L. Abell

发表

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Micah T. Nelp, J. Groves, J. Hunt, 2018, Proceedings of the National Academy of Sciences.

Oxygenase side reactions of acetolactate synthase and other carbanion-forming enzymes.

L. Abell, J. Schloss, 1991, Biochemistry.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

P. Sleph, L. Abell, D. Gordon, 2017 .

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

Biochemical Approaches to Herbicide Discovery: Advances in Enzyme Target Identification and Inhibitor Design

L. Abell, 1996, Weed Science.

Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.

M. Witmer, S. Gupta, D. Xie, 2016, Analytical biochemistry.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

David S. Taylor, P. Sleph, L. Abell, 2018, ACS medicinal chemistry letters.

Potent Triazolopyridine Myeloperoxidase Inhibitors.

P. Sleph, S. Jusuf, L. Abell, 2018, ACS medicinal chemistry letters.

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

J. Y. Roberge, D. Schnur, A. Cacace, 2013, Journal of medicinal chemistry.

Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.

Steven A. Spronk, P. Lam, D. Schnur, 2013, Journal of medicinal chemistry.

Effect of metal ions and adenylylation state on the internal thermodynamics of phosphoryl transfer in the Escherichia coli glutamine synthetase reaction.

J. Villafranca, L. Abell, Lynn M. Abell, 1991, Biochemistry.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

P. Sleph, L. Abell, D. Gordon, 2017, MedChemComm.

Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.

Steven A. Spronk, S. Jusuf, L. Abell, 2020, Bioorganic & medicinal chemistry.

Isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from Morganella morganii.

L. Abell, M. O'Leary, 1988, Biochemistry.

and Inhibitor Design

L. Abell, 1996 .

Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.

Kimberly A. Foster, C. Chu, A. Mathur, 2021, Journal of medicinal chemistry.

Active site inhibitors of acetolactate synthase

L. Abell, W. S. Hanna, J. Kerschen, 1995 .

Investigation of the mechanism of phosphinothricin inactivation of Escherichia coli glutamine synthetase using rapid quench kinetic technique.

J. Villafranca, L. Abell, Lynn M. Abell, 1991, Biochemistry.

Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

B. Beno, J. Marcinkeviciene, L. Abell, 2014, The Journal of Biological Chemistry.

Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader.

E. Liu, L. Abell, 2006, Analytical biochemistry.

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

David S. Taylor, Michael A. Galella, Hong Shen, 2018, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Dissecting the Activation of Thienopyridines by Cytochromes P450 Using a Pharmacodynamic Assay In Vitro

E. Liu, L. Abell, 2011, Journal of Pharmacology and Experimental Therapeutics.

Isotope effect studies of the pyruvate-dependent histidine decarboxylase from Lactobacillus 30a.

L. Abell, M. O'Leary, 1988, Biochemistry.

Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia

L. Abell, J. Gale, H. Hershey, 1999, Plant Molecular Biology.

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.

J. Macor, C. Weigelt, K. Kish, 2019, ACS medicinal chemistry letters.

Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

E. Janovitz, L. Abell, M. Tirmenstein, 2013, International journal of toxicology.

Nitrogen isotope effects on glutamate decarboxylase from Escherichia coli.

L. Abell, M. O'Leary, Lynn M. Abell, 1988, Biochemistry.

Effect of Metal Ions and Adenylylation State on the Energetics of the E. Coli Glutamine Synthetase Reaction

J. Villafranca, L. Abell, 1990 .

Use of the kinetic equilibrium between aminoacyl-tRNA formation and hydrolysis in inhibition assays of aminoacyl-tRNA synthetase.

D. Jordan, L. Abell, A. Rendina, 2001, Analytical Biochemistry.

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.

J. Macor, C. Weigelt, K. Kish, 2019, ACS medicinal chemistry letters.