J. Saharinen

发表

Identification of pathways regulating cell size and cell-cycle progression by RNAi

Jussi Taipale, Markku Varjosalo, Juha Saharinen, 2006, Nature.

The genome-wide patterns of variation expose significant substructure in a founder population.

Andrew Collins, Leena Peltonen, Samuli Ripatti, 2008, American journal of human genetics.

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Jussi Taipale, Guillermo Oliver, Caj Haglund, 2008, Cancer cell.

Identification and Characterization of a New Latent Transforming Growth Factor-β-binding Protein, LTBP-4*

O. Monni, J. Taipale, J. Keski‐Oja, 1998, The Journal of Biological Chemistry.

Critical immunological pathways are downregulated in APECED patient dendritic cells

L. Peltonen, J. Saharinen, N. Pöntynen, 2008, Journal of Molecular Medicine.

Role of the Latent Transforming Growth Factor β–Binding Protein 1 in Fibrillin‐Containing Microfibrils in Bone Cells In Vitro and In Vivo

L. Bonewald, J. Saharinen, D. Keene, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Christian Gieger, Thomas Meitinger, Mario Falchi, 2009, Nature Genetics.

Inter-tissue Networks Between the Basal Forebrain, Hippocampus, and Prefrontal Cortex in a Model for Depression Caused by Disturbed Sleep

T. Paunio, T. Porkka-Heiskanen, J. Saharinen, 2012, Journal of neurogenetics.

Gene expression patterns in a rodent model for depression

T. Paunio, T. Porkka-Heiskanen, J. Saharinen, 2010, The European journal of neuroscience.

Association of the small latent transforming growth factor‐beta with an eight cysteine repeat of its binding protein LTBP‐1.

J. Taipale, J. Keski‐Oja, J. Saharinen, 1996, The EMBO journal.

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.

J. Keski‐Oja, J. Saharinen, J. Keski‐oja, 2000, Molecular biology of the cell.

Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta.

J. Keski‐Oja, J. Saharinen, Krista Weikkolainen, 2002, Journal of cell science.

Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition.

J. Keski‐Oja, J. Saharinen, K. Koli, 2001, Journal of Cell Science.

Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases

L. Peltonen, M. Gentile, J. Cooper, 2008, BMC Genomics.

Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response

L. Peltonen, B. Ridha, M. Gentile, 2007, Journal of Molecular Medicine.

Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells

D. Capper, J. Keski‐Oja, J. Saharinen, 2009 .

Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro.

S. Thurner, K. Alitalo, P. Saharinen, 2007, Physiological genomics.

lymphatic endothelial cells ex vivo and in vitro Transcriptomal comparison of human dermal

S. Thurner, K. Alitalo, P. Saharinen, 2015 .

Association of Latent Transforming Growth Factor-β to Fibroblast Extracellular Matrix

J. Taipale, J. Keski‐Oja, J. Saharinen, 1995 .

Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids

Tanya M. Teslovich, Y. J. Kim, M. Rieder, 2010, Nature.

Latency, activation, and binding proteins of TGF‐β

J. Keski‐Oja, J. Saharinen, K. Koli, 2001, Microscopy research and technique.

Unregulated smooth-muscle myosin in human intestinal neoplasia

Darryl Shibata, Charis Eng, Jukka-Pekka Mecklin, 2008, Proceedings of the National Academy of Sciences.

Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky.

L. Peltonen, J. Saharinen, M. Kuokkanen, 2005, Human molecular genetics.

Indicative oligodendrocyte dysfunction in spinal cords of human fetuses suffering from a lethal motoneuron disease.

L. Peltonen, M. Gentile, J. Saharinen, 2005, Journal of neurobiology.

Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression

L. Peltonen, M. Gentile, J. Saharinen, 2007, Developmental neurobiology.

Secretion of human latent TGF-β-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-β

J. Keski‐Oja, J. Saharinen, Krista Weikkolainen, 2002 .

Novel non-TGF-β-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-β deposition

J. Keski‐Oja, J. Saharinen, K. Koli, 2001 .

Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β

Juha Saharinen, J. Keski‐Oja, J. Saharinen, 2000 .

Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.

J. Taipale, J. Keski‐Oja, J. Saharinen, 1999, Cytokine & growth factor reviews.

Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

J. Taipale, J. Keski‐Oja, J. Saharinen, 1998, Advances in cancer research.

Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer

S. Knuutila, J. Hollmén, S. Anttila, 2007, Oncogene.

FAST TRACK Modulation of TGF-b activity by latent TGF-b-binding protein 1 in human malignant glioma cells

M. Weller, W. Wick, D. Capper, 2009 .

Modulation of TGF‐β activity by latent TGF‐β‐binding protein 1 in human malignant glioma cells

M. Weller, W. Wick, D. Capper, 2009, International journal of cancer.

Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients

Jaakko Hollmén, Sakari Knuutila, Juha Saharinen, 2008, BMC Medical Genomics.

CanGEM: mining gene copy number changes in cancer

Samuel Myllykangas, Sakari Knuutila, Ilari Scheinin, 2007, Nucleic Acids Res..

INTERACTIONS OF SMALL LATENT TRANSFORMING GROWTH FACTOR-BETAS WITH THEIR BINDING PROTEINS, LTBPs

J. Saharinen, 2000 .

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

J. Taipale, J. Keski‐Oja, J. Saharinen, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors.

J. Schleutker, T. Tammela, O. Kallioniemi, 2006, Cancer research.

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

Leena Peltonen, Hannele Yki-Järvinen, Pekka Ellonen, 2008, PLoS medicine.

Functional interaction of AIRE with PIAS1 in transcriptional regulation.

J. Seeler, J. Saharinen, J. Palvimo, 2008, Molecular immunology.

cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia.

L. Peltonen, J. Saharinen, K. Nikali, 2002, Gene.

Candidate driver genes in microsatellite‐unstable colorectal cancer

Sampsa Hautaniemi, Raquel Seruca, Juha Saharinen, 2012, International journal of cancer.

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

Sampsa Hautaniemi, Jussi Taipale, Mikko Turunen, 2010, Molecular Cancer Research.

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase

K. Alitalo, C. Gahmberg, J. Saharinen, 1994, Molecular and cellular biology.

Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner*

J. Keski‐Oja, J. Saharinen, C. Koski, 1999, The Journal of Biological Chemistry.

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Karen L. Mohlke, Luigi Ferrucci, Florian Kronenberg, 2012, PLoS genetics.

Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients

S. Knuutila, A. Puustinen, J. Hollmén, 2008, BMC Medical Genomics.

Inter-tissue Networks Between the Basal Forebrain, Hippocampus, and Prefrontal Cortex in a Model for Depression Caused by Disturbed Sleep

T. Paunio, T. Porkka-Heiskanen, J. Saharinen, 2012, Journal of neurogenetics.

Role of the Latent Transforming Growth Factor β–Binding Protein 1 in Fibrillin‐Containing Microfibrils in Bone Cells In Vitro and In Vivo

L. Bonewald, J. Saharinen, D. Keene, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients

S. Knuutila, A. Puustinen, J. Hollmén, 2008, BMC Medical Genomics.

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

L. Aaltonen, D. Arango, S. Hautaniemi, 2010, Molecular Cancer Research.

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

L. Aaltonen, H. von Melchner, K. Alitalo, 2008, Cancer cell.