S. Agnihotri

发表

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

V. P. Collins, P. Sorensen, B. Faubert, 2013, Cell.

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

A. Goldenberg, J. Olson, Erwin G. Van Meir, 2017, Cancer cell.

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Gary D Bader, Trevor J Pugh, S. Scherer, 2014, Nature.

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

L. Cantley, J. Asara, G. Zadeh, 2017, Molecular cell.

Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

J. Rutka, C. Hawkins, S. Pajovic, 2014, Acta Neuropathologica.

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Michael Brudno, Jennifer Chan, Uri Tabori, 2014, Nature Genetics.

Spatial heterogeneity in medulloblastoma

Steven J. M. Jones, Gary D Bader, Richard A. Moore, 2017, Nature Genetics.

Targeting Metabolic Remodeling in Glioblastoma Multiforme

A. Guha, S. Agnihotri, Sameer Agnihotri, 2010, Oncotarget.

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

Joydeep Mukherjee, Cynthia Hawkins, C. Hawkins, 2011, The Journal of experimental medicine.

Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

Gelareh Zadeh, Cynthia Hawkins, J. Rutka, 2012, Archivum Immunologiae et Therapiae Experimentalis.

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway

M. Berens, S. Croul, S. Byron, 2014, Oncotarget.

GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity.

Gelareh Zadeh, Shahrzad Jalali, K. Aldape, 2014, Neuro-oncology.

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

C. Hawkins, S. Pajovic, A. Huang, 2020, Nature Communications.

A role for matrix remodelling proteins in invasive and malignant meningiomas

K. Aldape, S. Croul, G. Zadeh, 2014, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

CELL BIOLOGY AND SIGNALING

V. P. Collins, Michael A. Koldobskiy, R. Spang, 2010 .

The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment

Jennie W. Taylor, Susan M. Chang, M. J. van den Bent, 2021, Neuro-oncology advances.

Chitinase-3-like-1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma.

Qianghu Wang, C. Camacho, I. Pollack, 2021, The Journal of clinical investigation.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Dylan M. Marchione, B. Garcia, M. McConechy, 2019, Cancer cell.

ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.

D. Parsons, S. Pfister, Baoli Hu, 2021, Cancer discovery.

Not all mouse blood-brain barriers are created equal.

S. Agnihotri, James Felker, 2021, Neuro-oncology.

GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system

C. Hawkins, A. Guha, S. Agnihotri, 2009, Oncogene.

Overexpression of CD99 Increases the Migration and Invasiveness of Human Malignant Glioma Cells.

H. Seol, J. Rutka, Jong-Hee Chang, 2012, Genes & cancer.

The role of drebrin in glioma migration and invasion.

S. Croul, J. Rutka, S. Agnihotri, 2013, Experimental cell research.

Targeting NAD+ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance

D. L. Taylor, I. Pollack, D. Premkumar, 2020, Molecular Cancer Research.

Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous

A. Bahrami, A. Pappo, G. Zambetti, 2018, Acta Neuropathologica.

Hijacking a neurodevelopmental epigenomic program in metastatic dissemination of medulloblastoma

K. Herrup, W. Fellows-Mayle, Baoli Hu, 2022, Neuro-Oncology.

TM-02IDENTIFICATION OF THE AZOLE CLASS OF ANTIFUNGALS AS POTENT INHIBITORS OF HEXOKINASE II MEDIATED TUMOUR METABOLISM IN GLIOBLASTOMA.

K. Aldape, G. Zadeh, S. Agnihotri, 2014 .

Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas.

H. Seol, J. Rutka, S. Agnihotri, 2011, Neuro-oncology.

Serum lactate as a potential biomarker of malignancy in primary adult brain tumours

G. Zadeh, L. Venkatraghavan, S. Agnihotri, 2015, Journal of Clinical Neuroscience.

Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme

A. Guha, S. Agnihotri, D. Muñoz, 2009 .

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

Andrew R. Morton, P. Mischel, Qiulian Wu, 2019, Science Translational Medicine.

High-Grade Gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2012, Oxford Medicine Online.

Identification of novel RAS signaling therapeutic vulnerabilities in Diffuse Intrinsic Pontine Gliomas.

Lauren M. Sanders, C. James, I. Pollack, 2019, Cancer research.

Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

J. Rutka, C. Hawkins, P. Dirks, 2015, Molecular Cancer Therapeutics.

Loss of p53 cooperates with K‐ras activation to induce glioma formation in a region‐independent manner

C. Hawkins, G. Zadeh, A. Guha, 2013, Glia.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Dylan M. Marchione, B. Garcia, M. Lupien, 2019, Cancer cell.

The dominant TP53 hotspot mutation in IDH-mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications

S. Agnihotri, G. Murdoch, Daniel F Marker, 2021, Neuro-oncology advances.

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Aaron S. Gajadhar, J. Rutka, C. Hawkins, 2014, Cancer discovery.

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Aaron S. Gajadhar, K. Aldape, J. Sarkaria, 2012, The Journal of clinical investigation.

Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

Xin Wang, Peter Dirks, Stephen C. Mack, 2015, Oncotarget.

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Scott L. Pomeroy, Robert J. Wechsler-Reya, Stefan M. Pfister, 2013, Acta Neuropathologica.

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions.

Gelareh Zadeh, G. Zadeh, S. Agnihotri, 2016, Neuro-oncology.

Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

M. Harris, L. Silverman, K. Stevenson, 2021, Metabolomics.

A vaccine for glioma

J. Rich, S. Agnihotri, D. Mitchell, 2021, Nature Cancer.

A role for activated Cdc42 in glioblastoma multiforme invasion

Erwin G. Van Meir, A. Marcus, J. Rutka, 2016, Oncotarget.

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.

K. Aldape, G. Zadeh, S. Agnihotri, 2014, Neurosurgical focus.

Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma.

G. Zadeh, M. Remke, Michael D. Taylor, 2013, Journal of neurosurgery.

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme

A. Guha, S. Agnihotri, D. Muñoz, 2011, Neurobiology of Disease.

Molecular Signatures for Tumor Classification: An Analysis of The Cancer Genome Atlas Data.

A. Goldenberg, K. Aldape, G. Zadeh, 2017, The Journal of molecular diagnostics : JMD.

TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma

F. Lieberman, I. Pollack, Baoli Hu, 2021, Frontiers in Immunology.

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Lincoln D. Stein, John B Wojcik, P. Sorensen, 2020, Cell.

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

Aaron S. Gajadhar, K. Aldape, G. Fuller, 2011, The Journal of experimental medicine.

Childhood brain tumors: current management, biological insights, and future directions.

I. Pollack, S. Agnihotri, A. Broniscer, 2019, Journal of neurosurgery. Pediatrics.

Canonical TGF‐β Pathway Activity Is a Predictor of SHH‐Driven Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development

S. Croul, P. Northcott, Michael D. Taylor, 2013, Brain pathology.

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases

I. Pollack, D. Premkumar, E. Jane, 2020, Molecular oncology.

The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas.

T. Tateno, S. Asa, S. Ezzat, 2014, Endocrine-related cancer.

Clinical Utility of GlioSeq Next-Generation Sequencing Test in Pediatric and Young Adult Patients With Brain Tumors.

Wayne L Ernst, D. Born, I. Pollack, 2019, Journal of neuropathology and experimental neurology.

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

S. Croul, L. Ermini, M. Kool, 2015, Cancer research.

Brain tumor-initiating cells and cells of origin in glioblastoma

G. Zadeh, A. Guha, S. Agnihotri, 2011 .

Brain Tumor-i niT ia Ting Cells and Cells of o rigin

G. Zadeh, A. Guha, S. Agnihotri, 2011 .

The genomic landscape of schwannoma

Trevor J Pugh, K. Aldape, R. Beroukhim, 2016, Nature Genetics.

Inhibition of Ras Signaling for Brain Tumor Therapy

A. Guha, S. Agnihotri, D. Muñoz, 2009 .

Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas.

Adrian V. Lee, I. Pollack, L. Butterfield, 2018, JCI insight.

EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Tina N. Davis, Forrest M Kievit, Atique U. Ahmed, 2013 .

Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma

K. Aldape, G. Zadeh, S. Agnihotri, 2016, Oncotarget.

Epigenomic, genomic, and transcriptomic landscape of schwannomatosis

Trevor J Pugh, K. Aldape, T. Pugh, 2020, Acta Neuropathologica.

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Eric N. Anderson, T. Strom, J. Landers, 2021, Nature Communications.

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype

S. Croul, X. Wang, S. Pfister, 2015, Clinical Cancer Research.

SpinalMyxopapillary EpendymomasDemonstrate a Warburg Phenotype

S. Croul, J. Rutka, C. Hawkins, 2015 .

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

K. Aldape, T. Pugh, A. von Deimling, 2017, Nature Communications.

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

G. Fuller, P. Mischel, J. Rutka, 2016, Cancer research.

CIC protein instability contributes to tumorigenesis in glioblastoma

K. Aldape, A. von Deimling, G. Zadeh, 2019, Nature Communications.

Pre-clinical transgenic mouse models of nervous system tumors

A. Guha, S. Agnihotri, D. Muñoz, 2010 .

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

Mark W. Youngblood, Jacob S. Young, Sybren L. N. Maas, 2021, Research square.

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Richard Hill, Gelareh Zadeh, Michael Leung, 2013, Journal of visualized experiments : JoVE.

MALT1 is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-low, Triple-Negative Breast Cancer.

Adrian V. Lee, S. Oesterreich, D. Krappmann, 2021, Molecular cancer research : MCR.

Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells

K. Aldape, G. Zadeh, S. Agnihotri, 2018, Clinical Cancer Research.

Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

J. Rutka, C. Hawkins, G. Zadeh, 2013, Archivum Immunologiae et Therapiae Experimentalis.

Investigation of the In Vitro Therapeutic Efficacy of Nilotinib in Immortalized Human NF2-Null Vestibular Schwannoma Cells

G. Zadeh, A. Guha, S. Agnihotri, 2012, PloS one.

Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells.

J. Rutka, S. Agnihotri, R. Diaz, 2016, The American journal of pathology.

A functional genomics approach to identify pathways of drug resistance in medulloblastoma

J. Rutka, Michael D. Taylor, S. Agnihotri, 2018, Acta neuropathologica communications.

Anarchy or Respect the Hierarchy? The Complexity of Glioblastoma

S. Agnihotri, R. Koncar, 2020, Cancer Research.

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

K. Aldape, T. Pugh, A. von Deimling, 2017, Nature Communications.

High grade gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2022, Progress in Brain Research.