B. Fonseca

发表

Dissecting the role of mTOR: lessons from mTOR inhibitors.

Nahum Sonenberg, N. Sonenberg, R. Dowling, 2010, Biochimica et biophysica acta.

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

C. Proud, B. Fonseca, V. Lee, 2008, The Biochemical journal.

Masahiro Morita, T. Alain, C. Damgaard, 2015, The Journal of Biological Chemistry.

Calpain activity is generally elevated during transformation but has oncogene-specific biological functions.

N. Carragher, M. Frame, B. Fonseca, 2004, Neoplasia.

LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization

G. Kozlov, K. Gehring, B. Fonseca, 2021, RNA biology.

Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.

Jacob D. Durrant, Jesse C. Kaminsky, B. Fonseca, 2019, Structure.

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

Justin M. Richner, J. Greenblatt, G. Bourque, 2022, The Journal of biological chemistry.

Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90RSK in the Control of mTORC1 Protein Signaling by Phorbol Esters*

T. Alain, C. Proud, C. F. Bennett, 2011, The Journal of Biological Chemistry.

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1

C. Proud, B. Fonseca, J. Averous, 2008, Oncogene.

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

N. Sonenberg, T. Alain, O. Larsson, 2010, Science.

mTOR and Regulation of Translation

D. Ruggero, B. Fonseca, A. Parsyan, 2014 .

Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1

C. Proud, B. Fonseca, T. Healy, 2008, The FEBS journal.

LARP1 on TOP of ribosome production

T. Alain, C. Damgaard, B. Fonseca, 2018, Wiley interdisciplinary reviews. RNA.

PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex*

C. Proud, C. MacKintosh, B. Fonseca, 2007, Journal of Biological Chemistry.

Award Number: W81XWH-10-1-0357 TITLE: Studying the Role of Eukaryotic Translation Initiation Factor 4E (eIF4E) Phosphorylation by MNK1/2 Kinases in Prostate Cancer Development and Progression

Principal Investigator, B. Fonseca, 2012 .

Downstream Targets of mTORC1

C. Proud, B. Fonseca, 2009 .

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.

N. Sonenberg, T. Alain, A. Yanagiya, 2012, Cancer research.

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction

B. Fonseca, K. Cain, H. Meijer, 2020, Nucleic acids research.

Evolution of TOR and Translation Control

T. Alain, J. Avruch, B. Fonseca, 2016 .

The ever-evolving role of mTOR in translation.

T. Alain, A. Pause, B. Fonseca, 2014, Seminars in cell & developmental biology.

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

R. Nadon, N. Sonenberg, T. Alain, 2016, Nature Communications.

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

T. Alain, O. Larsson, B. Fonseca, 2018, Infection and Immunity.

Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling*

Hua Tang, C. Proud, M. Clemens, 2008, Journal of Biological Chemistry.

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

T. Alain, C. Damgaard, T. Maier, 2021, Nucleic acids research.

LARP1 is a major phosphorylation substrate of mTORC1

T. Alain, C. Damgaard, Yonghao Yu, 2018, bioRxiv.

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling*

N. Sonenberg, R. Andersen, T. Alain, 2012, The Journal of Biological Chemistry.

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

A. Gingras, N. Sonenberg, T. Alain, 2012, Molecular and Cellular Biology.

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

I. Nabi, C. Proud, M. Roberge, 2009, PloS one.

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

M. Diamond, N. Sonenberg, T. Alain, 2016, Nature Immunology.

Regulation of mTORC1 Signaling by pH

Karen K. Y. Lam, M. Roberge, Carla Zimmerman, 2011, PloS one.

The isolated La-module of LARP1 mediates 3’ poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1

G. Kozlov, K. Gehring, B. Fonseca, 2020, RNA biology.

T. Alain, B. Fonseca, S. Blagden, 2017, eLife.

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

N. Sonenberg, R. Dowling, I. Topisirovic, 2011 .

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

M. Diamond, N. Sonenberg, T. Alain, 2016, Nature Immunology.

Dissecting the role of mTOR: lessons from mTOR inhibitors.

N. Sonenberg, R. Dowling, I. Topisirovic, 2010, Biochimica et biophysica acta.