Chunhong Yan

发表

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

Micah T. Nelp, J. Groves, J. Hunt, 2018, Proceedings of the National Academy of Sciences.

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2004, Nature Structural &Molecular Biology.

Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin.

Wuyuan Lu, I. Szeto, Zhihui Feng, 2014, Antioxidants & redox signaling.

Design, synthesis and biological activities of quinazoline containing sorafenib analogs as antitumor agents

Chunhong Yan, F. Fu, Jingwen Zhang, 2017, Wuhan University Journal of Natural Sciences.

Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase

Grover L Waldrop, Igor Mochalkin, Chunhong Yan, 2008, Protein science : a publication of the Protein Society.

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.

Xiaoguang Chen, H. Ding, Shi-Yong Sun, 2015, Chemistry & biology.

A Synthetic Manassantin A Derivative Inhibits Hypoxia-Inducible Factor 1 and Tumor Growth

Chunhong Yan, Y. Li, Xiaoguang Chen, 2014, PloS one.

ATF3 Represses 72-kDa Type IV Collagenase (MMP-2) Expression by Antagonizing p53-dependent trans-Activation of the Collagenase Promoter*

D. Boyd, Chunhong Yan, Heng Wang, 2002, The Journal of Biological Chemistry.

Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.

Shana L. Posy, W. Metzler, R. Talbott, 2016, Analytical biochemistry.

Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.

J. Myers, D. Boyd, Chunhong Yan, 2005, Molecular cancer therapeutics.

Sin1 promotes proliferation and invasion of prostate Cancer cells by modulating mTORC2-AKT and AR signaling cascades.

Ziyan Wang, Zhenglin Yang, Chunhong Yan, 2020, Life sciences.

Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene.

D. Boyd, Chunhong Yan, Yao Wang, 2003, The American journal of pathology.

Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2005, Nature Structural &Molecular Biology.

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo

Wenyan Wang, L. Ye, Jingwei Tian, 2019, Acta pharmaceutica Sinica. B.

Ferroptosis: An emerging therapeutic opportunity for cancer

Chunhong Yan, Xiaoguang Chen, Li-yuan Wang, 2020, Genes & diseases.

Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage.

Jianyuan Luo, Zhijun Zhou, Chunhong Yan, 2017, Toxicology letters.

Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.

Zhihui Feng, Chunhong Yan, J. Long, 2016, Biochemical pharmacology.

Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction.

Chunhong Yan, Siyu Li, Haitao Wu, 2020, Food & function.

Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.

M. D. Hill, J. Tokarski, S. Sheriff, 2021, Bioorganic & medicinal chemistry letters.

Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.

M. D. Hill, J. Tokarski, S. Sheriff, 2021, Bioorganic & medicinal chemistry letters.

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.

J. Barrish, D. Xie, N. Murugesan, 2020, ACS medicinal chemistry letters.

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.

J. Sack, Chunhong Yan, S. E. Kiefer, 2015, Acta crystallographica. Section F, Structural biology communications.

Cytoskeleton-associated protein tyrosine phosphorylation involved in induction of differentiation in mouse melanoma cells

Chunhong Yan, R. Han, Rui Han, 1999 .

Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects*

R. D. Dyer, Adam R. Johnson, Chunhong Yan, 2007, Journal of Biological Chemistry.

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Chunhong Yan, Wenyan Sun, Bess Frost, 2016, Scientific Reports.

Adhesion induces matrix metalloproteinase-9 gene expression in ovarian cancer cells

Chunhong Yan, F. Xiao, F. Tian, 2002, Zhonghua zhong liu za zhi [Chinese journal of oncology].

Adhesion-induce protein tyrosine phosphory-lation is associated with invasive and metastatic potentials in B16-BL6 melanoma cells

Chunhong Yan, R. Han, Rui Han, 1998 .

Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.

David S. Taylor, J. Sack, Chunhong Yan, 2020, Bioorganic & medicinal chemistry letters.

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

T. Du, Chunhong Yan, Sen Zhang, 2019, Cellular and Molecular Life Sciences.

A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.

Hongbo Wang, Chunhong Yan, 2011, Neoplasia.

Structural characterization and anticoagulant activity of two polysaccharides from Patinopecten yessoensis viscera.

Chunhong Yan, Chunqing Ai, Chengrong Wen, 2019, International journal of biological macromolecules.

Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.

Becky Penhallow, Andrew Tebben, Jonathan Lippy, 2012, Bioorganic & medicinal chemistry letters.

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.

B. Beattie, E. Fauman, B. Finzel, 2008, Journal of structural biology.

Thymoquinone Inhibits Virulence Related Traits of Cronobacter sakazakii ATCC 29544 and Has Anti-biofilm Formation Potential

Chunhong Yan, Yue Sui, X. Xia, 2017, Front. Microbiol..

Regulation of matrix metalloproteinase gene expression

D. Boyd, Chunhong Yan, 2007, Journal of cellular physiology.

Punicalagin Inhibits Salmonella Virulence Factors and Has Anti-Quorum-Sensing Potential

Chunhong Yan, X. Xia, Baowei Yang, 2014, Applied and Environmental Microbiology.

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.

J. Buolamwini, Chunhong Yan, Hemantkumar S. Deokar, 2013, Biochemical pharmacology.

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

T. Du, H. Ding, Junran Zhang, 2019, Cell Death & Differentiation.

KiSS-1 Represses 92-kDa Type IV Collagenase Expression by Down-regulating NF-κB Binding to the Promoter as a Consequence of IκBα-induced Block of p65/p50 Nuclear Translocation*

D. Boyd, Chunhong Yan, Heng Wang, 2001, The Journal of Biological Chemistry.

Drugging the undruggable: transcription therapy for cancer.

P. Higgins, Chunhong Yan, 2013, Biochimica et biophysica acta.

G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity

Xianjun Zhu, Ziyan Wang, Zhenglin Yang, 2020, Molecular Cancer Research.

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

Jingwei Tian, Chunhong Yan, Gangqiang Yang, 2018, Toxicology and applied pharmacology.

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Jingwei Tian, Chunhong Yan, F. Fu, 2016, Acta pharmaceutica Sinica. B.

Loss of ATF3 Promotes Akt Activation and Prostate Cancer Development in a Pten Knockout Mouse Model

Tsonwin Hai, H. Ding, Ziyan Wang, 2014, Oncogene.

The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor

Tsonwin Hai, S. Hayward, Zhengxin Wang, 2012, Molecular and Cellular Biology.

Loss of ATF3 Promotes Hormone-induced Prostate Carcinogenesis and the Emergence of CK5+CK8+ Epithelial Cells

Tsonwin Hai, H. Ding, Ziyan Wang, 2015, Oncogene.

Histone H3 Acetylation and H3 K4 Methylation Define Distinct Chromatin Regions Permissive for Transgene Expression

Douglas D. Boyd, D. Boyd, Chunhong Yan, 2006, Molecular and Cellular Biology.

A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NFκB motif drives the transition from a repressed to an activated state of gene expression

B. Aggarwal, D. Boyd, Chunhong Yan, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma

H. Ding, Z. Dong, Chunhong Yan, 2021, Cell Death & Disease.

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway.

O. Fiehn, Jeong-Hyeon Choi, H. Ding, 2019, Cancer research.

A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis.

Jingwei Tian, Chunhong Yan, F. Fu, 2022, Pharmacological research.

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

H. Ding, H. Cui, Z. Dong, 2019, Oncogenesis.

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

H. Ding, Junran Zhang, Chunhong Yan, 2021, Cell reports.

The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation

Jindan Yu, Mingxiong Guo, Chunhong Yan, 2016, BMC Genomics.

A Knock-in Reporter for a Novel AR-Targeted Therapy

Chunhong Yan, 2016 .

A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression

Zhengxin Wang, R. Nair, D. Boyd, 2008, Molecular Pharmacology.

ATF3 Deficiency Promotes Genome Instability and Spontaneous Tumorigenesis in Mice

Tsonwin Hai, H. Ding, Bilian Jin, 2017, Oncogene.

The Stress-responsive Gene ATF3 Regulates the Histone Acetyltransferase Tip60

H. Ding, Yi Tang, Junran Zhang, 2015, Nature Communications.

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Tsonwin Hai, D. Boyd, D. Lu, 2005, The EMBO journal.

A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

Hongbing Wang, G. Narla, Z. Qiu, 2020, Cancer Research.

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.

Shuang Huang, Jeong-Hyeon Choi, H. Ding, 2016, Cell reports.

KDM 4 C and ATF 4 Coopera te in Transcriptional Control of Amino Acid Metabolism Graphical

Shuang Huang, Jeong-Hyeon Choi, H. Ding, 2022 .

Therapeutic Discovery A Small-Molecule Inhibitor of MDMX Activates p 53 and Induces Apoptosis

John K. Buolamwini, J. Buolamwini, Hongbo Wang, 2011 .

A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

John K. Buolamwini, J. Buolamwini, Hongbo Wang, 2010, Molecular Cancer Therapeutics.

MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3*

Hua Lu, D. Boyd, Hongbo Wang, 2010, The Journal of Biological Chemistry.

Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6*

Hongbo Wang, Chunhong Yan, Pingli Mo, 2010, The Journal of Biological Chemistry.

RNF126 as a Biomarker of a Poor Prognosis in Invasive Breast Cancer and CHEK1 Inhibitor Efficacy in Breast Cancer Cells

Zhefu Ma, Shunqiang Li, Hongbing Wang, 2018, Clinical Cancer Research.

Determinants of Gli2 co‐activation of wildtype and naturally truncated androgen receptors

Chunhong Yan, Na Li, R. Buttyan, 2014, The Prostate.

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells.

Shuang Huang, Jeong-Hyeon Choi, H. Ding, 2016, Cell reports.

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Zhihui Feng, Ying Wang, Ying Wang, 2015, Nucleic acids research.

BP 1 promotes microhomology-mediated end-joining in G 1-phase cells

Ying Wang, H. Willers, Zhihui Feng, 2015 .

Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer

T. Du, Chunhong Yan, Sen Zhang, 2019, Cellular and Molecular Life Sciences.

Post-translational modification of p53 by ubiquitin.

Chunhong Yan, 2010, Methods in molecular biology.

The Activating Transcription Factor 3 Protein Suppresses the Oncogenic Function of Mutant p53 Proteins*

D. Tang, Hongbo Wang, Chunhong Yan, 2014, The Journal of Biological Chemistry.

Competitive ubiquitination activates the tumor suppressor p53

T. Du, H. Ding, Junran Zhang, 2019, Cell Death & Differentiation.

Repression of 92-kDa Type IV Collagenase Expression by MTA1 Is Mediated through Direct Interactions with the Promoter via a Mechanism, Which Is Both Dependent on and Independent of Histone Deacetylation*

D. Boyd, Chunhong Yan, Y. Toh, 2003, The Journal of Biological Chemistry.

The Activating Transcription Factor 3 Protein Suppresses the Oncogenic Function of Mutant p 53 Proteins *

D. Tang, Hongbo Wang, Chunhong Yan, 2014 .

ATF3 Regulates the Stability of p53: A Link to Cancer

D. Boyd, Chunhong Yan, 2006, Cell cycle.

The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins*

H. Ding, Qi-En Wang, Junran Zhang, 2016, The Journal of Biological Chemistry.

Emerging roles of ATF3 in the suppression of prostate cancer

Ziyan Wang, Chunhong Yan, 2015, Molecular & cellular oncology.

Corrigendum: Thymoquinone Inhibits Virulence Related Traits of Cronobacter sakazakii ATCC 29544 and Has Anti-biofilm Formation Potential

Chunhong Yan, Yue Sui, X. Xia, 2018, Front. Microbiol..

Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway.

Chunhong Yan, X. Xia, Qi-An Han, 2016, Molecular nutrition & food research.

Data Independent Acquisition-Based Quantitative Proteomic Analysis Reveals the Protection Effect of Apigenin on Palmitate Induced Lipotoxicity in HAEC cells.

Chunhong Yan, X. Xia, C. Jin, 2020, Journal of agricultural and food chemistry.

Inhibitory Effect of Coenzyme Q0 on the Growth of Staphylococcus aureus.

Chunhong Yan, Chunling Zhang, X. Xia, 2019, Foodborne pathogens and disease.

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity.

Chunhong Yan, Xiangwei Gao, Mengqi Guo, 2019, European journal of medicinal chemistry.

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress

Zhefu Ma, Junran Zhang, Chunhong Yan, 2016, Oncotarget.

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.

D. Xie, S. Sheriff, Chunhong Yan, 2016, Acta crystallographica. Section D, Structural biology.

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression

Zhihui Feng, Jinzhi Lai, Analisa Difeo, 2015, Oncogene.

Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer.

M. Zhu, Chunhong Yan, Chunrong Qu, 2018, Cancer letters.

Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system.

Zhihui Feng, Xuebo Liu, Chunhong Yan, 2016, Molecular nutrition & food research.

The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity

Y. Cho, Qi-En Wang, Junran Zhang, 2023, Research square.

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation

T. Du, Chunhong Yan, Yubin Ji, 2019, OncoTargets and therapy.

Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.

Zhefu Ma, Q. She, Hongbing Wang, 2022, Cancer research.

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Jeong-Hyeon Choi, H. Ding, S. Huang, 2014, Cell Death and Disease.

Punicalagin Prevents Hepatic Steatosis Through Improving Lipid Homeostasis and Inflammation in Liver and Adipose Tissue and Modulating Gut Microbiota in Western diet-fed Mice.

Chunhong Yan, X. Xia, X. Peng, 2020, Molecular nutrition & food research.