Zeyu Lin

发表

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Micah T. Nelp, J. Groves, J. Hunt, 2018, Proceedings of the National Academy of Sciences.

Normalization strategy for the LC-MS bioanalysis of protein kinetics assays via internal proteolytic analyte utilized as control standard: application in studies of HIV-1 protease cleavage of HIV-1 Gag polyprotein in HIV maturation inhibition research

Zeyu Lin, Joseph L. Cantone, D. Drexler, 2017 .

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

N. Meanwell, Hong Yang, Zeyu Lin, 2016, PLoS pathogens.

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors*

Zeyu Lin, M. Krystal, B. Terry, 2008, Journal of Biological Chemistry.

Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia with kinase fusions in Taiwan

C. Mullighan, Sung-Liang Yu, Shu-Wha Lin, 2021, Scientific Reports.

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.

Alan S. Futran, Vijay T. Ahuja, Shana L. Posy, 2022, Journal of medicinal chemistry.

Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.

N. Meanwell, Zeyu Lin, S. Gerritz, 2010, Journal of combinatorial chemistry.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.

N. Meanwell, Zeyu Lin, M. Krystal, 2015, Bioorganic & medicinal chemistry letters.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

N. Meanwell, D. Langley, Zeyu Lin, 2019, Bioorganic & medicinal chemistry letters.

Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors

N. Meanwell, Zeyu Lin, M. Krystal, 2011 .

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile

N. Meanwell, Zeyu Lin, Joseph L. Cantone, 2021, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Benzyl amide-ketoacid inhibitors of HIV-integrase.

N. Meanwell, Zeyu Lin, M. Krystal, 2007, Bioorganic & Medicinal Chemistry Letters.

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.

A. Mathur, N. Meanwell, Zeyu Lin, 2020, Bioorganic & medicinal chemistry.

Nursing management of treatment-related venous thromboembolism in patients with multiple myeloma

Zeyu Lin, C. Geng, Chao Liu, 2023, Frontiers in Medicine.

The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.

D. Langley, Zeyu Lin, M. Krystal, 2008, Biochemistry.

The Second-Generation Maturation Inhibitor GSK3532795 Maintains Potent Activity Toward HIV Protease Inhibitor–Resistant Clinical Isolates

Zeyu Lin, M. Krystal, M. Nijhuis, 2017, Journal of acquired immune deficiency syndromes.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.