C. Fronticelli

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The heme-globin and dimerization equilibria of recombinant human hemoglobins carrying site-specific beta chains mutations.

E. Chiancone, A. Boffi, M. Gattoni, 2001, Archives of biochemistry and biophysics.

hemoglobin polymers in mouse -affinity recombinant 2 transfusion of high O Salvage of focal cerebral ischemic damage by

R. Koehler, D. Crafa, M. Nemoto, 2015 .

Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse.

R. Koehler, M. Nemoto, W. S. Brinigar, 2006, Journal of applied physiology.

A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter.

R. Koehler, R. Traystman, M. Nemoto, 2003, American journal of physiology. Heart and circulatory physiology.

Introduction of negative charges to a crosslinked hemoglobin: lack of effect on plasma half time.

C. Fronticelli, E. Bucci, H. Kwansa, 1997, Artificial cells, blood substitutes, and immobilization biotechnology.

Assembly of Human Hemoglobin

A. P. Koley, W. S. Brinigar, C. Fronticelli, 1997, The Journal of Biological Chemistry.

Allosteric free energy changes at the α1β2 interface of human hemoglobin probed by proton exchange of Trpβ37

C. Fronticelli, M. Mihailescu, I. M. Russu, 2001 .

A NEW METHOD FOR THE PREPARATION OF ALPHA AND BETA SUBUNITS OF HUMAN HEMOGLOBIN.

C. Fronticelli, E. Bucci, 1965, The Journal of biological chemistry.

Molecular engineering of a polymer of tetrameric hemoglobins

C. Fronticelli, D. Arosio, K. Bobofchak, 2001, Proteins.

Recombinant human hemoglobin: modification of the polarity of the beta-heme pocket by a valine67(E11)-->threonine mutation.

J. Olson, W. S. Brinigar, C. Fronticelli, 1993, Biochemistry.

Renal excretion of pseudo-cross-linked human, porcine and bovine hemoglobins.

C. Fronticelli, E. Bucci, Y. S. Lu, 1992, Biochimica et biophysica acta.

Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction.

C. Fronticelli, N. Pace, R. Dull, 2004, Journal of applied physiology.

Fluorescence intensity and anisotropy decays of the intrinsic tryptophan emission of hemoglobin measured with a 10-GHz fluorometer using front-face geometry on a free liquid surface

J. Lakowicz, C. Fronticelli, I. Gryczynski, 1992, Journal of Fluorescence.

Resolution at 2 GHz of Lifetimes and Correlation Times of Highly Purified Solutions of Human Hemoglobin

J. Lakowicz, C. Fronticelli, I. Gryczynski, 1989 .

THE PROPERTIES AND INTERACTIONS OF THE ISOLATED ALPHA AND BETA CHAINS OF HUMAN HAEMOGLOBIN. 3. OBSERVATIONS ON THE EQUILIBRIA AND KINETICS OF THE REACTIONS WITH GASES.

J. Wyman, E. Antonini, C. Fronticelli, 1965, Journal of molecular biology.

Properties and interactions of the isolated alpha and beta chains of human haemoglobin. II. Immunochemical behaviour of the chains: fractionation of an antigen.

J. Wyman, E. Antonini, C. Fronticelli, 1965, Journal of molecular biology.

Solvent perturbation evidence for a two-state system regulated by calcium in sarcoplasmic reticulum ATPase.

A. Shamoo, C. Fronticelli, E. Bucci, 1984, Biophysical chemistry.

Preparative and analytical applications of immobilized haemoglobin.

E. Chiancone, M. Gattoni, C. Fronticelli, 1995, Journal of chromatography. B, Biomedical applications.

rabbitshuman hemoglobin solutions in hemodiluted Cardiovascular and hemorheological effects of three

A. Popel, A. Alayash, C. Fronticelli, 2015 .

THE PROPERTIES AND INTERACTIONS OF THE ISOLATER ALPHA AND BETA CHAINS OF HUMAN HAEMOGLOBIN. I. SEDIMENTATION AND ELECTROPHORETIC BEHAVIOUR.

J. Wyman, E. Chiancone, E. Antonini, 1965, Journal of molecular biology.

STUDIES ON THE RELATIONS BETWEEN MOLECULAR AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN. V. THE INFLUENCE OF TEMPERATURE ON THE BOHR EFFECT IN HUMAN AND IN HORSE HEMOGLOBIN.

M. Brunori, J. Wyman, E. Antonini, 1965, The Journal of biological chemistry.

STUDIES ON THE RELATIONS BETWEEN MOLECULAR AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN. IV. THE BOHR EFFECT IN HUMAN HEMOGLOBIN MEASURED BY PROTON BINDING.

M. Brunori, J. Wyman, E. Antonini, 1963, The Journal of biological chemistry.

substitutes in a rat hemorrhage model Vascular resistance and the efficacy of red cell

B. Manjula, K. Vandegriff, R. Winslow, 2015 .

Conformational and functional characteristics of bovine hemoglobin.

C. Fronticelli, E. Bucci, 1994, Methods in enzymology.

The proton-binding behavior of human hemoglobin and its subunits in their native state.

C. Fronticelli, E. Bucci, B. Ragatz, 1968, The Journal of biological chemistry.

FURTHER STUDIES ON THE STRUCTURE AND PROPERTIES OF HUMAN HAEMOGLOBINS MODIFIED BY DIGESTION WITH THE CARBOXYPEPTIDASES.

C. Fronticelli, E. Bucci, N. Dance, 1965, Journal of molecular biology.

Measurement of the Bohr effect: dependence on pH of oxygen affinity of hemoglobin.

C. Fronticelli, E. Bucci, 1981, Methods in enzymology.

The oxygen equilibrium of the hybrids of canine and human haemoglobin.

M. Brunori, J. Wyman, E. Antonini, 1965, Biochimica et biophysica acta.

THE OXYGEN BOHR EFFECT OF HUMAN FETAL HEMOGLOBIN.

M. Brunori, J. Wyman, E. Antonini, 1964, Archives of biochemistry and biophysics.

The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. V. The reaction of alpha- and beta-chains.

J. Wyman, E. Chiancone, E. Antonini, 1966, Journal of molecular biology.

The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. IV. Immunological studies involving antibodies against the isolated chains.

J. Wyman, E. Antonini, C. Fronticelli, 1966, Journal of molecular biology.

Studies on acetylated human hemoglobin.

J. Wyman, E. Antonini, C. Fronticelli, 1963, Archives of biochemistry and biophysics.

Alpha-subunit oxidation in T-state crystals of a sebacyl cross-linked human hemoglobin with unusual autoxidation properties.

G. Gilliland, C. Fronticelli, E. Bucci, 1998, Biophysical chemistry.

Adenosine nucleotidases of human placenta.

C. Fronticelli, P. Cerletti, L. Zichella, 1960, Clinica chimica acta; international journal of clinical chemistry.

Conformation of the sebacyl β1Lys82–β2Lys82 crosslink in T‐state human hemoglobin

J. Moult, M. Braxenthaler, G. Gilliland, 1998 .

Specialized functional domains in hemoglobin: dimensions in solution of the apohemoglobin dimer labeled with fluorescein iodoacetamide.

C. Fronticelli, J. Liesegang, R. Steiner, 1984, Biochemistry.

Recombinant human hemoglobin: Expression and refolding of β-globin fromEscherichia coli

W. S. Brinigar, C. Fronticelli, J. K. O'donnell, 1991 .

A New Method for the Preparation of α and β Subunits of Human Hemoglobin

C. Fronticelli, E. Bucci, 1965 .

Approaches to the Engineering of Hemoglobin‐Based Oxygen Carriers

A. Bellelli, W. S. Brinigar, C. Fronticelli, 2004 .

The dissociation and recombination of subunits of human, horse, and canine hemoglobin.

J. Wyman, E. Antonini, C. Fronticelli, 1962, Journal of molecular biology.

of hemoglobin-based blood substitutes Model of nitric oxide diffusion in an arteriole: impact

A. Popel, N. Tsoukias, C. Fronticelli, 2005 .

Design of recombinant hemoglobins for use in transfusion fluids.

R. Koehler, C. Fronticelli, 2009, Critical care clinics.

Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacylhemoglobin.

J. H. Collins, R. Unger, J. Moult, 1996, Biochemistry.

Effect of intramolecular cross-links on the enthalpy and quaternary structure of the intermediates of oxygenation of human hemoglobin.

J. H. Collins, C. Fronticelli, Z. Gryczynski, 1993, Biochemistry.

Discontinuous release of heat at successive steps of oxygenation in human and bovine hemoglobin at pH 9.0.

C. Fronticelli, Z. Gryczynski, E. Bucci, 1991, Biochemistry.

Resolution of the lifetimes and correlation times of the intrinsic tryptophan fluorescence of human hemoglobin solutions using 2 GHz frequency-domain fluorometry.

J. Lakowicz, C. Fronticelli, I. Gryczynski, 1988, The Journal of biological chemistry.

Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted).

G. Gilliland, W. S. Brinigar, C. Fronticelli, 1994, The Journal of biological chemistry.

Solvent regulation of oxygen affinity in hemoglobin. Sensitivity of bovine hemoglobin to chloride ions.

C. Fronticelli, E. Bucci, C. Orth, 1984, The Journal of biological chemistry.

A possible new mechanism of oxygen affinity modulation in mammalian hemoglobins.

C. Fronticelli, 1990, Biophysical chemistry.

Allosteric Modulation by Tertiary Structure in Mammalian Hemoglobins

G. Pérez-Alvarado, W. S. Brinigar, C. Fronticelli, 1995, The Journal of Biological Chemistry.

RECOMBINANT HEMOGLOBINS FOR THE ELUCIDATION OF A NEW MECHANISM OF OXYGEN AFFINITY MODULATION BY CL − IONS

C. Fronticelli, 1992 .

Bovine hemoglobin pseudo-crosslinked with mono(3,5-dibromosalicyl)-fumarate.

C. Fronticelli, Z. Gryczynski, E. Bucci, 1990, European journal of biochemistry.

Effect of temperature on oxygen affinity and anion binding of bovine hemoglobin.

E. Di Cera, C. Fronticelli, Z. Gryczynski, 1990, Biophysical chemistry.

Modulation of oxygen affinity in hemoglobin by solvent components. Interaction of bovine hemoglobin with 2,3-diphosphoglycerate and monatomic anions.

C. Fronticelli, E. Bucci, A. Rażyńska, 1988, Journal of molecular biology.

Bovine hemoglobin as a potential source of hemoglobin-based oxygen carriers: crosslinking with bis(2,3-dibromosalycyl)fumarate.

C. Fronticelli, T. Sato, E. Bucci, 1986, Biochimica et biophysica acta.

Effect of disordered hemes on energy transfer rates between tryptophans and heme in myoglobin.

C. Fronticelli, Z. Gryczynski, Z Gryczynski, 1993, Biophysical journal.

Frequency domain lifetimes of liganded and unliganded hemoglobin measured with a 10-GHz instrument using front face geometry on a free liquid surface

Zygmunt Gryczynski, Joseph R. Lakowicz, Henryk M. Malak, 1990, Photonics West - Lasers and Applications in Science and Engineering.

Time-resolved emission spectra of hemoglobin on the picosecond time scale.

J. Lakowicz, C. Fronticelli, I. Gryczynski, 1988, Biophysical chemistry.

Introduction of a new regulatory mechanism into human hemoglobin.

W. S. Brinigar, C. Fronticelli, M. T. Sanna, 2002, Biophysical chemistry.

Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers.

R. Koehler, C. Fronticelli, E. Bucci, 2008, Biochimica et biophysica acta.

Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins.

G. Gilliland, C. Fronticelli, G. Vásquez, 1998, Acta crystallographica. Section D, Biological crystallography.

Cysteines β93 and β112 as Probes of Conformational and Functional Events at the Human Hemoglobin Subunit Interfaces

G. Gilliland, W. S. Brinigar, C. Fronticelli, 1999 .

Modification of α-Chain or β-Chain Heme Pocket Polarity by Val(E11) → Thr Substitution Has Different Effects on the Steric, Dynamic, and Functional Properties of Human Recombinant Hemoglobin

M. Leone, V. Militello, A. P. Koley, 1997, The Journal of Biological Chemistry.

Fluorescence studies of internal rotation in apohemoglobin α-chains

C. Fronticelli, R. Steiner, J. Otón, 1984 .

Molecular dynamics of hemoglobin subunits as seen by fluorescence spectroscopy.

C. Fronticelli, R. Steiner, J. Otón, 1981, The Journal of biological chemistry.

Some characteristics of the enzymic carboxyl activation of methionine.

C. Fronticelli, R. Rendi, A. Di Milia, 1958, Biochemical Journal.

Folding domains as functional tools in allosteric systems: a heme-dependent domain in hemoglobin beta subunits.

C. Fronticelli, D. Franchi, E Bucci, 1982, Biochemistry.

Modulation of calcium binding in sarcoplasmic reticulum adenosinetriphosphatase.

T. Watanabe, C. Fronticelli, R. Nakamoto, 1981, Biochemistry.

Oxidation rates and stability in solution of mono- and bivalently cross-linked human hemoglobin

R. Winslow, C. Fronticelli, D. Currell, 1991 .

Intravascular retention and renal handling of purified natural and intramolecularly cross-linked hemoglobins.

C. Fronticelli, E. Bucci, Q. Corteza, 1991, The Journal of laboratory and clinical medicine.

Conformational changes in the hemoglobin S system as seen by proton binding.

C. Fronticelli, E. Bucci, H. Scholberg, 1980, The Journal of biological chemistry.

Effect of disordered hemes and dimerization in isolated a-subunits of hemoglobin detected by time-resolved fluorescence spectroscopy in the picosecond range

Enrico Gratton, Zygmunt Gryczynski, Enrico Bucci, 1994, Photonics West - Lasers and Applications in Science and Engineering.

Properties of Human Hemoglobins with Increased Polarity in the α- or β-Heme Pocket

M. Leone, V. Militello, W. S. Brinigar, 1998, The Journal of Biological Chemistry.

Allosteric free energy changes at the alpha 1 beta 2 interface of human hemoglobin probed by proton exchange of Trp beta 37.

C. Fronticelli, M. Mihailescu, I. M. Russu, 2001, Proteins.

Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis (3,5-dibromosalicyl) fumarate or albumin.

C. Fronticelli, E. Bucci, B. Matheson-Urbaitis, 1995, The Journal of laboratory and clinical medicine.

Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.

K. Fidelis, J. Moult, G. Gilliland, 1996, Biochemistry.

Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces.

G. Gilliland, W. S. Brinigar, C. Fronticelli, 1999, Biophysical Journal.

Stabilization of the tetrameric structure of human and bovine hemoglobins by pseudocrosslinking with muconic acid.

J. H. Collins, C. Fronticelli, E. Bucci, 1996, Archives of Biochemistry and Biophysics.

The hemichromogen form of the isolated subunits of hemoglobin.

C. Fronticelli, E. Bucci, 1971, Biochimica et biophysica acta.

affinity and cooperativity on organ oxygen transport Theoretical analysis of effects of blood substitute

M. Leunig, C. Mazer, S. Takeoka, 2005 .

The properties and interactions of the isolated α and β chains of human haemoglobinI. Sedimentation and electrophoretic behaviour

J. Wyman, E. Chiancone, E. Antonini, 1965 .

Design, conformational, functional and physiological characterization of recombinant polymeric heme-proteins

R. Koehler, W. S. Brinigar, C. Fronticelli, 2006 .

Recombinant Hemoglobins as Artificial Oxygen Carriers

R. Koehler, W. S. Brinigar, C. Fronticelli, 2007, Artificial cells, blood substitutes, and immobilization biotechnology.

Fluorescence anisotropy decay studies upon hemoglobin A and its subunits

C. Fronticelli, R. Steiner, E. Bucci, 1979 .

Dynamic properties of some β‐chain mutant hemoglobins

M. Leone, V. Militello, W. S. Brinigar, 1995 .

Conformational properties of membrane-bound fumarate reductase of Escherichia coli.

C. Fronticelli, B. Rosen, E. Bucci, 1986, Archives of biochemistry and biophysics.