A. Poulsen

发表

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.

Chang Kai Soh, A. Poulsen, Meredith Williams, 2012, Bioorganic & medicinal chemistry letters.

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.

Kay Lin Goh, Z. Bonday, J. Wood, 2011, Journal of medicinal chemistry.

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2017, Biochemistry.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Shi Hua Ang, Eldwin Sum Wai Tan, C. Chuah, 2018, Journal of medicinal chemistry.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Rong Li, Sugunavathi Sepramaniam, A. Poulsen, 2019, ACS medicinal chemistry letters.

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

J. Yen, A. Poulsen, B. Dymock, 2016, Journal of medicinal chemistry.

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

A. Poulsen, A. William, B. Dymock, 2011, Leukemia.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

A. Poulsen, J. Cherian, Boping Liu, 2016, Journal of medicinal chemistry.

Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines.

W. Saw, G. Grüber, Joon Shin, 2020, Angewandte Chemie.

Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines

W. Saw, G. Grüber, Joon Shin, 2020, Angewandte Chemie.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

D. Tenen, Y. S. Tan, C. Verma, 2018, Proceedings of the National Academy of Sciences.

Application of Fragment-Based Drug Discovery against DNA Gyrase B.

A. Poulsen, Qiu Ying Lau, F. Ng, 2015, ChemPlusChem.

Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthr

J. Wood, A. Poulsen, A. William, 2012, Journal of medicinal chemistry.

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2015, Biochemistry.

Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.

A. Poulsen, Boping Liu, Jeffrey Hill, 2021, Bioorganic & medicinal chemistry.

2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.

Chang Kai Soh, Kay Lin Goh, Z. Bonday, 2012, Bioorganic & medicinal chemistry letters.

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Shi Hua Ang, Eldwin Sum Wai Tan, A. Poulsen, 2017, Journal of medicinal chemistry.

Pharmacophore and receptor models for neurokinin receptors

Klaus Gundertofte, Tommy Liljefors, Irina D. Pogozheva, 2003, J. Comput. Aided Mol. Des..

Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-

J. Wood, A. Poulsen, Meredith Williams, 2012, Journal of medicinal chemistry.

Combining the [2,3] sigmatropic rearrangement and ring-closing metathesis strategies for the synthesis of spirocyclic alkaloids. A short and efficient route to (±)-perhydrohistrionicotoxin

L. Hagberg, D. Tanner, A. Poulsen, 1999 .

Nutrient content in plant-based protein products intended for food composition databases

E. Trolle, A. Poulsen, J. Jakobsen, 2021, Journal of Food Composition and Analysis.

Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease

J. Chu, Jianhe Peng, W. Hong, 2016, Scientific Reports.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study.

A. Poulsen, Jeffrey Hill, Wen-Yang Wu, 2013, European journal of medicinal chemistry.

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors.

Kay Lin Goh, Z. Bonday, A. Poulsen, 2010, Bioorganic & medicinal chemistry letters.

SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents

A. Poulsen, Haishan Wang, Xukun Wang, 2006, Journal of biomolecular screening.

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Xiao Han, A. Pobbati, W. Hong, 2015, Structure.

Intranasal administration of a stapled relaxin‐3 mimetic has anxiolytic‐ and antidepressant‐like activity in rats

R. Kini, A. Poulsen, B. Dymock, 2019, British journal of pharmacology.

Discovery of Kinase Spectrum Selective Macrocycle

J. Wood, A. Poulsen, Meredith Williams, 2011 .

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lympho

Anders Poulsen, Stéphanie Blanchard, Harish Nagaraj, 2011, Journal of medicinal chemistry.

Identification of covalent active site inhibitors of dengue virus protease

S. Vasudevan, S. Gayen, A. Poulsen, 2015, Drug design, development and therapy.

A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes

Klaus Gundertofte, Tommy Liljefors, Anders Poulsen, 2002, J. Comput. Aided Mol. Des..

Fragment-based ligand design of novel potent inhibitors of tankyrases.

P. Nordlund, A. Poulsen, F. Ng, 2013, Journal of medicinal chemistry.

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2017, Journal of medicinal chemistry.

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Rong Li, A. Pobbati, W. Hong, 2018, The Biochemical journal.

Structure-based design of Aurora A & B inhibitors

Eric Sun, Anders Poulsen, Anthony William, 2008, J. Comput. Aided Mol. Des..

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)

A. Poulsen, Meredith Williams, H. Nagaraj, 2012, Journal of Molecular Modeling.

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.

Shi Hua Ang, G. Basarab, A. Poulsen, 2018, European journal of medicinal chemistry.

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

D. Herr, A. Poulsen, B. Dymock, 2016, Peptides.

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.

J. Yen, A. Poulsen, B. Dymock, 2018, European journal of medicinal chemistry.

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.

Anders Poulsen, Yan Li, Alex Matter, 2019, ACS infectious diseases.

Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602

Anders Poulsen, Stéphanie Blanchard, Angeline Lee, 2014, J. Chem. Inf. Model..

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome

A. Poulsen, B. Dymock, T. Dick, 2017, Antimicrobial Agents and Chemotherapy.

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria

E. Rubin, A. Poulsen, T. Dick, 2015, mBio.

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6).

A. Poulsen, B. Dymock, Lianbin Yao, 2018, Bioorganic & medicinal chemistry letters.

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony William, Stéphanie Blanchard, 2012, Journal of Computer-Aided Molecular Design.

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

J. Kwiatkowski, A. Poulsen, Jeffrey Hill, 2020, Journal of medicinal chemistry.

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

A. Poulsen, T. Dick, Jeffrey Hill, 2018, Front. Microbiol..

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors.

Rong Li, A. Poulsen, S. Yao, 2021, Angewandte Chemie.

Discovery and Optimization of a Porcupine Inhibitor.

Shi Hua Ang, Eldwin Sum Wai Tan, A. Poulsen, 2015, Journal of medicinal chemistry.

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study

J. Chu, Jianhe Peng, A. Poulsen, 2016, Journal of enzyme inhibition and medicinal chemistry.

Drug design for flavivirus proteases: what are we missing?

A. Poulsen, T. Keller, C. Kang, 2014, Current pharmaceutical design.

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex.

S. Cohen, Wei Zhang, A. Poulsen, 2015, Cellular signalling.

Structure-based design of PDK1 inhibitors.

Chang Kai Soh, A. Poulsen, Meredith Williams, 2012, Bioorganic & medicinal chemistry letters.

Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease

A. Poulsen, F. Ng, Jeffrey Hill, 2016, Journal of enzyme inhibition and medicinal chemistry.

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Shi Hua Ang, Eldwin Sum Wai Tan, J. Kwiatkowski, 2018, Journal of medicinal chemistry.