-expressed VP7 protein from rhesus rotavirus.

H. Greenberg, E. Mackow, F. Ruggeri, 1995, The Journal of general virology.

The rhesus rotavirus outer capsid protein VP4 functions as a hemagglutinin and is antigenically conserved when expressed by a baculovirus recombinant

H. Greenberg, E. Mackow, J. Barnett, 1989, Journal of virology.

Discrete Domains within the Rotavirus VP5* Direct Peripheral Membrane Association and Membrane Permeability

E. Mackow, E. Gorbunova, N. E. Golantsova, 2004, Journal of Virology.

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

E. Mackow, Megan C. Mladinich, Jonas N. Conde, 2021, mBio.

Zika Virus Persistently Infects and Is Basolaterally Released from Primary Human Brain Microvascular Endothelial Cells

J. Schwedes, E. Mackow, Megan C. Mladinich, 2017, mBio.

Pathogenic Hantaviruses Direct the Adherence of Quiescent Platelets to Infected Endothelial Cells

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2010, Journal of Virology.

Correlation between RNA synthesis and ppGpp content in Escherichia coli during temperature shifts

E. Mackow, F. Chang, 2004, Molecular and General Genetics MGG.

Virus interactions with endothelial cell receptors: implications for viral pathogenesis.

E. Mackow, Nadine A. Dalrymple, 2014, Current opinion in virology.

Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin-1 receptor expression.

R. Benya, R. Shaw, A. Bansal, 2010, Gastroenterology.

Rotavirus stimulates IL-8 secretion from cultured epithelial cells.

R. Shaw, S. J. Hempson, E. Mackow, 1996, Virology.

Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice

A. Bellamy, H. Greenberg, E. Mackow, 1991, Journal of virology.

Homotypic and heterotypic epitope-specific antibody responses in adult and infant rotavirus vaccinees: implications for vaccine development.

E. Mackow, K. Taniguchi, A. Kapikian, 1990, The Journal of infectious diseases.

Molecular determinant of rotavirus neutralization and protection.

H. Greenberg, E. Mackow, S. Matsui, 1989, Advances in virus research.

Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4

R. Shaw, H. Greenberg, E. Mackow, 1989, Journal of clinical microbiology.

Characterization of homotypic and heterotypic VP7 neutralization sites of rhesus rotavirus.

R. Shaw, H. Greenberg, E. Mackow, 1988, Virology.

Serotypic analysis of VP3 and VP7 neutralization escape mutants of rhesus rotavirus

M. Dyall-Smith, R. Shaw, H. Greenberg, 1988 .

The NY-1 Hantavirus Gn Cytoplasmic Tail Coprecipitates TRAF3 and Inhibits Cellular Interferon Responses by Disrupting TBK1-TRAF3 Complex Formation

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2008, Journal of Virology.

Cellular receptors and hantavirus pathogenesis.

E. Mackow, I. Gavrilovskaya, 2001, Current topics in microbiology and immunology.

Cellular Entry of Hantaviruses Which Cause Hemorrhagic Fever with Renal Syndrome Is Mediated by β3 Integrins

E. Mackow, I. Gavrilovskaya, E. Brown, 1999, Journal of Virology.

beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure.

R. Shaw, E. Mackow, I. Gavrilovskaya, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2013, Journal of Virology.

Slit2-Robo4 receptor responses inhibit ANDV directed permeability of human lung microvascular endothelial cells.

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2013, Antiviral research.

Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2010, Journal of Virology.

VEGFR2 and Src Kinase Inhibitors Suppress Andes Virus-Induced Endothelial Cell Permeability

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2010, Journal of Virology.

New York 1 and Sin Nombre Viruses Are Serotypically Distinct Viruses Associated with Hantavirus Pulmonary Syndrome

R. Shaw, B. Hjelle, E. Mackow, 1999, Journal of Clinical Microbiology.

The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches

E. Mackow, E. Gorbunova, Nadine A. Dalrymple, 2012, Advances in virology.

Pathogenic hantaviruses selectively inhibit β3 integrin directed endothelial cell migration

E. Mackow, I. Gavrilovskaya, T. Peresleni, 2002, Archives of Virology.

Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected

T. Honda, K. Kubo, Jiasen Zhang, 2015 .

Pathogenesis of the hantavirus pulmonary syndrome

E. Mackow, F. Koster, 2012 .

Elevated VEGF Levels in Pulmonary Edema Fluid and PBMCs from Patients with Acute Hantavirus Pulmonary Syndrome

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2012, Advances in virology.

Degrons at the C Terminus of the Pathogenic but Not the Nonpathogenic Hantavirus G1 Tail Direct Proteasomal Degradation

E. Mackow, Adrish Sen, N. Sen, 2007, Journal of Virology.

Degrons at the C Terminus of the Pathogenic but Not the Nonpathogenic Hantavirus G1 Tail Direct Proteasomal Degradation

E. Mackow, Adrish Sen, N. Sen, 2007, Journal of Virology.

Sequence analysis of the complete S genomic segment of a newly identified hantavirus isolated from the white-footed mouse (Peromyscus leucopus): Phylogenetic relationship with other sigmodontine rodent-borne hantaviruses

B. Hjelle, E. Mackow, I. Gavrilovskaya, 2004, Virus Genes.

More on hantavirus in New England and New York.

B. Luft, D. Goldgaber, E. Mackow, 1995, The New England journal of medicine.

Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses

E. Mackow, I. Gavrilovskaya, S. S. Koçer, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2008, Journal of Virology.

The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators

J. Baxter, E. Mackow, D. Leitman, 1992 .

The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

J. Baxter, E. Mackow, D. Leitman, 1992, Molecular and cellular biology.

Pathogenic hantaviruses bind plexin–semaphorin–integrin domains present at the apex of inactive, bent αvβ3 integrin conformers

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2005 .

The C-Terminal 42 Residues of the Tula Virus Gn Protein Regulate Interferon Induction

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2011, Journal of Virology.

The NY1 Hantavirus Gn Cytoplasmic Tail Coprecipitates TRAF 3 and Inhibits Cellular Interferon Responses by Disrupting TBK 1-TRAF 3 Complex Formation

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2008 .

Sequence analysis of gene 11 equivalents from "short" and "super short" strains of rotavirus

H. Greenberg, E. Mackow, S. Matsui, 1990, Journal of virology.

Andes Virus Recognition of Human and Syrian Hamster β3 Integrins Is Determined by an L33P Substitution in the PSI Domain

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2009, Journal of Virology.

Andes Virus Recognition of Human and Syrian Hamster (cid:1) 3 Integrins Is Determined by an L33P Substitution in the PSI Domain (cid:1)

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2009 .

Neutralizing epitopes on herpes simplex virus-1-expressed rotavirus VP7 are dependent on coexpression of other rotavirus proteins.

P. Dormitzer, H. Greenberg, E. Mackow, 1992, Virology.

Immunization with baculovirus-expressed VP4 protein passively protects against simian and murine rotavirus challenge

H. Greenberg, E. Mackow, D. Bass, 1990, Journal of virology.

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene.

J. Baxter, E. Mackow, D. Leitman, 1991, The Journal of biological chemistry.

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

E. Mackow, E. Gorbunova, William R. Schutt, 2020, bioRxiv.

Tyrosine Residues Direct the Ubiquitination and Degradation of the NY-1 Hantavirus G1 Cytoplasmic Tail

E. Mackow, I. Gavrilovskaya, E. Geimonen, 2003, Journal of Virology.

Histopathology of Peromyscus leucopus naturally infected with pathogenic NY-1 hantaviruses: pathologic markers of HPS viral infection in mice.

B. Luft, E. Mackow, I. Gavrilovskaya, 1996, Laboratory investigation; a journal of technical methods and pathology.

The epithelial cell response to rotavirus infection.

R. Shaw, N. Reich, H. Greenberg, 1999, Journal of immunology.

The Epithelial Cell Response to Rotavirus Infection 1

R. Shaw, N. Reich, H. Greenberg, 1999 .

VP4 Differentially Regulates TRAF2 Signaling, Disengaging JNK Activation while Directing NF-κB to Effect Rotavirus-specific Cellular Responses*

R. Shaw, R. Shaw, E. Mackow, 2001, The Journal of Biological Chemistry.

Selective Membrane Permeabilization by the Rotavirus VP5* Protein Is Abrogated by Mutations in an Internal Hydrophobic Domain

E. Mackow, R. Lamonica, E. Denisova, 2000, Journal of Virology.

Identification of the gene encoding the group B rotavirus VP7 equivalent: primary characterization of the ADRV segment 9 RNA.

E. Mackow, T. Hung, G. Chen, 1990, Virology.

cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment.

E. Mackow, T. Hung, G. Chen, 1990, Virology.

Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67, NSP2, or the Intrinsic Insolubility of NSP5 and Is Regulated by Cellular Phosphatases

E. Mackow, Adrish Sen, Darin Agresti, 2006, Journal of Virology.

Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67 or NSP2, and the Intrinsic Insolubility of NSP5 Is Regulated by Cellular Phosphatases

E. Mackow, Adrish Sen, Darin Agresti, 2006, Journal of Virology.

Humoral immune responses to VP4 and its cleavage products VP5* and VP8* in infants vaccinated with rhesus rotavirus

M. Rennels, G. Losonsky, H. Greenberg, 1992, Journal of clinical microbiology.

Rotavirus Capsid Protein VP5* Permeabilizes Membranes

R. Shaw, E. Mackow, F. Ruggeri, 1999, Journal of Virology.

Serologic analysis of human rotavirus serotypes P1A and P2 by using monoclonal antibodies

H. Greenberg, E. Mackow, K. Taniguchi, 1993, Journal of clinical microbiology.

VP4-specific intestinal antibody response to rotavirus in a murine model of heterotypic infection

R. Shaw, E. Mackow, W. Groene, 1991, Journal of virology.

The rhesus rotavirus gene encoding protein VP3: location of amino acids involved in homologous and heterologous rotavirus neutralization and identification of a putative fusion region.

H. Greenberg, E. Mackow, S. Matsui, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Functional expression of influenza A viral nucleoprotein in cells transformed with cloned DNA.

R. Chanock, E. Mackow, C. Lai, 1986, Virology.

NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells

P. Hearing, E. Mackow, Megan C. Mladinich, 2020, Journal of Virology.

Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformers.

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Integrin-Using Rotaviruses Bind α2β1 Integrin α2 I Domain via VP4 DGE Sequence and Recognize αXβ2 and αVβ3 by Using VP7 during Cell Entry

Y. Takada, E. Mackow, M. Robinson, 2003, Journal of Virology.

Rotavirus diarrhea is caused by nonreplicating viral particles

R. Shaw, S. J. Hempson, E. Mackow, 1995, Journal of virology.

Identification and partial characterization of a rhesus rotavirus binding glycoprotein on murine enterocytes.

H. Greenberg, E. Mackow, D. Bass, 1991, Virology.

NS35 and not vp7 is the soluble rotavirus protein which binds to target cells

H. Greenberg, E. Mackow, D. Bass, 1990, Journal of Virology.

NS35andNotvp7IstheSoluble Rotavirus Protein WhichBinds toTarget Cells

H. Greenberg, E. Mackow, D. Bass, 1990 .

Novel Infection of Pericytes by Andes Virus Enhances Endothelial Cell Permeability.

E. Mackow, Ramon D. Perez, Elena Gorbonova, 2021, Virus research.

19 – DNA Amplification-Restricted Transcription Translation (DARTT): Analysis of In Vitro and In Situ Protein Functions and Intermolecular Assembly

E. Mackow, 1995 .

DNA amplification-restricted transcription-translation: Rapid analysis of rhesus rotavirus neutralization sites

M. Yamanaka, H. Greenberg, E. Mackow, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Roles for Endothelial Cells in Dengue Virus Infection

E. Mackow, Nadine A. Dalrymple, 2012, Advances in virology.

Cloning full-length dengue type 4 viral DNA sequences: analysis of genes coding for structural proteins.

R. Chanock, E. Mackow, Y. Makino, 1986, Virology.

Endothelial Cells Elicit Immune-Enhancing Responses to Dengue Virus Infection

E. Mackow, Nadine A. Dalrymple, 2012, Journal of Virology.

The Formation of Viroplasm-Like Structures by the Rotavirus NSP5 Protein Is Calcium Regulated and Directed by a C-Terminal Helical Domain

E. Mackow, Adrish Sen, N. Sen, 2007, Journal of Virology.

Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.

Y. Takada, E. Mackow, M. Robinson, 2003, Journal of virology.

The VP8 fragment of VP4 is the rhesus rotavirus hemagglutinin.

H. Greenberg, E. Mackow, L. Fiore, 1991, Virology.

Recombinant baculovirus-expressed rotavirus protein (VP4) in an ELISPOT assay of antibody secretion.

R. Shaw, E. Mackow, W. Groene, 1992, Viral immunology.

Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1-Directed Beta Interferon Transcription by Blocking IRF3 Phosphorylation

E. Mackow, Nadine A. Dalrymple, V. Cimica, 2014, Journal of Virology.

The Pathogenic NY-1 Hantavirus G1 Cytoplasmic Tail Inhibits RIG-I- and TBK-1-Directed Interferon Responses

N. Reich, E. Mackow, E. Gorbunova, 2006, Journal of Virology.

Endothelial cell dysfunction in viral hemorrhage and edema

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2015, Front. Microbiol..

Vascular Endothelium and Hemorrhagic Fever Viruses

E. Mackow, E. Gorbunova, Nadine A. Dalrymple, 2013 .

Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386

M. J. Simons, E. Mackow, E. Gorbunova, 2019, Journal of Virology.

Hantavirus Regulation of Type I Interferon Responses

E. Mackow, V. Matthys, 2012, Advances in virology.

Hantavirus regulation of endothelial cell functions

E. Mackow, I. Gavrilovskaya, 2009, Thrombosis and Haemostasis.

Hantavirus interferon regulation and virulence determinants.

E. Mackow, E. Gorbunova, Nadine A. Dalrymple, 2014, Virus research.

An Innate Immunity-Regulating Virulence Determinant Is Uniquely Encoded within the Andes Virus Nucleocapsid Protein

E. Mackow, Nadine A. Dalrymple, V. Cimica, 2014, mBio.

Andes Virus Regulation of Cellular MicroRNAs Contributes to Hantavirus-Induced Endothelial Cell Permeability

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2010, Journal of Virology.

Hantavirus Pulmonary Syndrome-Associated Hantaviruses Contain Conserved and Functional ITAM Signaling Elements

E. Mackow, I. Gavrilovskaya, K. Springer, 2003, Journal of Virology.

Binding of the Andes Virus Nucleocapsid Protein to RhoGDI Induces the Release and Activation of the Permeability Factor RhoA

E. Mackow, E. Gorbunova, 2021, bioRxiv.

The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea

R. Shaw, A. Bansal, S. J. Hempson, 2005, Journal of Virology.

Production and characterization of murine IgA monoclonal antibodies to the surface antigens of rhesus rotavirus.

H. Greenberg, E. Mackow, F. Ruggeri, 1996, Virology.

Identification and baculovirus expression of the VP4 protein of the human group B rotavirus ADRV

E. Mackow, M. Fay, H. Tao, 1993, Journal of virology.

Expression of the major inner capsid protein of the group B rotavirus ADRV: primary characterization of genome segment 5.

E. Mackow, H. Tao, G. Chen, 1991, Virology.

Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant

E. Mackow, Nadine A. Dalrymple, V. Cimica, 2015, mBio.

The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins.

R. Chanock, E. Mackow, Y. Makino, 1987, Virology.

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA

M. J. Simons, E. Mackow, E. Gorbunova, 2016, mBio.

Productive Dengue Virus Infection of Human Endothelial Cells Is Directed by Heparan Sulfate-Containing Proteoglycan Receptors

E. Mackow, Nadine A. Dalrymple, 2011, Journal of Virology.

Establishment of a CPER reverse genetics system for Powassan virus defines attenuating NS1 glycosylation sites and an infectious NS1-GFP11 reporter virus

E. Wimmer, E. Mackow, E. Gorbunova, 2023, bioRxiv.

Age-dependent Powassan Virus Lethality and Neuropathogenesis in Mice

S. Tsirka, E. Mackow, E. Gorbunova, 2023, bioRxiv.

Powassan Viruses Spread Cell to Cell during Direct Isolation from Ixodes Ticks and Persistently Infect Human Brain Endothelial Cells and Pericytes

E. Mackow, E. Gorbunova, J. Benach, 2021, bioRxiv.

Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice.

M. Drebot, H. Artsob, E. Mackow, 2001, Virus research.

Andes Virus Infection of Lymphatic Endothelial Cells Causes Giant Cell and Enhanced Permeability Responses That Are Rapamycin and Vascular Endothelial Growth Factor C Sensitive

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2012, Journal of Virology.

Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus

S. W. Lee, B. Hjelle, E. Mackow, 1995, Journal of virology.

ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence

E. Mackow, Megan C. Mladinich, Jonas N. Conde, 2023, bioRxiv.

Processing of precursor ribosomal RNA and the presence of a modified ribosome assembly scheme in Escherichia coli relaxed strain

E. Mackow, F. Chang, 1985, FEBS letters.

Serotypic Analysis of VP3 and VP7 Neutralization Escape Mutants of Rhesus Rotavirus

M. Dyall-Smith, R. Shaw, H. Greenberg, 1988, Journal of virology.

Measuring for Dengue Infection Studies

E. Mackow, Megan C. Mladinich, Jonas N. Conde, 2021, Methods in Molecular Biology.

Pathogenic Hantaviruses Direct the Adherence of Quiescent Platelets to Infected Endothelial Cells

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2010, Journal of Virology.

Virus interactions with endothelial cell receptors: implications for viral pathogenesis.

E. Mackow, Nadine A. Dalrymple, 2014, Current opinion in virology.

Andes Virus Infection of Lymphatic Endothelial Cells Causes Giant Cell and Enhanced Permeability Responses That Are Rapamycin and Vascular Endothelial Growth Factor C Sensitive

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2012, Journal of Virology.

Andes Virus Recognition of Human and Syrian Hamster β3 Integrins Is Determined by an L33P Substitution in the PSI Domain

E. Mackow, E. Gorbunova, I. Gavrilovskaya, 2009, Journal of Virology.

Effect of ppGpp on the accuracy of protein biosynthesis.

R. Thompson, E. Mackow, F. Chang, 1983, Archives of biochemistry and biophysics.