P. Frost

发表

TARGETING TORC 2 IN MULTIPLE MYELOMA WITH A NEW mTOR KINASE INHIBITOR Running title : TORC 2 and multiple myeloma

J. Gera, A. Lichtenstein, T. Guglielmelli, 2010 .

THE MAMMALIAN TARGET OF RAPAMYCIN ( MTOR ) AS A TARGET FOR CANCER CHEMOTHERAPY

J. Skotnicki, P. Frost, J. Gibbons, 2005 .

Effect of autophagy on multiple myeloma cell viability

A. Lichtenstein, B. Hoang, P. Frost, 2009, Molecular Cancer Therapeutics.

PAK1 Kinase Promotes Cell Motility and Invasiveness through CRK-II Serine Phosphorylation in Non-Small Cell Lung Cancer Cells

F. Tamanoi, F. Moatamed, P. Frost, 2012, PloS one.

Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

P. Frost, M. Veena, Gilbert Gastelum, 2017, PloS one.

IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.

J. Gera, A. Lichtenstein, B. Hoang, 2008, Cancer research.

Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells.

P. Frost, A. Iida-Klein, T. Hahn, 1991, Bone.

IL-6-induced Enhancement of c-Myc Translation in Multiple Myeloma Cells

J. Gera, A. Lichtenstein, B. Hoang, 2010, The Journal of Biological Chemistry.

AcidoCEST MRI Evaluates the Bone Microenvironment in Multiple Myeloma

Yajun Ma, E. Chang, Jiang Du, 2021, Molecular Imaging and Biology.

AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells

Y. Shi, A. Lichtenstein, B. Hoang, 2007, Oncogene.

Molecular cloning and expression of two β-defensin and two mucin genes in common carp (Cyprinus carpio L.) and their up-regulation after β-glucan feeding.

P. Frost, S. F. Gonzalez, M. Adamek, 2012, Fish & shellfish immunology.

Molecular cloning and expression of two b-defensin and two mucin genes in common carp ( Cyprinus carpio L . ) and their up-regulation after b-glucan feeding

P. Frost, S. F. Gonzalez, D. Steinhagen, 2022 .

The Mammalian Target of Rapamycin and Multiple Myeloma

A. Lichtenstein, P. Frost, 2008 .

Metabolomics Identifies Pyrimidine Starvation as the Mechanism of 5-Aminoimidazole-4-Carboxamide-1-β-Riboside-Induced Apoptosis in Multiple Myeloma Cells

A. Lichtenstein, B. Hoang, P. Frost, 2013, Molecular Cancer Therapeutics.

Metabolomics Identi fi es Pyrimidine Starvation as the Mechanism of 5-Aminoimidazole-4-Carboxamide-1-b-Riboside-Induced Apoptosis in Multiple Myeloma Cells

A. Lichtenstein, B. Hoang, P. Frost, 2013 .

Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways

Huajun Yan, J. Gera, A. Lichtenstein, 2004, Oncogene.

SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism

A. Lichtenstein, B. Hoang, P. Frost, 2016, Molecular Cancer Research.

Immunosensitization of Melanoma Tumor Cells to Non-MHC Fas-Mediated Killing by MART-1-Specific CTL Cultures1

L. Butterfield, P. Frost, B. Bonavida, 2001, The Journal of Immunology.

MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells

R. Fukunaga, Y. Shi, J. Gera, 2013, Oncogene.

The influence of dietary β-glucan, PAMP exposure and Aeromonas salmonicida on apoptosis modulation in common carp (Cyprinus carpio).

G. Williams, P. Frost, A. Falcó, 2012, Fish & shellfish immunology.

Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance.

L. Goodglick, Huajun Yan, Li Zhu, 2006, Blood.

Cell-mediated cytotoxic responses induced in vivo and in vitro by a metastatic murine tumor.

R. Wiltrout, P. Frost, 1980, Journal of immunology.

Immunosensitization of prostate carcinoma cell lines for lymphocytes (CTL, TIL, LAK)-mediated apoptosis via the Fas-Fas-ligand pathway of cytotoxicity.

A. Belldegrun, P. Frost, B. Bonavida, 1997, Cellular immunology.

IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats

M. Wong, R. M. Barrientos, P. Frost, 2001, Journal of Neuroimmunology.

A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity

J. Gera, A. Lichtenstein, P. Frost, 2019, Molecular Cancer Therapeutics.

Immunotoxicity of cocaethylene.

F. Chiappelli, P. Frost, P. Lee, 1995, Immunopharmacology and immunotoxicology.

Cocaine blunts human CD4+ cell activation.

F. Chiappelli, P. Frost, S. Daley, 1994, Immunopharmacology.

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

P. Frost, J. Skotnicki, C. Discafani, 2001, Endocrine-related cancer.

Steroid Receptor‐Mediated Modulation of CD4+CD62L+ Cell Homing. Implications for Drug Abusers a

F. Chiappelli, P. Frost, P. Lee, 1994, Annals of the New York Academy of Sciences.

Immunosensitization of resistant human tumor cells to cytotoxicity by tumor infiltrating lymphocytes.

A. Belldegrun, P. Frost, B. Bonavida, 2003, International journal of oncology.

chemoresistance expression which participates in enhanced adhesion to fibronectin and Oncogenic ras mutations in myeloma cells selectively induce COX-2

Huajun Yan, A. Lichtenstein, B. Hoang, 2013 .

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade

Huajun Yan, J. Gera, A. Lichtenstein, 2005, Molecular Cancer Therapeutics.

Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements.

P. Frost, A. Falcó, D. Hoole, 2012, Fish & shellfish immunology.

Intensity of Neobenedenia girellae (Monogenea: Capsalidae) on the halfmoon, Medialuna californiensis (Perciformes: Kyphosidae), examined using a new method for detection

P. Frost, I. Gaida, 1991 .

Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

J. Gera, A. Lichtenstein, T. Guglielmelli, 2010, Blood.

MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

J. Gera, A. Lichtenstein, B. Hoang, 2014, PloS one.

Sensitization of immunoresistant prostate carcinoma cell lines to Fas/Fas ligand‐mediated killing by cytotoxic lymphocytes: Independence of de novo protein synthesis

P. Frost, B. Bonavida, A. Belldegrun, 1999, The Prostate.

Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and rapamycin

J. Gera, A. Lichtenstein, B. Hoang, 2009, Molecular Cancer Therapeutics.

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis.

Huajun Yan, J. Gera, A. Lichtenstein, 2006, Cancer research.

The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance*

J. Gera, A. Lichtenstein, B. Hoang, 2012, The Journal of Biological Chemistry.

J. Skotnicki, C. Discafani, P. Frost, 2001 .

Dietary β-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection.

P. Frost, A. Falcó, A. Shrive, 2013, Fish & shellfish immunology.

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

Jerzy O. Szablowski, P. Dervan, P. Frost, 2016, Molecular Cancer Research.

Mammalian Target of Rapamycin Inhibitors Induce Tumor Cell Apoptosis In Vivo Primarily by Inhibiting VEGF Expression and Angiogenesis

J. Gera, A. Lichtenstein, B. Hoang, 2013, Journal of oncology.

multiple myeloma cells in a xenograft model In vivo anti-tumor effects of the mTOR inhibitor, CCI-779, against human

F. Moatamed, Huajun Yan, P. Frost, 2013 .

In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model.

F. Moatamed, Huajun Yan, P. Frost, 2004, Blood.

Running Head: In vivo efficacy of CCI-779 in myeloma

Huajun Yan, P. Frost, J. Gera, 2004 .

Isotope-release cytotoxicity assay with the use of indium-111: advantage over chromium-51 in long-term assays.

R. Wiltrout, P. Frost, G. Cummings, 1978, Journal of the National Cancer Institute.

Chemosensitization of human prostate carcinoma cell lines to anti-fas-mediated cytotoxicity and apoptosis.

A. Belldegrun, P. Frost, B. Bonavida, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Mechanism by Which mTOR Inhibitors Sesitize Multiple Myeloma Cells to Dexamethasone-Induced Apoptosis.

Huajun Yan, J. Gera, A. Lichtenstein, 2005 .

DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells

R. Finn, J. Gera, A. Lichtenstein, 2014, Genes & cancer.

Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?

C. Lamb, P. Frost, M. Sarafyan, 2021, Frontiers in Oncology.

The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics.

J Licinio, J. Licinio, P. Frost, 2000, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Circumvention of tumor cell escape following specific immunotherapy.

P. Frost, B. Bonavida, 2000, Cancer biotherapy & radiopharmaceuticals.

Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.

M. Penichet, R. Finn, J. Gera, 2016, Cancer research.

CytotoxicPropertiesofaDEPTOR-mTORInhibitor in Multiple Myeloma Cells

M. Penichet, R. Finn, J. Gera, 2016 .

The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat.

J. Licinio, S. Bornstein, D. Heber, 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Intestinal Helminth Parasites of the Bay Goby, Lepidogobius lepidus (Perciformes: Gobiidae), from Bodega Bay, California, U.S.A

P. Frost, D. Buth, D. García, 2004 .

Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

J. Gera, A. Lichtenstein, T. Guglielmelli, 2010, Blood.

J. Gera, A. Lichtenstein, B. Hoang, 2012, The Journal of Biological Chemistry.

Metabolomics Identifies Pyrimidine Starvation as the Mechanism of 5- Aminoimidazole-4-carboxamide-1-β-riboside (aicar) Induced Apoptosis in Multiple Myeloma Cells

B. Hoang, P. Frost, Yijiang Shi, 2022 .