T. Fukushima

发表

Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and Metabolic Actions

T. Uchida, T. Asano, H. Kurihara, 2013, The Journal of Biological Chemistry.

The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors

M. Komada, Akinori Endo, T. Fukushima, 2019, Journal of Cell Science.

Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.

M. Komada, Toshiaki Tanaka, Y. Inagaki, 2016, The American journal of pathology.

Glucose deprivation attenuates sortilin levels in skeletal muscle cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2017, Endocrine journal.

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines

T. Asano, H. Sakoda, M. Fujishiro, 2015, PloS one.

Resistin-Like Molecule &bgr; Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development

H. Aburatani, Koichi Nishiyama, T. Asano, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling.

F. Hakuno, L. Girnita, T. Fukushima, 2016, Progress in molecular biology and translational science.

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

F. Hakuno, Shin-ichiro Takahashi, T. Fukushima, 2015, Front. Endocrinol..

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Y. Saeki, Keiji Tanaka, T. Asano, 2015, Nature Communications.

Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.

D. Dunger, K. Siddle, H. Firth, 2003, The Journal of clinical endocrinology and metabolism.

4F2hc stabilizes GLUT1 protein and increases glucose transport activity.

T. Asano, H. Kurihara, H. Katagiri, 2011, American journal of physiology. Cell physiology.

Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation

M. Komada, Akinori Endo, Beni Lestari, 2022, Molecular biology and evolution.

Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity*

T. Uchida, N. Horike, T. Asano, 2010, The Journal of Biological Chemistry.

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic 1 steatohepatitis in a rodent model 2 3 1

T. Asano, H. Sakoda, M. Fujishiro, 2015 .

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice

T. Inaba, T. Asano, H. Katagiri, 2016, Scientific Reports.

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

T. Asano, H. Sakoda, M. Fujishiro, 2015, American journal of physiology. Endocrinology and metabolism.

Metabolic Control By Inflammation and Immunity DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages , adipocytes , and mouse livers by suppressing NF-B activation

T. Asano, H. Sakoda, M. Fujishiro, 2015 .

Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation*

T. Asano, F. Hakuno, Shin-ichiro Takahashi, 2012, The Journal of Biological Chemistry.

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.

T. Asano, H. Sakoda, M. Fujishiro, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice

T. Asano, H. Sakoda, M. Fujishiro, 2017, International journal of molecular sciences.

Insulin receptor substrate‐1 (IRS‐1) forms a ribonucleoprotein complex associated with polysomes

T. Asano, N. Kataoka, F. Hakuno, 2013, FEBS letters.

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

M. Komada, Akinori Endo, Toshiaki Tanaka, 2018, Biochemical and biophysical research communications.

Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities

M. Komada, Akinori Endo, S. Matsumoto, 2018, Journal of Cell Science.

IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

M. Komada, T. Asano, N. Kataoka, 2018, Oncotarget.

Paraquat-induced Oxidative Stress Represses Phosphatidylinositol 3-Kinase Activities Leading to Impaired Glucose Uptake in 3T3-L1 Adipocytes*

T. Asano, F. Hakuno, Shin-ichiro Takahashi, 2010, The Journal of Biological Chemistry.

Novel missense mutation in the IGF‐I receptor L2 domain results in intrauterine and postnatal growth retardation

K. Higaki, F. Hakuno, Shin-ichiro Takahashi, 2012, Clinical endocrinology.

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

M. Komada, T. Asano, T. Natsume, 2017, Biochemical and biophysical research communications.

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

Shin-ichiro Takahashi, M. Ariga, T. Fukushima, 2011, Molecular and Cellular Endocrinology.

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2008, Endocrinology.

Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells.

Y. Ito, F. Hakuno, Shin-ichiro Takahashi, 2001, Biochimica et biophysica acta.

Biosynthesis from gluconate of a random copolyester consisting of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by Pseudomonas sp. 61-3.

T. Fukushima, H. Abe, Y. Doi, 1994, International journal of biological macromolecules.

Isolation and preparation of pterins from biological materials.

T. Fukushima, 1980, Methods in enzymology.

Insulin Receptor Substrate-1 Associates with Small Nucleolar RNA Which Contributes to Ribosome Biogenesis

T. Asano, N. Kataoka, F. Hakuno, 2014, Front. Endocrinol..

Placental mammals acquired the functional region and domain in NRK for regulating the CK2-PTEN-AKT pathway and placental cell proliferation

M. Komada, Akinori Endo, Beni Lestari, 2021, bioRxiv.

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice

T. Asano, H. Sakoda, M. Fujishiro, 2013, Adipocyte.

Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model*

T. Uchida, T. Inaba, T. Asano, 2012, The Journal of Biological Chemistry.

Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.

I. Hisatome, Shin-ichiro Takahashi, E. Nanba, 2005, The Journal of clinical endocrinology and metabolism.

Interactive roles of gut microbiota and gastrointestinal motility in the development of inflammatory disorders

T. Asano, H. Sakoda, M. Fujishiro, 2015 .

Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.

T. Asano, H. Sakoda, M. Fujishiro, 2013, American journal of physiology. Gastrointestinal and liver physiology.

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

T. Asano, Shin-ichiro Takahashi, H. Sakoda, 2015, Mediators of inflammation.

RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development

W. H. Chan, M. Komada, M. Wakefield, 2019, Scientific Reports.

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Y. Saeki, Keiji Tanaka, T. Asano, 2012, Biochemical and biophysical research communications.

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.

I. Komuro, T. Asano, H. Kurihara, 2012, American journal of physiology. Endocrinology and metabolism.

Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis

T. Uchida, N. Horike, T. Asano, 2011, The Journal of Biological Chemistry.

M. Komada, Akinori Endo, T. Fukushima, 2020, FEBS letters.

Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development

T. Asano, H. Kurihara, H. Sakoda, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit*

H. Kiyonari, T. Uchida, T. Asano, 2015, The Journal of Biological Chemistry.

Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

M. Komada, A. Kidera, Akinori Endo, 2021, Communications Biology.

Familial short stature is associated with a novel dominant‐negative heterozygous insulin‐like growth factor 1 receptor (IGF1R) mutation

F. Hakuno, Shin-ichiro Takahashi, T. Fukushima, 2014, Clinical endocrinology.

Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.

F. Hakuno, Shin-ichiro Takahashi, T. Nedachi, 2012, Molecular endocrinology.

Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection

Beni Lestari, K. Shiraki, K. Kinbara, 2023, Analytical chemistry.

RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development

W. H. Chan, M. Komada, M. Wakefield, 2019, Scientific Reports.

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.

T. Asano, H. Sakoda, M. Fujishiro, 2015, American journal of physiology. Gastrointestinal and liver physiology.

4F2hc stabilizes GLUT1 protein and increases glucose transport activity.

T. Asano, H. Kurihara, H. Katagiri, 2011, American journal of physiology. Cell physiology.

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Y. Saeki, Keiji Tanaka, T. Asano, 2015, Nature Communications.

Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit*

H. Kiyonari, T. Uchida, T. Asano, 2015, The Journal of Biological Chemistry.

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

M. Komada, Akinori Endo, Toshiaki Tanaka, 2018, Biochemical and biophysical research communications.

Integrator complex plays an essential role in adipose differentiation.

T. Asano, Shin-ichiro Takahashi, H. Katagiri, 2013, Biochemical and biophysical research communications.