A. Wilks

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The mechanism of heme transfer from the cytoplasmic heme binding protein PhuS to the delta-regioselective heme oxygenase of Pseudomonas aeruginosa.

Mehul N Bhakta, A. Wilks, 2006, Biochemistry.

Diatomic Ligand Discrimination by the Heme Oxygenases from Neisseria meningitidis and Pseudomonas aeruginosa*

T. Poulos, A. Wilks, Y. Meharenna, 2007, Journal of Biological Chemistry.

Synthesis and Characterization of a Novel Diels - Alder Adduct of Codeine.

Alexander D. MacKerell, A. Wilks, A. Coop, 2010, Helvetica chimica acta.

Proteomic Analysis of the Pseudomonas aeruginosa Iron Starvation Response Reveals PrrF Small Regulatory RNA-Dependent Iron Regulation of Twitching Motility, Amino Acid Metabolism, and Zinc Homeostasis Proteins

Luke K. Brewer, Angela T. Nguyen, Amanda G. Oglesby-Sherrouse, 2019, Journal of bacteriology.

Proteomic analysis of the Pseudomonas aeruginosa iron starvation response reveals PrrF sRNA-dependent regulation of amino acid metabolism, iron-sulfur cluster biogenesis, motility, and zinc homeostasis

Luke K. Brewer, Angela T. Nguyen, Amanda G. Oglesby-Sherrouse, 2018, bioRxiv.

Comparison of Once-Daily Versus Twice-Daily Gentamicin Dosing Regimens in Infants ≥2500 g

A. Wilks, R. Pildes, G. Agarwal, 2002, Journal of Perinatology.

Furosemide prevents the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus.

A. Wilks, T. Yeh, R. Pildes, 1982, The Journal of pediatrics.

Identical mRNA for preproglucagon in pancreas and gut.

A. Wilks, A. Wilks, G. Buell, 1987, European journal of biochemistry.

The lipoxygenase activity of myoglobin. Oxidation of linoleic acid by the ferryl oxygen rather than protein radical.

M. Hamberg, P. Ortiz de Montellano, A. Wilks, 1994, The Journal of biological chemistry.

Degradation of Heme in Gram-Negative Bacteria: the Product of the hemO Gene of Neisseriae Is a Heme Oxygenase

A. Wilks, Wenming Zhu, I. Stojiljković, 2000, Journal of bacteriology.

Heme oxygenase active-site residues identified by heme-protein cross-linking during reduction of CBrCl3.

P. Ortiz de Montellano, K. Medzihradszky, A. Wilks, 1998, Biochemistry.

Extracellular Heme Uptake and the Challenge of Bacterial Cell Membranes.

A. Wilks, Weiliang Huang, 2017, Annual review of biochemistry.

Heme Utilization by Pathogenic Bacteria: Not All Pathways Lead to Biliverdin

M. Ikeda-Saito, A. Wilks, 2014, Accounts of chemical research.

Heme oxygenation and the widening paradigm of heme degradation.

A. Wilks, Geoffrey A. Heinzl, Geoffrey A Heinzl, 2014, Archives of biochemistry and biophysics.

Extracellular heme uptake and the challenges of bacterial cell membranes.

A. Wilks, A. Smith, 2017, Current topics in membranes.

Homologues of Neisserial Heme Oxygenase in Gram-Negative Bacteria: Degradation of Heme by the Product of thepigA Gene of Pseudomonas aeruginosa

A. Wilks, Wenming Zhu, I. Stojiljković, 2001, Journal of bacteriology.

Metallotherapeutics development in the age of iron-clad bacteria.

A. Wilks, F. Xue, Garrick Centola, 2020, Metallomics : integrated biometal science.

Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO)

Mehul N Bhakta, A. Wilks, K. Fleming, 2012, Proceedings of the National Academy of Sciences.

Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid.

Mehul N Bhakta, A. Wilks, K. Wimalasena, 2008, Journal of inorganic biochemistry.

Intramolecular translocation of the protein radical formed in the reaction of recombinant sperm whale myoglobin with H2O2.

P. Ortiz de Montellano, A. Wilks, Angela Wilks, 1992, The Journal of biological chemistry.

Homologues of Neisserial Heme Oxygenase in Gram-Negative Bacteria: Degradation of Heme by the Product of thepigA Gene of Pseudomonas aeruginosa

A. Wilks, R. Deshmukh, Wenming Zhu, 2001, Journal of bacteriology.

Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa.

A. MacKerell, A. Wilks, Weiliang Huang, 2016, Journal of medicinal chemistry.

The prrF-Encoded Small Regulatory RNAs Are Required for Iron Homeostasis and Virulence of Pseudomonas aeruginosa

Angela T. Nguyen, Amanda G. Oglesby-Sherrouse, A. Wilks, 2014, Infection and Immunity.

Recombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle

A. Wilks, F. Xue, N. Frankenberg‐Dinkel, 2021, Frontiers in Microbiology.

Adaptation of Iron Homeostasis Pathways by a Pseudomonas aeruginosa Pyoverdine Mutant in the Cystic Fibrosis Lung

Angela T. Nguyen, Amanda G. Oglesby-Sherrouse, A. Wilks, 2014, Journal of bacteriology.

Mutant in the Cystic Fibrosis Lung by a Pseudomonas aeruginosa Pyoverdine Adaptation of Iron Homeostasis Pathways

Angela T. Nguyen, Amanda G. Oglesby-Sherrouse, A. Wilks, 2014 .

Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase

Jana K. Shen, P. Wintrode, A. Wilks, 2017, Proceedings of the National Academy of Sciences.

Oxidation of heme to β- and δ-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme

M. A. Eastman, M. Rivera, A. Wilks, 2002 .

The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis *

P. Ortiz de Montellano, J. Oyarzábal, A. Wilks, 2000, The Journal of Biological Chemistry.

Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants

J. Bolton, A. Allentoff, A. Wilks, 1992 .

Bacterial Heme Oxygenases

A. Wilks, I. Stojiljković, Melanie Ratliff-Griffin, 2004 .

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets.

Alexander D. MacKerell, Pedro E. M. Lopes, A. Wilks, 2007, Journal of medicinal chemistry.

The Cytoplasmic Heme-binding Protein (PhuS) from the Heme Uptake System of Pseudomonas aeruginosa Is an Intracellular Heme-trafficking Protein to the δ-Regioselective Heme Oxygenase*

A. Wilks, G. Lukat-Rodgers, K. Rodgers, 2006, Journal of Biological Chemistry.

Assignment of the heme axial ligand(s) for the ferric myoglobin (H93G) and heme oxygenase (H25A) cavity mutants as oxygen donors using magnetic circular dichroism.

S. Boxer, P. Ortiz de Montellano, M. Ikeda-Saito, 1999, Biochemistry.

Extra corporeal membrane oxygenation (ECMO) for neonatal respiratory failure

A. Wilks, J. Meller, G. Srinivasan, 1990, Indian Journal of Pediatrics.

Resonance Raman and EPR spectroscopic studies on heme-heme oxygenase complexes.

J. Sun, P. Ortiz de Montellano, A. Wilks, 1993, Biochemistry.

Heme Oxygenase Structure and Mechanism

Angela Wilks, A. Wilks, Paul R. Ortiz de Montellano, 2000 .

Ligation of the iron in the heme-heme oxygenase complex: X-ray absorption, electronic absorption and magnetic circular dichroism studies.

P. Ortiz de Montellano, J. Dawson, A. Wilks, 1996, Biochimica et biophysica acta.

Crystal structure of human heme oxygenase-1

D. J. Schuller, T. Poulos, A. Wilks, 1999, Nature Structural Biology.

Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase.

P. Ortiz de Montellano, A. Wilks, S. Black, 1995, Biochemistry.

Identification of histidine 25 as the heme ligand in human liver heme oxygenase.

J. Sun, P. Ortiz de Montellano, A. Wilks, 1994, Biochemistry.

Proton NMR investigation of substrate-bound heme oxygenase: evidence for electronic and steric contributions to stereoselective heme cleavage.

R. Paolesse, P. Ortiz de Montellano, G. Hernández, 1994, Biochemistry.

Purification and characterization of heme oxygenase.

A. Wilks, 2003, Current protocols in toxicology.

Rat liver heme oxygenase. High level expression of a truncated soluble form and nature of the meso-hydroxylating species.

P. Ortiz de Montellano, A. Wilks, Angela Wilks, 1993, The Journal of biological chemistry.

Characterization of the periplasmic heme-binding protein shut from the heme uptake system of Shigella dysenteriae.

J. Dawson, A. Wilks, A. Ghosh, 2005, Biochemistry.

Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme.

M. A. Eastman, M. Rivera, A. Wilks, 2002, Journal of the American Chemical Society.

Identification of the Proximal Ligand His-20 in Heme Oxygenase (Hmu O) from Corynebacterium diphtheriae

A. Wilks, P. Moënne‐Loccoz, 2000, The Journal of Biological Chemistry.

Expression and characterization of a heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Iron acquisition requires oxidative cleavage of the heme macrocycle.

A. Wilks, M. Schmitt, 1998, The Journal of biological chemistry.

Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis.

J. Sun, P. Ortiz de Montellano, A. Wilks, 1996, Biochemistry.

Heme oxygenase: evolution, structure, and mechanism.

A. Wilks, 2002, Antioxidants & redox signaling.

Heme uptake and utilization by hypervirulent Acinetobacter baumannii LAC-4 is dependent on a canonical heme oxygenase (abHemO).

A. Wilks, Weiliang Huang, Bennett J. Giardina, 2019, Archives of biochemistry and biophysics.

Gallium (III) Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition.

A. Wilks, Yong Ai, F. Xue, 2020, ACS infectious diseases.

HutZ Is Required for Efficient Heme Utilization in Vibrio cholerae

A. Wilks, M. Schmitt, S. Payne, 2004, Journal of bacteriology.

The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

A. Wilks, M. Barbier, Weiliang Huang, 2023, bioRxiv.

The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus

A. Wilks, Susana Mouriño, Tyree Wilson, 2021, The Journal of biological chemistry.

Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia

Amanda G. Oglesby-Sherrouse, A. Wilks, F. H. Damron, 2016, Scientific Reports.

Differential Contributions of the Outer Membrane Receptors PhuR and HasR to Heme Acquisition in Pseudomonas aeruginosa*

A. Wilks, A. Smith, 2015, The Journal of Biological Chemistry.

The P. aeruginosa heme binding protein PhuS is a heme oxygenase titratable regulator of heme uptake.

A. Wilks, Maura J. O'Neill, 2013, ACS chemical biology.

The Role of the Cytoplasmic Heme-binding Protein (PhuS) of Pseudomonas aeruginosa in Intracellular Heme Trafficking and Iron Homeostasis*

A. Wilks, A. Kaur, Ila B Lansky, 2009, Journal of Biological Chemistry.

The role of the cytoplasmic heme-binding protein (PhuS) of Pseudomonas aeruginosa in quorum sensing and intracellular iron homeostasis

A. Wilks, A. Kaur, 2007 .

Heme Degradation:: Mechanistic and Physiological Implications

A. Wilks, 2009 .

Understanding RNA Binding by the Nonclassical Zinc Finger Protein CPSF30, a Key Factor in Polyadenylation during Pre-mRNA Processing.

M. Kane, A. Wilks, Weiliang Huang, 2021, Biochemistry.

Holo- and Apo-bound Structures of Bacterial Periplasmic Heme-binding Proteins*

T. Poulos, Huiying Li, Yong Tong, 2007, Journal of Biological Chemistry.

Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis.

A. Wilks, Susana Mouriño, 2021, Advances in microbial physiology.

Heme and virulence: how bacterial pathogens regulate, transport and utilize heme.

A. Wilks, Kimberly A. Burkhard, 2007, Natural product reports.

PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database

David S. Wishart, Ana Marcu, Weiliang Huang, 2017, Nucleic Acids Res..

Replacement of the proximal histidine iron ligand by a cysteine or tyrosine converts heme oxygenase to an oxidase.

P. Ortiz de Montellano, Y. Liu, A. Mauk, 1999, Biochemistry.

DOES PULMONARY HEMORRHAGE CONTRIBUTE TO EXCESS MORTALITY IN EXTREMELY LOW BIRTH WEIGHT (ELBW) NEONATES RECEIVING SURFACTANT THERAPY? 1240

A. Wilks, V. Geraldo, V. Agrawal, 1996, Pediatric Research.

Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa*

H. Reyes-caballero, A. Wilks, Susana Mouriño, 2016, The Journal of Biological Chemistry.

The roles of His-64, Tyr-103, Tyr-146, and Tyr-151 in the epoxidation of styrene and beta-methylstyrene by recombinant sperm whale myoglobin.

P. Ortiz de Montellano, A. Wilks, S. Rao, 1993, The Journal of biological chemistry.

Heme oxidation in a chimeric protein of the alpha-selective Neisseriae meningitidis heme oxygenase with the distal helix of the delta-selective Pseudomonas aeruginosa.

M. Rivera, A. Wilks, R. Bunce, 2005, Biochemistry.

Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa.

T. Poulos, Huiying Li, A. Wilks, 2004, Biochemistry.

Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa.

W. Lanzilotta, A. Wilks, Trokourey Albert, 2021, Biochemistry.

Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport

A. Wilks, Alecia T Dent, 2020, The Journal of Biological Chemistry.

Post-transcriptional regulation of the Pseudomonas aeruginosa heme assimilation system (Has) fine-tunes extracellular heme sensing

A. Wilks, Weiliang Huang, Susana Mouriño, 2018, The Journal of Biological Chemistry.

Spectroscopic Determination of Distinct Heme Ligands in Outer-Membrane Receptors PhuR and HasR of Pseudomonas aeruginosa.

J. Dawson, A. Wilks, A. Smith, 2015, Biochemistry.

Heme Oxygenase His25Ala Mutant: Replacement of the Proximal Histidine Iron Ligand by Exogenous Bases Restores Catalytic Activity

A. Wilks, P. R. Montellano, T. Loehr, 1995 .

Analysis of Heme and Hemoproteins

A. Wilks, 2002 .

Small molecule antivirulents targeting the iron-regulated heme oxygenase (HemO) of P. aeruginosa.

Alexander D. MacKerell, Pedro E. M. Lopes, A. Wilks, 2013, Journal of medicinal chemistry.

Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1.

T. Poulos, A. Wilks, I. Stojiljković, 2001, Biochemistry.

Crystallization of recombinant human heme oxygenase‐1

T. Poulos, A. Wilks, P. O. D. Montellano, 1998, Protein science : a publication of the Protein Society.

Heme oxygenase (HO-1). Evidence for electrophilic oxygen addition to the porphyrin ring in the formation of alpha-meso-hydroxyheme.

P. Ortiz de Montellano, A. Wilks, J. Torpey, 1994, The Journal of biological chemistry.

Heme dependent transcriptional regulation of the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus by the cytoplasmic heme binding protein PhuS

A. Wilks, Susana Mouriño, Tyree Wilson, 2020, bioRxiv.

Mixed regioselectivity in the Arg-177 mutants of Corynebacterium diphtheriae heme oxygenase as a consequence of in-plane heme disorder.

M. Rivera, A. Wilks, R. Bunce, 2004, Biochemistry.

Crystal Structures of the NO- and CO-bound Heme Oxygenase from Neisseriae meningitidis

T. Poulos, Huiying Li, A. Wilks, 2003, Journal of Biological Chemistry.

Solution NMR Characterization of an Unusual Distal H-bond Network in the Active Site of the Cyanide-inhibited, Human Heme Oxygenase Complex of the Symmetric Substrate, 2,4-Dimethyldeuterohemin* 210

P. Ortiz de Montellano, A. Wilks, R. Syvitski, 2002, The Journal of Biological Chemistry.

Solution 1H NMR Investigation of the Molecular and Electronic Structure of the Active Site of Substrate-Bound Human Heme Oxygenase: the Nature of the Distal Hydrogen Bond Donor to Bound Ligands

A. Wilks, G. N. Mar, C. M. Gorst, 1998 .

425 FUROSEMIDE (F) PREVENTS THE RENAL SIDE EFFECTS OF INDOMETHACIN (I) IN PREMATURE INFANTS WITH PDA AND OLIGURIA

A. Wilks, T. Yeh, R. Pildes, 1985, Pediatric Research.

Indomethacin therapy in premature infants with patent ductus arteriosus and oliguria.

A. Wilks, T. Yeh, R. Pildes, 1986, Developmental pharmacology and therapeutics.

A rapid seamless method for gene knockout in Pseudomonas aeruginosa

A. Wilks, Weiliang Huang, 2017, BMC Microbiology.

13C NMR spectroscopy of core heme carbons as a simple tool to elucidate the coordination state of ferric high-spin heme proteins.

M. Rivera, A. Wilks, R. Bunce, 2006, Inorganic chemistry.

The Asp99–Arg188 salt bridge of the Pseudomonas aeruginosa HemO is critical in allowing conformational flexibility during catalysis

A. Wilks, Weiliang Huang, F. Xue, 2018, JBIC Journal of Biological Inorganic Chemistry.

Expression and Characterization of a Heme Oxygenase (Hmu O) fromCorynebacterium diphtheriae

A. Wilks, M. Schmitt, 1998, The Journal of Biological Chemistry.

Characterization of the Outer Membrane Receptor ShuA from the Heme Uptake System of Shigella dysenteriae

A. Wilks, Kimberly A. Burkhard, 2007, Journal of Biological Chemistry.

The hydroxide complex of Pseudomonas aeruginosa heme oxygenase as a model of the low-spin iron(III) hydroperoxide intermediate in heme catabolism: 13C NMR spectroscopic studies suggest the active participation of the heme in macrocycle hydroxylation.

M. Rivera, A. Wilks, R. Bunce, 2003, Journal of the American Chemical Society.

Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO).

A. Wilks, Yue Li, Wenbo Yu, 2018, Bioorganic & medicinal chemistry letters.

The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

A. Wilks, M. Barbier, Weiliang Huang, 2023, mSphere.

Metabolic Flux of Extracellular Heme Uptake in Pseudomonas aeruginosa Is Driven by the Iron-regulated Heme Oxygenase (HemO)*

A. Wilks, Kylie D. Barker, Katalin Barkovits, 2012, The Journal of Biological Chemistry.

The Asp99–Arg188 salt bridge of the Pseudomonas aeruginosa HemO is critical in allowing conformational flexibility during catalysis

A. Wilks, Weiliang Huang, F. Xue, 2018, JBIC Journal of Biological Inorganic Chemistry.

Transition metals in oxidative stress

A. Wilks, C. Catalano, P. R. Montellano, 1990 .

Pseudomonas aeruginosa heme metabolites biliverdin IXβ and IXδ are integral to lifestyle adaptations associated with chronic infection

A. Wilks, Weiliang Huang, Susana Mouriño, 2024, mBio.