D. Stec

D. Stec, C. Sigmund, 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity.

D. Stec, R. Parker, Sabrina A. Bardowell, 2010, The Journal of nutrition.

Common Variants of Cytochrome P450 4F2 Exhibit Altered Vitamin E-v-Hydroxylase

D. Stec, R. Parker, Sabrina A. Bardowell, 2010 .

Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells.

S. Satchell, D. Stec, J. Rimoldi, 2018, American journal of physiology. Regulatory, integrative and comparative physiology.

Mother Baby Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells

S. Satchell, D. Stec, J. Rimoldi, 2018 .

Carbon Monoxide Donors or HO-1 Overexpression Block Interleukin-18-Mediated NF- κ B-PTEN-Dependent Human Cardiac Endothelial Cell Death

A. J. Valente, D. Stec, J. Rimoldi, 2009 .

Role of carbon monoxide in kidney function: is a little carbon monoxide good for the kidney?

L. Juncos, H. Drummond, D. Stec, 2012, Current pharmaceutical biotechnology.

HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice.

D. Stec, J. Reckelhoff, S. Kelsen, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Distribution of cytochrome P-450 4A and 4F isoforms along the nephron in mice.

R. Roman, D. Stec, Averia K. Flasch, 2003, American journal of physiology. Renal physiology.

Bilirubin, Renal Hemodynamics, and Blood Pressure

D. Stec, J. Granger, P. Hosick, 2012, Front. Pharmacol..

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

T. Hinds, D. Stec, O. O. Badmus, 2022, Clinical science.

Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.

J. Falck, R. Roman, D. Stec, 1996, The American journal of physiology.

Kidney-Specific Induction of Heme Oxygenase-1 Prevents Angiotensin II Hypertension

D. Stec, S. Kelsen, Trinity Vera, 2008, Hypertension.

The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury

L. Juncos, D. Stec, K. Nath, 2012, International journal of hypertension.

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α*♦

T. Hinds, D. Stec, A. Nestor-Kalinoski, 2016, The Journal of Biological Chemistry.

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a–C5aR1 Pathway

A. Bulmer, Z. Nemeth, T. Woodruff, 2019, The Journal of Immunology.

The loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity.

T. Hinds, D. Stec, D. Stec, 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

Heme oxygenase inhibition increases blood pressure in pregnant rats.

D. Stec, J. Granger, E. George, 2013, American journal of hypertension.

Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins*

Grant Smith, D. Stec, A. A. da Silva, 2010, The Journal of Biological Chemistry.

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α*

Michael W. Hankins, J. V. Vanden Heuvel, H. Drummond, 2016, The Journal of Biological Chemistry.

Changes in urinary metabolome related to body fat involve intermediates of choline processing by gut microbiota

D. Stec, D. Stec, P. Voziyan, 2019, Heliyon.

Antihypertensive Actions of Moderate Hyperbilirubinemia: Role of Superoxide Inhibition

D. Stec, Megan V. Storm, Monette U Gousette, 2012, American journal of hypertension.

Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure.

H. Drummond, D. Stec, J. Rimoldi, 2005, Journal of the American Society of Nephrology : JASN.

Heme oxygenase-1 induction does not improve vascular relaxation in angiotensin II hypertensive mice.

D. Stec, J. Rimoldi, S. Kelsen, 2008, American journal of hypertension.

Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein.

R. Roman, D. Stec, M. Schwartzman, 1996, Archives of biochemistry and biophysics.

Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas.

H. Drummond, D. Stec, J. Granger, 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats.

F. Rodríguez, G. Li Volti, D. Stec, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Impact on Studies of Salt-Sensitive Hypertension

T. Kurtz, M. Pravenec, R. Roman, 1994 .

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells.

T. Hinds, D. Stec, S. Adeosun, 2018, American journal of physiology. Renal physiology.

Pharmacological and Clinical Significance of Heme Oxygenase-1

N. Abraham, D. Stec, 2021, Antioxidants.

Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells.

H. Drummond, D. Stec, Joshua S. Speed, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Inhibition of Biliverdin Reductase Increases Angiotensin II-Dependent Superoxide Levels in Cultured Renal Tubular Epithelial Cells

H. Drummond, D. Stec, S. Kelsen, 2009 .

Cre-Recombinase Lower Blood Pressure in Floxed Angiotensinogen Mice After Adenoviral Delivery of

D. Stec, C. Sigmund, H. Keen, 2002 .

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate

T. Hinds, D. Stec, Justin F. Creeden, 2020, Frontiers in Pharmacology.

Renal vascular responses to CORM-A1 in the mouse.

H. Drummond, D. Stec, J. Rimoldi, 2006, Pharmacological research.

20-Hydroxyeicosatetraenoic Acid (20-HETE) Stimulates Migration of Vascular Smooth Muscle Cells

H. Drummond, D. Stec, Kimberly P. Gannon, 2007, Cellular Physiology and Biochemistry.

Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension

D. Stec, J. Rimoldi, J. Granger, 2017, American journal of hypertension.

CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation.

T. Hinds, D. Stec, C. Anderson, 2019, Archives of biochemistry and biophysics.

Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells.

H. Drummond, D. Stec, J. Rimoldi, 2008, American journal of physiology. Renal physiology.

Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension.

L. Juncos, Paul L Huang, J. Pollock, 2016, Journal of the American Society of Nephrology : JASN.

Functional polymorphism in human CYP4F2 decreases 20-HETE production.

M. Rieder, R. Roman, D. Stec, 2007, Physiological genomics.

Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α

T. Hinds, R. Mccullumsmith, D. Stec, 2020, The Journal of Biological Chemistry.

Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway.

L. Rodella, R. Rezzani, N. Abraham, 2007, American journal of physiology. Renal physiology.

Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats.

H. Jacob, H. Drummond, R. Roman, 1997, Hypertension.

Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats.

H. Jacob, T. Kurtz, M. Pravenec, 1996, The Journal of clinical investigation.

Positive Effects of Heme Oxygenase Upregulation on Adiposity and Vascular Dysfunction: Gene Targeting vs. Pharmacologic Therapy

N. Abraham, D. Stec, S. Peterson, 2019, International journal of molecular sciences.

Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice.

D. Stec, C. Sigmund, S. Morimoto, 2001, BioTechniques.

Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt-sensitive hypertension.

R. Morris, M. Pravenec, R. Roman, 1994, Hypertension.

Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications.

N. Abraham, D. Stec, S. Peterson, 2021, Pharmacology & therapeutics.

Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein Vivo *

B. Davidson, D. Stec, C. Sigmund, 1999, The Journal of Biological Chemistry.

Bilirubin as a Metabolic Hormone: The Physiological Relevance of Low Levels.

T. Hinds, D. Stec, Darren M. Gordon, 2020, American journal of physiology. Endocrinology and metabolism.

Chapter 38 – Pathophysiology of Obesity—Induced Hypertension and Target Organ Damage

Daniel W. Jones, D. Stec, Z. Ying, 2007 .

Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase.

D. Stec, C. Sigmund, 2001, Methods in molecular medicine.

Renal inflammation and elevated blood pressure in a mouse model of reduced {beta}-ENaC.

H. Drummond, D. Stec, J. Barnard, 2011, American journal of physiology. Renal physiology.

ENaC proteins contribute to VSMC migration.

H. Drummond, D. Stec, Kimberly P. Gannon, 2006, American journal of physiology. Heart and circulatory physiology.

βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension.

H. Drummond, D. Stec, 2015, Journal of nephrology research.

Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses

D. Stec, I. Paul, J. Piletz, 2003, Brain Research.

Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1

T. Hinds, L. Koch, S. Britton, 2020, Antioxidants.

Modifiable Gene Expression in Mice: Kidney-Specific Deletion of a Target Gene via the Cre-loxP System

D. Stec, C. Sigmund, 1998, Nephron Experimental Nephrology.

Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension.

D. Stec, C. Sigmund, R. Davisson, 1998, Trends in cardiovascular medicine.

Bilirubin, a Cardiometabolic Signaling Molecule

T. Hinds, D. Stec, 2018, Hypertension.

Bilirubin protects the ageing heart

D. Stec, S. Adeosun, 2017, Acta physiologica.

Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension.

D. Stec, Trinity Vera, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.

D. Stec, J. Granger, Trinity Vera, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

bENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.

H. Drummond, D. Stec, Ruisheng Liu, 2022, American journal of physiology. Renal physiology.

Renal Intramedullary Infusion of Tempol Normalizes the Blood Pressure Response to Intrarenal Blockade of Heme Oxygenase‐1 in Angiotensin II‐Dependent Hypertension

D. Stec, Monette U. Gousset, 2013, Journal of the American Society of Hypertension : JASH.

Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension.

H. Drummond, N. Abraham, D. Stec, 2012, Journal of the American Society of Nephrology : JASN.

Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice.

D. Stec, C. Sigmund, Y. Ding, 1999, Physiological genomics.

Moderate Hyperbilirubinemia Improves Renal Hemodynamics in Angiotensin II‐Dependent Hypertension

D. Stec, Trinity Vera, 2010 .

Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice.

Michael E. Hall, D. Stec, J. Hall, 2011, American journal of physiology. Heart and circulatory physiology.

Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease

T. Hinds, D. Stec, M. M. Soundarapandian, 2023, Biomolecules.

Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin

T. Hinds, D. Stec, D. Thomas, 2022, Antioxidants.

Bilirubin: A Ligand of the PPARα Nuclear Receptor

T. Hinds, D. Stec, Darren M. Gordon, 2021, Nuclear Receptors.

Powering the powerhouse: Heme oxygenase‐1 regulates mitochondrial function in non‐alcoholic fatty liver disease (NAFLD)

T. Hinds, D. Stec, C. Tiribelli, 2023, Acta physiologica.

Cutting edge concepts: Does bilirubin enhance exercise performance?

T. Hinds, D. Stec, L. Vítek, 2023, Frontiers in Sports and Active living.

Chronic Carbon Monoxide Treatment Attenuates Development of Obesity and Remodels Adipocytes in Mice Fed a High Fat Diet

D. Stec, P. Hosick, Abdulhadi A. Alamodi, 2013, International Journal of Obesity.

The physiology of bilirubin: health and disease equilibrium.

T. Hinds, D. Stec, C. Tiribelli, 2023, Trends in molecular medicine.

Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health

T. Hinds, D. Stec, 2019, Current Hypertension Reports.

Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content

H. Moseley, R. Flight, T. Hinds, 2023, Metabolites.

pathwayby an increase in the antiapoptotic signaling Genetic suppression of HO-1 exacerbates renal damage:

L. Rodella, R. Rezzani, N. Abraham, 2016 .

Role of carbon monoxide in blood pressure regulation.

H. Drummond, D. Stec, Trinity Vera, 2008, Hypertension.

Sex-Dependent Effects of HO-1 Deletion from Adipocytes in Mice

Michael W. Hankins, D. Stec, P. Hosick, 2017, International journal of molecular sciences.

the hypothalamus related to decreased activity of nitric oxide synthase in The weight loss elicited by cobalt protoporphyrin is

N. Abraham, Dong Hyun Kim, D. Stec, 2015 .

Carbon Monoxide (CO) Protects Renal Tubular Epithelial Cells against Cold-Rewarm Apoptosis

D. Stec, J. Rimoldi, A. Salahudeen, 2007, Renal failure.

The loss of hepatic PPARα in mice causes hypertension and cardiovascular disease.

T. Hinds, D. Stec, Lucy C Taylor, 2023, American journal of physiology. Regulatory, integrative and comparative physiology.

Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease

T. Hinds, D. Stec, O. Badmus, 2023, Current Hypertension Reports.

Blood pressure and renal blow flow responses in heme oxygenase-2 knockout mice.

D. Stec, M. Ryan, Trinity Vera, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet

D. Stec, J. Granger, P. Hosick, 2014, BMC Obesity.

Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension.

H. Drummond, D. Stec, J. Stout, 2013, Journal of the American Society of Hypertension : JASH.

Bilirubin, a novel endocrine hormone with fat burning properties

T. Hinds, D. Stec, Darren M. Gordon, 2018 .

Melanocortin-4 Receptor–Deficient Mice Are Not Hypertensive or Salt-Sensitive Despite Obesity, Hyperinsulinemia, and Hyperleptinemia

D. Stec, L. Tallam, M. Willis, 2005, Hypertension.

Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice

D. Stec, G. Derumeaux, R. Foresti, 2020, Redox biology.

The Emerging Role of Heme Oxygenase and Its Metabolites in the Regulation of Cardiovascular Function

N. Abraham, D. Stec, D. Sacerdoti, 2012, International Journal of Hypertension.

Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.

Michael E. Hall, D. Stec, J. Hall, 2014, American journal of physiology. Endocrinology and metabolism.

Chronic Carbon Monoxide Treatment Attenuates Development of Obesity and Remodels Adipocytes in Mice Fed a High Fat Diet

D. Stec, P. Hosick, Abdulhadi A. Alamodi, 2013, International Journal of Obesity.

Renal Inhibition of Heme Oxygenase-1 Increases Blood Pressure in Angiotensin II-Dependent Hypertension

D. Stec, E. Csongrádi, Megan V. Storm, 2011, International journal of hypertension.

In vivo inhibition of renal heme oxygenase with an imidazole-dioxolane inhibitor.

D. Stec, J. Rimoldi, Trinity Vera, 2010, Pharmacological research.

Fenoldopam Preconditioning: Role of Heme Oxygenase-1 in Protecting Human Tubular Cells and Rodent Kidneys Against Cold-Hypoxic Injury

S. Doré, D. Stec, A. Salahudeen, 2011, Transplantation.

Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders

B. Wegiel, D. Stec, Terry Hinds, Jr, 2021, Frontiers in Pharmacology.

Reactive Oxygen Species (ROS) and Antioxidants as Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin Oxygenase and Bilirubin

D. Stec, M. Detsika, Nicholas Delcimmuto, 2022 .

Vascular smooth muscle-specific deletion of the leptin receptor attenuates leptin-induced alterations in vascular relaxation.

Michael W. Hankins, D. Stec, J. Sasser, 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity.

T. Hinds, D. Stec, S. Adeosun, 2018, Reactive oxygen species.