Y. Sai

发表

Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis

Y. Ishigaki, E. Higashihara, K. Miyamoto, 2011, Laboratory Investigation.

Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice

T. Shimada, K. Miyamoto, Y. Sai, 2011 .

Characterization of the transdermal transport of flurbiprofen and indomethacin.

Y. Kato, Y. Sai, A. Tsuji, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion.

Y. Sai, T. Nishimura, M. Tomi, 2013, Journal of pharmaceutical sciences.

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

Y. Sai, K. Naruhashi, I. Tamai, 2000, The Journal of pharmacology and experimental therapeutics.

Palonosetron on Days 1 and 5 Versus Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy

T. Shimada, H. Yaegashi, Y. Sai, 2019, In Vivo.

Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.

T. Nakanishi, Y. Sai, Takuma Sasaki, 1997, Cancer research.

Prediction of theophylline clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test.

Y. Sai, M. Isawa, E. Nakashima, 2005, Drug metabolism and pharmacokinetics.

PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS

P. Artursson, Y. Kato, Y. Sai, 2006, Drug Metabolism and Disposition.

Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier.

Y. Sai, I. Tamai, A. Tsuji, 1997, The Journal of pharmacology and experimental therapeutics.

Design and Synthesis of Peptides Passing through the Blood-Brain Barrier

Y. Sai, S. Kusumoto, I. Tamai, 1998 .

Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers

Y. Sai, T. Nishimura, M. Tomi, 2022, Pharmaceutical research.

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells

T. Shimada, K. Miyamoto, T. Nakanishi, 2018, Biopharmaceutics & drug disposition.

A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers.

K. Miyamoto, Y. Sai, J. Sugama, 2011, Journal of pharmaceutical sciences.

cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter.

H. Yamamoto, H. Takanaga, Y. Sai, 1995, Biochemical and biophysical research communications.

Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy

T. Shimada, Y. Sai, K. Nishimura, 2020, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

J. Nezu, A. Oku, M. Shimane, 2000, Biochemical and biophysical research communications.

Influx mechanism of 2',3'-dideoxyinosine and uridine at the blood-placenta barrier.

Y. Sai, T. Nishimura, E. Nakashima, 2009, Placenta.

DMD # 19125-1-Involvement of multidrug resistance-associated protein 2 ( Abcc 2 ) in molecular weight-dependent biliary excretion of ß-lactam antibiotics

Y. Kato, Y. Sai, I. Tamai, 2008 .

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics

Y. Kato, Y. Sai, I. Tamai, 2008, Drug Metabolism and Disposition.

Characterization of the Uptake Mechanism for a Novel Loop Diuretic, M17055, in Caco-2 Cells: Involvement of Organic Anion Transporting Polypeptide (OATP)-B

Y. Kato, Y. Sai, A. Tsuji, 2006, Pharmaceutical Research.

Functional Characterization of Human Organic Anion Transporting Polypeptide B (OATP-B) in Comparison with Liver-Specific OATP-C

J. Nezu, Y. Sai, I. Tamai, 2001, Pharmaceutical Research.

Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats.

Y. Kato, Y. Sai, A. Tsuji, 2004, Journal of pharmaceutical sciences.

The genetic polymorphism of drug transporters: functional analysis approaches.

T. Ishikawa, Y. Sai, H. Endou, 2004, Pharmacogenomics.

Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1.

Y. Sai, I. Tamai, A. Tsuji, 2002, The Journal of pharmacology and experimental therapeutics.

GENETIC POLYMORPHISM OF DRUG TRANSPORTERS

J. Nezu, A. Oku, M. Shimane, 2000 .

Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

J. Nezu, A. Oku, M. Shimane, 1997, FEBS letters.

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

T. Shimada, Y. Sai, Hironori Kitade, 2018, Journal of Pharmaceutical Health Care and Sciences.

Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin.

Y. Kato, Y. Sai, A. Tsuji, 2003, Drug metabolism and pharmacokinetics.

Pharmacokinetics Parameters in Drug Package Inserts (3)

Y. Sai, T. Ogihara, K. Morimoto, 2011 .

Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700.

Keiko Nakamura, Y. Kato, Y. Sai, 2006, Journal of pharmaceutical sciences.

Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins

Y. Kato, Y. Sai, A. Tsuji, 2004, Pharmaceutical Research.

Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate.

Y. Sai, T. Nishimura, M. Tomi, 2011, Journal of pharmaceutical sciences.

Enhancement of Zidovudine Uptake by Dehydroepiandrosterone Sulfate in Rat Syncytiotrophoblast Cell Line TR-TBT 18d-1

T. Terasaki, Y. Sai, Young-Sook Kang, 2008, Drug Metabolism and Disposition.

Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

J. Nezu, A. Oku, M. Shimane, 2001, Molecular pharmacology.

Molecular and Physiological Evidence for Multifunctionality of Carnitine / Organic Cation Transporter OCTN 2

J. Nezu, A. Oku, M. Shimane, 2001 .

CCR 5 Plays a Critical Role in Obesity-Induced Adipose Tissue In fl ammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M 1 / M 2 Status

S. Kaneko, Hiroshi Yamamoto, N. Mukaida, 2012 .

DB111506 1680..1690

Hiroshi Yamamoto, N. Mukaida, K. Miyamoto, 2012 .

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

S. Kaneko, Hiroshi Yamamoto, N. Mukaida, 2012, Diabetes.

A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy

Y. Sai, J. Ishizaki, Y. Suga, 2020, The Annals of pharmacotherapy.

Investigation for Risk Factor and Preventive Effect of NSAIDs, Opioid on Gemcitabine-induced Vascular Pain

K. Miyamoto, Y. Sai, K. Arai, 2012 .

Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.

Y. Sai, I. Tamai, A. Tsuji, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Y. Kido, M. Kasuga, S. Kaneko, 2011, Diabetes.

Mechanism by which cAMP activates PI3-kinase and increases bile acid secretion in WIF-B9 cells.

L. Varticovski, Y. Sai, I. Arias, 2002, American journal of physiology. Cell physiology.

Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

J. Nezu, Y. Sai, I. Tamai, 2007, Reproduction.

Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

T. Nakanishi, J. Nezu, Y. Sai, 2004, Molecular pharmaceutics.

Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney.

J. Nezu, Y. Sai, I. Tamai, 2001, Biochimica et biophysica acta.

PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2

Y. Kato, Y. Sai, A. Tsuji, 2005, Molecular Pharmacology.

Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse

Y. Kato, Y. Sai, I. Tamai, 2006, Molecular Pharmacology.

Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart.

Y. Kato, Y. Sai, A. Tsuji, 2008, Drug metabolism and pharmacokinetics.

Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice*

J. Nezu, A. Oku, M. Shimane, 2000, The Journal of Biological Chemistry.

Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.

Y. Kato, Y. Sai, A. Tsuji, 2004, Journal of pharmaceutical sciences.

Mechanisms of lower maintenance dose of tacrolimus in obese patients.

K. Miyamoto, Y. Sai, K. Sawamoto, 2014, Drug metabolism and pharmacokinetics.

Drug delivery system based on transport characteristics of biological membranes Transporter-mediated organ-specific delivery of drugs

Y. Sai, 2006 .

Blood-Brain Barrier Transport of H1-Antagonist Ebastine and its Metabolite Carebastine

Y. Sai, I. Tamai, A. Tsuji, 2000, Journal of drug targeting.

Intestinal Brush‐border Membrane Transport of Monocarboxylic Acids Mediated by Proton‐coupled Transport and Anion Antiport Mechanisms

H. Takanaga, Y. Sai, I. Tamai, 1997, The Journal of pharmacy and pharmacology.

Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice

T. Shimada, K. Miyamoto, Y. Sai, 2012, Journal of Natural Medicines.

Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters.

Y. Sai, I. Tamai, A. Tsuji, 1997, The Journal of pharmacology and experimental therapeutics.

Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P‐glycoprotein

Y. Sai, K. Naruhashi, I. Tamai, 2001, The Journal of pharmacy and pharmacology.

Quantitative Comparison of Breast Cancer Resistance Protein (BCRP/ABCG2) Expression and Function Between Maternal Blood-Brain Barrier and Placental Barrier in Mice at Different Gestational Ages

Y. Sai, T. Nishimura, M. Tomi, 2022, Frontiers in Drug Delivery.

Expression and Functional Characterization of the Adhesion Molecule Spermatogenic Immunoglobulin Superfamily in the Mouse Testis1

Miyuki Yamamoto, Y. Sai, A. Tsuji, 2003, Biology of reproduction.

Secretory transport of p‐aminohippuric acid across intestinal epithelial cells in Caco‐2 cells and isolated intestinal tissue

Y. Sai, K. Naruhashi, I. Tamai, 2001, The Journal of pharmacy and pharmacology.

Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice

T. Soga, Y. Sai, S. Tsukita, 2014, PloS one.

Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells

H. Takanaga, Y. Sai, I. Tamai, 1996, Pharmaceutical Research.

Immunohistochemical and Functional Characterization of pH‐dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1

H. Takanaga, Y. Sai, I. Tamai, 1999, The Journal of pharmacy and pharmacology.

Multidrug Resistance—Associated Protein 1 Functions as an Efflux Pump of Xenobiotics in the Skin

T. Imai, Y. Kato, Y. Sai, 2005, Pharmaceutical Research.

Salacia reticulata has therapeutic effects on obesity

H. Matsui, T. Shimada, K. Miyamoto, 2014, Journal of Natural Medicines.

Sodium and Chloride Ion‐Dependent Transport of β‐Alanine Across the Blood‐Brain Barrier

T. Terasaki, Y. Sai, I. Tamai, 1996, Journal of neurochemistry.

Transporter-mediated renal handling of nafamostat mesilate.

Y. Kato, Y. Sai, I. Tamai, 2004, Journal of pharmaceutical sciences.

Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells.

Y. Sai, A. Nies, I. Arias, 1999, Journal of cell science.

Small GTP-binding proteins on rat liver lysosomal membranes.

Y. Sai, S. Ohkuma, 1992, Cell structure and function.

Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β‐lactam antibiotics

T. Nakanishi, Y. Sai, I. Tamai, 1996, FEBS letters.

The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils.

Y. Sai, N. Ishizaka, M. Fujimura, 1996, Laboratory investigation; a journal of technical methods and pathology.

Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier

Y. Sai, Yasuna Kobayashi, T. Nishimura, 2010, Drug Metabolism and Disposition.

Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats.

Y. Sai, S. Tsukita, H. Iizasa, 2010, Biological & pharmaceutical bulletin.

Risk factors for interstitial lung disease induced by gemcitabine plus albumin-bound paclitaxel therapy in pancreatic ductal adenocarcinoma patients

Y. Sai, K. Ohtsubo, Tsutomu Shimada, 2022, Journal of pharmaceutical health care and sciences.

Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.

T. Nakanishi, Y. Sai, I. Tamai, 2002, Drug metabolism and pharmacokinetics.

Heterophilic Binding of the Adhesion Molecules Poliovirus Receptor and Immunoglobulin Superfamily 4A in the Interaction Between Mouse Spermatogenic and Sertoli Cells1

Y. Kitamura, Y. Kato, Y. Sai, 2007, Biology of reproduction.

Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study

T. Shimada, Y. Sai, K. Izumi, 2017, Journal of Pharmaceutical Health Care and Sciences.

Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study

T. Shimada, Y. Sai, Shingo Itai, 2019, Journal of pharmaceutical health care and sciences.

Active drug delivery by heterologous expression of membrane transporters

Y. Sai, 2003 .

Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous Expression of Human Oligopeptide Transporter at the Blood-Brain Barrier

Y. Sai, I. Tamai, A. Tsuji, 2003, Journal of Pharmacology and Experimental Therapeutics.

Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.

H. Yamamoto, Y. Sai, E. Takeda, 1996, Biochimica et biophysica acta.

Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats.

K. Miyamoto, Y. Sai, M. Nomura, 2010, Cancer letters.

Influence of Drugs and Nutrients on Transporter Gene Expression Levels in Caco-2 and LS180 Intestinal Epithelial Cell Lines

Y. Kato, Y. Sai, I. Tamai, 2003, Pharmaceutical Research.

PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine

Y. Sai, K. Naruhashi, I. Tamai, 2002, Pharmaceutical Research.

Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.

Y. Sai, I. Tamai, A. Tsuji, 1998, The American journal of physiology.

Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood‐brain barrier

Y. Sai, I. Tamai, A. Tsuji, 2001, The Journal of pharmacy and pharmacology.

Title Disposition kinetics of taxanes in peritoneal dissemination

T. Shimada, Y. Sai, Y. Yonemura, 2017 .

Disposition Kinetics of Taxanes in Peritoneal Dissemination

T. Shimada, Y. Sai, Y. Yonemura, 2012, Gastroenterology research and practice.

Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models.

T. Shimada, K. Miyamoto, Y. Sai, 2012, European journal of pharmacology.

Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H+-ATPase

Y. Sai, S. Ohkuma, K. Kinoshita, 1993, In Vitro Cellular & Developmental Biology - Animal.

Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.

Y. Sai, H. Iizasa, T. Nishimura, 2013, Journal of pharmaceutical sciences.

Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus

T. Shimada, Y. Sai, J. Nishigami, 2015, Journal of pharmaceutical health care and sciences.

Blood‐brain‐barrier Transport of Lipid Microspheres Containing Clinprost, a Prostaglandin I2 Analogue

Y. Sai, K. Sakanaka, I. Tamai, 1996, The Journal of pharmacy and pharmacology.

Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: Clinical, biochemical, and pathological improvements

T. Shimada, Y. Sai, W. Mackenzie, 2015, Molecular genetics and metabolism reports.

PDZK 1 Directly Regulates the Function of Organic Cation / Carnitine Transporter OCTN 2

Y. Kato, Y. Sai, A. Tsuji, 2004 .

Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival.

M. Berens, K. Miyamoto, J. Hamada, 2013, Neuro-oncology.

Platelet‐derived growth factor‐BB (PDGF‐BB) induces differentiation of bone marrow endothelial progenitor cell‐derived cell line TR‐BME2 into mural cells, and changes the phenotype

T. Terasaki, Y. Sai, H. Iizasa, 2005, Journal of cellular physiology.

Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.

H. Takanaga, Y. Sai, H. Higashida, 1995, Biochemical and biophysical research communications.

Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter.

Y. Sai, N. Yui, T. Ooya, 2002, Bioconjugate chemistry.

Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity.

Jia Yu, K. Miyamoto, Y. Sai, 2010, Biological & pharmaceutical bulletin.

Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients.

T. Shimada, Y. Sai, Y. Suga, 2020, Biological & pharmaceutical bulletin.

Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice

T. Shimada, K. Miyamoto, Y. Sai, 2012, Journal of Natural Medicines.

Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients

K. Miyamoto, Y. Sai, K. Yokogawa, 2010 .

Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression.

T. Shimada, Y. Sai, Katsuhiko Nagase, 2020, Drug metabolism and pharmacokinetics.

Possible Role of Anion Exchanger AE2 as the Intestinal Monocarboxylic Acid/Anion Antiporter

Y. Sai, I. Tamai, A. Tsuji, 1998, Pharmaceutical Research.

Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.

J. Nezu, A. Oku, M. Shimane, 1999, The Journal of pharmacology and experimental therapeutics.

Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells.

Y. Sai, K. Naruhashi, I. Tamai, 2003, Journal of pharmaceutical sciences.

Title Enantioselective disposition of clenbuterol in rats

H. Kotaki, K. Miyamoto, Hiroshi Ito, 2017 .

Enantioselective disposition of clenbuterol in rats

H. Kotaki, K. Miyamoto, Hiroshi Ito, 2014, Biopharmaceutics & drug disposition.

Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes.

Y. Sai, T. Nishimura, M. Tomi, 2012, Drug metabolism and pharmacokinetics.

Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition.

Y. Sai, Yoshimichi Sai, 2005, Drug metabolism and pharmacokinetics.

Transporter-mediated drug delivery: recent progress and experimental approaches.

Akira Tsuji, Y. Sai, A. Tsuji, 2004, Drug discovery today.

Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin.

H. Kusuhara, Y. Sugiyama, K. Miyamoto, 2013, Journal of pharmaceutical sciences.

p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.

Y. Minemoto, Y. Sai, E. Takeda, 2000, Biochemical and biophysical research communications.

Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

J. Nezu, A. Oku, M. Shimane, 1998, The Journal of Biological Chemistry.

Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion

A. Hirao, H. Sato, K. Miyamoto, 2013, British Journal of Cancer.

Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells.

T. Shimada, K. Miyamoto, Y. Sai, 2011, Biological & pharmaceutical bulletin.

Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4.

T. Ishikawa, Y. Matsuda, Y. Sai, 2002, Gene.

Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein

J. Nezu, Y. Sai, I. Tamai, 2002, Journal of Pharmacology and Experimental Therapeutics.

Molecular and Functional Characterization of Carnitine/Organic Cation Transporter OCTN Family in Human and Mouse.

J. Nezu, A. Oku, M. Shimane, 2000 .

Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate.

K. Miyamoto, Y. Sai, K. Arai, 2012, Biological & pharmaceutical bulletin.

Aberrant Glycogen Synthase Kinase 3β Is Involved in Pancreatic Cancer Cell Invasion and Resistance to Therapy

K. Kawakami, T. Minamoto, Y. Ishigaki, 2013, PloS one.

Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer

T. Shimada, H. Yaegashi, Y. Sai, 2020, AntiCancer Research.

Contribution of organic anion transporting polypeptide OATP‐C to hepatic elimination of the opioid pentapeptide analogue [d‐Ala 2 , d‐Leu5]‐enkephalin

Akira Tsuji, J. Nezu, Y. Sai, 2003, The Journal of pharmacy and pharmacology.

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

J. Nezu, Y. Sai, I. Tamai, 2002, The Journal of pharmacology and experimental therapeutics.

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

G. Tsujimoto, T. Matsuishi, J. Nezu, 1999, Nature Genetics.

Functional relevance of carnitine transporter OCTN2 to brain distribution of l‐carnitine and acetyl‐l‐carnitine across the blood–brain barrier

J. Nezu, Y. Sai, I. Tamai, 2001, Journal of neurochemistry.

Phase II Study of a Comprehensive Treatment Using Perioperative Chemotherapy Combined with Cytoreductive Surgery for Curatively Resected Gastric Cancer Patients with Positive Peritoneal Wash Cytology

Yan Li, S. Ikeda, Y. Sai, 2014 .

Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells.

Y. Sai, H. Iizasa, T. Nishimura, 2014, Biological & pharmaceutical bulletin.

Risk Factors for Peripheral Neuropathy Induced by Albumin-bound Paclitaxel Plus Gemcitabine Therapy in Pancreatic Cancer Patients

T. Shimada, Y. Sai, Y. Suga, 2019, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

Incidence and Risk Factors of Cholinergic Syndromes Induced by FOLFIRINOX in Advanced Pancreatic Adenocarcinoma

T. Shimada, Y. Sai, Junya Nakade, 2018, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome

K. Miyamoto, N. Ito, Y. Nishibori, 2011, Laboratory Investigation.

Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus

T. Shimada, Y. Sai, J. Nishigami, 2015, Journal of pharmaceutical health care and sciences.

Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment.

T. Terasaki, Y. Sai, H. Iizasa, 2007, Drug metabolism and pharmacokinetics.

Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats.

K. Miyamoto, Y. Sai, H. Ohkawa, 2013, Drug metabolism and pharmacokinetics.

Involvement of Multidrug Resistance-Associated Protein 2 in Intestinal Secretion of Grepafloxacin in Rats

Y. Sai, K. Naruhashi, I. Tamai, 2002, Antimicrobial Agents and Chemotherapy.

Effect of Low-Dose Paclitaxel and Docetaxel on Endothelial Progenitor Cells

Y. Sai, M. Toi, E. Nakashima, 2009, Oncology.

Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.

J. Nezu, A. Oku, M. Shimane, 1999, The Journal of pharmacology and experimental therapeutics.

Expression, Localization, and Binding Activity of the Ezrin/Radixin/Moesin Proteins in the Mouse Testis

Y. Sai, T. Wakayama, S. Iseki, 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma

T. Shimada, Y. Sai, Y. Suga, 2020, In Vivo.

Pharmacist-based Donepezil Outpatient Consultation Service to improve medication persistence

K. Miyamoto, Y. Sai, H. Umegaki, 2012, Patient Preference and Adherence.

Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P‐Glycoprotein Functioning as an Absorption Barrier

Y. Sai, I. Tamai, A. Tsuji, 1996, The Journal of pharmacy and pharmacology.

Hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil or oral S-1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer

O. Matsui, Y. Sai, H. Itoh, 2013, Molecular and clinical oncology.

Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): roles in carnitine recognition.

Y. Kato, Y. Sai, M. Ishiguro, 2004, Drug metabolism and pharmacokinetics.

Pharmacokinetics of docetaxel during hyperthermic intraperitoneal chemotherapy for peritoneal metastasis.

S. Ikeda, Y. Sai, Y. Yonemura, 2014, Gan to kagaku ryoho. Cancer & chemotherapy.

6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs.

Y. Sai, S. Ohtsuki, Young-Sook Kang, 2011, Journal of pharmaceutical sciences.

Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study

T. Shimada, Y. Sai, Shingo Itai, 2019, Journal of pharmaceutical health care and sciences.

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.

K. Miyamoto, T. Nakanishi, Y. Sai, 2015, Journal of pharmaceutical sciences.

Acetyl‐L‐carnitine permeability across the blood–brain barrier and involvement of carnitine transporter OCTN2

Y. Sai, I. Tamai, A. Tsuji, 2003, Biopharmaceutics & drug disposition.

Cytosol Treated with GTPγS Disintegrates Lysosomes in Vitro

Y. Sai, K. Arai, S. Ohkuma, 1994 .

System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.

Y. Sai, T. Nishimura, M. Tomi, 2014, Biochimica et biophysica acta.

Na+/H+ exchanger 3 affects transport property of H+/oligopeptide transporter 1.

Yukio Kato, Akira Tsuji, Yoshiyuki Kubo, 2005, Drug metabolism and pharmacokinetics.

Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes.

T. Shimada, K. Miyamoto, Y. Sai, 2011, Journal of ethnopharmacology.

Glycogen Synthase Kinase 3β Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway

T. Minamoto, K. Miyamoto, Hiroshi Sato, 2014, Molecular Cancer Therapeutics.

Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent.

Y. Sai, I. Tamai, A. Tsuji, 1999, The Journal of pharmacology and experimental therapeutics.

T. Shimada, Y. Sai, K. Izumi, 2017, Journal of pharmaceutical health care and sciences.

Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis

T. Shimada, M. Kawano, Y. Sai, 2017, Journal of pharmaceutical health care and sciences.

[Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer].

J. Kinoshita, Y. Sai, H. Kitagawa, 2013, Gan to kagaku ryoho. Cancer & chemotherapy.

Salacia reticulata has therapeutic effects on obesity

H. Matsui, T. Shimada, K. Miyamoto, 2014, Journal of Natural Medicines.

Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent.

Y. Sugiyama, Y. Sai, I. Tamai, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

T. Shimada, H. Tsuchiya, Y. Kato, 2018, Journal of Pharmaceutical Health Care and Sciences.

Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment

T. Shimada, Y. Sai, Junya Nakade, 2021, Therapeutic drug monitoring.

The Predominant Contribution of Oligopeptide Transporter PepT1 to Intestinal Absorption of β‐Lactam Antibiotics in the Rat Small Intestine

T. Nakanishi, Y. Sai, H. Higashida, 1997, The Journal of pharmacy and pharmacology.

PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

T. Shimada, K. Miyamoto, Y. Sai, 2015, Journal of pharmaceutical health care and sciences.

Disintegration of lysosomes mediated by GTPgammaS-treated cytosol: possible involvement of phospholipases.

Y. Sai, K. Arai, S. Ohkuma, 1998, Journal of biochemistry.

Title Aberrant Glycogen Synthase Kinase 3 β Is Involved in Pancreatic CancerCell Invasion and Resistance to Therapy

K. Kawakami, T. Minamoto, Y. Ishigaki, 2017 .

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods

T. Shimada, Y. Sai, Hironori Kitade, 2018, Journal of pharmaceutical health care and sciences.

Adsorptive-Mediated Transcytosis of a Synthetic Basic Peptide, 001-C8 in Caco-2 Cells

Y. Sai, I. Tamai, A. Tsuji, 1998, Pharmaceutical Research.

Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis.

Y. Sai, I. Tamai, A. Tsuji, 1998, Bioorganic & medicinal chemistry.

Hepatocyte growth factor and c‐Met expression in pericytes: implications for atherosclerotic plaque development

A. Heagerty, Y. Sai, Y. Liu, 2007, The Journal of pathology.

Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study

T. Shimada, Y. Sai, Y. Suga, 2019, Journal of Pharmaceutical Health Care and Sciences.

Characterization of the Mechanism of Zidovudine Uptake by Rat Conditionally Immortalized Syncytiotrophoblast Cell Line TR-TBT

T. Terasaki, Y. Sai, Young-Sook Kang, 2008, Pharmaceutical Research.