A. Kamen

发表

Limiting factors governing protein expression following polyethylenimine-mediated gene transfer in HEK293-EBNA1 cells.

Y. Durocher, É. Carpentier, S. Paris, 2007, Journal of biotechnology.

On-line measurement of green fluorescent protein (GFP) fluorescence for the monitoring of recombinant adenovirus production

A. Kamen, P. Gilbert, A. Garnier, 2000, Biotechnology Letters.

Study of Adenovirus Production in Serum‐Free 293SF Suspension Culture by GFP‐Expression Monitoring

A. Kamen, A. Garnier, J. Côté, 1997, Biotechnology progress.

Large-Scale Transient Transfection of Suspension Mammalian Cells for VLP Production.

A. Kamen, L. Cervera, 2018, Methods in molecular biology.

Advancements in mammalian cell transient gene expression (TGE) technology for accelerated production of biologics

A. Kamen, L. Cervera, F. Gòdia, 2018, Critical reviews in biotechnology.

Production of Lentiviral Vectors Encoding Recombinant Factor VIII Expression in Serum-Free Suspension Cultures

D. Covas, A. Kamen, A. Caron, 2015 .

1.28 – Cell Transfection

Y. Durocher, A. Kamen, P. Chahal, 2011 .

Large-Scale transfection of mammalian cells for the fast production of recombinant protein

Amine Kamen, Yves Durocher, Y. Durocher, 2006, Molecular biotechnology.

Large‐scale transient transfection of serum‐free suspension‐growing HEK293 EBNA1 cells: Peptone additives improve cell growth and transfection efficiency

Y. Durocher, A. Kamen, S. Perret, 2003, Biotechnology and bioengineering.

Recombinant Protein Production by Transient Transfection of Suspension-Growing Cells

Y. Durocher, A. Kamen, S. Perret, 2001 .

Exploiting heparin-binding properties of MoMLV-based retroviral vectors for affinity chromatography.

A. Kamen, A. Garnier, María Mercedes Segura, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Purification and characterization of retrovirus vector particles by rate zonal ultracentrifugation.

A. Kamen, A. Garnier, María Mercedes Segura, 2006, Journal of virological methods.

Current and Emerging Cell Culture Manufacturing Technologies for Influenza Vaccines

Amine A. Kamen, A. Kamen, Ernest Milián, 2015, BioMed research international.

Effect of surface charge on the cellular uptake and cytotoxicity of fluorescent labeled cellulose nanocrystals.

J. Luong, A. Kamen, K. Mahmoud, 2010, ACS applied materials & interfaces.

Monitoring the physiological state of mammalian cell perfusion processes by on-line estimation of intracellular fluxes

M. Perrier, A. Kamen, O. Henry, 2007 .

Use of cell bleed in a high cell density perfusion culture and multivariable control of biomass and metabolite concentrations

Michel Perrier, André Desbiens, Amine Kamen, 2006 .

Improving Glucose and Glutamine Metabolism of Human HEK 293 and Trichoplusiani Insect Cells Engineered To Express a Cytosolic Pyruvate Carboxylase Enzyme

Amine Kamen, Yves Durocher, Y. Durocher, 2003, Biotechnology progress.

Large-scale adenovirus and poxvirus-vectored vaccine manufacturing to enable clinical trials.

A. Kamen, H. Kallel, 2015, Biotechnology journal.

Manufacturing of viral vectors: part II. Downstream processing and safety aspects

A. Kamen, M. Schweizer, P. Chahal, 2014 .

Establishing a Robust Manufacturing Platform for Recombinant Veterinary Vaccines: An Adenovirus-Vector Vaccine to Control Newcastle Disease Virus Infections of Poultry in Sub-Saharan Africa

A. Kamen, H. Kallel, Khaled Trabelsi, 2020, Vaccines.

Production and formulation of adenovirus vectors.

John O. Konz, R. K. Evans, A. Kamen, 2005, Advances in biochemical engineering/biotechnology.

Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography

A. Kamen, N. Coulombe, M. Acchione, 2020, Molecular therapy. Methods & clinical development.

Titre : Title : Metabolic and Kinetic analyses of influenza production in perfusion HEK 293 cell culture Auteurs :

A. Kamen, D. Jacob, Sven Ansorge, 2019 .

Generation of monoclonal pan-hemagglutinin antibodies for the quantification of multiple strains of influenza

J. Baardsnes, Y. Durocher, A. Kamen, 2017, PloS one.

Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system.

A. Kamen, P. Chahal, M. Aucoin, 2007, Journal of virological methods.

ON-LINE MONITORING OF CELL SIZE DISTRIBUTION IN MAMMALIAN CELL CULTURE PROCESSES

A. Kamen, Sven Ansorge, O. Henry, 2007 .

Monitoring motility, spreading, and mortality of adherent insect cells using an impedance sensor.

J H Luong, K B Male, J. Luong, 2001, Analytical chemistry.

Probing inhibitory effects of nanocrystalline cellulose: inhibition versus surface charge.

J. Luong, A. Kamen, K. Male, 2012, Nanoscale.

Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: inhibition vs chemical structure.

J. Luong, Bing-Lan Liu, Y. Tzeng, 2009, The Analyst.

Probing inhibitory effects of Antrodia camphorata isolates using insect cell-based impedance spectroscopy: inhibition vs chemical structure.

J. Luong, Y. Tzeng, Y. K. Rao, 2008, Chemical research in toxicology.

Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture

A. Kamen, D. Jacob, Sven Ansorge, 2011, BMC biotechnology.

Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing.

A. Kamen, D. Jacob, Sven Ansorge, 2010, Vaccine.

Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors.

M. Perrier, A. Kamen, O. Henry, 2005, Metabolic engineering.

Overview of current scalable methods for purification of viral vectors.

A. Kamen, A. Garnier, María Mercedes Segura, 2011, Methods in molecular biology.

Purification of retrovirus particles using heparin affinity chromatography.

A. Kamen, A. Garnier, María Mercedes Segura, 2008, Methods in molecular biology.

A novel purification strategy for retrovirus gene therapy vectors using heparin affinity chromatography.

A. Kamen, A. Garnier, María Mercedes Segura, 2005, Biotechnology and bioengineering.

Size-exclusion chromatography purification of high-titer vesicular stomatitis virus G glycoprotein-pseudotyped retrovectors for cell and gene therapy applications.

A. Kamen, J. Galipeau, D. Jaalouk, 2003, Human gene therapy.

Quantitation of baculovirus particles by flow cytometry.

A. Kamen, J. Meghrous, C. Shen, 2002, Journal of virological methods.

Manufacturing of recombinant adeno‐associated viruses using mammalian expression platforms

A. Kamen, P. Chahal, R. Gilbert, 2017, Biotechnology journal.

Critical assessment of current adeno-associated viral vector production and quantification methods.

M. Perrier, A. Kamen, M. Aucoin, 2008, Biotechnology advances.

Improving AAV vector yield in insect cells by modulating the temperature after infection

M. Perrier, A. Kamen, M. Aucoin, 2007, Biotechnology and bioengineering.

Dystrophin expression in muscle following gene transfer with a fully deleted ("gutted") adenovirus is markedly improved by trans-acting adenoviral gene products.

J. Nalbantoglu, A. Kamen, S. Fletcher, 2001, Human gene therapy.

Insect cell technology is a versatile and robust vaccine manufacturing platform

A. Kamen, J. Mena, 2011, Expert review of vaccines.

Characterization of influenza H1N1 Gag virus-like particles and extracellular vesicles co-produced in HEK-293SF.

A. Kamen, Sven Ansorge, P. Chahal, 2019, Vaccine.

Efficient human hematopoietic cell transduction using RD114- and GALV-pseudotyped retroviral vectors produced in suspension and serum-free media.

A. Kamen, M. Olszewska, I. Rivière, 2009, Human gene therapy.

Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media

A. Kamen, S. Cottin, M. Caruso, 2007, Gene Therapy.

Decision letter for "Recent advances and current challenges in process intensification of cell culture‐based influenza virus vaccine manufacturing"

A. Kamen, O. Henry, C. A. Silva, 2021, The Canadian Journal of Chemical Engineering.

Establishment of the upstream processing for renewable production of hydrogen using vermicomposting-tea and molasses as substrate.

J. Domínguez, A. Kamen, D. Oseguera-Galindo, 2022, Waste management.

Proteomic Analysis of Highly Purified with Retroviral Vector Particles by Identification of Host Proteins Associated

A. Kamen, A. Garnier, A. Meneses-Acosta, 2013 .

Identification of Host Proteins Associated with Retroviral Vector Particles by Proteomic Analysis of Highly Purified Vector Preparations

A. Kamen, A. Garnier, María Mercedes Segura, 2007, Journal of Virology.

Serum-free production of rVSV-ZEBOV in Vero cells: microcarrier bioreactor versus scale-X™ hydro fixed-bed.

A. Kamen, Jean-François Gélinas, Sascha Kiesslich, 2020, Journal of biotechnology.

Enhanced growth of Sf-9 cells to a maximum density of 5.2 x 10(7) cells per mL and production of beta-galactosidase at high cell density by fed batch culture.

A. Kamen, C. Elias, A. Zeiser, 2000, Biotechnology and bioengineering.

Fed-batch culture of Sf-9 cells supports 3 3 10 7 cells per ml and improves baculovirus-expressed recombinant protein yields

A. Kamen, S. Perret, C. Bédard, 1997, Biotechnology Letters.

Process optimization and scale-up for production of rabies vaccine live adenovirus vector (AdRG1.3).

A. Kamen, D. Jacob, S. Lanthier, 2012, Vaccine.

Characterization of Extracellular Vesicles Secreted in Lentiviral Producing HEK293SF Cell Cultures

Jianjun Li, A. Kamen, Alexandra T. Star, 2021, Viruses.

Comparative Transcriptomics Analyses of a Vero Cell Line in Suspension Versus Adherent Culture Conditions

A. Kamen, Yu Xia, Marie-Angélique Sène, 2021 .

Cell Transfection

A. Kamen, P. Chahal, D. Sharon, 2019, Comprehensive Biotechnology.

Development of a simple and high-yielding fed-batch process for the production of influenza vaccines.

A. Kamen, D. Jacob, M. Cox, 2009, Vaccine.

A simple macroscopic model for the diffusion and adsorption kinetics of r‐adenovirus

A. Kamen, P. Gilbert, A. Garnier, 2007, Biotechnology and bioengineering.

Kinetics of Mass Transfer with Chemical Reaction in Gas-Liquid and Liquid-Liquid Systems

A. Kamen, H. Renon, A. Gaunand, 1984 .

Adenovirus-mediated utrophin gene transfer mitigates the dystrophic phenotype of mdx mouse muscles.

K. Davies, J. Nalbantoglu, S. Ebihara, 1999, Human gene therapy.

Production of Lentiviral Vectors Using a HEK-293 Producer Cell Line and Advanced Perfusion Processing

A. Kamen, M. Tran, 2022, Frontiers in Bioengineering and Biotechnology.

Identiﬁcation of Host Proteins Associated with Retroviral Vector Particles by Proteomic Analysis of Highly Puriﬁed Vector Preparations (cid:1)

A. Kamen, A. Garnier, A. Meneses-Acosta, 2008 .

Titration methods for rVSV-based vaccine manufacturing

A. Kamen, R. Gilbert, Sascha Kiesslich, 2020, MethodsX.

From the first to the third generation adenoviral vector: what parameters are governing the production yield?

M. Perrier, A. Kamen, E. Dormond, 2009, Biotechnology advances.

An efficient and scalable process for helper‐dependent adenoviral vector production using polyethylenimine‐adenofection

M. Perrier, Y. Durocher, A. Kamen, 2009, Biotechnology and bioengineering.

Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems

A. Kamen, Christine M Thompson, O. Henry, 2015, BMC Biotechnology.

Development of a suspension serum-free helper-dependent adenovirus production system and assessment of co-infection conditions.

Y. Durocher, A. Kamen, D. Jacob, 2008, Journal of virological methods.

Improvement of recombinant protein production with the human adenovirus/293S expression system using fed-batch strategies.

C. Chavarie, A. Kamen, A. Garnier, 2000, Biotechnology and bioengineering.

From functional genomics of vero cells to CRISPR‐based genomic deletion for improved viral production rates

A. Kamen, Yu Xia, Marie-Angélique Sène, 2022, Biotechnology and bioengineering.

A nanoparticle-based COVID-19 vaccine candidate elicits broad neutralizing antibodies and protects against SARS-CoV-2 infection

P. Savard, A. Kamen, D. Leclerc, 2022, Nanomedicine: Nanotechnology, Biology and Medicine.

Evaluation of novel HIV vaccine candidates using recombinant vesicular stomatitis virus vector produced in serum-free Vero cell cultures.

A. Kamen, A. Garnier, Nasha Nassoury, 2020, Vaccine.

Particle quantification of influenza viruses by high performance liquid chromatography.

A. Kamen, Christine M Thompson, E. Petiot, 2015, Vaccine.

Retroviral vector production using suspension‐adapted 293GPG cells in a 3L acoustic filter‐based perfusion bioreactor

A. Kamen, A. Garnier, J. Transfiguracion, 2006, Biotechnology and bioengineering.

Modeling of the Diffusion/ Adsorption Process of 293S Cells Infected by Recombinant Adenoviruses

A. Kamen, P. Gilbert, A. Garnier, 2001 .

Only a small fraction of cells produce assembled capsids during transfection‐based manufacturing of adeno‐associated virus vectors

A. Kamen, D. Sharon, A. Mullick, 2021, Biotechnology and bioengineering.

Increased Production of Active Human β2-Adrenergic/Gαs Fusion Receptor in Sf-9 Cells Using Nutrient Limiting Conditions

Y. Durocher, É. Carpentier, A. Kamen, 2001 .

Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use

A. Kamen, J. P. C. Fulber, 2022, Viruses.

Vectored-Vaccine Platforms Enabled Rapid Development of Safe and Effective Vaccines in Response to COVID-19 Pandemic Situation

A. Kamen, 2021, Vaccines.

Manufacturing of adenovirus vectors: production and purification of helper dependent adenovirus.

A. Kamen, E. Dormond, 2011, Methods in molecular biology.

An efficient process for the purification of helper-dependent adenoviral vector and removal of helper virus by iodixanol ultracentrifugation.

M. Perrier, A. Kamen, P. Chahal, 2010, Journal of virological methods.

Identification of critical infection parameters to control helper-dependent adenoviral vector production.

M. Perrier, A. Kamen, E. Dormond, 2009, Journal of biotechnology.

Production of adenovirus vector for gene therapy.

A. Kamen, I. Nadeau, 2003, Biotechnology advances.

Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells.

A. Kamen, Sven Ansorge, P. Chahal, 2019, Vaccine.

Improving adeno‐associated vector yield in high density insect cell cultures

A. Kamen, P. Chahal, J. Mena, 2010, The journal of gene medicine.

Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

D. Covas, Y. Durocher, A. Kamen, 2011, BMC biotechnology.

Baculovirus expression system scaleup by perfusion of high‐density Sf‐9 cell cultures

A. Kamen, B. Massie, A. Caron, 1994, Biotechnology and bioengineering.

Vero cell upstream bioprocess development for the production of viral vectors and vaccines

Sascha Kiesslich, Amine A. Kamen, A. Kamen, 2020, Biotechnology Advances.

Bioprocessing of baculovirus vectors: a review.

A. Kamen, J. Mena, M. Aucoin, 2010, Current Gene Therapy.

Production of Virus-Like Particles for Vaccination.

A. Kamen, Christine M Thompson, M. Aucoin, 2016, Methods in molecular biology.

An initiative to manufacture and characterize baculovirus reference material.

K. Airenne, A. Kamen, M. V. van Oers, 2011, Journal of invertebrate pathology.

Development and validation of a HPLC method for the quantification of baculovirus particles.

A. Kamen, J. Mena, M. Aucoin, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High yield purification of functional baculovirus vectors by size exclusion chromatography.

A. Kamen, D. Jacob, J. Transfiguracion, 2007, Journal of virological methods.

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells.

Y. Durocher, A. Kamen, S. Perret, 2002, Nucleic acids research.

Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Pranav R H Joshi, Alina Venereo-Sanchez, Parminder S Chahal, 2020, Biotechnology journal.

On‐line monitoring of respiration in recombinant‐baculovirus infected and uninfected insect cell bioreactor cultures

R Tom, A. Kamen, S. Perret, 1996, Biotechnology and bioengineering.

Improved yields of the extracellular domain of the epidermal growth factor receptor produced using the baculovirus expression system by medium replacement following infection

A. Kamen, B. Massie, C. Bédard, 1995, Applied Microbiology and Biotechnology.

Dissolved carbon dioxide accumulation in a large scale and high density production of TGFβ receptor with baculovirus infected Sf-9 cells

A. Kamen, A. Garnier, S. Perret, 2004, Cytotechnology.

Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures

A. Kamen, Roseanne Tom, B. Massie, 2004, Cytotechnology.

RNA interference technology to improve the baculovirus-insect cell expression system.

A. Kamen, Cuitlahuac Chavez-Pena, 2018, Biotechnology advances.

Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production

Amine Kamen, Yasuo Konishi, Y. Konishi, 2007, Cytotechnology.

Growth, Nutrient Consumption, and End‐Product Accumulation in Sf‐9 and BTI‐EAA Insect Cell Cultures: Insights into Growth Limitation and Metabolism

R Tom, A. Kamen, C Bédard, 1993, Biotechnology progress.

Culture of insect cells in helical ribbon impeller bioreactor

C. Chavarie, A. Kamen, Roseanne Tom, 1991, Biotechnology and bioengineering.

Insights into the Central Metabolism of Spodoptera frugiperda (Sf‐9) and Trichoplusia ni BTI‐Tn‐5B1‐4(Tn‐5) Insect Cells by Radiolabeling Studies

A. Kamen, J. Hawari, C. Elias, 2008, Biotechnology progress.

Scale-up of recombinant virus and protein production in stirred-tank reactors.

A. Kamen, B. Massie, A. Caron, 1995, Methods in molecular biology.

Advancements in the design and scalable production of viral gene transfer vectors

A. Kamen, D. Sharon, 2018, Biotechnology and bioengineering.

Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells

A. Kamen, A. Garnier, J. Côté, 2004, Cytotechnology.

Serum-free production of recombinant proteins and adenoviral vectors by 293SF-3F6 cells.

A. Kamen, A. Garnier, J. Côté, 1998, Biotechnology and bioengineering.

Adeno‐Associated Viral Vectors for Homology‐Directed Generation of CAR‐T Cells

A. Kamen, N. Aharony, Pablo D. Moço, 2020, Biotechnology journal.

Identification and crystallization of a protease-resistant core of calnexin that retains biological activity.

D. Tessier, D. Y. Thomas, J. Schrag, 1998, Journal of structural biology.

A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms

A. Kamen, Sven Ansorge, Sean Nesdoly, 2020, Scientific Reports.

Establishment and validation of new complementing cells for production of E1-deleted adenovirus vectors in serum-free suspension culture.

A. Kamen, L. Bourget, B. Massie, 2014, Journal of virological methods.

Production of lentiviral vectors by large‐scale transient transfection of suspension cultures and affinity chromatography purification

Y. Durocher, A. Kamen, A. Garnier, 2007, Biotechnology and bioengineering.

Critical Assessment of Purification and Analytical Technologies for Enveloped Viral Vector and Vaccine Processing and Their Current Limitations in Resolving Co-Expressed Extracellular Vesicles

A. Kamen, Aline Do Minh, 2021, Vaccines.

Downstream processing of oncoretroviral and lentiviral gene therapy vectors.

A. Kamen, A. Garnier, María Mercedes Segura, 2006, Biotechnology advances.

Development of a scalable process for high‐yield lentiviral vector production by transient transfection of HEK293 suspension cultures

Y. Durocher, A. Kamen, Sven Ansorge, 2009, The journal of gene medicine.

High-performance liquid chromatographic total particles quantification of retroviral vectors pseudotyped with vesicular stomatitis virus-G glycoprotein.

A. Kamen, J. Transfiguracion, H. Coelho, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture.

R. Stocco, M. Abramovitz, Y. Durocher, 2000, Analytical biochemistry.

Recent progress in lentiviral vector mass production

Amine Kamen, Olivier Henry, Sven Ansorge, 2010 .

Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures

A. Kamen, S. Wootton, L. Susta, 2021, Vaccines.

Critical phases of viral production processes monitored by capacitance.

A. Kamen, Sven Ansorge, M. Rosa-Calatrava, 2017, Journal of biotechnology.

Hyperosmotic pressure on HEK 293 cells during the growth phase, but not the production phase, improves adenovirus production.

Amine Kamen, A. Kamen, Chun Fang Shen, 2012, Journal of biotechnology.

Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery

A. Kamen, P. Chahal, J. Montes, 2013, Journal of Virological Methods.

Development and optimization of an adenovirus production process

Amine Kamen, Olivier Henry, A. Kamen, 2004, The journal of gene medicine.

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation

A. Kamen, D. Leclerc, Fouad Brahimi, 2020, Vaccines.

Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections.

X. Qiu, A. Kamen, Nasha Nassoury, 2017, Human gene therapy.

Critical review of current and emerging quantification methods for the development of influenza vaccine candidates.

A. Kamen, A. Manceur, Aziza P Manceur, 2015, Vaccine.

Stability of Serum‐Free and Purified Baculovirus Stocks under Various Storage Conditions

A. Kamen, R. Tran, H. Jorio, 2006, Biotechnology progress.

Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines

A. Kamen, I. González-Domínguez, C. Toussaint, 2022, Vaccines.

Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

J. Nalbantoglu, Y. Durocher, A. Kamen, 2007, Journal of virological methods.

Recombinant Protein Production in Large-Scale Agitated Bioreactors Using the Baculovirus Expression Vector System.

A. Kamen, Christine M Thompson, M. Aucoin, 2016, Methods in molecular biology.

Analysis of baculovirus aggregates using flow cytometry.

A. Kamen, L. Bourget, J. Meghrous, 2006, Journal of virological methods.

On‐Line Monitoring of Physiological Parameters of Insect Cell Cultures during the Growth and Infection Process

Robert Voyer, A. Kamen, C. Elias, 2000, Biotechnology progress.

On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements.

R Voyer, R Tom, A. Kamen, 1999, Biotechnology and bioengineering.

Manufacturing of viral vectors for gene therapy: part I. Upstream processing

A. Kamen, M. Schweizer, P. Chahal, 2014 .

Extended gene expression for Gag VLP production achieved at bioreactor scale

A. Kamen, L. Cervera, F. Gòdia, 2018, Journal of Chemical Technology & Biotechnology.

Insights into adenoviral vector production kinetics in acoustic filter‐based perfusion cultures

Michel Perrier, Amine Kamen, Olivier Henry, 2004, Biotechnology and bioengineering.

Acoustic cell filter: a proven cell retention technology for perfusion of animal cell cultures.

Amine Kamen, A. Kamen, Stephane Lanthier, 2004, Biotechnology advances.

Understanding factors that limit the productivity of suspension-based perfusion cultures operated at high medium renewal rates.

A. Kamen, S. Mercille, B. Massie, 2000, Biotechnology and bioengineering.

Optimization and scale-up of cell culture and purification processes for production of an adenovirus-vectored tuberculosis vaccine candidate.

A. Kamen, D. Jacob, T. Zhu, 2016, Vaccine.

Reassessing culture media and critical metabolites that affect adenovirus production

A. Kamen, R. Voyer, C. Shen, 2009, Biotechnology progress.

Evaluation of homogeneity and genetic stability of REOLYSIN® (pelareorep) by complete genome sequencing of reovirus after large scale production

Zhenbao Yu, B. Thompson, D. Onions, 2014, Applied Microbiology and Biotechnology.

Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery

A. Kamen, L. Poulsen, O. Sundnes, 2017, The Journal of Immunology.

New protocol for lentiviral vector mass production.

Y. Durocher, A. Kamen, A. Garnier, 2010, Methods in molecular biology.

Optimization and scale-up of cell culture and purification processes for production of an adenovirus-based tuberculosis vaccine

A. Kamen, D. Jacob, T. Zhu, 2015, BMC Proceedings.

Influence of HEK293 metabolism on the production of viral vectors and vaccine.

A. Kamen, M. Čuperlović-Culf, E. Petiot, 2015, Vaccine.

Improved high-performance liquid chromatographic method in the analysis of adenovirus particles.

V. Klyushnichenko, A. Kamen, E. Harmsen, 2001, Journal of chromatography. B, Biomedical sciences and applications.

293SF Metabolic Flux Analysis during Cell Growth and Infection with an Adenoviral Vector

M. Perrier, A. Kamen, D. Jacob, 2000, Biotechnology progress.

Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System

J. Schrag, A. Kamen, S. Zolotukhin, 2019, Molecular therapy. Methods & clinical development.

Virus-like particle and viral vector production using the baculovirus expression vector system/insect cell system: adeno-associated virus-based products.

A. Kamen, D. Jacob, P. Chahal, 2007, Methods in molecular biology.

Adaptive Control at Low Glucose Concentration of HEK‐293 Cell Serum‐Free Cultures

J H Luong, M Perrier, J Côté, 1999, Biotechnology progress.

Transient gene expression in HEK293 cells: peptone addition posttransfection improves recombinant protein synthesis.

Y. Durocher, É. Carpentier, A. Kamen, 2005, Biotechnology and bioengineering.

A Scalable Process for Helper-Dependent Adenoviral Vector Production Using PEI-Derived Transfection Strategy in Suspension Culture

M. Perrier, Y. Durocher, A. Kamen, 2010 .

A TrkA-selective, Fast Internalizing Nerve Growth Factor-Antibody Complex Induces Trophic but Not Neuritogenic Signals*

A. Cuello, K. Neet, A. Kamen, 1998, The Journal of Biological Chemistry.

Titre : Title : Analytical technologies for influenza virus-like particle candidate vaccines : challenges and emerging approaches Auteurs :

A. Kamen, Christine M Thompson, O. Henry, 2019 .

Analytical technologies for influenza virus-like particle candidate vaccines: challenges and emerging approaches

A. Kamen, Christine M Thompson, O. Henry, 2013, Virology Journal.

Vero cell upstream bioprocess development for the production of viral vectors and vaccines

A. Kamen, Sascha Kiesslich, S. Kiesslich, 2020, Biotechnology Advances.

Haplotype-resolved de novo assembly of the Vero cell line genome

J. Ragoussis, H. Djambazian, A. Kamen, 2021, npj Vaccines.

Haplotype-resolved de novo assembly of the Vero cell line genome

J. Ragoussis, H. Djambazian, A. Kamen, 2021, NPJ vaccines.

Bioreactor production of rVSV‐based vectors in Vero cell suspension cultures

A. Kamen, Gyoung Nyoun Kim, Sascha Kiesslich, 2021, Biotechnology and bioengineering.

Development of suspension adapted Vero cell culture process technology for production of viral vaccines.

A. Kamen, R. Gilbert, C. Guilbault, 2019, Vaccine.

Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis

M. Jolicoeur, A. Kamen, O. Henry, 2011, Bioprocess and biosystems engineering.

Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9

J. Schrag, A. Kamen, P. Chahal, 2021, Molecular therapy. Methods & clinical development.

Monitoring lentiviral vector production kinetics using online permittivity measurements

Amine Kamen, Olivier Henry, Sven Ansorge, 2011 .

On-line monitoring of glucose in mammalian cell culture using a flow injection analysis (FIA) mediated biosensor.

J H Luong, K B Male, J. Luong, 1997, Biotechnology and bioengineering.

Design parameters and performance of a surface baffled helical ribbon impeller bioreactor for the culture of shear sensitive cells

Amine Kamen, C. Chavarie, A. Kamen, 1992 .

Micro-quantitation of lipids in serum-free cell culture media: a critical aspect is the minimization of interference from medium components and chemical reagents.

Amine Kamen, Jalal Hawari, A. Kamen, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Validation of a high-performance liquid chromatographic assay for the quantification of adenovirus type 5 particles.

A. Kamen, P. Chahal, A. Bernier, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Production of Choristoneura fumiferana Nucleopolyhedrovirus in C. fumiferana (CF-2C1 Cells) in a 3 Litre Bioreactor Using Serum-free Medium

A. Kamen, S. Sohi, S. Bédard, 2000 .

Development and Validation of an Anion Exchange High-Performance Liquid Chromatography Method for Analysis of Empty Capsids and Capsids Encapsidating Genetic Material in a Purified Preparation of Recombinant Adeno-Associated Virus Serotype 5

A. Kamen, P. Chahal, Alice Bernier, 2021, Human gene therapy.

A Four-Step Purification Process for Gag VLPs: From Culture Supernatant to High-Purity Lyophilized Particles

A. Kamen, I. González-Domínguez, L. Cervera, 2021, Vaccines.

Monitoring the Recombinant Adeno-Associated Virus Production using Extended Kalman Filter

M. Bolic, A. Kamen, N. Belacel, 2022, Processes.

A rapid procedure to generate stably transfected HEK293 suspension cells for recombinant protein manufacturing: Yield improvements, bioreactor production and downstream processing.

Ayyappasamy Sudalaiyadum Perumal, A. Kamen, D. Leclerc, 2023, Protein expression and purification.

Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line.

A. Kamen, L. Bourget, P. Chahal, 2017, Vaccine.

Hemagglutinin and neuraminidase containing virus-like particles produced in HEK-293 suspension culture: An effective influenza vaccine candidate.

A. Kamen, P. Chahal, Xuguang Li, 2016, Vaccine.

Real‐time monitoring of influenza virus production kinetics in HEK293 cell cultures

A. Kamen, Petiot Emma, 2013, Biotechnology progress.

Accelerated mass production of influenza virus seed stocks in HEK-293 suspension cell cultures by reverse genetics.

A. Kamen, M. Rosa-Calatrava, E. Petiot, 2017, Vaccine.

Evaluation of homogeneity and genetic stability of REOLYSIN® (pelareorep) by complete genome sequencing of reovirus after large scale production

Zhenbao Yu, B. Thompson, D. Onions, 2014, Applied Microbiology and Biotechnology.

Low‐protein medium affects the 293SF central metabolism during growth and infection with adenovirus

M. Perrier, A. Kamen, P. Gilbert, 2002, Biotechnology and bioengineering.

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

S. Prakash, A. Kamen, A. Paul, 2012, International journal of nanomedicine.

Production of Recombinant Adeno‐Associated Viral Vectors Using a Baculovirus/Insect Cell Suspension Culture System: From Shake Flasks to a 20‐L Bioreactor

A. Kamen, D. Jacob, P. Chahal, 2008, Biotechnology progress.

Production of adeno‐associated viral vectors in insect cells using triple infection: Optimization of baculovirus concentration ratios

M. Perrier, A. Kamen, M. Aucoin, 2006, Biotechnology and bioengineering.

Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis.

M Perrier, M. Perrier, A. Kamen, 2000, Metabolic engineering.

Development of a vectored vaccine against hepatitis E virus.

A. Kamen, H. Kallel, Khaled Trabelsi, 2014, Vaccine.

Titre : Title : Critical assessment of influenza VLP production in Sf 9 and HEK 293 expression systems Auteurs :

A. Kamen, Christine M Thompson, O. Henry, 2018 .

NRC Publications Archive Archives des publications du CNRC

P. G. Arnison, Bing-Lan Liu, Y. Tzeng, 2011 .

NRC Publications Archive Archives des publications du CNRC

Bing-Lan Liu, Y. Tzeng, D. Klug, 2011 .

Overview of recent advances in Vero cells genomic characterization and engineering for high‐throughput vaccine manufacturing

A. Kamen, Yu Xia, Marie-Angélique Sène, 2022, Clinical and Translational Discovery.

Puri W cation of recombinant proteins from mammalian cell culture using a generic double-a Y nity chromatography scheme

Y. Durocher, A. Kamen, P. L. Pham, 2004 .

Enhanced Adenovirus Production by 293 Cells Using a Low-Protein Medium: A Metabolic Flux Analysis

M. Perrier, A. Kamen, D. Jacob, 2001 .

Successful Development of a Robust Adenovirus Production Process Primarily Relies on a Better Understanding of Packaging Cell Line Physiology and Vector Replication Kinetics

Amine Kamen, Olivier Henry, Danielle Jacob, 2005 .

Scale-up of the adenovirus expression system for the production of recombinant protein in human 293 S cells

A. Kamen, A. Garnier, J. Côté, 2022 .

Bioreactor production of rVSV-vectored vaccines in Vero cell suspension cultures

A. Kamen, Gyoung Nyoun Kim, C. Kang, 2021 .

Handling Massive Proportion of Missing Labels in Multivariate Long-Term Time Series Forecasting

M. Bolic, A. Kamen, N. Belacel, 2021, Journal of Physics: Conference Series.

Protein-free culture medium improvement: testing additives and their interactive effects in 96-well plates

A. Kamen, J. Côté, G. André, 1993, Applied Microbiology and Biotechnology.

Comparative Transcriptomic Analyses of a Vero Cell Line in Suspension versus Adherent Culture Conditions

A. Kamen, Yu Xia, Marie-Angélique Sène, 2023, International journal of cell biology.

Validation of a high-performance liquid chromatographic assay for the quantification of Reovirus particles type 3.

A. Kamen, P. Chahal, Alice Bernier, 2007, Journal of pharmaceutical and biomedical analysis.

Optimization and scale-up of cell culture and purification processes for production of an adenovirus-vectored tuberculosis vaccine candidate.

A. Kamen, D. Jacob, T. Zhu, 2016, Vaccine.

Development of an Integrated Continuous Manufacturing Process for the rVSV-Vectored SARS-CoV-2 Candidate Vaccine

A. Kamen, Omar Farnós, M. Tran, 2023, Vaccines.