Derek W. Abbott

发表

Mitogen-activated Protein Kinase Kinase 2 Activation Is Essential for Progression through the G2/M Checkpoint Arrest in Cells Exposed to Ionizing Radiation*

Derek W. Abbott, J. Holt, Jeffrey T. Holt, 1999, The Journal of Biological Chemistry.

Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants

Benjamin T. Porebski, G. Nolan, M. Cox, 2019, bioRxiv.

ABIN-1 Regulates RIPK1 Activation by Bridging M1 ubiquitination with K63 Deubiquitination in TNF-RSC

Junying Yuan, Hong Zhu, Derek W. Abbott, 2017, Nature Cell Biology.

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Noula Shembade, E. Harhaj, Derek W. Abbott, 2011, Nature Immunology.

Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains

L. Cantley, M. Kelliher, Derek W. Abbott, 2007, Molecular and Cellular Biology.

Identification of RIP1 kinase as a specific cellular target of necrostatins.

Alexei Degterev, Chengye Yuan, Junying Yuan, 2008, Nature chemical biology.

CpG-B Oligodeoxynucleotides Inhibit TLR-Dependent and -Independent Induction of Type I IFN in Dendritic Cells

Clifford V. Harding, Derek W. Abbott, C. Harding, 2010, The Journal of Immunology.

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

W. Hahn, L. Cantley, J. Asara, 2009, Molecular cell.

TLR2 Signaling Depletes IRAK1 and Inhibits Induction of Type I IFN by TLR7/9

Derek W. Abbott, C. Harding, W. Boom, 2012, The Journal of Immunology.

Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

Mark B. Jones, Derek W. Abbott, J. M. Marinis, 2013, Cell reports.

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.

Yang Shen, Hannah Gilmore, J. Condeelis, 2018, Cancer discovery.

TH17 cells promote CNS inflammation by sensing danger signals via Mincle

G. Dubyak, Renliang Zhang, R. Bermel, 2022, Nature communications.

Myeloid Glycosylation Defects Lead to a Spontaneous Common Variable Immunodeficiency-like Condition with Associated Hemolytic Anemia and Antilymphocyte Autoimmunity

Derek W. Abbott, B. Cobb, Sean O. Ryan, 2014, The Journal of Immunology.

Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses.

Derek W. Abbott, S. Leal, E. Pearlman, 2014, Glycobiology.

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

G. Dubyak, Derek W. Abbott, T. Xiao, 2018, Science Immunology.

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

G. Dubyak, F. Shi, R. Ransohoff, 2018, The Journal of clinical investigation.

IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair

A. Gasbarrini, L. Lopetuso, V. Petito, 2018, Proceedings of the National Academy of Sciences.

A Discrete Ubiquitin-Mediated Network Regulates the Strength of NOD2 Signaling

Xiaodong Bai, Derek W. Abbott, Justine T. Tigno-Aranjuez, 2012, Molecular and Cellular Biology.

Tsc 2 lacking Feedback inhibition of Akt signaling limits the growth of tumors data

A. Lipovsky, D. Kwiatkowski, B. Manning, 2005 .

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.

Dirk E. Smith, James J. Lee, Derek W. Abbott, 2016, The American journal of pathology.

MEKK4 Sequesters RIP2 to Dictate NOD2 Signal Specificity

Derek W. Abbott, B. Cobb, Jill M. Marinis, 2008, Current Biology.

of Type I IFN in Dendritic Cells TLR-Dependent and -Independent Induction CpG-B Oligodeoxynucleotides Inhibit

Derek W. Abbott, C. Harding, Yi C. Liu, 2010 .

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

G. Dubyak, Derek W. Abbott, K. Pestonjamasp, 2020, Nature Communications.

NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2*

M. Kelliher, C. Sassetti, Derek W. Abbott, 2007, Journal of Biological Chemistry.

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition.

G. Dubyak, Derek W. Abbott, T. Xiao, 2018, Structure.

IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

N. Morrice, S. Ley, Derek W. Abbott, 2012, Molecular and Cellular Biology.

Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies

Bowen Zhou, G. Dubyak, Derek W. Abbott, 2022, Science Signaling.

Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain

Derek W. Abbott, Steven M. Chirieleison, S. Kertesy, 2016, The Journal of Immunology.

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

L. Cantley, B. Turk, J. Asara, 2007, Molecular and cellular biology.

"Chemical modulation of gasdermin-mediated pyroptosis and therapeutic potential".

Bowen Zhou, Derek W. Abbott, Hannah C. Kondolf, 2021, Journal of molecular biology.

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

G. Dubyak, Derek W. Abbott, A. Boyd-Tressler, 2016, The Journal of Immunology.

This information is current as Blocked by Lanthanides Pores That Precede Pyroptotic Lysis and Are Active Caspase-1 Induces Plasma Membrane

R. George, Derek W. Abbott, A. Boyd-Tressler, 2016 .

Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation

K. Ley, Derek W. Abbott, W. Xin, 2013, Proceedings of the National Academy of Sciences.

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

G. Dubyak, Derek W. Abbott, K. Pestonjamasp, 2020, Nature Communications.

Live-cell visualization of gasdermin D-driven pyroptotic cell death

G. Dubyak, Derek W. Abbott, T. Xiao, 2017, The Journal of Biological Chemistry.

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

Jason D. Heaney, A. Simmons, A. Ivanov, 2022, Cell.

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Derek W. Abbott, Bowen Zhou, 2021, Cell reports.

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage.

Bowen Zhou, Derek W. Abbott, T. Xiao, 2020, Immunity.

Human polymorphisms in GSDMD alter the inflammatory response

Derek W. Abbott, T. Xiao, Joseph K. Rathkey, 2020, The Journal of Biological Chemistry.

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.

Derek W. Abbott, T. Xiao, Chuanping Wang, 2019, Immunity.

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

G. Dubyak, Derek W. Abbott, T. Xiao, 2018, Proceedings of the National Academy of Sciences.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Benjamin T. Porebski, G. Nolan, M. Cox, 2019, Nature Immunology.

IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway

L. Cantley, B. Turk, J. Asara, 2007, Molecular and Cellular Biology.

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease

G. Dubyak, Derek W. Abbott, Steven M. Chirieleison, 2017, The Journal of Biological Chemistry.

β7 Integrin Deficiency Suppresses B Cell Homing and Attenuates Chronic Ileitis in SAMP1/YitFc Mice

K. Ley, Derek W. Abbott, F. Cominelli, 2010, The Journal of Immunology.

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

Deborah S. Barkauskas, D. Stearns, Derek W. Abbott, 2016, Science.

Finkel-Biskis-Reilly Osteosarcoma Virus v-Fos Inhibits Adipogenesis and Both the Activity and Expression of CCAAT/Enhancer Binding Protein α, a Key Regulator of Adipocyte Differentiation*

Derek W. Abbott, J. Holt, 1997, The Journal of Biological Chemistry.

TH17 cells promote CNS inflammation by sensing danger signals via Mincle

G. Dubyak, Renliang Zhang, R. Bermel, 2022, Nature Communications.

A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses*

C. Homer, Derek W. Abbott, C. McDonald, 2010, The Journal of Biological Chemistry.

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair*

R. Jensen, G. Tomlinson, Derek W. Abbott, 1999, The Journal of Biological Chemistry.

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

L. Cantley, R. Husson, Derek W. Abbott, 2005, Genes & development.

The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO

L. Cantley, J. Asara, Derek W. Abbott, 2004, Current Biology.

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Lewis C Cantley, L. Cantley, A. Lipovsky, 2005, Genes & development.

Cervical cancer screening: from the Papanicolaou smear to the vaccine era.

B. Quade, C. Crum, Derek W. Abbott, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

RIP2 activity in inflammatory disease and implications for novel therapeutics

Derek W. Abbott, F. Cominelli, Janice C. Jun, 2013, Journal of leukocyte biology.

Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity

Derek W. Abbott, Steven M. Chirieleison, Joseph K. Rathkey, 2018, Science Signaling.

A rapid method for determining protein kinase phosphorylation specificity

Lewis C Cantley, Peter Storz, A. Toker, 2004, Nature Methods.

Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.

Shaoman Yin, F. Nakamura, Derek W. Abbott, 2009, The Journal of clinical investigation.

In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease*

Xiaodong Bai, Derek W. Abbott, F. Cominelli, 2014, The Journal of Biological Chemistry.

IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling

L. Cantley, C. Homer, Derek W. Abbott, 2012, Molecular and Cellular Biology.

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

J. Asara, Derek W. Abbott, Justine T. Tigno-Aranjuez, 2010, Genes & development.

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

P. Scacheri, E. Harhaj, Derek W. Abbott, 2009, Current Biology.

Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease.

Derek W. Abbott, Justine T Tigno-Aranjuez, Derek W Abbott, 2012, Biochimica et biophysica acta.

NOD 2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip 2 *

M. Kelliher, C. Sassetti, Derek W. Abbott, 2007 .

Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fosInhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner*

D. W. Abbott, Derek W. Abbott, J. Holt, 1997, The Journal of Biological Chemistry.

Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase

Derek W. Abbott, T. Xiao, Yinghua Chen, 2017, The Journal of Biological Chemistry.

An IκB Kinase-Regulated Feedforward Circuit Prolongs Inflammation.

Derek W. Abbott, Jessica M. Perez, S. Chirieleison, 2015, Cell reports.

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

Junying Yuan, Derek W. Abbott, Heling Pan, 2017, Nature Cell Biology.

Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells.

D. W. Abbott, Derek W. Abbott, J. Holt, 1998, Journal of the National Cancer Institute.

Research Online Research Online Modeling the effect of p53 on tumor heterogeneity and the mutator Modeling the effect of p53 on tumor heterogeneity and the mutator phenotype phenotype

M. Berryman, Derek W. Abbott, 2020 .

Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis

G. Dubyak, Derek W. Abbott, Hannah C. Kondolf, 2023, The Journal of biological chemistry.

Discovery of a redox-thiol switch regulating cellular energy metabolism

P. Arvan, M. Parisien, R. Kibbey, 2019, bioRxiv.

Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism*

M. Chance, P. Arvan, M. Cameron, 2020, Molecular & Cellular Proteomics.