V. Krymskaya

发表

Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation

D. Kwiatkowski, M. Chou, D. Noonan, 2002, The Journal of Biological Chemistry.

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

E. Chilvers, R. Plevin, A. Eszterhas, 1999, American journal of physiology. Lung cellular and molecular physiology.

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

E. Chilvers, R. Plevin, A. Eszterhas, 1999, American journal of physiology. Lung cellular and molecular physiology.

IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway.

D. Choubey, A. Eszterhas, R. Panettieri, 2003, American journal of physiology. Lung cellular and molecular physiology.

CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis

Jilly F. Evans, V. Krymskaya, K. Obraztsova, 2021, International journal of molecular sciences.

Arrestin Specificity for G Protein-coupled Receptors in Human Airway Smooth Muscle* 210

S. Mundell, J. Benovic, R. Panettieri, 2001, The Journal of Biological Chemistry.

Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.

A. Gow, W. Linehan, L. Schmidt, 2014, Cell reports.

fibroblast proliferation hypoxia-induced pulmonary artery adventitial mammalian target of rapamycin is necessary for Activation of phosphatidylinositol 3-kinase, Akt, and

K. Stenmark, E. Goncharova, D. Goncharov, 2015 .

PHOSPHATIDYLINOSITOL 3-KINASE IS REQUIRED FOR PROLIFERATION AND MIGRATION OF HUMAN PULMONARY VASCULAR SMOOTH MUSCLE CELLS

A. Ammit, E. Goncharova, A. Eszterhas, 2002 .

PI 3 K is required for proliferation and migration of human pulmonary vascular smooth muscle cells

A. Ammit, E. Goncharova, A. Eszterhas, 2002 .

Lymphangioleiomyomatosis: a complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation.

V. Krymskaya, J. Shipley, J. Michael Shipley, 2003, American journal of respiratory cell and molecular biology.

Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration.

C. Walker, E. Goncharova, R. Panettieri, 2002, American journal of physiology. Lung cellular and molecular physiology.

PECAM‐1 (CD31) engagement activates a phosphoinositide‐independent, nonspecific cation channel in endothelial cells

Guangju Ji, V. Krymskaya, S. Albelda, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TGF-β1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells.

A. Eszterhas, R. Panettieri, V. Krymskaya, 1997, American journal of physiology. Lung cellular and molecular physiology.

MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation.

J. Benovic, A. Eszterhas, R. Panettieri, 1999, American journal of physiology. Lung cellular and molecular physiology.

Interferons modulate mitogen-induced protein synthesis in airway smooth muscle.

E. Goncharova, D. Goncharov, A. Eszterhas, 2010, American journal of physiology. Lung cellular and molecular physiology.

Immune Checkpoint Ligand PD‐L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis

A. Gow, M. Swartz, I. Kang, 2018, American journal of respiratory cell and molecular biology.

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.

G. Wertheim, M. Betts, V. Krymskaya, 2019, The Journal of clinical investigation.

Nanoparticle-Induced Augmentation of Neutrophils’ Phagocytosis of Bacteria

V. Krymskaya, Jia Nong, G. Worthen, 2022, bioRxiv.

Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells

E. Goncharova, D. Goncharov, V. Krymskaya, 2012, Respiratory Research.

Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts

E. Goncharova, D. Goncharov, V. Krymskaya, 2014, PloS one.

Airway smooth muscle cells enhance C3a‐induced mast cell degranulation following cell‐cell contact

K. Jordan-Sciutto, D. Goncharov, R. Panettieri, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

J. Moldvay, J. Pongrácz, V. Krymskaya, 2020, Frontiers in Oncology.

Normalization of enzyme expression and activity regulating vitamin A metabolism increases RAR-beta expression and reduces cellular migration in diseases caused by tuberous sclerosis gene mutations

J. Moldvay, J. Pongrácz, V. Krymskaya, 2020 .

Endothelins in Pulmonary Development

R. Panettieri, V. Krymskaya, 1998 .

PI3K/mTORC1 activation in hamartoma syndromes: Therapeutic prospects

E. Goncharova, V. Krymskaya, 2009, Cell cycle.

Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

S. Spiegel, S. Peters, A. Ammit, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IFN-γ inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway

D. Choubey, A. Eszterhas, R. Panettieri, 2003 .

Chapter 17 – Airway Smooth Muscle

R. Panettieri, V. Krymskaya, A. Lazaar, 2002 .

RESEARCH PAPER Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and

V. Krymskaya, O. Tliba, G. Damera, 2009 .

Mechanisms underlying TNF-α effects on agonist-mediated calcium homeostasis in human airway smooth muscle cells.

R. Panettieri, V. Krymskaya, Y. Amrani, 1997, American journal of physiology. Lung cellular and molecular physiology.

DHEA-S inhibits human neutrophil and human airway smooth muscle migration.

E. Goncharova, R. Panettieri, V. Krymskaya, 2012, Biochimica et biophysica acta.

β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein.

E. Goncharova, D. Goncharov, R. Panettieri, 2012, American journal of respiratory cell and molecular biology.

Muscle Cells Phosphorylation in Human Airway Smooth Cbl 3-Kinase and Induces p120 VCAM-1 Activates Phosphatidylinositol

V. Krymskaya, A. Lazaar, Susan K. P. Das, 2000 .

Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent.

E. Goncharova, V. Krymskaya, A. Lazaar, 2004, American journal of physiology. Lung cellular and molecular physiology.

Mechanisms underlying TNF-alpha effects on agonist-mediated calcium homeostasis in human airway smooth muscle cells.

R. Panettieri, V. Krymskaya, Y. Amrani, 1997, The American journal of physiology.

Doxycycline inhibits matrix metalloproteinase‐2 secretion from TSC2‐null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells

V. Krymskaya, T. Santa, J. Black, 2011, British journal of pharmacology.

mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

E. Goncharova, D. Goncharov, V. Krymskaya, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Endothelin in Lung Development and Tissue Growth

R. Panettieri, V. Krymskaya, 1999 .

Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells.

A. Ammit, A. Eszterhas, R. Panettieri, 2001, American journal of physiology. Lung cellular and molecular physiology.

Phosphodiesterases regulate airway smooth muscle function in health and disease.

R. Panettieri, V. Krymskaya, 2007, Current topics in developmental biology.

Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells

E. Goncharova, D. Goncharov, A. Eszterhas, 2006, Nature Protocols.

The Role of TSC Proteins in Regulating Cell Adhesion and Motility

V. Krymskaya, 2006 .

Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2.

D. Noonan, E. Goncharova, A. Eszterhas, 2006, American journal of respiratory cell and molecular biology.

Wild Type Mesenchymal Cells Contribute to the Lung Pathology of Lymphangioleiomyomatosis

V. Krymskaya, Simon R. Johnson, D. Clements, 2015, PloS one.

Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions.

E. Henske, V. Krymskaya, Heng-Jia Liu, 2019, Chest.

A phase II clinical trial of the Safety Of Simvastatin (SOS) in patients with pulmonary lymphangioleiomyomatosis and with tuberous sclerosis complex.

V. Krymskaya, R. Kotloff, M. Kreider, 2020, Respiratory medicine.

International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease.

J. Rossi, E. Jaffe, N. Munshi, 2018, Blood.

Special Report International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease

J. Rossi, E. Jaffe, N. Munshi, 2019 .

Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration

E. Goncharova, D. Goncharov, V. Krymskaya, 2006, Nature Protocols.

Assays for monitoring p70 S6 kinase and RSK activation.

M. Chou, V. Krymskaya, H. Qi, 2001, Methods in enzymology.

TSC2 modulates cell adhesion and migration via integrin-α1β1.

V. Krymskaya, J. Black, L. M. Moir, 2012, American journal of physiology. Lung cellular and molecular physiology.

TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells.

A. Eszterhas, R. Panettieri, V. Krymskaya, 1997, The American journal of physiology.

Prolonged Remission Achieved in a Relapsing Idiopathic Multicentric Castleman Disease Patient with a Novel, Targeted Treatment Approach

V. Krymskaya, S. Pierson, D. Shilling, 2017 .

Adoptive T Cell Transfer to Treat Lymphangioleiomyomatosis.

V. Krymskaya, I. L. Le Poole, S. Henning, 2020, American journal of respiratory cell and molecular biology.

Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis.

A. Gow, V. Krymskaya, E. Atochina-Vasserman, 2014, American journal of respiratory cell and molecular biology.

Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target

J. Pongrácz, K. Kvell, V. Krymskaya, 2018, Oncogene.

Enlightening Ways to Relax Airway Smooth Muscle: Opsins

V. Krymskaya, R. Penn, 2020, American journal of respiratory cell and molecular biology.

Inhibition of Growth of TSC2-Null Cells by a PI3K/mTOR Inhibitor but Not by a Selective MNK1/2 Inhibitor

Jilly F. Evans, V. Krymskaya, A. Mukhitov, 2019, Biomolecules.

Pharmacological targeting of VEGFR signaling with axitinib inhibits Tsc2-null lesion growth in the mouse model of lymphangioleiomyomatosis.

A. Gow, N. Ersumo, V. Krymskaya, 2015, American journal of physiology. Lung cellular and molecular physiology.

Microsoft Word-14123389-file00

E. Goncharova, D. Goncharov, R. Panettieri, 2009 .

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors

D. Cines, V. Krymskaya, Y. Parfyonova, 2017, The Journal of Biological Chemistry.

Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis.

V. Krymskaya, 2008, Proceedings of the American Thoracic Society.

Pulmonary lymphangioleiomyomatosis (LAM): Progress and current challenges

E. Goncharova, V. Krymskaya, 2008, Journal of cellular biochemistry.

Treatment option(s) for pulmonary lymphangioleiomyomatosis: progress and current challenges.

V. Krymskaya, 2012, American journal of respiratory cell and molecular biology.

Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth Muscle

V. Krymskaya, 2012, BioDrugs.

Idiopathic multicentric Castleman's disease: a systematic literature review.

Dermot Kelleher, R. Kurzrock, V. Krymskaya, 2016, The Lancet. Haematology.

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity

B. Viollet, W. Linehan, L. Schmidt, 2020, bioRxiv.

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

E. Goncharova, D. Goncharov, V. Krymskaya, 2011, Molecular and Cellular Biology.

mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

Jilly F. Evans, Shanru Li, E. Morrisey, 2020, Nature Communications.

Tumour suppressors hamartin and tuberin: intracellular signalling.

V. Krymskaya, 2003, Cellular signalling.

An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma

C. Brightling, P. Cooper, K. Druey, 2012, PloS one.

Therapeutic strategies for treatment of pulmonary lymphangioleiomyomatosis

V. Krymskaya, 2014, Expert opinion on orphan drugs.

Lymphangioleiomyomatosis: A Monogenic Model of Malignancy.

V. Krymskaya, F. McCormack, 2017, Annual review of medicine.

Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

K. Strauss, M. Baybis, P. Crino, 2013, Science Translational Medicine.

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle.

J. Benovic, A. Eszterhas, R. Panettieri, 2000, American journal of respiratory cell and molecular biology.

Airway Smooth Muscle

R. Panettieri, V. Krymskaya, O. Tliba, 2009 .

Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells

D. Coulter, D. Cines, D. Lynch, 2021, Scientific Reports.

International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.

J. Rossi, E. Jaffe, É. Oksenhendler, 2017, Blood.

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

Hayden Huang, P. Ongusaha, E. Henske, 2012, PloS one.

Interferon β Augments Tuberous Sclerosis Complex 2 (TSC2)-Dependent Inhibition of TSC2-Null ELT3 and Human Lymphangioleiomyomatosis-Derived Cell Proliferation

E. Goncharova, D. Goncharov, R. Panettieri, 2008, Molecular Pharmacology.

EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells.

A. Eszterhas, R. Panettieri, V. Krymskaya, 1999, American journal of physiology. Lung cellular and molecular physiology.

Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling.

D. Goncharov, V. Krymskaya, E. Atochina-Vasserman, 2013, American journal of respiratory cell and molecular biology.

Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM)

T. Colby, O. Hino, E. Goncharova, 2012, Science Translational Medicine.

PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells.

Reynold A Panettieri, Elena A Goncharova, A. Ammit, 2002, American journal of physiology. Lung cellular and molecular physiology.

Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis.

D. Noonan, E. Goncharova, V. Krymskaya, 2006, American journal of respiratory cell and molecular biology.

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

D. Noonan, D. Goncharov, V. Krymskaya, 2004, The Journal of cell biology.

Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration

A. Ammit, E. Goncharova, D. Goncharov, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration.

C. Billington, A. Vorotnikov, V. Tkachuk, 2003, American journal of respiratory cell and molecular biology.

Syndecan-2: Old Player in a New Field

Jilly F. Evans, V. Krymskaya, K. Obraztsova, 2019, American journal of respiratory cell and molecular biology.

Cross‐talk between tuberin, calmodulin, and estrogen signaling pathways

T. Vanaman, D. Lou, D. Noonan, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TSC 2 Modulates Actin Cytoskeleton and Focal Adhesion Through TSC 1-Binding Domain and the Rac 1 GTPase

D. Noonan, D. Goncharov, V. Krymskaya, 2004 .

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

H. DeLisser, R. Tuder, E. Goncharova, 2014, Circulation.

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

H. DeLisser, R. Tuder, E. Goncharova, 2014, Circulation.

Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis

E. Goncharova, D. Goncharov, R. Panettieri, 2009, Molecular Pharmacology.

The PP2A-associated Protein α4 Plays a Critical Role in the Regulation of Cell Spreading and Migration*

C. Thompson, D. Goncharov, V. Krymskaya, 2007, Journal of Biological Chemistry.

Targeted Approaches toward Understanding and Treating Pulmonary Lymphangioleiomyomatosis (LAM)

S. Hammes, V. Krymskaya, 2013, Hormones and Cancer.

Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex

D. Kwiatkowski, J. Asara, E. Henske, 2021, Cancer Research.

Lymphangioleiomyomatosis (LAM) Cell Atlas

D. Kwiatkowski, E. Henske, M. Guo, 2022, Thorax.

Oligoclonal Expansion of Cd8+ T Cells during Idiopathic Multicentric Castleman Disease Flares Suggests an Antigen Driven Process

Abhishek S. Rao, V. Krymskaya, D. Shilling, 2018, Blood.

Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells

Jilly F. Evans, B. Himes, M. Bartolomei, 2018, PloS one.

Doxycycline reduces the migration of tuberous sclerosis complex-2 null cells - effects on RhoA-GTPase and focal adhesion kinase

V. Krymskaya, J. Burgess, J. Black, 2015, Journal of cellular and molecular medicine.

Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited

J. Pongrácz, V. Krymskaya, E. M. Abdelwahab, 2021, Apoptosis.

Vitamin D inhibits growth of human airway smooth muscle cells through growth factor‐induced phosphorylation of retinoblastoma protein and checkpoint kinase 1

E. Goncharova, R. Panettieri, V. Krymskaya, 2009, British journal of pharmacology.

VCAM-1 Activates Phosphatidylinositol 3-Kinase and Induces p120Cbl Phosphorylation in Human Airway Smooth Muscle Cells 1

V. Krymskaya, A. Lazaar, Susan K. P. Das, 2001, The Journal of Immunology.

CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Pharmacological targeting of VEGFR signaling with axitinib inhibits Tsc2-null lesion growth in the mouse model of lymphangioleiomyomatosis

Nathan Tessema Ersumo, A. Gow, N. Ersumo, 2015 .

Sorafenib inhibits invasion of multicellular organoids that mimic Lymphangioleiomyomatosis nodules

L. K. Gautam, J. Nawroth, S. Murthy, 2023, bioRxiv.