Carson C. Thoreen

发表

A unifying model for mTORC1-mediated regulation of mRNA translation

D. Sabatini, N. Gray, Tim Wang, 2012, Nature.

Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.

Joshua E. Elias, S. Gygi, J. Elias, 2003, Journal of proteome research.

Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column.

S. Gygi, Junmin Peng, Carson C. Thoreen, 2002, Analytical chemistry.

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

D. Sabatini, N. Gray, W. M. Kuehl, 2009, Cell.

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

David M. Sabatini, Yoav D. Shaul, Robert A Lindquist, 2008, Science.

Cooperative nutrient accumulation sustains growth of mammalian cells

D. Sabatini, S. Manalis, M. V. Vander Heiden, 2015, Scientific Reports.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

D. Sabatini, N. Gray, Qingsong Liu, 2010, Journal of medicinal chemistry.

Archaeal ribosomal proteins possess nuclear localization signal-type motifs: implications for the origin of the cell nucleus.

D. Söll, S. Melnikov, Carson C. Thoreen, 2019, Molecular biology and evolution.

Development of ATP-competitive mTOR inhibitors.

D. Sabatini, N. Gray, Qingsong Liu, 2012, Methods in molecular biology.

Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs

Carson C. Thoreen, Lucas Philippe, Antonia van den Elzen, 2020, Proceedings of the National Academy of Sciences.

Measuring mRNA Decay with Roadblock‐qPCR

Carson C. Thoreen, Maegan J. Watson, 2022, Current protocols.

Split-personality inhibitors

Carson C. Thoreen, 2021, Nature Chemical Biology.

Many roads from mTOR to eIF4F.

Carson C. Thoreen, 2013, Biochemical Society transactions.

Many roads from mTOR to eIF 4 F

Carson C. Thoreen, 2013 .

signaling S 6 K pathway − TORC 1 Drosophila melanogaster regulators of Genome-scale RNAi on living-cell microarrays identifies novel Material Supplemental

Anne E Carpenter, Katherine L. Madden, T. Jones, 2011 .

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1*

D. Sabatini, N. Gray, Qingsong Liu, 2009, Journal of Biological Chemistry.

Roadblock-qPCR: a simple and inexpensive strategy for targeted measurements of mRNA stability

Carson C. Thoreen, Yeonwoo Park, Maegan J. Watson, 2020, RNA.

Huntingtin aggregates ask to be eaten

D. Sabatini, Carson C. Thoreen, 2004, Nature Genetics.

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Jacob D. Jaffe, S. Carr, D. Sabatini, 2006, Current Biology.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

D. Guertin, J. Moffat, D. Sabatini, 2006, Developmental cell.

Mammalian Target of Rapamycin ( mTOR ) Inhibitor for Treatment of Cancer

D. Sabatini, N. Gray, Qingsong Liu, 2011 .

Controversies around the function of LARP1

Philippe P Roux, Carson C. Thoreen, Z. Dedeic, 2020, RNA biology.

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Gordon B Mills, David M Sabatini, G. Mills, 2016, Cancer research.

mTOR Mediated Anti-Cancer Drug Discovery.

D. Sabatini, N. Gray, Qingsong Liu, 2009, Drug discovery today. Therapeutic strategies.

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Carson C. Thoreen, Lucas Philippe, A. Reyna-Neyra, 2017, Cell reports.

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

S. Elledge, D. Sabatini, M. Niepel, 2013, Cancer research.

Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR Citation

S. Elledge, D. Sabatini, M. Niepel, 2013 .

ATM , and ATR Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR

S. Elledge, D. Sabatini, M. Niepel, 2013 .

mTOR , ATM and ATR Characterization of Torin 2 , an ATP-competitive inhibitor of

S. Elledge, D. Sabatini, M. Niepel, 2013 .

Therapeutics , Targets , and Chemical Biology Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR

S. Elledge, D. Sabatini, M. Niepel, 2013 .

Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division

D. Guertin, D. Sabatini, G. Bell, 2006, Current Biology.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Anne E Carpenter, David M Sabatini, Thouis R Jones, 2011, Genome research.

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

S. Carr, Robert A Lindquist, D. Sabatini, 2007, Molecular cell.

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer

D. Sabatini, N. Gray, Qingsong Liu, 2011 .

The molecular basis of mTORC1-regulated translation.

Carson C. Thoreen, 2017, Biochemical Society transactions.

Rapamycin inhibits mTORC1, but not completely

D. Sabatini, Carson C. Thoreen, 2009, Autophagy.

Archaeal ribosomal proteins possess nuclear localization signal-type motifs: implications for the origin of the cell nucleus

D. Söll, S. Melnikov, Carson C. Thoreen, 2019, bioRxiv.

Loss of protein synthesis quality control in host-restricted organisms

D. Söll, S. Melnikov, Carson C. Thoreen, 2018, Proceedings of the National Academy of Sciences.

A proteomics approach to understanding protein ubiquitination

Steven P Gygi, Joshua E Elias, Junmin Peng, 2003, Nature Biotechnology.

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

Carson C. Thoreen, Antonia van den Elzen, Maegan J. Watson, 2022, bioRxiv.

Carson C. Thoreen, Lucas Philippe, J. Vasseur, 2017, Nucleic acids research.

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics*

P. Sorger, D. Sabatini, A. Look, 2012, The Journal of Biological Chemistry.

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.

D. Sabatini, N. Gray, Qingsong Liu, 2011, Bioorganic & medicinal chemistry letters.

Carson C. Thoreen, Lucas Philippe, J. Vasseur, 2018, Nucleic acids research.

AMPK and p53 help cells through lean times.

D. Sabatini, Carson C. Thoreen, 2005, Cell metabolism.

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1*

D. Sabatini, N. Gray, Qingsong Liu, 2009, Journal of Biological Chemistry.

MIT Open Access Articles Cooperative nutrient accumulation sustains growth of mammalian cells

S. Manalis, M. V. Heiden, Carson C. Thoreen, 2022 .