P. Shepherd

发表

NVP‐BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells

S. Fitter, Sally K. Martin, S. Gronthos, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status*

David Carling, D. Carling, L. Fryer, 2004, Journal of Biological Chemistry.

Natural variants of human p85α phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity

S. O’Rahilly, G. Panayotou, R. Stein, 2000, Diabetologia.

Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle*

K. Siddle, J. Zierath, H. Wallberg-henriksson, 1997, The Journal of Biological Chemistry.

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation.

J. Kim, P. Shepherd, C. Chaussade, 2009, Biochemical and biophysical research communications.

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

I. Gout, C. Downes, N. Leslie, 2004, The Journal of cell biology.

Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.

B. Kahn, P. Shepherd, P. Shepherd, 1999, The New England journal of medicine.

Human cell systems for drug discovery.

P. Shepherd, C. Horrocks, R. Halse, 2003, Current opinion in drug discovery & development.

Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival

A. Zannettino, S. Fitter, Angel F. Lopez, 2013, PLoS biology.

Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.

R. Wolfe, V. Hughes, R. Fielding, 1993, The American journal of physiology.

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism

K. Siddle, C. Proud, J. Zierath, 1997, Diabetologia.

Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: a comparative controlled clinical trial in general practice.

P. Shepherd, A. Miller, I. James, 1990, Current Medical Research and Opinion.

Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet

P. Shepherd, J. Jaiswal, C. Hedges, 2021, Biomolecules.

Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

P. Shepherd, A. Hickey, C. Hedges, 2020, Bioscience reports.

Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in model systems of cancer

Khanh B. Tran, P. Shepherd, Q. Wang, 2020, bioRxiv.

Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in animal cancer models

Khanh B. Tran, P. Shepherd, Q. Wang, 2020, Biotechnology reports.

Direct Interaction of Major Histocompatibility Complex Class II-derived Peptides with Class Ia Phosphoinositide 3-Kinase Results in Dose-dependent Stimulatory Effects*

G. Panayotou, P. Shepherd, Lazaros C Foukas, 2004, Journal of Biological Chemistry.

eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.

P. Shepherd, L. Foukas, 2004, Biochemical and biophysical research communications.

The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function.

M. Waterfield, P. Shepherd, C. Beeton, 1999, Molecular cell biology research communications : MCBRC.

in sedentary middle-aged men both myofibrillar and mitochondrial protein synthesis Concurrent resistance and aerobic exercise stimulates

Michael J. Short, R. Duffield, C. Donges, 2012 .

TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase.

P. Shepherd, L. O'Rourke, C. Ktori, 2003, Biochemical and biophysical research communications.

Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.

M. Schwartz, P. Shepherd, D. Grattan, 2012, The Biochemical journal.

Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes.

S. Ozanne, P. Shepherd, G. Smith, 1997, The American journal of physiology.

Altered adipocyte properties in the offspring of protein malnourished rats

S. Ozanne, C. Hales, N. Crowther, 1997, British Journal of Nutrition.

High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.

B. Kahn, P. Shepherd, L. Gnudi, 1995, Endocrinology.

Saturated-fat diet induces moderate diabetes and severe glomerulosclerosis in hamsters

M. Simionescu, P. Shepherd, D. Popov, 2003, Diabetologia.

Glucose-dependent Regulation of Cholesterol Ester Metabolism in Macrophages by Insulin and Leptin*

P. Shepherd, S. Yeaman, L. M. Grønning, 2002, The Journal of Biological Chemistry.

β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding

P. Shepherd, T. Merry, Stewart W C Masson, 2020, Molecular metabolism.

Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men.

Michael J. Short, R. Duffield, C. Donges, 2012, Journal of applied physiology.

The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice

P. Shepherd, A. Brooks, S. Jamieson, 2019, International Journal of Obesity.

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry

T. Merriman, J. Chase, P. Shepherd, 2021, Diabetologia.

Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver

P. Shepherd, M. Morris, M. K. H. Chowdhury, 2015, Archives of physiology and biochemistry.

Leptin regulates glucose homeostasis via the canonical WNT pathway

P. Shepherd, J. Horsfield, D. Grattan, 2021, bioRxiv.

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.

J. Heitman, C. Alarcón, M. Cárdenas, 1997, Biochemical and biophysical research communications.

The Māori and Pacific specific CREBRF variant and adult height

J. Hindmarsh, O. Dewes, T. Merriman, 2019, International Journal of Obesity.

Growth factor regulation of the novel class II phosphoinositide 3-kinases.

P. Shepherd, R. Brown, R. Brown, 2001, Biochemical Society transactions.

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

W. Denny, G. Rewcastle, C. Buchanan, 2017, The Biochemical journal.

Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.

M. Palacín, A. Zorzano, P. Shepherd, 1998, Molecular endocrinology.

Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.

P. Shepherd, J. Ruzzin, J. Jensen, 2005, Cellular signalling.

Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis.

B. Kahn, P. Shepherd, L. Gnudi, 1995, The American journal of physiology.

Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice

B. Kahn, P. Shepherd, G. Gould, 1992, Diabetologia.

Human Small Intestine Facilitative Fructose/Glucose Transporter (GLUT5) Is Also Present in Insulin-Responsive Tissues and Brain: Investigation of Biochemical Characteristics and Translocation

B. Kahn, P. Shepherd, G. Gould, 1992, Diabetes.

The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters

Diana G. Kulawiec, J. Chase, P. Shepherd, 2021, Journal of diabetes science and technology.

α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models

P. Shepherd, Brie Sorrenson, Kate L. Lee, 2020, The Biochemical journal.

Variability in Estimated Modelled Insulin Secretion

J. Chase, P. Shepherd, R. Murphy, 2021, Journal of diabetes science and technology.

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

B. Kahn, P. Shepherd, L. Gnudi, 1993, The Journal of biological chemistry.

Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin

P. Shepherd, Brie Sorrenson, Waruni C. Dissanayake, 2021, bioRxiv.

Extended treatment with selective phosphatidylinositol 3‐kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength

G. Rewcastle, W. Han, J. Cornish, 2013, The FEBS journal.

The role of phosphoinositide 3-kinase in insulin signalling.

S. O’Rahilly, P. Shepherd, B. Navé, 1996, Journal of molecular endocrinology.

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues.

P. Shepherd, 2005, Acta physiologica Scandinavica.

Phosphoinositide 3-kinases and membrane traffic.

Barbara J. Reaves, P. Shepherd, H. Davidson, 1996, Trends in cell biology.

Insulin Activates the α Isoform of Class II Phosphoinositide 3-Kinase*

M. Waterfield, A. Arcaro, P. Shepherd, 1999, The Journal of Biological Chemistry.

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

C. Buchanan, P. Shepherd, J. Dickson, 2013, PloS one.

&bgr;‐catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3‐L1 adipocytes

W. E. Hughes, P. Shepherd, E. Cognard, 2018, Experimental cell research.

Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

S. O’Rahilly, P. Shepherd, M. Soos, 2001, Archives of biochemistry and biophysics.

Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function

P. Shepherd, B. Oliver, J. Burgess, 2011, Journal of Pharmacology and Experimental Therapeutics.

The phosphoinositide 3′‐kinase p110δ modulates contractile protein production and IL‐6 release in human airway smooth muscle

P. Shepherd, Maree H. Poniris, B. Oliver, 2012, Journal of cellular physiology.

Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway.

P. Shepherd, L. Gnudi, P. Jat, 2006, American journal of physiology. Endocrinology and metabolism.

A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion.

P. Shepherd, Brie Sorrenson, Fengyun Hu, 2021, The Biochemical journal.

How can we make publishing less painful

P. Shepherd, 2012 .

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, The Biochemical journal.

Insulin Induces SOCS-6 Expression and Its Binding to the p85 Monomer of Phosphoinositide 3-Kinase, Resulting in Improvement in Glucose Metabolism*

D. Kioussis, P. Shepherd, P. Anderson, 2004, Journal of Biological Chemistry.

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

G. Rewcastle, P. Shepherd, B. Baguley, 2015, Front. Oncol..

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

D. Alessi, D. Withers, P. Shepherd, 1999, The Biochemical journal.

Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.

K. Siddle, P. Shepherd, B. Navé, 1996, The Biochemical journal.

Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.

G. Rewcastle, J. Cornish, M. Watson, 2010, Biochemical and biophysical research communications.

Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.

P. Shepherd, J. Flanagan, 2014, Biochemical Society transactions.

Beta-testing of PI3-kinase inhibitors: is beta better?

W. Denny, P. Shepherd, 2012, Cancer discovery.

Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.

K. Siddle, P. Shepherd, B. Navé, 1997, Biochemical Society transactions.

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

B. Viollet, D. Vertommen, F. Dequiedt, 2013, The Biochemical journal.

β-Cells retain a pool of insulin-containing secretory vesicles regulated by adherens junctions and the cadherin-binding protein p120 catenin

P. Shepherd, Waruni C. Dissanayake, 2022, The Journal of biological chemistry.

-catenin regulates insulin secretion

P. Shepherd, Brie Sorrenson, Kate L. Lee, 2020 .

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

Claire L. Lill, W. Denny, G. Rewcastle, 2012, Bioorganic & medicinal chemistry.

PI 3-kinase p110beta: a new target for antithrombotic therapy.

A. Robertson, P. Shepherd, P. Thompson, 2005, Nature medicine.

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.

K. Siddle, P. Shepherd, B. Navé, 1995, The Biochemical journal.

Secrets of insulin and IGF-1 regulation of insulin secretion revealed.

P. Shepherd, 2004, The Biochemical journal.

Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

C. Print, G. Rewcastle, A. Lasham, 2019, Acta pharmaceutica Sinica. B.

Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L1 adipocytes.

K. Siddle, P. Shepherd, B. Navé, 1995, Biochemical Society transactions.

Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance

G. C. Smith, P. Shepherd, N. Petersen, 2014, Schizophrenia Research.

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.

P. Shepherd, C. Beeton, E. Chance, 2000, The Biochemical journal.

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR.

Claire L. Lill, K. Y. Tsang, W. Denny, 2012, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors

W. Denny, G. Rewcastle, P. Shepherd, 2007 .

The Potential of Anti-Diabetic Rākau Rongoā (Māori Herbal Medicine) to Treat Type 2 Diabetes Mellitus (T2DM) Mate Huka: A Review

P. Shepherd, J. Koia, 2020, Frontiers in Pharmacology.

Phosphorylation of glycosyl‐phosphatidylinositol by phosphatidylinositol 3‐kinase changes its properties as a substrate for phospholipases

P. Shepherd, I. Varela-Nieto, A. Alonso, 2005, FEBS letters.

Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK

Khanh B. Tran, G. Rewcastle, P. Shepherd, 2021, BMC cancer.

Biological characterization of SN 32976 , a selective inhibitor of PI 3 K and mTOR with preferential activity to PI 3 K α , in comparison to established pan PI 3 K inhibitors

K. Y. Tsang, G. Rewcastle, D. J. Matthews, 2017 .

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

G. Rewcastle, P. Shepherd, C. Chaussade, 2009, Biochemical and biophysical research communications.

Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity

M. Schwartz, P. Shepherd, D. Grattan, 2010, The Journal of Neuroscience.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

O. Sansom, V. Meniel, W. Phillips, 2018, Cancer discovery.

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model

Kathryn E. Crosier, Khanh B. Tran, P. Shepherd, 2018, Disease Models & Mechanisms.

Long-term stability in the gut microbiome over 46 years in the life of Billy Apple®

P. Shepherd, P. Tsai, J. O'Sullivan, 2017 .

Evolution of molecular targets in melanoma treatment.

Khanh B. Tran, C. Buchanan, P. Shepherd, 2020, Current pharmaceutical design.

Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.

P. Shepherd, M. McConnell, M. Rowe, 2016, International journal of oncology.

Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma

K. Frei, O. Pardo, A. Arcaro, 2014, PloS one.

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds

W. Denny, G. Rewcastle, C. Buchanan, 2018, Acta Pharmacologica Sinica.

Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase

C. Buchanan, P. Shepherd, J. Dickson, 2013, Bioscience reports.

Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo

W. Phillips, P. Shepherd, C. Beeton, 2004, Molecular and Cellular Biology.

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

P. Shepherd, A. Hickey, C. Hedges, 2023, Nature Aging.

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

P. Shepherd, K. Anderson, J. Jensen, 2002, The Journal of biological chemistry.

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation

A. Xu, Yu Wang, P. Shepherd, 2013, Oncotarget.

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

G. Rewcastle, W. Han, P. Shepherd, 2011, The Biochemical journal.

For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

C. Buchanan, P. Shepherd, Kathryn Lee, 2019, Biomolecules.

Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure*

Ashley J. Waardenberg, C. Wells, B. Dalrymple, 2011, The Journal of Biological Chemistry.

Both p110α and p110β Isoforms of Phosphatidylinositol 3‐OH‐Kinase are Required for Insulin Signalling in the Hypothalamus

P. Shepherd, D. Grattan, R. A. Augustine, 2010, Journal of neuroendocrinology.

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Shaun P Jackson, W. Denny, G. Rewcastle, 2007, The Biochemical journal.

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

P. Shepherd, C. Beeton, E. Chance, 2000 .

Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.

P. Shepherd, M. Morris, N. J. Smith, 2016, The Biochemical journal.

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.

Claire L. Lill, W. Denny, G. Rewcastle, 2015, Bioorganic & medicinal chemistry.

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012, Science Signaling.

Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012 .

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

W. Denny, G. Rewcastle, C. Buchanan, 2011, The Biochemical journal.

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

W. Denny, G. Rewcastle, P. Shepherd, 2009, Bioorganic & medicinal chemistry letters.

Feeding and glucagon‐like peptide‐1 receptor activation stabilise β‐catenin in specific hypothalamic nuclei in male rats

P. Shepherd, D. Grattan, A. Tups, 2018, Journal of neuroendocrinology.

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

S. Gamage, W. Denny, G. Rewcastle, 2019, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

K. Y. Tsang, S. Gamage, W. Denny, 2017, Bioorganic & medicinal chemistry.

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

K. Siddle, D. Withers, P. Shepherd, 1998, The Biochemical journal.

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes.

K. Siddle, P. Shepherd, A. Hayward, 1996, The Biochemical journal.

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Claire L. Lill, S. Gamage, W. Denny, 2013, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Claire L. Lill, S. Gamage, W. Denny, 2011, Journal of medicinal chemistry.

Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models.

P. Shepherd, Deborah Hay, E. Cognard, 2013, The Biochemical journal.

Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.

P. Shepherd, Sasha H Anagnostou, 2008, The Biochemical journal.

The atypical anti-psychotic clozapine decreases bone mass in rats in vivo

J. Cornish, K. Callon, M. Watson, 2011, Schizophrenia Research.

DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.

G. Rewcastle, C. Buchanan, P. Shepherd, 2012, Clinical science.

Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.

K. Y. Tsang, J. A. Spicer, S. Gamage, 2019, Chemistry, an Asian journal.

Derivation of induced pluripotent stem cell lines from New Zealand donors

P. Shepherd, A. Davidson, Veronika Sander, 2020, Journal of the Royal Society of New Zealand.

Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

R. Moon, A. Xu, Yu Wang, 2009, PloS one.

Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma

Euan J. Rodger, C. Print, M. Eccles, 2020, Pigment cell & melanoma research.

Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial

J. Hindmarsh, T. Merriman, P. Shepherd, 2023, Frontiers in Endocrinology.

Phosphoinositide 3-kinase: the protein kinase that time forgot.

P. Shepherd, L. Foukas, 2004, Biochemical Society transactions.

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

K. Y. Tsang, S. Gamage, W. Denny, 2017, Oncotarget.

The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling*

D. James, F. Fostira, W. E. Hughes, 2007, Journal of Biological Chemistry.

Phosphoinositide 3-kinase: the key switch in insulin signalling

K. Siddle, D. Withers, P. Shepherd, 1998 .

A role for β‐catenin in diet‐induced skeletal muscle insulin resistance

M. Gram, D. Rowlands, P. Shepherd, 2023, Physiological reports.

β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake

P. Shepherd, R. D’Souza, T. Merry, 2021, The Journal of physiology.

The α‐isoform of class II phosphoinositide 3‐kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs

B. Ursø, S. O’Rahilly, K. Siddle, 1999 .

Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways.

P. Shepherd, S. Yeaman, L. O'Rourke, 2001, Diabetes.

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

A. Shelling, W. Phillips, P. Shepherd, 2012, BMC Cancer.

The role of adherens junction proteins in the regulation of insulin secretion

P. Shepherd, Brie Sorrenson, Waruni C. Dissanayake, 2018, Bioscience reports.

The role of phosphoinositide 3-kinase C2alpha in insulin signaling.

D. James, F. Fostira, W. E. Hughes, 2007, The Journal of biological chemistry.

PI 3-kinase p110β: a new target for antithrombotic therapy

A. Robertson, P. Shepherd, P. Thompson, 2005, Nature Medicine.

Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat

G. C. Smith, P. Shepherd, M. Vickers, 2011, Archives of physiology and biochemistry.

Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: Implications for glucose metabolism and food choice behaviour

P. Shepherd, M. Vickers, Greg C. Smith, 2009, Schizophrenia Research.

Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding.

P. Shepherd, L. O'Rourke, 2002, The Biochemical journal.

Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice

N. Turner, P. Shepherd, Greg C. Smith, 2022, Cells.

Neuregulin Signaling on Glucose Transport in Muscle Cells*

M. Palacín, A. Zorzano, J. Bertran, 2004, Journal of Biological Chemistry.

A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization*

W. E. Hughes, W. Han, P. Shepherd, 2016, The Journal of Biological Chemistry.

Caffeine and theophylline block insulin‐stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles

R. Zorec, P. Shepherd, M. Kreft, 2010, Acta physiologica.

Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat

G. C. Smith, P. Shepherd, M. Vickers, 2008, Diabetologia.

The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect

G. C. Smith, P. Shepherd, J. Steinberg, 2014, Psychopharmacology.

MOLECULAR CANCER THERAPEUTICS | SMALL MOLECULE THERAPEUTICS Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/b-Catenin Signaling in BRAF-mutant Colorectal Cancer Models

C. Buchanan, P. Shepherd, S. Deva, 2022 .

Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice.

P. Shepherd, Z. Andrews, D. Grattan, 2013, Endocrinology.

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry

T. Merriman, J. Chase, P. Shepherd, 2021, Diabetologia.

Identification of peptides from autolysates of Saccharomyces cerevisiae that exhibit glucose tolerance factor activity in a yeast assay.

P. Shepherd, P. Buckley, L. Blackwell, 1990, The International journal of biochemistry.

Distribution of GLUT3 glucose transporter protein in human tissues.

B. Kahn, P. Shepherd, G. Gould, 1992, Biochemical and biophysical research communications.

Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes

N. Turner, R. Gilchrist, P. Shepherd, 2017, Scientific Reports.

Inhibitors of phosphoinositide 3-kinase block exocytosis but not endocytosis of transferrin receptors in 3T3-L1 adipocytes.

K. Siddle, P. Shepherd, M. Soos, 1995, Biochemical and biophysical research communications.

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.

M. Febbraio, M. Karin, G. Rewcastle, 2012, The Biochemical journal.

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition

T. Merriman, P. Shepherd, L. Plank, 2021, medRxiv.

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand

D. Weeks, O. Dewes, A. Shelling, 2018, Diabetologia.

Discordant association of the CREBRF rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa New Zealand

D. Weeks, J. Hindmarsh, O. Dewes, 2017, bioRxiv.

Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models

Khanh B. Tran, C. Buchanan, P. Shepherd, 2022, Molecular cancer therapeutics.

Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.

J. Zierath, D. Galuska, B. Kahn, 1995, The Biochemical journal.

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds

W. Denny, G. Rewcastle, C. Buchanan, 2018, Acta Pharmacologica Sinica.

Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: Implications for nutrient partitioning

B. Kahn, P. Shepherd, L. Gnudi, 1996, Proceedings of the Nutrition Society.

NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand

M. Eccles, P. Shepherd, A. Chatterjee, 2016, Oncotarget.

Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”

D. Weeks, O. Dewes, A. Shelling, 2018, International Journal of Obesity.

Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: variation of the central linker group

Claire L. Lill, K. Y. Tsang, W. Denny, 2014 .

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors.

Claire L. Lill, K. Y. Tsang, W. Denny, 2017, Bioorganic & medicinal chemistry letters.

GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3.

P. Shepherd, J. Jensen, Y. Lai, 2007, Cellular signalling.

Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver

P. Shepherd, M. Morris, M. K. H. Chowdhury, 2015, Archives of physiology and biochemistry.

D. Weeks, J. Hindmarsh, O. Dewes, 2017, bioRxiv.

Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases

P. Shepherd, K. Anderson, J. Jensen, 2002, The Journal of Biological Chemistry.

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

G. Rewcastle, P. Shepherd, C. Chaussade, 2009, Biochemical and biophysical research communications.

Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes.

K. Siddle, P. Shepherd, B. Navé, 1995, Biochemical Society Transactions.

Abstract 1644: Design and discovery of PWT33597 (VDC-597), a dual inhibitor of PI3-kinase alpha and mTOR

S. Gamage, W. Denny, G. Rewcastle, 2014 .

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.

Claire L. Lill, W. Denny, G. Rewcastle, 2015, Bioorganic & medicinal chemistry.

Both p110α and p110β Isoforms of Phosphatidylinositol 3‐OH‐Kinase are Required for Insulin Signalling in the Hypothalamus

P. Shepherd, D. Grattan, R. A. Augustine, 2010, Journal of neuroendocrinology.