T. Lampidis

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Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines

M. Wangpaichitr, N. Savaraj, Johnathan C. Maher, 2008, Molecular Cancer Therapeutics.

Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins.

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2008, European journal of pharmacology.

Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry.

H. Tapiero, T. Lampidis, G. Valet, 1989, Biochemical pharmacology.

Selective toxicity of rhodamine 123 in carcinoma cells in vitro.

I. Summerhayes, T. Lampidis, L B Chen, 1983, Cancer research.

The wonders of 2‐deoxy‐d‐glucose

M. Kurtoğlu, T. Lampidis, Haibin Xi, 2014, IUBMB life.

Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture

T. Lampidis, G. Moreno, C. Salet, 1984, Agents and Actions.

Relationship of multidrug resistance to rhodamine-123 selectivity between carcinoma and normal epithelial cells: taxol and vinblastine modulate drug efflux.

N. Savaraj, T. Lampidis, C. Wu, 1995, Cancer research.

Interaction of rhodamine 123 with mitochondria isolated from drug-sensitive and -resistant Friend leukemia cells.

H. Tapiero, T. Lampidis, W. Abou-Khalil, 1985, Biochemical and biophysical research communications.

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

M. Kurtoğlu, T. Lampidis, M. Lehrman, 2014, Cancer Chemotherapy and Pharmacology.

Efficacy of 2-halogen substituted d-glucose analogs in blocking glycolysis and killing “hypoxic tumor cells”

K. Ginalski, Johnathan C. Maher, M. Kurtoğlu, 2006, Cancer Chemotherapy and Pharmacology.

Structural and functional effects of adriamycin on cardiac cells in vitro.

T. Lampidis, I. Henderson, M. Israel, 1980, Cancer research.

Effect of verapamil on rhodamine 123 mitochondrial damage in adriamycin resistant cells.

H. Tapiero, A. Sbarbati, T. Lampidis, 1986, Anticancer research.

Relevance of the chemical charge of rhodamine dyes to multiple drug resistance.

H. Tapiero, N. Savaraj, T. Lampidis, 1989, Biochemical pharmacology.

Procollagen Alpha 1 Type I: A Potential Aide in Histopathological Grading of Glioma

N. Savaraj, T. Lampidis, Chunjing Wu, 2005, Cancer investigation.

2-Deoxy-GlucoseDownregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation , Induction of Endoplasmic Reticulum Stress , and GSK 3 b Activation

T. Lampidis, C. Decatur, J. Merchan, 2016 .

2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3β Activation

T. Lampidis, C. Decatur, J. Merchan, 2015, Molecular Cancer Therapeutics.

Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LHBETATAG retinoblastoma tumors

W. Feuer, T. Lampidis, J. Merchan, 2011, Clinical ophthalmology.

In Vivo Cancers Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung 2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Updated

L. Young, N. Savaraj, T. Lampidis, 2004 .

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

M. Kurtoğlu, T. Lampidis, G. Leclerc, 2016, Oncotarget.

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

M. Kurtoğlu, T. Lampidis, R. Brenneman, 2013, Cancer Chemotherapy and Pharmacology.

Phase II study of homoharringtonine in patients with recurrent primary malignant central nervous system tumors

H. Levin, N. Savaraj, T. Lampidis, 1990, Journal of Neuro-Oncology.

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Rakesh Kumar, M. Kurtoğlu, T. Lampidis, 2013, Cancer Chemotherapy and Pharmacology.

Phase I trial of glycolitic inhibition with 2-deoxyglucose and docetaxel for patients with solid tumors

J. Schlesselman, T. Lampidis, L. Raez, 2006 .

Differential Sensitivity to 2-Deoxy-D-glucose Between Two Pancreatic Cell Lines Correlates With GLUT-1 Expression

N. Savaraj, Johnathan C. Maher, T. Lampidis, 2005, Pancreas.

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

N. Savaraj, T. Lampidis, W. Priebe, 2002, Biochemical pharmacology.

Multidrug-resistant gene expression in small-cell lung cancer.

T. Lampidis, C. Wu, N. Savaraj, 1997, American journal of clinical oncology.

Increased hypoxia following vessel targeting in a murine model of retinoblastoma.

W. Feuer, T. Lampidis, C. Cebulla, 2009, Investigative ophthalmology & visual science.

Retinoblastoma Molecular Genomics: Regional Differences in the Molecular Genomics Expression Following Treatment With 2-Deoxy-D-Glucose in LHBETATAG Retinal Tumors

W. Scott, T. Lampidis, L. Nathanson, 2010 .

Potentiation of adriamycin accumulation and effectiveness in adriamycin-resistant cells by aclacinomycin A.

H. Tapiero, T. Lampidis, G. Trincal, 1988, Leukemia research.

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

N. Savaraj, T. Lampidis, R. Rubin, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Effects of colchicine on cardiac cell function indicate possible role for membrane surface tubulin.

T. Lampidis, R. Rubin, K. Trevorrow, 1986, Experimental cell research.

Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells.

J. Zou, T. Lampidis, C. Wu, 2000, Biochemical pharmacology.

Differential Expression of Glut 1 mRNA and Protein Levels Correlates with Increased Sensitivity to the Glyco-Conjugated Nitric Oxide Donor (2-glu-SNAP) in Different Tumor Cell Types

T. Lampidis, B. Ardalan, P. Wang, 2008, Journal of chemotherapy.

High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors

L. Boise, M. Kurtoğlu, T. Lampidis, 2010, Cancer Chemotherapy and Pharmacology.

Nuclear and mitochondrial effects of adriamycin in singly isolated pulsating myocardial cells.

T. Lampidis, G. Moreno, F. Vinzens, 1979, Journal of molecular and cellular cardiology.

Reversal of intrinsic resistance to adriamycin in normal cells by verapamil.

H. Tapiero, T. Lampidis, A. Krishan, 1986, Cancer drug delivery.

Letter: Gamma-irradiation of mammalian beating heart cells in vitro. Effects on cellular function.

R. Weichselbaum, J. Little, T. Lampidis, 1975, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Phenotypic diversity in human fibroblasts from myelometaplasic and non‐myelometaplasic hematopoietic tissues

M. Le Bousse-Kerdilès, T. Lampidis, D. Brouty‐boye, 1998 .

Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors.

W. Feuer, T. Lampidis, C. Decatur, 2012, Investigative ophthalmology & visual science.

Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LHBETATAG retinal tumors

W. Feuer, T. Lampidis, C. Decatur, 2011, Clinical ophthalmology.

Antiproliferative activity of taxol on human tumor and normal breast cells vs. effects on cardiac cells

T. Lampidis, D. Brouty‐boye, D. Kolonias, 1995, International journal of cancer.

T. Lampidis, G. E. Schaiberger, 1975, Experimental cell research.

Structural requirements of simple organic cations for recognition by multidrug-resistant cells.

H. Tapiero, N. Savaraj, T. Lampidis, 1992, Cancer research.

Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge.

H. Tapiero, N. Savaraj, T. Lampidis, 1997, Biochemistry.

Cytotoxic and photodynamic effects of Photofrin on sensitive and multi-drug-resistant Friend leukaemia cells.

H. Tapiero, T. Lampidis, G. Moreno, 1992, International journal of radiation biology.

Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.

T. Lampidis, L. B. Chen, J. R. Wong, 1985, The Journal of biological chemistry.

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.

I. Summerhayes, J. J. Nadakavukaren, T. Lampidis, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

T. Lampidis, L. B. Chen, S. Bernal, 1983, Science.

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro.

I. Summerhayes, T. Lampidis, L. B. Chen, 1982, Science.

Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea. Demonstration by combined biochemical and autoradiographic techniques.

J. Little, T. Lampidis, 1977, Experimental cell research.

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

M. Wangpaichitr, N. Savaraj, M. Kurtoğlu, 2011, Cancer Chemotherapy and Pharmacology.

Probing mitochondria in living cells with rhodamine 123.

I. Summerhayes, T. Lampidis, L. B. Chen, 1982, Cold Spring Harbor symposia on quantitative biology.

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2019, Molecular Cancer Research.

Glucose and mannose analogs inhibit KSHV replication by blocking N‐glycosylation and inducing the unfolded protein response

T. Lampidis, E. Mesri, J. Naipauer, 2022, Journal of medical virology.

Under normoxia, 2-deoxy-d-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

A. Lane, M. Wangpaichitr, N. Savaraj, 2007, Molecular Cancer Therapeutics.

Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.

Johnathan C. Maher, M. Kurtoğlu, T. Lampidis, 2007, Antioxidants & redox signaling.

Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells.

N. Savaraj, T. Lampidis, K. Carraway, 2003, Biochemical pharmacology.

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

T. Lampidis, C. Muñoz-Pinedo, Clara Lucía León-Annicchiarico, 2015, The FEBS journal.

Activation of the Unfolded Protein Response by 2-Deoxy-d-Glucose Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication and Gene Expression

M. Kurtoğlu, T. Lampidis, E. M. Duran, 2012, Antimicrobial Agents and Chemotherapy.

α-Smooth muscle actin expression in cultured cardiac fibroblasts of newborn rat

N. Savaraj, T. Lampidis, D. Brouty‐boye, 1992, In Vitro Cellular & Developmental Biology - Animal.

Overcoming cisplatin resistance by mTOR inhibitor in lung cancer

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2005, Molecular Cancer.

Targeting hypoxia, a novel treatment for advanced retinoblastoma.

W. Feuer, T. Lampidis, C. Cebulla, 2008, Investigative ophthalmology & visual science.

Cross-resistance to rhodamine 123 in Adriamycin- and daunorubicin-resistant Friend leukemia cell variants.

H. Tapiero, T. Lampidis, A. Fourcade, 1984, Cancer research.

Selective killing of carcinoma cells "in vitro" by lipophilic-cationic compounds: a cellular basis.

T. Lampidis, L. B. Chen, Y. Hasin, 1985, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Phenotypic diversity in human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues.

M. Le Bousse-Kerdilès, T. Lampidis, D. Brouty‐boye, 1998, International journal of cancer.

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy.

T. Lampidis, J. Merchan, Haibin Xi, 2013, Biochemical pharmacology.

ρ0 tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs

N. Savaraj, T. Lampidis, C. Moraes, 2000 .

2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo

N. Savaraj, T. Lampidis, W. Priebe, 2004, Cancer Research.

3'-Deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin conquers multidrug resistance by rapid influx following higher frequency of formation of DNA single- and double-strand breaks.

H. Tapiero, Y. Sugimoto, T. Lampidis, 1990, Cancer research.

Models and discovery strategies for new therapies of retinoblastoma

T. Lampidis, T. Murray, S. Houston, 2013, Expert opinion on drug discovery.

Reversal of resistance to rhodamine 123 in adriamycin-resistant Friend leukemia cells.

H. Tapiero, T. Lampidis, A. Krishan, 1985, Cancer research.

The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2012, Molecular Cancer Therapeutics.

Therapeutic Discovery The Relationship of Thioredoxin-1 and Cisplatin Resistance : Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2012 .

Structurally different anthracyclines provoke different effects on cell cycle and tumor B cell differentiation.

H. Tapiero, T. Lampidis, N. Gruel, 1998, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors.

M. Kurtoğlu, T. Lampidis, 2009, Molecular nutrition & food research.

Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine.

M. Wangpaichitr, N. Savaraj, T. Lampidis, 2003, International journal of oncology.

Inhibition of Akt Potentiates 2-DG–Induced Apoptosis via Downregulation of UPR in Acute Lymphoblastic Leukemia

T. Lampidis, G. Leclerc, Jeffim N. Kuznetsov, 2012, Molecular Cancer Research.

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-d-glucose

M. Wangpaichitr, N. Savaraj, Johnathan C. Maher, 2007, Molecular Cancer Therapeutics.

Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LHBETATAG retinal tumors

W. Scott, T. Lampidis, L. Nathanson, 2012, Clinical ophthalmology.

Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.

W. Feuer, T. Lampidis, W. Shi, 2010, Investigative ophthalmology & visual science.

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

Awtar Krishan, Johnathan C. Maher, T. Lampidis, 2004, Cancer Chemotherapy and Pharmacology.

Hypersensitization of tumor cells to glycolytic inhibitors.

N. Savaraj, T. Lampidis, W. Priebe, 2001, Biochemistry.

Responses to the combination of the glycolytic inhibitor 2-deoxy-glucose (2DG) and docetaxel (DC) in patients with lung and head and neck (H/N) carcinomas

K. Papadopoulos, S. Kroll, T. Lampidis, 2007 .

The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.

X. Chen, A. Gomes, F. Fontanesi, 2022, Developmental cell.

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

F. Fontanesi, T. Lampidis, A. Barrientos, 2020, Frontiers in Cell and Developmental Biology.

Selec t ive Toxicity of Rhodamine 123 in Carcinoma Cells in Vitro

T. Lampidis, L. Chen, S. Bernal, 2007 .

Signaling and Regulation Inhibition of Akt Potentiates 2-DG – Induced Apoptosis via Downregulation of UPR in Acute Lymphoblastic Leukemia

T. Lampidis, G. Leclerc, J. Barredo, 2012 .

Interferon Inhibits Cardiac Cell Function in Vitro

T. Lampidis, Danièle Brouty-Boyé, 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

T. Lampidis, M. Lehrman, G. Leclerc, 2015, Leukemia research.

Antiangiogenic Activity of 2-Deoxy-D-Glucose

M. Kurtoğlu, T. Lampidis, M. Lehrman, 2010, PloS one.

Effects of adriamycin on rat heart cells in culture: increased accumulation and nucleoli fragmentation in cardiac muscle v. non-muscle cells.

T. Lampidis, M. Israel, L. Johnson, 1981, Journal of molecular and cellular cardiology.

Abstract 4642: Combined glycolytic inhibition and anti-vascular treatment in retinoblastoma: Novel strategy for tumor control avoids chemotherapy

T. Lampidis, C. Decatur, T. Murray, 2012 .

Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs.

N. Savaraj, T. Lampidis, C. Moraes, 2000, Biochemical pharmacology.

Mitochondria in tumor cells effects of cytoskeleton on distribution and as targets for selective killing

I. Summerhayes, T. Lampidis, L. Chen, 1984 .

Combining glycolytic inhibitors with chemotherapy: Phase I trial of 2-deoxyglucose and docetaxel in patients with solid tumors

J. Schlesselman, K. Papadopoulos, T. Lampidis, 2005 .

RHODAMINE‐123 IS SELECTIVELY TOXIC AND PREFERENTIALLY RETAINED IN CARCINOMA CELLS IN VITRO *

I. Summerhayes, T. Lampidis, L. Chen, 1982 .

Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins.

T. Lampidis, M. Kuo, C. Wu, 1994, Cancer Investigation.

Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells

H. Tapiero, N. Savaraj, T. Lampidis, 1997, Leukemia.

2-DEOXY-GLUCOSE DOWN REGULATES ENDOTHELIAL AKT AND ERK VIA INTERFERENCE WITH N-LINKED GLYCOSYLATION, INDUCTION OF ENDOPASMIC RETICULUM STRESS AND GSK-3 β ACTIVATION INHIBITION OF ENDOTHELIAL AKT AND ERK BY

T. Lampidis, C. Decatur, Christina L Decatur, 2015 .

ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

T. Lampidis, C. Muñoz-Pinedo, Clara Lucía León-Annicchiarico, 2015, The FEBS journal.

Comparison of topoisomerase I and II expression in primary brain tumor and lung cancer.

T. Lampidis, C. Wu, N. Savaraj, 1997, Oncology Report.