M. Remedi

Y. Alippe, M. Remedi, R. Civitelli, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality.

F. Chen, A. Toib, C. Nichols, 2012, Journal of molecular and cellular cardiology.

Should I Stay or Should I Go: A Clash of α-Cell Identity.

M. Remedi, 2017, Cell metabolism.

The diabetic β‐cell: hyperstimulated vs. hyperexcited

C. Nichols, M. Remedi, C. Nichols, 2012, Diabetes, obesity & metabolism.

Hyperinsulinism in mice with heterozygous loss of KATP channels

M. Mcdaniel, D. Piston, C. Nichols, 2006, Diabetologia.

Cardiovascular consequences of KATP overactivity in Cantu syndrome.

Yan Huang, R. Mecham, C. Nichols, 2018, JCI insight.

Cognitive deficits and impaired hippocampal long-term potentiation in KATP-induced DEND syndrome

S. Mennerick, M. Remedi, D. Wozniak, 2021, Proceedings of the National Academy of Sciences.

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.

C. Nichols, M. Remedi, J. Koster, 2005, Diabetes.

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

C. Thummel, M. Remedi, B. Finck, 2016, Molecular metabolism.

Expression and function of ATP-dependent potassium channels in zebrafish islet Î2-cells

Zihan, L. G. Moss, C. Nichols, 2022 .

Kir6.1‐dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain‐of‐function

B. Zinselmeyer, C. Nichols, M. Remedi, 2020, The Journal of physiology.

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry

C. Nichols, Jin-Moo Lee, M. Remedi, 2019, American journal of medical genetics. Part C, Seminars in medical genetics.

Hypotension Due to Kir 6 . 1 Gain-of-Function in Vascular Smooth Muscle

Anlong Li, R. Knutsen, R. Mecham, 2013 .

Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP).

T. Flagg, C. Nichols, A. Lopatin, 2005, Journal of molecular and cellular cardiology.

Inhibitory effects of human α2-macroglobulin on Trypanosoma cruzi epimastigote proteinases

M. Remedi, G. Bonacci, G. Chiabrando, 1997 .

HIV protease inhibitors acutely impair glucose-stimulated insulin release.

C. Nichols, P. Hruz, M. Remedi, 2003, Diabetes.

Palmitoylation couples insulin hypersecretion with β cell failure in diabetes.

F. Urano, D. Piston, B. Dickinson, 2023, Cell metabolism.

Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.

C. Nichols, M. Remedi, Zhiyu Wang, 2014, Cell metabolism.

Neonatal Diabetes: Permanent Neonatal Diabetes and Transient Neonatal Diabetes

P. Arvan, C. Nichols, M. Remedi, 2017 .

KATP Channels in the Pancreas

C. Nichols, M. Remedi, 2016 .

Effects of Hyperglycaemia on Islet Function : Glucose Stimulation and Excitation are Normally Tightly Linked

M. Remedi, C. Nichols, 2012 .

KATP channelopathies in the pancreas

M. Remedi, J. Koster, 2010, Pflügers Archiv - European Journal of Physiology.

Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.

C. Nichols, M. Remedi, 2009, Cell metabolism.

Expression of ATP-Insensitive KATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

C. Nichols, M. Remedi, J. Koster, 2006, Diabetes.

Expression of ATP-Insensitive K ATP Channels in Pancreatic -Cells Underlies a Spectrum of Diabetic

C. Nichols, M. Remedi, A. Tong, 2006 .

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

C. Bogardus, R. Hanson, P. Bennett, 2015, Diabetes.

Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes

C. Nichols, P. Hruz, M. Remedi, 2011, Diabetes.

Arginine kinase of the flagellate protozoa Trypanosoma cruzi

M. Remedi, L. Cochella, C. Pereira, 2001, FEBS letters.

Trypanosoma cruzi: cruzipain and membrane-bound cysteine proteinase isoform(s) interacts with human alpha(2)-macroglobulin and pregnancy zone protein.

M. Remedi, V. Duschak, G. Chiabrando, 2002, Experimental parasitology.

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

M. Mcdaniel, F. Urano, P. Saftig, 2017, Autophagy.

A Unique High‐Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome

C. Nichols, M. Remedi, D. Grange, 2022, Journal of the American Heart Association.

The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome

C. Nichols, Jin-Moo Lee, M. Remedi, 2020, Function.

Y. Huang, C. Nichols, M. Remedi, 2019, Nature Communications.

Therapeutic Strategies to Increase Human β-Cell Growth and Proliferation by Regulating mTOR and GSK-3/β-Catenin Pathways.

M. Mcdaniel, M. Remedi, K. Pappan, 2010, The open endocrinology journal.

Enzymatic and Ultrastructural Changes in Thoracic Muscles of Triatomine Insects during the Last Stages of Metamorphosis

M. Remedi, P. Y. Scaraffia, C. Maldonado, 1997 .

Sulfonylureas target the neurovascular response to decrease Alzheimer’s pathology

D. Holtzman, J. Culver, C. Nichols, 2021, bioRxiv.

Glucokinase Inhibition: A Novel Treatment for Diabetes?

C. Nichols, M. Remedi, 2023, Diabetes.

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

C. Nichols, M. Remedi, Nathaniel W. York, 2022, Diabetes.

Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion

C. Nichols, M. Remedi, R. French, 2012, EMBO molecular medicine.

KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

D. Holtzman, C. Nichols, M. Remedi, 2022, bioRxiv.

Pancreatic β‐cell identity in diabetes

M. Remedi, C. Emfinger, Christopher H. Emfinger, 2016, Diabetes, obesity & metabolism.

Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion

David W Piston, D. Piston, C. Nichols, 2006, PLoS biology.

Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets

D. Piston, D. Meyer, C. Nichols, 2019, Physiological Reports.

Hyperinsulinism induced by targeted suppression of beta cell KATP channels

T. Flagg, M. Remedi, J. Koster, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells

C. Nichols, M. Remedi, 2008, PLoS medicine.

Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus

C. Nichols, M. Remedi, B. Marshall, 2017, Pediatric diabetes.

Remission of Severe Neonatal Diabetes With Very Early Sulfonylurea Treatment

N. White, C. Nichols, M. Remedi, 2015, Diabetes Care.

Contribution of systemic inflammation to permanence of KATP-induced neonatal diabetes in mice.

C. Nichols, P. Hruz, M. Remedi, 2018, American journal of physiology. Endocrinology and metabolism.

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel

C. Nichols, M. Remedi, Jonathan B Friedman, 2017, The Journal of general physiology.

Genome-edited zebrafish model of ABCC8 loss-of-function disease

C. Nichols, M. Remedi, Nathaniel W. York, 2021, bioRxiv.

The role of membrane excitability in pancreatic β-cell glucotoxicity

C. Nichols, M. Remedi, Zhiyu Wang, 2019, Scientific Reports.

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells

L. G. Moss, C. Nichols, M. Remedi, 2017, Royal Society Open Science.

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function

C. Nichols, M. Remedi, Min Li, 2023, Function.

Digital Digital Cognitive deficits and impaired hippocampal long-term Cognitive deficits and impaired hippocampal long-term potentiation in K ATP-induced DEND syndrome potentiation in K ATP-induced DEND syndrome

S. Mennerick, M. Remedi, Zihan Yan, 2021 .

Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.

F. Charpentier, T. Flagg, C. Nichols, 2004, American journal of physiology. Heart and circulatory physiology.

HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels.

C. Nichols, M. Remedi, Alejandro Akrouh, 2011, Journal of molecular and cellular cardiology.

1354-P: Alternate-Day Intermittent Fasting Improves Diabetes and Protects Beta-Cell Function in Polygenic Mouse Models of T2DM

M. Remedi, Zihan Yan, Sumitkumar Patel, 2022, Diabetes.

Intermittent fasting protects β-cell identity and function in a type-2 diabetes model.

M. Remedi, Zihan Yan, Sumitkumar Patel, 2024, Metabolism: clinical and experimental.

Loss of β-cell identity and dedifferentiation, not an irreversible process?

M. Remedi, Sumitkumar Patel, 2024, Frontiers in endocrinology.