K. Obata

发表

Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt

T. Murohara, K. Nagata, X. Cheng, 2008, Journal of hypertension.

Discrimination of Nonobstructive Hypertrophic Cardiomyopathy From Hypertensive Left Ventricular Hypertrophy on the Basis of Strain Rate Imaging by Tissue Doppler Ultrasonography

T. Kato, A. Yamada, H. Izawa, 2004, Circulation.

Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice

J. Inoue, T. Akiyama, Dai Shiba, 2015, PloS one.

Left ventricular mechanoenergetics in excised, cross-circulated rat hearts under hypo-, normo-, and hyperthermic conditions

K. Obata, H. Morita, D. Takeshita, 2018, Scientific Reports.

Influence of calcium on proliferation and phenotype alteration of cardiomyocyte in vitro

R. Akins, R. Tuan, K. Obata, 1998, Journal of cellular physiology.

Possible peripheral mechanism for taste disorder in rats administered S-1

H. Kuniyasu, K. Obata, M. Kurihara, 2013, International Journal of Clinical Oncology.

The energy-saving effect of a new myosin activator, omecamtiv mecarbil, on LV mechanoenergetics in rat hearts with blood-perfused isovolumic contraction model

K. Obata, H. Morita, M. Takaki, 2019, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pitavastatin Improves Cardiac Function and Survival in Association With Suppression of the Myocardial Endothelin System in a Rat Model of Hypertensive Heart Failure

H. Izawa, T. Murohara, K. Nagata, 2006, Journal of cardiovascular pharmacology.

Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy.

T. Kato, H. Izawa, T. Murohara, 2008, JACC. Cardiovascular imaging.

Serial Alterations of β-Adrenergic Signaling in Dilated Cardiomyopathic Hamsters

Y. Ishikawa, T. Yokoi, T. Murohara, 2004 .

Effects of angiotensin type I receptor blockade on the cardiac Raf/MEK/ERK cascade activated via adrenergic receptors.

K. Murao, Xiao Yu, K. Obata, 2010, Journal of pharmacological sciences.

Heart‐selective expression of the chicken FK506‐binding protein (FKBP) 12.6 gene during embryonic development

S. Sasaki, K. Obata, M. Yokota, 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

Role of FK506-binding protein 12 in development of the chick embryonic heart.

K. Nagata, R. Tuan, K. Obata, 2001, Biochemical and biophysical research communications.

Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice

K. Obata, H. Morita, N. Kawao, 2018, The Journal of Physiological Sciences.

Serial alterations of beta-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of myocardial oxidative stress.

Y. Ishikawa, T. Yokoi, T. Murohara, 2004, Circulation journal : official journal of the Japanese Circulation Society.

Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors.

T. Kato, A. Yamada, H. Izawa, 2006, Journal of molecular and cellular cardiology.

Mechanism of Diastolic Stiffening of the Failing Myocardium and Its Prevention by Angiotensin Receptor and Calcium Channel Blockers

K. Okumura, T. Murohara, K. Nagata, 2009, Journal of cardiovascular pharmacology.

AT1 Receptor Blockade Reduces Cardiac Calcineurin Activity in Hypertensive Rats

H. Izawa, K. Nagata, K. Obata, 2002, Hypertension.

Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters.

K. Nagata, K. Obata, A. Noda, 2008, Journal of cardiac failure.

Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.

K. Nagata, K. Obata, A. Noda, 2006, Cardiovascular research.

Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1

K. Obata, H. Morita, M. Takaki, 2020, The Journal of Physiological Sciences.

Elastolytic Cathepsin Induction/Activation System Exists in Myocardium and Is Upregulated in Hypertensive Heart Failure

H. Izawa, T. Murohara, K. Nagata, 2006, Hypertension.

Cardiovascular , Pulmonary and Renal Pathology Superoxide-Dependent Cathepsin Activation Is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotensin II Type 1 Receptor Blocker Treatment

H. Izawa, K. Okumura, T. Murohara, 2010 .

Role of follistatin in muscle and bone alterations induced by gravity change in mice

K. Obata, H. Morita, N. Kawao, 2018, Journal of cellular physiology.

ATTENUATION OF VENTRICULAR HYPERTROPHY AND FIBROSIS IN RATS BY PITAVASTATIN: POTENTIAL ROLE OF THE RhoA–EXTRACELLULAR SIGNAL‐REGULATED KINASE–SERUM RESPONSE FACTOR SIGNALLING PATHWAY

H. Izawa, K. Nagata, K. Obata, 2006, Clinical and experimental pharmacology & physiology.

Effects of FK506 and rapamycin on formation of the neural tube in chick embryos

K. Nagata, S. Sasaki, R. Tuan, 2002 .

K. Obata, K. Horiguchi, M. Takaki, 2012, American journal of physiology. Cell physiology.

Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.

A. Nishiyama, K. Obata, Y. Nagai, 2009, American journal of physiology. Heart and circulatory physiology.

Changes in contractile and electrical activity in the ileum of DSS-induced colitis model W/Wv mutant mice.

K. Obata, Guo-Xing Zhang, M. Takaki, 2010, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia-reperfusion in the rat.

K. Murao, K. Obata, Guo-Xing Zhang, 2010, American journal of physiology. Heart and circulatory physiology.

Methods for the Preparation of an Excised, Cross-Circulated Rat Heart.

K. Obata, M. Takaki, 2018, Methods in molecular biology.

Mineralocorticoid Receptor Antagonism Ameliorates Left Ventricular Diastolic Dysfunction and Myocardial Fibrosis in Mildly Symptomatic Patients With Idiopathic Dilated Cardiomyopathy: A Pilot Study

T. Kato, H. Izawa, K. Okumura, 2005, Circulation.

unmasking of functional tachykinin responses in vitro receptors mediate inflammation-induced

D. Sharp, T. Hales, H. Kuniyasu, 2015 .

Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect.

A. Yamada, H. Izawa, T. Murohara, 2003, Journal of molecular and cellular cardiology.

Nicorandil Promotes Myocardial Capillary and Arteriolar Growth in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats

T. Naoe, H. Izawa, T. Murohara, 2005, Hypertension.

Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest.

K. Obata, Guo-Xing Zhang, S. Taniguchi, 2010, American journal of physiology. Heart and circulatory physiology.

The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice

K. Obata, H. Morita, N. Kawao, 2016, Physiological reports.

Mineralocorticoid Receptor Antagonism Attenuates Cardiac Hypertrophy and Failure in Low-Aldosterone Hypertensive Rats

T. Kato, H. Izawa, T. Murohara, 2006, Hypertension.

Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats

H. Izawa, K. Okumura, T. Murohara, 2010, Journal of hypertension.

A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts

K. Obata, D. Takeshita, S. Mitsuyama, 2012, The Journal of Physiological Sciences.

Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients.

T. Kato, A. Yamada, H. Izawa, 2005, Journal of the American College of Cardiology.

Gene expression of FK506-binding proteins 12.6 and 12 during chicken development.

S. Sasaki, K. Obata, M. Yokota, 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts.

K. Obata, Guo-Xing Zhang, D. Takeshita, 2011, American journal of physiology. Heart and circulatory physiology.

Prognostic value of pacing-induced mechanical alternans in patients with mild-to-moderate idiopathic dilated cardiomyopathy in sinus rhythm.

T. Kato, A. Yamada, H. Izawa, 2006, Journal of the American College of Cardiology.

Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice

K. Obata, H. Morita, N. Kawao, 2018, The Journal of Physiological Sciences.

Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments

Masaki Shirakawa, Dai Shiba, Masaki Shirakawa, 2015, PloS one.

CALL FOR PAPERS Intestinal Stem Cells in GI Physiology and Disease Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT 4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats

H. Kuniyasu, K. Obata, H. Fujii, 2012 .

Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions

K. Obata, K. Torimoto, K. Fujimoto, 2013, The Journal of Physiological Sciences.

Cardioprotective effects of a novel calpain inhibitor , SNJ-1945 for 1 reperfusion injury after cardioplegic cardiac arrest 2 3 4

K. Obata, Guo-Xing Zhang, S. Taniguchi, 2009 .

Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats.

H. Kuniyasu, K. Obata, H. Fujii, 2012, American journal of physiology. Gastrointestinal and liver physiology.

In Vivo Imaging of Enteric Neurogenesis in the Deep Tissue of Mouse Small Intestine

Yi Luo, H. Kuniyasu, K. Obata, 2013, PloS one.

In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation.

H. Kuniyasu, K. Obata, Guo-Xing Zhang, 2011, Biochemical and biophysical research communications.

Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions

K. Obata, K. Torimoto, K. Fujimoto, 2013, The Journal of Physiological Sciences.

The energy-saving effect of a new myosin activator, omecamtiv mecarbil, on LV mechanoenergetics in rat hearts with blood-perfused isovolumic contraction model

K. Obata, H. Morita, M. Takaki, 2019, Naunyn-Schmiedeberg's Archives of Pharmacology.

Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway.

H. Izawa, T. Murohara, K. Nagata, 2005, Biochemical and biophysical research communications.

Left ventricular mechanoenergetics in excised, cross-circulated rat hearts under hypo-, normo-, and hyperthermic conditions

K. Obata, H. Morita, D. Takeshita, 2018, Scientific Reports.

A 5‐HT4‐receptor activation‐induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult

H. Kuniyasu, K. Obata, M. Takaki, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Function of FK506 binding protein (FKBP) in chick embryonic cardiac development.

R. Tuan, K. Obata, M. Yokota, 1997, Heart and vessels.

A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts

K. Obata, M. Tanaka, D. Takeshita, 2013, The Journal of Physiological Sciences.

Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats

K. Obata, M. Hirabayashi, Guo-Xing Zhang, 2012, The Journal of Physiological Sciences.

A cardioprotective agent of a novel calpain inhibitor, SNJ-1945, exerts beta1 actions on left ventricular mechanical work and energetics.

K. Obata, Guo-Xing Zhang, S. Taniguchi, 2010, American journal of physiology. Heart and circulatory physiology.

Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.

H. Izawa, K. Okumura, T. Murohara, 2009, European journal of pharmacology.

Low-Aldosterone Hypertensive Rats Mineralocorticoid Receptor Antagonism Attenuates Cardiac Hypertrophy and Failure in

H. Izawa, T. Murohara, K. Obata, 2006 .

NHE-1 blockade reversed changes in calcium transient in myocardial slices from isoproterenol-induced hypertrophied rat left ventricle.

S. Matsuoka, A. Takeuchi, K. Obata, 2012, Biochemical and biophysical research communications.