A. William

发表

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.

Chang Kai Soh, A. Poulsen, Meredith Williams, 2012, Bioorganic & medicinal chemistry letters.

SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis

J. Wood, A. William, B. Dymock, 2012, The Journal of Immunology.

Palladium‐ and Nickel‐Catalyzed Coupling Reactions of α‐Bromoalkenylphosphonates with Arylboronic Acids and Lithium Alkenylborates

A. William, Yuichi Kobayashi, 2004 .

Scope and limitation of the nickel-catalyzed coupling reaction between lithium borates and mesylates

A. William, Yuichi Kobayashi, R. Mizojiri, 2002 .

Coupling Reactions of α-Bromoalkenyl Phosphonates with Aryl Boronic Acids and Alkenyl Borates

A. William, Yuichi Kobayashi, 2002 .

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies

A. Poulsen, A. William, B. Dymock, 2011, Leukemia.

Sharpless asymmetric dihydroxylation of trans-propenylphosphonate by using a modified AD-mix-alpha and the synthesis of fosfomycin.

A. William, Y. Tokoro, Y. Kobayashi, 2001, The Journal of organic chemistry.

Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthr

J. Wood, A. Poulsen, A. William, 2012, Journal of medicinal chemistry.

Synthesis of tetrahydrocannabinols based on an indirect 1,4-addition strategy.

A. William, Yuichi Kobayashi, 2002, The Journal of organic chemistry.

Palladium-catalyzed decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides

A. William, L. R. Chennamaneni, C. Johannes, 2015 .

Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-

J. Wood, A. Poulsen, Meredith Williams, 2012, Journal of medicinal chemistry.

A method to accomplish a 1,4-addition reaction of bulky nucleophiles to enones and subsequent formation of reactive enolates.

A. William, Y. Kobayashi, 2001, Organic letters.

Synthesis of Tetrahydrocannabinols Based on an Indirect 1,4‐Addition Strategy.

A. William, Yuichi Kobayashi, 2003 .

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors.

Kay Lin Goh, Z. Bonday, A. Poulsen, 2010, Bioorganic & medicinal chemistry letters.

Discovery of Kinase Spectrum Selective Macrocycle

J. Wood, A. Poulsen, Meredith Williams, 2011 .

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lympho

Anders Poulsen, Stéphanie Blanchard, Harish Nagaraj, 2011, Journal of medicinal chemistry.

Structure-based design of Aurora A & B inhibitors

Eric Sun, Anders Poulsen, Anthony William, 2008, J. Comput. Aided Mol. Des..

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)

A. Poulsen, Meredith Williams, H. Nagaraj, 2012, Journal of Molecular Modeling.

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony William, Stéphanie Blanchard, 2012, Journal of Computer-Aided Molecular Design.

Improved Synthesis of Pyridyl—Biaryl Ring Systems via Benzidine Rearrangements.

A. William, C. Johannes, G. Y. C. Leung, 2014 .

Improved synthesis of pyridyl–biaryl ring systems via benzidine rearrangements

A. William, C. Johannes, G. Y. C. Leung, 2014 .

A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1.1]pentane.

A. William, P. Bernardo, C. Johannes, 2014, Organic letters.

SB1518: A Potent and Orally Active JAK2 Inhibitor for the Treatment of Myeloproliferative Disorders.

Z. Bonday, J. Wood, J. Griffin, 2007 .

nonaene ( SB 1578 ) , a Potent Inhibitor of Janus Kinase 2 / Fms-LikeTyrosine Kinase-3 ( JAK 2 / FLT 3 ) for the Treatment of Rheumatoid Arthritis

Anders Poulsen, Harish Nagaraj, Evelyn Tan, 2012 .

TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties

J. Wood, A. William, B. Dymock, 2012, Leukemia.

SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis

J. Wood, A. William, B. Dymock, 2012, The Journal of Immunology.

Supporting Information: Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl- ethoxy)-14,19-dioxa-5,7,26-triaza- tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa- 1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment o

Harish, J. Wood, Meredith Williams, 2011 .