S. Bhanot

发表

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

B. Monia, Xing Yu, S. Pandey, 2008, American journal of physiology. Endocrinology and metabolism.

Effects of bis (maltolato) oxovanadium (IV) on protein serine kinases in skeletal muscle of streptozotocin-diabetic rats

S. Bhanot, J. McNeill, Jaspal Girn, 1999, Molecular and Cellular Biochemistry.

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.

G. Shulman, G. Cline, B. Monia, 2009, Cell metabolism.

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

G. Shulman, L. Goedeke, Dongyan Zhang, 2018, Diabetologia.

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

Mark Graham, Susan F Murray, B. Monia, 2006, Cell metabolism.

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

S. McCall, B. Monia, Xing Yu, 2007, Hepatology.

Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes

S. Bhanot, B. Baker, R. Geary, 2018, Diabetes Care.

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

N. Porksen, J. Gromada, B. Berridge, 2004, The Journal of clinical investigation.

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

G. Shulman, G. Cline, R. Kibbey, 2016, Proceedings of the National Academy of Sciences.

Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

S. Bhanot, B. Baker, R. Geary, 2020, The lancet. Gastroenterology & hepatology.

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

B. Monia, Pengxiang She, S. Bhanot, 2004, Diabetes.

In vivo regulation of protein-serine kinases by insulin in skeletal muscle of fructose-hypertensive rats.

B. Salh, S. Pelech, S. Bhanot, 1999, The American journal of physiology.

In vivo regulation of protein-serine kinases by insulin in skeletal muscle of fructose-hypertensive rats.

B. Salh, S. Pelech, S. Bhanot, 1999, American journal of physiology. Endocrinology and metabolism.

Insulin and hypertension: a causal relationship?

S. Bhanot, J. McNeill, Sanjay Bhanot, 1996, Cardiovascular research.

Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1994, The Journal of pharmacology and experimental therapeutics.

Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats.

S. Bhanot, J. McNeill, M. Bryer-Ash, 1994, Hypertension.

In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats

S. Bhanot, J. McNeill, L. Marzban, 2001, Molecular and Cellular Biochemistry.

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

G. Shulman, J. Geisler, B. Monia, 2006, Diabetes.

Factor XI antisense oligonucleotide for prevention of venous thrombosis.

G. Raskob, H. Büller, B. Monia, 2014, The New England journal of medicine.

Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods

S. Bhanot, B. Baker, R. Geary, 2021, Nucleic acid therapeutics.

First proof of pharmacology in humans of a novel glucagon receptor antisense drug

J. Romijn, S. Bhanot, M. D. de Kam, 2015, Journal of clinical pharmacology.

AENDO August 40/2

B. Salh, S. Pelech, S. Bhanot, 1999 .

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

G. Shulman, S. Bornstein, Dongyan Zhang, 2015, Aging.

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

G. Shulman, J. Geisler, B. Monia, 2007 .

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

G. Shulman, Dongyan Zhang, S. Bhanot, 2013, Proceedings of the National Academy of Sciences.

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.

Mitchel R. Stacy, L. Ragolia, D. Dione, 2014, American journal of physiology. Endocrinology and metabolism.

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

S. Bhanot, V. Polotsky, Qiaoling Yao, 2012, PloS one.

In vivo effects of vanadium in diabetic rats are independent of changes in PI‐3 kinase activity in skeletal muscle

S. Bhanot, J. McNeill, Askar Mohammad, 2001, Molecular and Cellular Biochemistry.

Role of resistin in diet-induced hepatic insulin resistance.

B. Monia, E. D. Muse, L. Rossetti, 2004, The Journal of clinical investigation.

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice.

B. Monia, N. Dean, S. Murray, 2002, Diabetes.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

G. Shulman, B. Monia, D. Weismann, 2009, Cell metabolism.

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

M. Martínez-Chantar, A. Mora, S. Bhanot, 2022, Nature communications.

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.

B. Monia, S. Bhanot, M. Michael, 2005, Diabetes.

Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance*

G. Shulman, J. Geisler, G. Cline, 2007, Journal of Biological Chemistry.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

B. Monia, Xing Yu, S. Pandey, 2005, Hepatology.

The role of the carbohydrate response element-binding protein in male fructose-fed rats.

M. Gillum, Kisha Mitchell, G. Shulman, 2013, Endocrinology.

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

G. Shulman, J. Geisler, B. Monia, 2007, The Journal of clinical investigation.

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

K. Petersen, G. Shulman, G. Cline, 2013, Diabetes.

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

G. Shulman, G. Cline, J. M. Brown, 2013, Proceedings of the National Academy of Sciences.

Direct Vasodepressor Effects of Pioglitazone in Spontaneously Hypertensive Rats

E. Arikawa, S. Bhanot, J. McNeill, 1998, Pharmacology.

Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.

S. Kash, B. Monia, S. Murray, 2007, Endocrinology.

Reactivity of mesenteric arteries from fructose hypertensive rats to endothelin-1.

I. Laher, S. Bhanot, J. McNeill, 1997, American journal of hypertension.

Defective endothelium-dependent relaxation in fructose-hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1996, American journal of hypertension.

Effect of chronic endothelin blockade in hyperinsulinemic hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1995, The American journal of physiology.

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids

Robert V Farese, S. Watkins, S. Bhanot, 2009, Hepatology.

Chronic T-type Ca2+ channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1997, Cardiovascular research.

Decreased vascular reactivity in metformin-treated fructose-hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1996, Metabolism: clinical and experimental.

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis*

G. Shulman, M. Roden, G. Cline, 2014, The Journal of Biological Chemistry.

Chronic glucose-lowering effects of rosiglitazone and bis(ethylmaltolato)oxovanadium(IV) in ZDF rats.

S. Bhanot, M. Battell, J. McNeill, 2003, Canadian journal of physiology and pharmacology.

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Richard G. Lee, A. Andréasson, M. Bohlooly-y, 2019, Molecular metabolism.

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Shuling Guo, B. Monia, B. Kahn, 2014, Diabetes.

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Michael R. Green, Gina M. Butrico, G. Shulman, 2016, Nature Communications.

Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.

S. Bhanot, M. Battell, J. McNeill, 2002, Canadian journal of physiology and pharmacology.

Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy

S. Bhanot, M. Krebs, B. Baker, 2019, Diabetes Care.

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.

G. Shulman, G. Cline, S. Hirabara, 2020, Cell metabolism.

Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats

K. Petersen, G. Shulman, R. Kursawe, 2013, Hepatology.

Specific Reduction of Hepatic Glucose 6-Phosphate Transporter-1 Ameliorates Diabetes while Avoiding Complications of Glycogen Storage Disease*

B. Monia, S. Booten, S. Murray, 2007, Journal of Biological Chemistry.

Vanadyl sulfate lowers plasma insulin and blood pressure in spontaneously hypertensive rats.

S. Bhanot, J. McNeill, Sanjay Bhanot, 1994, Hypertension.

Metformin decreases plasma insulin levels and systolic blood pressure in spontaneously hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1994, American Journal of Physiology.

Preparation and characterization of vanadyl complexes with bidentate maltol-type ligands; in vivo comparisons of anti-diabetic therapeutic potential

S. Bhanot, J. McNeill, V. Karunaratne, 2002, JBIC Journal of Biological Inorganic Chemistry.

Antisense therapies for cardiovascular/metabolic diseases

S. Bhanot, R. Crooke, R. Geary, 2013 .

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

I. G. Fantus, S. Najjar, S. Bhanot, 2014, American journal of physiology. Endocrinology and metabolism.

Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice.

B. Monia, E. D. Muse, L. Rossetti, 2005, The Journal of clinical investigation.

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

B. Monia, Xing Yu, S. Bhanot, 2013, PloS one.

Essential trace elements of potential importance in nutritional management of diabetes mellitus

S. Bhanot, J. McNeill, K. Thompson, 1994 .

Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension.

S. Bhanot, J. McNeill, S. Verma, 1999, European journal of pharmacology.

Vascular insulin resistance in fructose-hypertensive rats.

S. Bhanot, J. McNeill, S. Verma, 1997, European journal of pharmacology.

Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice.

B. Monia, Pengxiang She, S. Bhanot, 2005, Metabolism: clinical and experimental.

Modulation of glucocorticoid receptor expression

S. Freier, N. Dean, S. Bhanot, 1991 .

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

H. Askari, J. Geisler, M. Connelly, 2012, Journal of Lipid Research.

Diacylglycerol acyltranferase 1 anti‐sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis

S. McCall, B. Monia, Xing Yu, 2007, Hepatology.

Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD

S. Bhanot, R. Yu, R. Geary, 2021, Kidney international reports.

PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients

S. Bhanot, R. Yu, R. Geary, 2021, CPT: pharmacometrics & systems pharmacology.

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

K. Petersen, G. Shulman, S. Bhanot, 2015, Journal of Lipid Research.

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

S. Crooke, S. Bhanot, Nelson Salgado, 2017, Nucleic acid therapeutics.

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

J. Waring, R. Ulrich, S. Crosby, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Christopher E. Hart, H. Bui, S. Crooke, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes

Richard G. Lee, S. Bhanot, M. Graham, 2016, Diabetes Care.

Bis(maltolato)Oxovanadium(IV) Attenuates Hyperinsulinemia and Hypertension in Spontaneously Hypertensive Rats

S. Bhanot, J. McNeill, A. Cheung, 1994, Diabetes.

The chemical and biological aspects of fluoroquinolones: reality and dreams.

S. Bhanot, M. Singh, N. R. Chatterjee, 2001, Current pharmaceutical design.

Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates.

S. Bhanot, S. Henry, S. Burel, 2017, Nucleic acid therapeutics.

SirT1 Regulates Adipose Tissue Inflammation

Alexander S. Banks, Dorothy D. Sears, M. Gillum, 2011, Diabetes.

Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ

J. Gustafsson, U. Kintscher, S. Bhanot, 2008, PLoS genetics.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Michael J. MacDonald, Richard G. Kibbey, Gary W. Cline, 2014, Nature.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Alexander S. Banks, P. Puigserver, L. Alhonen, 2014, Nature.

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.

J. Geisler, G. Cline, S. Bhanot, 2018, Endocrinology.

The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

S. Crooke, S. Bhanot, B. Baker, 2017, Nucleic acid therapeutics.

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

B. Monia, Hiraku Ono, A. Pocai, 2006, The Journal of clinical investigation.

Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice*

B. Monia, Xing Yu, S. Pandey, 2007, Journal of Biological Chemistry.

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

G. Shulman, J. Geisler, G. Cline, 2006, The Journal of clinical investigation.

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.

B. Monia, S. Booten, S. Murray, 2009, Endocrinology.

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

M. Gillum, T. Horvath, G. Shulman, 2009, Proceedings of the National Academy of Sciences.

OR27-4 Placebo-Controlled and Open-Label Extension Study of a Novel Hepatic-Targeted Antisense Cimdelirsen (IONIS-GHR-LRx) Under Investigation in Acromegaly Patients

S. Melmed, M. Fleseriu, S. Bhanot, 2022, Journal of the Endocrine Society.

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

A. Mora, S. Bhanot, J. Banales, 2022, Nature Communications.

Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins

P. Tso, A. Pocai, L. Rossetti, 2007, Nature Medicine.

Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase

A. Moser, S. Bhanot, Jianguo Li, 2008, Circulation research.

ISIS-FXIRx, A Novel and Specific Antisense Inhibitor of Factor XI, Caused Significant Reduction in FXI Antigen and Activity and Increased aPTT without Causing Bleeding in Healthy Volunteers

B. Monia, S. Bhanot, C. Bethune, 2011 .

Antisense Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes

Richard G. Lee, S. Bhanot, M. Graham, 2016 .

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

P. Stawowy, U. Kintscher, S. Bhanot, 2013, Cell Communication and Signaling.

Assessment of the Effect of Organ Impairment on the Pharmacokinetics of 2′‐MOE and Phosphorothioate Modified Antisense Oligonucleotides

E. Hurh, S. Bhanot, S. Henry, 2022, Journal of clinical pharmacology.

Antihypertensive effects of vanadium compounds in hyperinsulinemic, hypertensive rats

S. Bhanot, J. McNeill, A. Michoulas, 1995, Molecular and Cellular Biochemistry.

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

G. Shulman, G. Cline, B. Monia, 2011, Diabetologia.

Second‐generation antisense oligonucleotides against β‐catenin protect mice against diet‐induced hepatic steatosis and hepatic and peripheral insulin resistance

K. Petersen, G. Shulman, Dongyan Zhang, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

G. Raskob, H. Büller, B. Monia, 2014 .

Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques

B. Monia, S. Bhanot, J. Heemskerk, 2014, Arteriosclerosis, thrombosis, and vascular biology.

cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis*

M. Gillum, G. Shulman, G. Cline, 2013, The Journal of Biological Chemistry.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

B. Monia, Xing Yu, S. Pandey, 2005 .

Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.

B. Monia, S. Booten, S. Murray, 2009, Endocrinology.

Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice.

B. Monia, Xing Yu, S. Booten, 2008, American journal of physiology. Endocrinology and metabolism.

Developing Antisense Drugs for Metabolic Diseases: A Novel Therapeutic Approach

S. Bhanot, 2007 .

rats. Vanadyl sulfate lowers plasma insulin and blood pressure in spontaneously hypertensive

S. Bhanot, J. McNeill, 2014 .

Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model

Richard Geary, S. Bhanot, S. Henry, 2017, Journal of Pharmacokinetics and Pharmacodynamics.

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.

J. Gromada, B. Monia, S. Bhanot, 2004, The Journal of clinical investigation.

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

H. Askari, J. Geisler, M. Connelly, 2012, Journal of Lipid Research.

Pharmacokinetics and Pharmacodynamics of Ionis-FXIRx, an Antisense Inhibitor of Factor XI, in Patients with End-Stage Renal Disease on Hemodialysis

S. Bhanot, R. Yu, R. Geary, 2017 .

E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment

S. Gaztambide, S. Bhanot, J. Crespo, 2021, Cancer Research.