K. Hara

发表

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

J. Avruch, N. Oshiro, Samuel Long, 2002, Cell.

Dissociation of raptor from mTOR is a mechanism of rapamycin‐induced inhibition of mTOR function

J. Avruch, N. Oshiro, C. Tokunaga, 2004, Genes to cells : devoted to molecular & cellular mechanisms.

Characterization of ubiquilin 1, an mTOR-interacting protein.

J. Avruch, A. Mikhailov, K. Yonezawa, 2002, Biochimica et biophysica acta.

Effects of Insulin Degludec and Insulin Glargine U300 on Day-to-Day Fasting Plasma Glucose Variability in Individuals with Type 1 Diabetes: A Multicenter, Randomized, Crossover Study (Kobe Best Basal Insulin Study 2)

K. Iida, W. Ogawa, T. Matsuda, 2018, Diabetes Therapy.

Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.

K. Kaneko, K. Yonezawa, K. Hara, 1998, Biochemical and biophysical research communications.

Immunological aspects of 'fulminant type 1 diabetes'.

K. Hara, H. Moriyama, Minoru Kishi, 2007, Diabetes research and clinical practice.

Analysis of time-dependent alterations of parameters related to erythrocytes after ipragliflozin initiation

W. Ogawa, T. Matsuda, K. Hara, 2020, Diabetology International.

Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon.

P. Parker, K. Yonezawa, K. Hara, 1999, The Journal of biological chemistry.

Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.

M. Matsuo, C. Tokunaga, S. Hidayat, 2003, Biochemical and biophysical research communications.

A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication

K. Hara, S. Todó, K. Yokono, 2017, Oxford medical case reports.

Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model

T. Kitamura, H. Sakaue, K. Hara, 2021, Diabetology & Metabolic Syndrome.

Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model

T. Kitamura, H. Sakaue, K. Hara, 2021, Diabetology & Metabolic Syndrome.

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes.

D. James, M. Kasuga, K. Kotani, 1995, Biochemical and biophysical research communications.

Usefulness of 18F‐fluorodeoxyglucose positron emission tomography for diagnosis of asymptomatic giant cell arteritis in a patient with Alzheimer's disease

K. Urakami, K. Hara, T. Sakurai, 2011, Geriatrics & gerontology international.

[Case Report; Gastric mucosa in patients with autoimmune thyroiditis. (Discussion about a case of autoimmune polyendocrine syndrome 3B)].

K. Hara, T. Takeuchi, S. Ohata, 2016, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

Molecular Cloning and Characterization of a Novel p70 S6 Kinase, p70 S6 Kinase β Containing a Proline-rich Region*

I. Gout, M. Waterfield, K. Yonezawa, 1998, The Journal of Biological Chemistry.

Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice.

K. Hara, H. Moriyama, Minoru Kishi, 2010, Clinical immunology.

Autoreactive T Cell Response in CD25‐Negative Fraction of Peripheral Blood Mononuclear Cells in Established Type 1 Diabetes

K. Hara, H. Moriyama, Minoru Kishi, 2008, Annals of the New York Academy of Sciences.

Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.

E. Nishida, Y. Gotoh, T. Kadowaki, 1992, The Journal of biological chemistry.

A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events.

K. Hara, H. Akita, K. Yokono, 2012, Internal medicine.

Role of S6K1 in regulation of SREBP1c expression in the liver.

M. Kasuga, W. Ogawa, K. Hara, 2011, Biochemical and biophysical research communications.

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

M. Nakafuku, T. Kadowaki, T. Kitamura, 1994, The Journal of biological chemistry.

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

N. Kimura, B. Kemp, L. Witters, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

BIGUANIDE, BUT NOT THIAZOLIDINEDIONE, IMPROVED INSULIN RESISTANCE IN WERNER SYNDROME

K. Hara, H. Moriyama, K. Yokono, 2010, Journal of the American Geriatrics Society.

Upregulation of the mTOR Complex 1 Pathway by Rheb in Pancreatic β Cells Leads to Increased β Cell Mass and Prevention of Hyperglycemia

Rika Nakayama, K. Hara, H. Moriyama, 2009 .

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy.

M. Scherrer-Crosbie, A. Rosenzweig, T. Matsui, 2010, American journal of physiology. Cell physiology.

Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

M. Kasuga, M. Waterfield, T. Matozaki, 1995, The Journal of Biological Chemistry.

Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids

M. Hirai, K. Hara, H. Moriyama, 2012, Geriatrics & gerontology international.

Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes.

K. Hara, H. Moriyama, Minoru Kishi, 2010, Biochemical and biophysical research communications.

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

M. Kasuga, I. Gout, M. Waterfield, 1992, The Journal of biological chemistry.

Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.

E. Nishida, Y. Gotoh, T. Kadowaki, 1991, The Journal of biological chemistry.

Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.

K. Hara, H. Moriyama, K. Yokono, 2011, Biochemical and biophysical research communications.

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42.

K. Yonezawa, K. Hara, Y. Tsujishita, 1998, Biochemical and biophysical research communications.

Kinase activities associated with mTOR.

C. Tokunaga, K. Yoshino, K. Yonezawa, 2004, Current topics in microbiology and immunology.

Epidemic Myalgia Associated with Human Parechovirus Type 3 Infection

K. Hara, T. Fujimoto, Nozomu Hanaoka, 2019, Internal medicine.

Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules.

H. Hamada, K. Hara, H. Moriyama, 2008, Diabetes research and clinical practice.

Regulation of eIF-4E BP1 Phosphorylation by mTOR*

M. Kasuga, J. Avruch, I. Nishimoto, 1997, The Journal of Biological Chemistry.

The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1*

A. Nakashima, J. Avruch, U. Kikkawa, 2007, Journal of Biological Chemistry.

Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.

K. Hara, H. Moriyama, Y. Okumachi, 2007, Diabetes research and clinical practice.

In vitro association of phosphatidylinositol 3-kinase activity with the activated insulin receptor tyrosine kinase.

W. Ogawa, Y. Kaburagi, R. Yamamoto-Honda, 1992, The Journal of biological chemistry.

The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif*

J. Avruch, N. Oshiro, C. Tokunaga, 2003, The Journal of Biological Chemistry.

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*

J. Avruch, M. T. Kozlowski, K. Yonezawa, 1998, The Journal of Biological Chemistry.

One amino acid difference is critical for suppression of the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulinB:9-23 peptide.

K. Hara, H. Moriyama, Minoru Kishi, 2008, Biochemical and biophysical research communications.

Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck.

M. Kasuga, I. Gout, M. Waterfield, 1996, Biochemical and biophysical research communications.

Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways

J. Avruch, K. Yonezawa, K. Hara, 1999, The Journal of Biological Chemistry.

, Kazuyoshi Yonezawa and Hiroyuki Multiple Initiation Processes : COMPARISON WITH THE EFFECTS OF INSULIN Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating

M. Kawamura, H. Nawa, N. Takei, 2001 .

Alpha4 protein as a common regulator of type 2A‐related serine/threonine protein phosphatases 1

C. Tokunaga, K. Yonezawa, K. Hara, 1999, FEBS letters.

Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal Dendrites

Kenta Hara, M. Kawamura, H. Nawa, 2004, The Journal of Neuroscience.

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

T. Kitamura, H. Sakaue, K. Yonezawa, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity.

Y. Maniwa, H. Hamada, K. Hara, 2007, Human gene therapy.

Involvement of phosphoinositide 3‐kinase in insulin‐ or IGF‐1‐induced membrane ruffling.

F. Grigorescu, H. Sakaue, K. Yonezawa, 1994, The EMBO journal.

Nutrient-dependent Multimerization of the Mammalian Target of Rapamycin through the N-terminal HEAT Repeat Region*

T. Maeda, H. Sorimachi, K. Yonezawa, 2006, Journal of Biological Chemistry.

Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro *

Kenta Hara, Joseph Avruch, J. Avruch, 1999, The Journal of Biological Chemistry.

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

M. Kasuga, P. Hawkins, L. Stephens, 1994, Current Biology.

PI 3‐kinase: structural and functional analysis of intersubunit interactions.

M. Kasuga, G. Panayotou, I. Gout, 1994, The EMBO journal.

Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes

M. Kawamura, H. Nawa, N. Takei, 2001, The Journal of Biological Chemistry.

Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.

M. Nakayama, K. Hara, H. Moriyama, 2008, The Kobe journal of medical sciences.

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

M. Murakami, T. Ichisaka, S. Yamanaka, 2004, Molecular and Cellular Biology.

Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

Rika Nakayama, K. Hara, H. Moriyama, 2009, Diabetes.

Kobe University Repository : Kernel タイトル Tit le Regulat ion of Hypoxia-inducible Factor 1 by Glucose Availability under Hypoxic

K. Hirota, K. Yonezawa, K. Hara, 2018 .

Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.

K. Hirota, K. Yonezawa, K. Hara, 2007, The Kobe journal of medical sciences.

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

J. Avruch, Y. Lin, Samuel Long, 2006, Oncogene.

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

J. Avruch, K. Yonezawa, K. Hara, 2001, Progress in molecular and subcellular biology.

Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro

H. Inoue, T. Takahashi, K. Hara, 2000, Genes to cells : devoted to molecular & cellular mechanisms.

A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis

K. Hara, K. Yokono, Katsuhito Nishiyama, 2019, Oxford medical case reports.

Structural requirement of leucine for activation of p70 S6 kinase

H. Miyake, K. Yonezawa, K. Hara, 1999, FEBS letters.

The Dual Role of Scavenger Receptor Class A in Development of Diabetes in Autoimmune NOD Mice

K. Hara, Kazuma Takahashi, K. Yokono, 2014, PloS one.

Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε*

P. Parker, K. Yonezawa, K. Hara, 1999, The Journal of Biological Chemistry.

Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase.

M. Kasuga, M. Waterfield, H. Sakaue, 1995, Biochemical and biophysical research communications.

Cardiac mTOR protects the heart against ischemia-reperfusion injury.

Masaya Takahashi, M. Scherrer-Crosbie, A. Rosenzweig, 2012, American journal of physiology. Heart and circulatory physiology.

Comprehensive Evaluation of Combination Therapy with Basal Insulin and Either Lixisenatide or Vildagliptin in Japanese Patients with Type 2 Diabetes: A Randomized, Open-Label, Parallel-Group, Multicenter Study

W. Ogawa, N. Hashimoto, K. Hara, 2018, Diabetes Therapy.

Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α

I. Gout, N. Oshiro, C. Tokunaga, 2001 .

Intravenous Administration of Proinsulin 1 or 2–Expressing Fiber‐Mutant Recombinant Adenovirus Vector Protects against the Development of Diabetes in NOD Mice

K. Hara, H. Moriyama, Minoru Kishi, 2008, Annals of the New York Academy of Sciences.

[A case of elderly onset loss of consciousness due to bacterial meningitis and subsequent vasculitis].

K. Hara, T. Sakurai, T. Takata, 2008, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

A complex of GRB2‐dynamin binds to tyrosine‐phosphorylated insulin receptor substrate‐1 after insulin treatment.

N. Hirokawa, I. Gout, T. Takenawa, 1994, The EMBO journal.

Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling.

M. Kasuga, K. Yonezawa, K. Hara, 1995, Biochemical and biophysical research communications.

Bleeding from the small intestine and aortic regurgitation in Noonan syndrome.

K. Hara, H. Akita, H. Yoshino, 2011, Internal medicine.

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy.

M. Scherrer-Crosbie, A. Rosenzweig, T. Matsui, 2010, American journal of physiology. Cell physiology.

A possible association of Pro12Ala polymorphism in peroxisome proliferator–activated receptor γ2 gene with obesity in native Javanese in Indonesia

M. Nakayama, K. Hara, K. Hara, 2005, Diabetes/metabolism research and reviews.

Effects of ipragliflozin on glycemic control, appetite and its related hormones: A prospective, multicenter, open‐label study (SOAR‐KOBE Study)

W. Ogawa, K. Hara, Y. Tamori, 2019, Journal of diabetes investigation.

Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.

K. Hirota, K. Yonezawa, K. Hara, 2007, The Kobe journal of medical sciences.