A. Balog

发表

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Micah T. Nelp, J. Groves, J. Hunt, 2018, Proceedings of the National Academy of Sciences.

Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex.

M. Gross, J. A. Newitt, A. Balog, 2021, Cell chemical biology.

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists

J. Arezzo, M. Salvati, A. Balog, 2011, The Prostate.

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

S. Spergel, G. Trainor, L. Schweizer, 2015, ACS medicinal chemistry letters.

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

J. Chen, L. Schweizer, M. Salvati, 2010, Bioorganic & medicinal chemistry letters.

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.

Michael A. Galella, A. Fura, S. Krystek, 2008, Bioorganic & medicinal chemistry letters.

Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.

J. Hunt, Donna D Wei, M. Salvati, 2005, Bioorganic & medicinal chemistry letters.

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

K. Kish, S. Krystek, Donna D Wei, 2005, Bioorganic & medicinal chemistry letters.

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

J. Tokarski, A. Mathur, L. Leith, 2004, Bioorganic & medicinal chemistry letters.

Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor

J. Hunt, J. Gullo-Brown, A. Balog, 2020, Molecular Cancer Therapeutics.

Native Mass Spectrometry and Gas-Phase Fragmentation Provide Rapid and In-Depth Topological Characterization of a PROTAC Ternary Complex

M. Gross, J. A. Newitt, A. Balog, 2021, Cell chemical biology.

Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.

J. Hunt, M. Salvati, A. Balog, 2005, Bioorganic & medicinal chemistry letters.

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.

Kimberly A. Foster, J. Fargnoli, J. Hunt, 2021, ACS medicinal chemistry letters.

The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells

N. Rosen, L. Sepp-Lorenzino, A. Balog, 1999, Prostate Cancer and Prostatic Diseases.

The Discovery of BMS-737 as a Potent, CYP17 Lyase-Selective Inhibitor for the Treatment of Castration-Resistant Prostate Cancer.

J. Tokarski, A. Fura, L. Jayaraman, 2022, Bioorganic & medicinal chemistry letters.

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.

A. Doweyko, G. Trainor, A. Fura, 2016, ACS medicinal chemistry letters.

Total Synthesis of Epothilone A.

A. Balog, E. J. Sorensen, S. Danishefsky, 1996 .

Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.

L. Schweizer, M. Salvati, Weifang Shan, 2009, Cancer research.

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.

K. Savin, T. Chou, A. Balog, 1998, Angewandte Chemie.

Total Syntheses of Epothilones A and B

A. Balog, E. J. Sorensen, S. Danishefsky, 1997 .

REMOTE EFFECTS IN MACROLIDE FORMATION THROUGH RING-FORMING OLEFIN METATHESIS : AN APPLICATION TO THE SYNTHESIS OF FULLY ACTIVE EPOTHILONE CONGENERS

T. Chou, A. Balog, E. J. Sorensen, 1997 .

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationship of the Epothilones and the First In Vivo Comparison with Paclitaxel†

Susan Band Horwitz, T. Chou, A. Balog, 1997 .

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

T. Chou, S. Kuduk, S. Stachel, 2002, The Journal of organic chemistry.

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.

N. Rosen, M. Moasser, N. Kohl, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

K. Savin, T. Chou, S. Kuduk, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

K. Savin, J. Bertino, A. Balog, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

Susan Band Horwitz, Erik J. Sorensen, T. Chou, 1997 .

Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies

Weifang Shan, A. Balog, Andrew X. Zhang, 2014, Journal of the American Chemical Society.

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Michael A. Galella, G. Trainor, Weifang Shan, 2016, Bioorganic & medicinal chemistry letters.

New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol Condensation

K. Savin, S. Kuduk, A. Balog, 1999 .

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

K. Kish, S. Krystek, M. Salvati, 2005, Bioorganic & medicinal chemistry letters.

Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

Susan Band Horwitz, Erik J. Sorensen, T. Chou, 1997 .

Synthesis and Biological Evaluation of Biaryl Alkyl Ethers as Inhibitors of IDO1.

Xin Li, J. Hunt, L. Jayaraman, 2023, Bioorganic & medicinal chemistry letters.

Rotational features of carbon-nitrogen bonds in axially chiral o-tert-butyl anilides and related molecules. Potential substrates for the ‘prochiral auxiliary’ approach to asymmetric synthesis

A. Balog, S. Geib, D. Curran, 1997 .

Synthesis of [3α-(3) H] 17α-hydroxy pregnenolone and [3α-(3) H] pregnenolone.

A. Balog, S. Bonacorsi, Sharon X Gong, 2014, Journal of labelled compounds & radiopharmaceuticals.

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

J. Hunt, David K. Williams, Weifang Shan, 2018, Bioorganic & medicinal chemistry letters.

Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.

L. Schweizer, M. Salvati, Weifang Shan, 2009, Cancer research.

ADDITIVE AND MEDIUM EFFECTS ON LEWIS ACID-PROMOTED CATIONIC PI -CYCLIZATIONS OF ALKENYL- AND ALKYNYLCYCLOPENTANE-1,3-DIONES

A. Balog, D. Curran, Steven V. Geib, 1995 .

Total Syntheses of Epothilones A and B.

A. Balog, E. J. Sorensen, S. Danishefsky, 1998 .

Ring-Enlarging Annulations. A One-Step Conversion of Cyclic Silyl Acyloins and .omega.-Alkynyl Acetals to Polycyclic Enediones

A. Balog, D. Curran, 1995 .

Annulative ring expansions. Direct conversion of .omega.-alkynyl acetals to polycyclic unsaturated ketones

A. Balog, D. Curran, J. Sisko, 1992 .

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.

K. Savin, T. Chou, A. Balog, 1998, Angewandte Chemie.