D. Middleton

发表

Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR

S. Baldwin, P. Henderson, S. G. Patching, 2008, Molecular membrane biology.

A Case History

David G. Reid, D. Middleton, L. K. MacLachlan, 1997 .

Apolipoprotein E‐derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

P. Sinnis, S. Neil, D. Middleton, 2007, The FEBS journal.

Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR.

D. Middleton, A. Watts, M. Esmann, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Labelling approaches for protein structural studies by solution-state and solid-state NMR

L. Lian, D. Middleton, 2001 .

Solid‐State NMR Spectroscopy in Drug Design and Discovery

S. G. Patching, D. Middleton, 2013 .

Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function.

D. Middleton, E. Hughes, Rachel Edwards, 2010, Biochemical and biophysical research communications.

Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample**

D. Middleton, I. Hamley, V. Castelletto, 2013, Angewandte Chemie.

Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction.

S. Radford, L. Serpell, P. Stockley, 2008, Journal of the American Chemical Society.

Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR.

Naomi E. Stanhope, D. Middleton, J. Griffin, 2019, Chemical communications.

Studies of the aggregation of an amyloidogenic α-synuclein peptide fragment

A. Doig, D. Middleton, A. Kitmitto, 2005 .

Novel stereoselective bufadienolides reveal new insights into the requirements for Na+, K+-ATPase inhibition by cardiotonic steroids

D. Middleton, R. Jiang, T. Chung, 2016, Scientific Reports.

Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.

D. Middleton, N. Fedosova, M. Esmann, 2015, Biochemistry.

Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

D. Middleton, J. Clayton, E. Hughes, 2009, Biochimica et biophysica acta.

Solid-state NMR and Functional Measurements Indicate That the Conserved Tyrosine Residues of Sarcolipin Are Involved Directly in the Inhibition of SERCA1*

D. Middleton, A. Kitmitto, J. Clayton, 2007, Journal of Biological Chemistry.

Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells

Lu Jin, C. Luo, D. Middleton, 2014, Natural product research.

The aggregation and membrane-binding properties of an α-synuclein peptide fragment

A. Doig, D. Middleton, J. Madine, 2004 .

A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers.

A. Doig, D. Middleton, J. Madine, 2006, Biochemistry.

Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

Geoffrey R Akien, S. Radford, D. Middleton, 2018, The Journal of Biological Chemistry.

Correlation between high‐field t2‐ weighted MR imaging and histology of ischemic lesions in gerbil brain

S. Rose, D. Doddrell, S. Crozier, 1995, Journal of magnetic resonance imaging : JMRI.

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

N. Fullwood, E. Yates, D. Middleton, 2020, Biochemistry.

Comparison of the Structure and Function of Phospholamban and the Arginine-14 Deficient Mutant Associated with Dilated Cardiomyopathy

D. Middleton, E. Hughes, 2014, PloS one.

Sensitive Morphological Characterization of Oriented High‐Density Lipoprotein Nanoparticles Using 31 P NMR Spectroscopy

D. Middleton, Sophie Lau, 2020, Angewandte Chemie.

Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011

Y. Li, S. Kitson, S. Baldwin, 2012 .

The conformation of an inhibitor bound to the gastric proton pump

David G. Reid, D. Middleton, A. Watts, 1997, FEBS letters.

Solid-state NMR spectroscopy detects interactions between tryptophan residues of the E. coli sugar transporter GalP and the alpha-anomer of the D-glucose substrate.

P. Henderson, S. G. Patching, D. Middleton, 2008, Journal of the American Chemical Society.

Substrate affinities for membrane transport proteins determined by 13C cross-polarization magic-angle spinning nuclear magnetic resonance spectroscopy.

P. Henderson, S. G. Patching, D. Middleton, 2004, Journal of the American Chemical Society.

Image directed proton spectroscopy of gerbil brain at 7 Tesla

S. Rose, D. Doddrell, P. Hockings, 1995, NMR in biomedicine.

Raman spectroscopy with 2D perturbation correlation moving windows for the characterisation of heparin-amyloid interactions.

D. Middleton, L. Ashton, David Townsend, 2020, Analytical chemistry.

Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils.

D. Middleton, 2007, Biochemical Society transactions.

The economical synthesis of [2'-(13)C, 1,3-(15)N2]uridine; preliminary conformational studies by solid state NMR.

P. Henderson, S. G. Patching, D. Middleton, 2003, Organic & biomolecular chemistry.

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils.

Geoffrey R Akien, S. Radford, S. Hung, 2016, Journal of the American Chemical Society.

Insights into the interactions between a drug and a membrane protein target by fluorine cross‐polarization magic angle spinning NMR

D. Middleton, Martin P Boland, 2004, Magnetic resonance in chemistry : MRC.

The conformation of ATP within the Na,K-ATPase nucleotide site: a statistically constrained analysis of REDOR solid-state NMR data.

D. Middleton, M. Esmann, E. Hughes, 2011, Angewandte Chemie.

Detection of nucleotide binding to Na,K‐ATPase in an aqueous membrane suspension by 13C cross‐polarization magic‐angle spinning NMR spectroscopy

D. Middleton, M. Esmann, Louise Odgaard Jakobsen, 2006, FEBS letters.

REDOR NMR on a hydrophobic peptide in oriented membranes.

D. Middleton, A. Watts, C. Glaubitz, 2000, Journal of magnetic resonance.

The conformations of a functional spin-labeled derivative of gastric H/K-ATPase investigated by EPR spectroscopy.

D. Middleton, A. Watts, D. Reid, 1995, Biochemistry.

Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR.

A. Doig, D. Middleton, J. Madine, 2008, Journal of the American Chemical Society.

Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks.

D. Middleton, I. Hamley, J. Madine, 2012, Chemical communications.

Structures, chemotaxonomic significance, cytotoxic and Na(+),K(+)-ATPase inhibitory activities of new cardenolides from Asclepias curassavica.

D. Middleton, W. Ye, Ya-Fang Tan, 2014, Organic & biomolecular chemistry.

Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues

L. Lian, D. Middleton, J. Madine, 2008, Molecular membrane biology.

A Model of Reversible Inhibitors in the Gastric H+/K+-ATPase Binding Site Determined by Rotational Echo Double Resonance NMR*

D. Middleton, A. Watts, Jude A. Watts, 2001, The Journal of Biological Chemistry.

Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H–19F dipolar couplings† †Electronic supplementary information (ESI) available. CCDC 1584785. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8cp01064a

D. Middleton, J. Griffin, M. Coogan, 2018, Physical chemistry chemical physics : PCCP.

Probing the structure of a potent acetylcholinesterase inhibitor in the binding site using solid state nuclear magnetic resonance.

D. Middleton, A. Watts, P. Howe, 2002 .

Inhibitors of protein aggregation and toxicity.

A. Doig, D. Middleton, J. Madine, 2009, Biochemical Society transactions.

A solid-state NMR study of the phospholamban transmembrane domain: local structure and interactions with Ca2+-ATPase

D. Middleton, A. Watts, Z. Ahmed, 2000 .

Membrane protein structure: the contribution and potential of novel solid state NMR approaches.

D. Middleton, A. Watts, A. Ulrich, 1995, Molecular membrane biology.

Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

S. Radford, E. Yates, D. Middleton, 2017, Journal of molecular biology.

Membrane protein structure determination by solid state NMR.

D. Middleton, A. Watts, C. Glaubitz, 1999, Natural product reports.

Heparin and Methionine Oxidation Promote the Formation of Apolipoprotein A-I Amyloid Comprising α-Helical and β-Sheet Structures.

D. Middleton, G. Siligardi, R. Hussain, 2017, Biochemistry.

A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain.

D. Middleton, I. Barsukov, M. Esmann, 2011, Biochimica et biophysica acta.

Solid‐state NMR detection of 14N13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architecture

D. Middleton, 2011, Magnetic resonance in chemistry : MRC.

Solid-state NMR Reveals Structural Changes in Phospholamban Accompanying the Functional Regulation of Ca2+-ATPase*

D. Middleton, E. Hughes, 2003, Journal of Biological Chemistry.

The cytoplasmic domains of phospholamban and phospholemman associate with phospholipid membrane surfaces.

D. Middleton, J. Clayton, E. Hughes, 2005, Biochemistry.

The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR.

D. Middleton, Martin P. Boland, 2008, Physical chemistry chemical physics : PCCP.

Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity.

D. Middleton, J. Madine, E. Hughes, 2013, Biochemistry.

Nuclear Magnetic Resonance (NMR) of Proteins: Solid State

D. Middleton, 2012 .

Crystallography and NMR: Applications to Structural Biology

D. Middleton, 2009 .

NMR Methods for Characterising Ligand-Receptor and Drug–Membrane Interactions in Pharmaceutical Research

D. Middleton, David A. Middleton, 2006 .

Spectroscopic studies of phospholamban variants in phospholipid bilayers.

D. Middleton, J. Clayton, E. Hughes, 2005, Biochemical Society transactions.

Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.

E. Yates, D. Middleton, J. Madine, 2009, Organic & biomolecular chemistry.

Structural descriptions of ligands in their binding site of integral membrane proteins at near physiological conditions using solid-state NMR

D. Middleton, A. Watts, C. Glaubitz, 1998, European Biophysics Journal.

The effect of sample freezing on proton magic‐angle spinning NMR spectra of biological tissue

D. Middleton, S. Connor, P. Mullins, 1998, Magnetic resonance in medicine.

Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site.

D. Middleton, J. Madine, Rachel Edwards, 2010, Physical chemistry chemical physics : PCCP.

Solid-state NMR measurements of the kinetics of the interaction between phospholamban and Ca2 + -ATPase in lipid bilayers

D. Middleton, E. Hughes, 2005, Molecular membrane biology.

The effects of α-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

Jillian Madine, A. Doig, D. Middleton, 2008, Molecular membrane biology.

The organization of aromatic side groups in an amyloid fibril probed by solid-state 2H and 19F NMR spectroscopy.

S. Radford, P. Stockley, D. Middleton, 2006, Journal of the American Chemical Society.

Sensitive Morphological Characterization of Oriented High‐Density Lipoprotein Nanoparticles Using 31P NMR Spectroscopy

D. Middleton, Sophie Lau, 2020, Angewandte Chemie.

Evaluation of β‐Alanine‐ and GABA‐Substituted Peptides as Inhibitors of Disease‐Linked Protein Aggregation

David R. Brown, D. Middleton, J. Madine, 2009, Chembiochem : a European journal of chemical biology.

Conformational analysis by solid-state NMR and its application to restrained structure determination from powder diffraction data.

A. Markvardsen, K. Shankland, W. David, 2002, Chemical communications.

Labeling Approaches for Protein Structural Studies by Solution‐State and Solid‐State NMR

L. Lian, D. Middleton, 2002 .

Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structure.

Martin Volk, Raphaël Lévy, D. Middleton, 2012, ACS nano.

Molecular Conformations of the Polymorphic Forms of Cimetidine from 13C Solid-State NMR Distance and Angle Measurements

D. Middleton, C. S. L. Duff, D. Saunders, 2000 .

A cross-polarization magic-angle spinning 13C NMR characterization of the stable solid-state forms of cimetidine.

D. Middleton, D. Reid, C. L. Le Duff, 1997, Journal of pharmaceutical sciences.

Comparisons with Amyloid-β Reveal an Aspartate Residue That Stabilizes Fibrils of the Aortic Amyloid Peptide Medin

D. Middleton, J. Madine, H. Davies, 2015, The Journal of Biological Chemistry.

Expression and purification of the aortic amyloid polypeptide medin.

D. Middleton, M. Wilkinson, Hannah A Davies, 2014, Protein expression and purification.

Solid‐state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

D. Middleton, J. Madine, Hannah A Davies, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

D. Middleton, J. Madine, 2010, European Biophysics Journal.

Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro.

N. Fullwood, D. Middleton, G. Siligardi, 2020, ACS chemical neuroscience.

Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR.

S. Radford, D. Middleton, J. Griffin, 2018, The journal of physical chemistry letters.

Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction.

S. Radford, L. Serpell, P. Stockley, 2008, Journal of the American Chemical Society.

Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample**

D. Middleton, I. Hamley, V. Castelletto, 2013, Angewandte Chemie.

Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.

D. Middleton, N. Fedosova, M. Esmann, 2015, Biochemistry.

Combined quantitative and mechanistic study of drug-membrane interactions using a novel 2H NMR approach.

D. Middleton, A. Watts, D. Reid, 2004, Journal of pharmaceutical sciences.

An NMR strategy for obtaining multiple conformational constraints for 15N-13C spin-pair labelled organic solids.

D. Middleton, J. Madine, 2006, Physical chemistry chemical physics : PCCP.

Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function.

D. Middleton, E. Hughes, Rachel Edwards, 2010, Biochemical and biophysical research communications.

Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements.

L. Serpell, D. Middleton, J. Madine, 2009, Biochemistry.

Site-Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid-State NMR Spectroscopy**

S. Radford, E. Yates, D. Middleton, 2012, Angewandte Chemie.

Probing the oligomeric state of phospholamban variants in phospholipid bilayers from solid-state NMR measurements of rotational diffusion rates.

D. Middleton, J. Clayton, E. Hughes, 2005, Biochemistry.