P. Helquist

发表

Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts

O. Wiest, Zachary T. Wehrmann, Tyler Hulett, 2012, PloS one.

On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.

O. Wiest, P. Helquist, Di-Fei Wang, 2004, Journal of medicinal chemistry.

Zinc binding in HDAC inhibitors: a DFT study.

O. Wiest, P. Helquist, Di-Fei Wang, 2007, The Journal of organic chemistry.

Inhibition of histone deacetylases: a pharmacological approach to the treatment of non-cancer disorders.

O. Wiest, P. Helquist, J. Fisher, 2009, Current topics in medicinal chemistry.

Rapid virtual screening of enantioselective catalysts using CatVS

Rebecca E. Meadows, O. Wiest, P. Helquist, 2018, Nature Catalysis.

Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases.

O. Wiest, P. Helquist, Di-Fei Wang, 2005, Journal of medicinal chemistry.

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

P. Meikle, P. Helquist, N. Mellett, 2013, Diabetologia.

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

Paul Helquist, Olaf Wiest, Frederick R Maxfield, 2011, Proceedings of the National Academy of Sciences.

Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors

Paul Helquist, Olaf Wiest, O. Wiest, 2013, Neurotherapeutics.

Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase.

O. Wiest, P. Helquist, C. Stauffacher, 2004, Bioorganic & medicinal chemistry.

Synthesis of readily cleavable immobilized 1,10-phenanthroline resins.

Stephen M. Canham, P. Helquist, V. Krchňák, 2004, Organic letters.

Molecular Mechanics Predictions and Experimental Testing of Asymmetric Palladium-Catalyzed Allylation Reactions Using New Chiral Phenanthroline Ligands.

P. Helquist, P. Norrby, J. Oslob, 1996 .

Diastereoselectivity in Lewis-acid-catalyzed Mukaiyama aldol reactions: a DFT study.

O. Wiest, P. Helquist, Joshua M Lee, 2012, Journal of the American Chemical Society.

Ligand and substrate effects on the mechanism of rhodium-catalyzed hydrogenation of enamides.

O. Wiest, P. Helquist, Patrick J. Donoghue, 2007, The Journal of organic chemistry.

Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation.

O. Wiest, P. Helquist, Elaine Limé, 2014, Journal of chemical theory and computation.

Design and synthesis of a siderophore conjugate as a potent PSMA inhibitor and potential diagnostic agent for prostate cancer.

P. Helquist, Marvin J Miller, Pingyu Ding, 2008, Bioorganic & medicinal chemistry.

Design, synthesis and pharmacological activity of novel enantiomerically pure phosphonic acid-based NAALADase inhibitors.

P. Helquist, Marvin J Miller, Pingyu Ding, 2007, Organic & biomolecular chemistry.

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics.

O. Wiest, F. Maxfield, P. Helquist, 2009, Journal of medicinal chemistry.

Single-Flask Multicomponent Synthesis of Highly Substituted α-Pyrones via a Sequential Enolate Arylation and Alkenylation Strategy.

O. Wiest, P. Helquist, Michael Grigalunas, 2016, Organic letters.

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

Bruce J. Melancon, O. Wiest, F. Maxfield, 2021, ACS pharmacology & translational science.

On the mechanism of the rhodium catalyzed acrylamide hydrogenation

O. Wiest, P. Helquist, P. Norrby, 2010 .

Formation, isolation, and identification of products from the inactivation of virginiamycin M1 by Actinoplanes utahensis.

P. Vannuffel, P. Helquist, M. Di Giambattista, 1994, The Journal of antibiotics.

Functionalized oxazoles from rhodiumi-catalyzed reaction of dimethyl diazomalonate with nitriles

R. D. Connell, P. Helquist, B. Åkermark, 1986 .

Microsecond timescale MD simulations at the transition state of PmHMGR predict remote allosteric residues†

Xuhui Huang, O. Wiest, Wei Wang, 2019, Chemical science.

Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide.

O. Wiest, P. Helquist, Q. Peng, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of carbamate derivatives of iejimalides. Retention of normal antiproliferative activity and localization of binding in cancer cells.

V. Davisson, G. Jarori, P. Helquist, 2007, Bioorganic & medicinal chemistry.

Reaction of aryl and vinyl halides with zerovalent nickel - preparative aspects and the synthesis of alnusone

P. Helquist, M. Semmelhack, L. D. Jones, 1982 .

Synthesis, structure, and metal complexation behavior of a new type of functionalized chiral phenanthroline derivative.

O. Wiest, P. Helquist, B. Noll, 2008, The Journal of organic chemistry.

Samarium-promoted coupling of 1,10-phenanthroline with carbonyl compounds for synthesis of new ligands.

P. Helquist, D. O'Neill, B. Mowery, 2004, The Journal of organic chemistry.

Samarium-promoted coupling of pyridine-based heteroaryl analogues of benzylic acetates with carbonyl compounds.

P. Helquist, Jonathan D Mortison, J. A. Weitgenant, 2005, Organic letters.

Current status of drug therapy development for Niemann-Pick type C disease

O. Wiest, P. Helquist, 2009 .

Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.

O. Wiest, F. Maxfield, P. Helquist, 2010, Journal of medicinal chemistry.

2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.

Bruce J. Melancon, O. Wiest, F. Maxfield, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Revisiting the Stereodetermining Step in Enantioselective Iridium-Catalyzed Imine Hydrogenation

O. Wiest, P. Andersson, P. Helquist, 2018 .

Proofreading experimentally assigned stereochemistry through Q2MM predictions in Pd-catalyzed allylic aminations

O. Wiest, P. Helquist, J. Wahlers, 2021, Nature Communications.

Synthesis of a 5-Azaindole Phosphonic Acid as a Computationally Designed Inhibitor of the Low Molecular Weight Phosphatase HCPTP

O. Wiest, P. Helquist, C. Stauffacher, 2006 .

Biocompatible, Multi-Mode, Fluorescent, T2 MRI Contrast Magnetoelectric-Silica Nanoparticles (MagSiNs), for On-Demand Doxorubicin Delivery to Metastatic Cancer Cells

M. Stack, R. Roeder, P. Helquist, 2022, Pharmaceuticals.

Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic.

A. Bhardwaj, O. Wiest, D. Wüstner, 2020, The Journal of organic chemistry.

Synthesis and photochemical behavior of coumarin-caged cholesterol.

O. Wiest, P. Helquist, Q. Peng, 2013, Bioorganic & medicinal chemistry letters.

Iejimalides A and B inhibit lysosomal vacuolar H+‐ATPase (V‐ATPase) activity and induce S‐phase arrest and apoptosis in MCF‐7 cells

V. Davisson, P. Helquist, D. Schweitzer, 2009, Journal of cellular biochemistry.

Total synthesis of iejimalide B.

V. Davisson, P. Helquist, D. Schweitzer, 2011, The Journal of organic chemistry.

A Quantum-Guided Molecular Mechanics Force Field for the Ferrocene Scaffold.

O. Wiest, P. Helquist, A. Rosales, 2022, The Journal of organic chemistry.

Stereoselectivity Predictions for the Pd-Catalyzed 1,4-Conjugate Addition Using Quantum-Guided Molecular Mechanics.

O. Wiest, P. Helquist, A. Rosales, 2021, The Journal of organic chemistry.

Transition State Force Field for the Asymmetric Redox Relay Heck Reaction.

O. Wiest, P. Helquist, A. Rosales, 2020, Journal of the American Chemical Society.

Palladium hydrides in organic synthesis. Reduction of aryl halides by sodium methoxide catalyzed by tetrakis(triphenylphosphine)palladium

P. Helquist, A. Zask, 1978 .

Functionalized aryllithium intermediates a new route to 3,4-dihydroisoquinolines.

P. Helquist, J. Tagat, C. Hergrueter, 1977 .

Evolution of Concise and Flexible Synthetic Strategies for Trichostatic Acid and the Potent Histone Deacetylase Inhibitor Trichostatin A

Douglas J. Schauer, O. Wiest, P. Helquist, 2013 .

Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction.

P. Helquist, C. Cosner, 2011, Organic letters.

Palladium hydrides in organic synthesis. Reduction of aryl bromides by sodium formate catalyzed by tetrakis(triphenylphosphine)palladium

P. Helquist, 1978 .

Stereocontrolled Synthesis of the C(1)–C(11) Subunit of the Iejimalides

P. Helquist, T. Rein, Matthew T. Mendlik, 1997 .

Synthesis of steroid precursors. Intramolecular Diels-Alder approach to the trans-hydrindenone system.

P. Helquist, Swati A. Bal, 1981 .

Stereoselectivity Predictions for the Pd-Catalyzed 1,4-Conjugate Addition Using Q2MM

O. Wiest, P. Helquist, A. Rosales, 2021 .

Synthesis of diquinanes from butadiene and N,N-dimethylallylamine via palladium-catalyzed processes

P. Helquist, C. Moberg, K. Nordström, 1992 .

Total synthesis of (+)-sparsomycin. Approaches using cysteine and serine inversion

D. Hwang, P. Helquist, M. Shekhani, 1985 .

The synthesis of large-ring methylenecycloalkanes by the cyclization of allylic dibromides with nickel carbonyl

E. Corey, P. Helquist, 1975 .

Synthesis with Zerovalent Nickel. Coupling of Alkenyl Halides with Bis(1,5-cyclooctadiene)nickel(0)

P. Helquist, M. Semmelhack, J. Gorzynski, 1971 .

Synthesis of Anti-Angiogenic Isocoumarins

P. Helquist, Richard E. Taylor, Haiqing Yuan, 2004 .

Development of a Q2MM Force Field for the Asymmetric Rhodium Catalyzed Hydrogenation of Enamides.

Per-Ola Norrby, Paul Helquist, Olaf Wiest, 2008, Journal of chemical theory and computation.

Palladium- and nickel-catalyzed alkenylation of enolates.

P. Helquist, C. Cosner, T. Ankner, 2013, Chemistry.

Short intramolecular Diels-Alder approach to functionalized spiro[4.5]decanes

P. Helquist, J. Nyström, T. Mccanna, 1985 .

Ti(o-i-pr)4 mediated lactamizations

P. Helquist, M. Mader, 1988 .

Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization.

O. Wiest, P. Helquist, P. Norrby, 2015, Journal of the American Chemical Society.

Palladium-catalyzed alkenylation of ketone enolates under mild conditions.

O. Wiest, P. Helquist, P. Norrby, 2014, Organic letters.

Reagent- and solvent-dependent stereoselectivity in organocopper addition to a bicyclic alkenone

P. Helquist, Shikai Zhao, 1991 .

An efficient, palladium-catalyzed route to protected allylic amines

R. D. Connell, P. Helquist, B. Aakermark, 1988 .

Methyl 3‐(Dimethylamino)propionate

P. Helquist, 2001 .

Development of Carbene Complexes of Iron as New Reagents for Synthetic Organic Chemistry

P. Helquist, 1991 .

Highly diastereofacial selective chelation of a phosphite-containing .alpha.,.beta.-unsaturated ketone system to the Fe(CO)2 group

D. Enders, P. Helquist, Wei Zhang, 1988 .

Intramolecular C-H insertion reactions of (eta(5)-cyclopentadienyl)dicarbonyliron carbene complexes: scope of the reactions and application to the synthesis of (+/-)-sterpurene and (+/-)-pentalenene.

P. Helquist, G. Mehta, S. Ishii, 2001, The Journal of organic chemistry.

Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide.

O. Wiest, P. Helquist, John T. Markiewicz, 2010, The Journal of organic chemistry.

Direct conversion of alkenes into methyl-substituted cyclopropanes using an organoiron ethylidene transfer reagent☆

P. Helquist, K. Kremer, 1985 .

Ethylidenation of olefins using a convenient iron-containing cyclopropanation reagent

P. Helquist, R. Kerber, K. Kremer, 1981 .

Synthesis of a major subunit of the iejimalides

P. Helquist, B. Åkermark, N. Kann, 1995 .

Single-Flask Multicomponent Palladium-Catalyzed α,γ-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds.

O. Wiest, P. Helquist, P. Norrby, 2015, Angewandte Chemie.

Enantioselective Synthesis of Salmeterol via Asymmetric Borane Reduction.

Ragnar Stare, Paul Helquist, P. Helquist, 1994 .

Selective Halogen‐Lithium Exchange Reactions of 2‐(2′‐Halophenyl)Ethyl Halides: Synthesis of 4,5‐Methylenedioxybenzocyclobutene and 1‐Phenyl‐3,4‐Dihydro‐6,7‐Methylenedioxyisoquinoline

P. Helquist, L. D. Jones, Dennis J. Jakiela, 2003 .

Mechanistic test for carbocationic alkene cyclization initiated by cationic iron carbene complex formation

P. Helquist, C. Baker, M. Mattson, 1995 .

Transition Metal-Catalyzed Hydrogenations

O. Wiest, P. Helquist, Vincenzo Verdolino, 2012 .

Stereoselectivity in (Acyloxy)borane-Catalyzed Mukaiyama Aldol Reactions.

O. Wiest, P. Helquist, P. Norrby, 2016, The Journal of organic chemistry.

Prediction of enantioselectivity in rhodium catalyzed hydrogenations.

Per-Ola Norrby, Paul Helquist, Olaf Wiest, 2009, Journal of the American Chemical Society.

Enantioconvergent synthesis by sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed allylic substitution reactions.

D. Tanner, P. Helquist, P. Norrby, 2001, Journal of the American Chemical Society.

HIGHLY STEREOSELECTIVE SYNTHESIS OF TRISUBSTITUTED OLEFINS VIA ADDITION OF ALKYLCOPPER COMPLEXES TO ACETYLENES

P. Helquist, A. Marfat, P. McGuirk, 1980 .

.beta.-Amino ester enolate as an acrylate anion equivalent for the synthesis of .alpha.-methylene esters, acids, and lactones

P. Helquist, Lin-Chen Yu, 1981 .

A β-amino ester enolate as all acrylate anion equivalent

P. Helquist, Lin-Chen Yu, 1978 .

SHORT SYNTHESIS OF ()-STERPURENE

P. Helquist, Shikai Zhao, 1990 .

Cyclopentanone Annulation via Cyclopropanone Derivatives: (3aβ,9bβ)‐1,2,3a,4,5,9b‐Hexahydro‐9b‐Hydroxy‐3a‐Methyl‐3H‐Benz[e]Inden‐3‐One

P. Helquist, Michael J. Bradlee, 2003 .

Rhodium‐Catalyzed Heterocycloaddition of a Diazomalonate and a Nitrile: 4‐Carbomethoxy‐5‐Methoxy‐2‐Phenyl‐1,3‐Oxazole

P. Helquist, J. S. Tullis, 2003 .

Synthesis of .alpha.-carbalkoxy ene thiols: a class of tautomeric thiopyruvate derivatives. Application to griseoviridin

P. Helquist, J. Butera, J. Rini, 1985 .

Synthesis of the oxazole- and diene-containing C9–C23 fragment of the type a streptogramin antibiotics

J. Iqbal, P. Helquist, A. Gangloff, 1993 .

Rhodium-catalyzed heterocycloaddition route to 1,3-oxazoles as building blocks in natural products synthesis

R. D. Connell, P. Helquist, A. Gangloff, 1993 .

Direct preparation of 4-carboethoxy-1,3-oxazoles

R. D. Connell, P. Helquist, B. Åkermark, 1991 .

A novel method for cyclopentanone annulation. The use of 1-(2-ketoalkyl) cyclopropanols to obtain cyclopentanones.

P. Helquist, J. T. Carey, 1988 .

Direct formation of a tricyclic cycloheptanone-containing system by enolate condensation with a cyclopropanone derivative

P. Helquist, J. T. Carey, C. Knors, 1986 .

Preparation of α,β-dehydro-β-amino acid derivatives by tin-promoted addition of malonates to simple nitriles

P. Helquist, F. Scavo, 1985 .

Synthesis of a major subunit of the iejimalides

P. Helquist, B. Åkermark, N. Kann, 1995 .

Synthesis of the branched nine-carbon unit of the type A streptogramins and other antibiotics

P. Helquist, F. Kaźmierczak, 1989 .

Methylene and Nonfunctionalized Alkylidene Transfer to Form Cyclopropanes

P. Helquist, 1991 .

Selective oxidation of benzylic and allylic alcohols using Mn(OAc)3/catalytic 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.

P. Helquist, C. Cosner, Katherine M. Byrd, 2011, Organic letters.

Addition of an Ethylcopper Complex to 1‐Octyne: (E)‐5‐Ethyl‐1,4‐Undecadiene

P. Helquist, R. S. Iyer, 2003 .

ADDITION OF A METHYLCOPPER COMPLEX TO ACETYLENES. SYNTHESIS OF TRISUBSTITUTED OLEFINS

P. Helquist, A. Marfat, P. McGuirk, 1978 .

Facile route to 1-phosphoryl- and 1-sulfonyl-1,3-dienes via palladium-catalyzed elimination of allylic acetates

P. Helquist, J. Bäckvall, B. Åkermark, 1984 .

Synthesis of (±)-Pentalenene

P. Helquist, G. Mehta, Shikai Zhao, 1991 .

Highly stereoselective synthesis of trisubstituted olefins via addition of alkylcopper complexes to acetylenes

P. Helquist, A. Marfat, P. McGuirk, 1979 .

New methodology for the synthesis of protected, primary pentadienylamines

R. D. Connell, P. Helquist, B. Aakermark, 1989 .

Mild and efficient desymmetrization of diynes via hydroamination: application to the synthesis of (+/-)-monomorine I.

O. Wiest, P. Helquist, Vincenzo Verdolino, 2010, The Journal of organic chemistry.

Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts.

O. Wiest, P. Helquist, W. Wuest, 2008, Organic letters.

Preparation of lactone systems. Total synthesis of (.+-.)-quadrone

P. Helquist, J. Ponton, S. Bhagwat, 1981 .

δ-Valerolactone Annulation: Application to the Total Synthesis of Quadrone

P. Helquist, 1989 .

Substituted hydrazulenones via cyclopropanone addition, cyclopropanol rearrangement, and a retroaldol/re-aldol sequence

P. Helquist, Valérie Reydellet, 1989 .

Light-induced, iodine-catalyzed aerobic oxidation of unsaturated tertiary amines

P. Helquist, A. Gangloff, T. Judge, 1990 .

Syntheses of conformationally constricted molecules as potential NAALADase/PSMA inhibitors.

O. Wiest, P. Helquist, Marvin J. Miller, 2004, Organic letters.

Use of Methyl 3- (N, N-Dimethylamino) Propionate as a Synthon for the Construction of α-Methylene γ-Butyrolactones

P. Helquist, Lin-Chen Yu, 1981 .

Copper-catalyzed conjugate addition of an acetal-containing grignard reagent. A method for cyclopentene annulation.

P. Helquist, A. Marfat, 1978 .

Six-membered-ring annulation via a conjugate addition-alkylation sequence using functionalized aryllithium reagents and vinyl sulfones

P. Helquist, J. Ponton, P. Fuchs, 1981 .

Cyclopentene and cyclohexene annulation via copper-catalyzed conjugate addition of acetal-containing Grignard reagents

P. Helquist, A. Marfat, Swati A. Bal, 1982 .

Generation and reactions of allylidene complexes of the (.eta.5-cyclopentadienyl)dicarbonyliron and (.eta.5-cyclopentadienyl)(trimethyl phosphite)carbonyliron

P. Helquist, G. Kuo, R. Kerber, 1984 .

Stereoselective synthesis of homoallylic alcohols containingtrisubstituted olefinic double bonds

P. Helquist, A. Marfat, P. McGuirk, 1978 .

Direct preparation of 5-amino-1,3-pentadienes through use of palladium-promoted reactions

P. Helquist, J. Baeckvall, R. Aslanian, 1984 .

Intramolecular carbon-hydrogen insertion reactions of (cyclopentadienyl)dicarbonyl iron carbene complexes

P. Helquist, Shikai Zhao, C. Knors, 1989 .

Improved one-flask preparations of cyclopropanation reagents: (.eta.5-C5H5)(CO)2FeCH2S(CH3)2+ BF4- and [.eta.5-C5(CH3)5](CO)2FeCH2S(CH3)2+ BF4-

P. Helquist, V. Stolarski, J. Bays, 1989 .

(.eta.5-C5H5)(CO)2FeCH2S+(CH3)2 BF4-: a methylene transfer reagent for the direct cyclopropanation of alkenes

P. Helquist, E. O'Connor, S. Brandt, 1987 .

Cyclopropanation Using an Iron‐Containing Methylene Transfer Reagent: 1,1‐Diphenylcyclopropane

P. Helquist, M. Mattson, E. O'Connor, 2003 .

Generation of (.eta.5-cyclopentadienyl)dicarbonyliron carbene complexes via protonation of the corresponding alkenyl complexes

P. Helquist, G. Kuo, R. Kerber, 1982 .

Cyclopropanation of olefins with a stable, iron-containing methylene transfer reagent

P. Helquist, S. Brandt, 1979 .

Intramolecular C-H Insertion Reactions of (Cyclopentadienyl)dicarbonyliron Carbene Complexes.

P. Helquist, Shikai Zhao, C. Knors, 1990 .

Dicarbonyl(cyclopentadienyl)[(dimethylsulfonium)methyl]iron Tetrafluoroborate†

P. Helquist, 2001 .

Improved One-Flask Preparations of Cyclopropanation Reagents: (η5-C5H5)(CO)2FeCH2S(CH3)2+BF4- and (η5-C5(CH3)5)(CO)2FeCH2S(CH3)2+BF4-.

P. Helquist, V. Stolarski, J. Bays, 1989 .

Cationic cyclization of an iron carbene complex

P. Helquist, Pascale Seutet, 1988 .

(η5‐C5H5)(CO)2FeCH2S+(CH3)2BF‐ 4: A Methylene Transfer Reagent for the Direct Cyclopropanation of Alkenes.

P. Helquist, E. O'Connor, S. Brandt, 1987 .

Preparation, structure, and reactions of stable mono(alkylthio)carbene iron complexes of the (.eta.5-C5H5)(CO)2Fe system

P. Helquist, C. Eigenbrot, G. Kuo, 1987 .

Palladium hydrides in organic synthesis. Reduction of aryl halides by sodium methoxide catalyzed by tetrakis(triphenylphosphine)palladium

P. Helquist, A. Zask, 1978 .

Cleavage of Tetrahydrofuran by tert-Butyldimethylsilyl Iodide and Further Transformations of the Resulting 1-Silyloxy-4-Iodobutane

P. Helquist, J. Nyström, T. Mccanna, 1988 .

Synthesis of 4-methyldienoates using a vinylogous Horner-Wadsworth-Emmons reagent. Application to the synthesis of trichostatic acid.

Douglas J. Schauer, O. Wiest, P. Helquist, 2010, The Journal of organic chemistry.

Synthesis of polyconjugated aldehydes using a new Horner--Wadsworth--Emmons reagent.

P. Helquist, B. Åkermark, T. Rein, 1988, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

Synthesis of 4-Methyldienoates Using a Vinylogous Horner—Wadsworth—Emmons Reagent. Application to the Synthesis of Trichostatic Acid (VIII).

Douglas J. Schauer, O. Wiest, P. Helquist, 2010 .

Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives.

O. Wiest, P. Helquist, Q. Peng, 2012, The Journal of organic chemistry.

Conjugate addition of vinylcopper complexes derived from addition of alkylcopper complexes to acetylenes. A stereospecific synthesis of trisubstituted olefins

P. Helquist, A. Marfat, R. Kramer, 1977 .

GENERATION AND REACTIONS OF THE LITHIUM ENOLATE OF THE IRON ACETYL COMPLEX CP(CO)2FECOCH3

P. Helquist, K. Brinkman, 1985 .

Synthesis of substituted cyclic 1,3-dienes via selective 1,4-elimination of benzenesulfinic acid from allylic phenyl sulfones

P. Helquist, J. Baeckvall, M. Sellén, 1991 .

New functionalized Horner-Wadsworth-Emmons reagents: useful building blocks in the synthesis of polyunsaturated aldehydes. A short synthesis of (.+-.)-(E,E)-coriolic acid

P. Helquist, B. Åkermark, N. Kann, 1990 .

Application of Q2MM to predictions in stereoselective synthesis.

Per-Ola Norrby, Anna Tomberg, Xin Zhang, 2018, Chemical communications.

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.

Bruce J. Melancon, M. Saito, P. Helquist, 2016, Nature chemical biology.

Stable precursors of transition-metal carbene complexes. Simplified preparation and crystal structure of (.eta.5-cyclopentadienyl)[(dimethylsulfonium)methyl]dicarbonyliron(II) fluorosulfonate

P. Helquist, E. O'Connor, 1982 .

η5-CYCLOPENTADIENYLDICARBONYL(PHENYLTHIOCARBENIUM)IRON HEXAFLUOROPHOSPHATE

P. Helquist, C. Knors, 1988 .

Synthesis of Substituted Cyclic 1,3-Dienes via Selective 1,4- Elimination of Benzenesulfinic Acid from Allylic Phenyl Sulfones.

P. Helquist, J. Baeckvall, M. Sellén, 1991 .

Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors

O. Wiest, F. Maxfield, P. Helquist, 2013, Neurotherapeutics.

Facile synthesis of substituted phenanthroline ligands by samarium-promoted coupling of phenanthroline with ketones.

P. Helquist, D. O'Neill, 1999, Organic letters.

An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A.

O. Wiest, P. Helquist, A. Chatterjee, 2010, Organic letters.

Synthetic Applications of Asymmetric Horner-Wadsworth-Emmons Condensations: Approaches to Marine Natural Products

P. Helquist, T. Rein, J. S. Tullis, 1999 .

Palladium(II)-Catalyzed 1,4-Oxidation of 2-Aryl-1,3-cyclohexadienes. Application to the Synthesis of (+/-)-Epibatidine and Analogues.

P. Helquist, J. Bäckvall, A. Larsson, 1999, The Journal of organic chemistry.

Palladium(II)‐Catalyzed 1,4‐Oxidation of 2‐Aryl‐1,3‐cyclohexadienes. Application to the Synthesis of (.+‐.)‐Epibatidine and Analogues.

P. Helquist, J. Baeckvall, A. Larsson, 1999 .

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

O. Wiest, L. Neckers, F. Maxfield, 2021, bioRxiv.

Design and synthesis of a crosslinker for studying intracellular steroid trafficking pathways.

G. Estiu, O. Wiest, P. Helquist, 2015, Bioorganic & medicinal chemistry.

Mild Zinc-Promoted Horner-Wadsworth-Emmons Reactions of Diprotic Phosphonate Reagents

Douglas J. Schauer, P. Helquist, 2006 .

pHP-Tethered N-Acyl Carbamate: A Photocage for Nicotinamide.

O. Wiest, P. Helquist, C. Stauffacher, 2018, Organic letters.

Synthesis and anionic properties of 1,3-dithiane 1-oxide

P. Helquist, R. Carlson, 1968 .

A short, efficient, synthetic pathway to the 6,7,8,9-tetrahydro-5-dibenz[]azonine system

P. Helquist, A. Marfat, S. Brandt, 1979 .

pH dependent inhibition from ammonium ions in the Pseudomonas mevalonii HMG-CoA Reductase crystallization environment

O. Wiest, A. Mesecar, P. Helquist, 2020, bioRxiv.

Effects of Iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines

P. Helquist, D. Schweitzer, Wei-lin Wang, 2008, Journal of cellular biochemistry.

Total synthesis of iejimalide B. An application of the Shiina macrolactonization.

P. Helquist, D. Strand, D. Schweitzer, 2007, Organic letters.

Purification of air-sensitive organometallic compounds by a modified flash chromatography procedure

P. Helquist, K. Kremer, 1984 .

Dicarbonyl(cyclopentadienyl)(1‐phenylthioethyl)iron

P. Helquist, 2001 .

Functionalized aryllithium intermediates. A synthesis of benzocyclobutenes.

P. Helquist, J. Tagat, C. Hergrueter, 1977 .

Negative Data in Data Sets for Machine Learning Training.

Connor W. Coley, O. Wiest, Nessa Carson, 2023, The Journal of organic chemistry.

Generation and use of a zinc derivative of a functionalized 1,3-oxazole. Solution of the virginiamycin/madumycin oxazole problem

P. Helquist, A. Gangloff, B. Aakermark, 1992 .

QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids.

Paul Helquist, Olaf Wiest, O. Wiest, 2004, Bioorganic & medicinal chemistry letters.

Automated fitting of transition state force fields for biomolecular simulations

O. Wiest, P. Helquist, Kevin J Koh, 2020, PloS one.

Stereochemistry of intramolecular cyclopropanation of an organoiron reagent

P. Helquist, G. Kuo, R. S. Iyer, 1985 .

Conformational and SAR analysis of NAALADase and PSMA inhibitors.

O. Wiest, P. Helquist, Marvin J. Miller, 2003, Bioorganic & medicinal chemistry.

Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas mevalonii HMG-CoA Reductase.

O. Wiest, P. Helquist, Brandon E. Haines, 2023, The journal of physical chemistry. B.

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.

M. Saito, P. Helquist, P. Matthias, 2016, Nature chemical biology.

Application of Q2MM to predictions in stereoselective synthesis.

O. Wiest, P. Helquist, A. Rosales, 2018, Chemical communications.

Molecular Mechanics Predictions and Experimental Testing of Asymmetric Palladium-Catalyzed Allylation Reactions Using New Chiral Phenanthroline Ligands

P. Helquist, P. Norrby, A. Ishii, 1996 .

Finding Relevant Retrosynthetic Disconnections for Stereocontrolled Reactions.

P. Helquist, P. Norrby, Christoph Bauer, 2024, Journal of Chemical Information and Modeling.

Interplay of Computation and Experiment in Enantioselective Catalysis: Rationalization, Prediction, and─Correction?

O. Wiest, P. Helquist, P. Norrby, 2023, ACS Catalysis.

Negative Data in Data Sets for Machine Learning Training.

Connor W. Coley, O. Wiest, Nessa Carson, 2023, Organic letters.