P. McMullen

发表

Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

Melvin E. Andersen, Patrick D. McMullen, Sudin Bhattacharya, 2012, Archives of Toxicology.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

Melvin E. Andersen, Sudin Bhattacharya, Brett A. Howell, 2012, Front. Physio..

PLETHEM – An interactive open-source platform for bridging the source-to-outcome continuum

H. Clewell, R. Clewell, P. McMullen, 2017 .

The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.

Chantel I. Nicolas, M. Andersen, K. Mansouri, 2019, Toxicology and applied pharmacology.

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.

Michael B. Black, M. Andersen, K. Mansouri, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

Chantel I. Nicolas, H. Clewell, R. Clewell, 2022, Frontiers in Toxicology.

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2017, Toxicology and Applied Pharmacology.

Case Studies in Cellular Stress: Defining Adversity/Adaptation Tipping Points

Yeyejide A. Adeleye, Russell S. Thomas, I. Shah, 2017 .

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Rick A. Fasani, A. Fornace, Alexandra Maertens, 2016, Archives of Toxicology.

A toxicogenomic approach for the risk assessment of the food contaminant acetamide

Michael B. Black, M. Andersen, T. Zacharewski, 2019, Toxicology and Applied Pharmacology.

Beyond Pharmaceuticals: Fit-for-Purpose New Approach Methodologies for Environmental Cardiotoxicity Testing

P. McMullen, Mark C. Daley, Bum-Rak Choi, 2022, ALTEX.

A Systematic Approach to Evaluate Plausible Modes of Actions for Mouse Lung Tumors in Mice Exposed to 4-Methylimidozole.

Michael B. Black, M. Andersen, P. McMullen, 2021, Regulatory toxicology and pharmacology : RTP.

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

R. Morimoto, P. McMullen, Daniel M. Czyz, 2013, PLoS genetics.

Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System

Michael B. Black, Bethany B. Parks, E. Berg, 2019 .

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

Chantel I. Nicolas, G. Patlewicz, M. Andersen, 2022, Frontiers in Pharmacology.

Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

M. Andersen, S. Bhattacharya, P. McMullen, 2012, Archives of Toxicology.

Michael B. Black, M. Andersen, P. McMullen, 2018, Regulatory toxicology and pharmacology : RTP.

Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1‐day and multi‐week exposures

Michael B. Black, M. Andersen, P. McMullen, 2017, Toxicology and applied pharmacology.

A map of the PPARα transcription regulatory network for primary human hepatocytes.

Melvin E Andersen, Rebecca A Clewell, Sudin Bhattacharya, 2014, Chemico-biological interactions.

Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling

Harvey J. Clewell, Patrick D. McMullen, Miyoung Yoon, 2020 .

Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology.

Michael B. Black, P. McMullen, Jessica K. Hartman, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

Melvin E. Andersen, Patrick D. McMullen, Saad Haider, 2018, Front. Pharmacol..

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2017, Critical reviews in toxicology.

Application of transcriptomic data, visualization tools and bioinformatics resources for informing mode of action

Melvin E. Andersen, Michael B. Black, Patrick D. McMullen, 2018, Current Opinion in Toxicology.

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).

Harvey J Clewell, Melvin E Andersen, Patrick D McMullen, 2019, ALTEX.

Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress

Patrick D. McMullen, Erin Z. Aprison, Peter B. Winter, 2012, PLoS Comput. Biol..

NAM-based Prediction of Point-of-contact Toxicity in the Lung: A Case Example With 1,3-dichloropropene.

Aarati R. Ranade, M. Andersen, P. McMullen, 2022, Toxicology.

Pathway Based Toxicology and Fit-for-Purpose Assays.

Melvin E Andersen, Rebecca A Clewell, Yeyejide Adeleye, 2016, Advances in experimental medicine and biology.

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells

Michael B. Black, Russell S. Thomas, L. Pluta, 2014, PloS one.

The Human Toxome Project

Melvin E Andersen, Alexandra Maertens, Thomas Hartung, 2015, ALTEX.

Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis

Miyoung Yoon, Bethany B. Parks, Briana Foley, 2018, Toxicology and applied pharmacology.

The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium

Melvin E. Andersen, Patrick D. McMullen, Thomas Hartung, 2016, Front. Pharmacol..

Developing tools for defining and establishing pathways of toxicity

D. Krewski, M. Andersen, P. McMullen, 2015, Archives of Toxicology.

Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens.

Michael B. Black, M. Andersen, P. McMullen, 2015, Regulatory toxicology and pharmacology : RTP.

Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity

Michael B. Black, Aarati R. Ranade, M. Andersen, 2022, International journal of toxicology.

Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

Harvey J Clewell, Melvin E Andersen, Martin B Phillips, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Harvey J Clewell, Melvin E Andersen, Salil N Pendse, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Physically grounded approach for estimating gene expression from microarray data

Patrick D McMullen, R. Morimoto, L. Amaral, 2010, Proceedings of the National Academy of Sciences.

Assessing the basal gene expression of cancer cell lines for in vitro transcriptomic toxicology screening

Michael B. Black, P. McMullen, A. R. Barutcu, 2023, bioRxiv.

The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations

Melvin E. Andersen, Harvey J. Clewell, Patrick D. McMullen, 2020 .

RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days

Michael B. Black, M. Andersen, P. McMullen, 2021, Data in brief.