S. Cushman

发表

transfected rat adipose cells. ras in regulating translocation of GLUT4 in Roles of 1-phosphatidylinositol 3-kinase and

M. Kasuga, Hui Chen, M. Quon, 2013 .

Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle.

S. Cushman, J. Brozinick, D. Dean, 1998, American journal of physiology. Endocrinology and metabolism.

Molecular mechanisms involved in GLUT4 translocation in muscle during insulin and contraction stimulation.

A. Klip, L. Goodyear, E. Ralston, 1998, Advances in experimental medicine and biology.

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

M. Kasuga, M. Quon, S. Taylor, 1995, Molecular and cellular biology.

Adiponectin gene activation by thiazolidinediones requires PPARγ2, but not C/EBPα—evidence for differential regulation of the aP2 and adiponectin genes

Maia M. Jack, U. Smith, S. Cushman, 2003 .

Insulin Stimulates Translocation of Human GLUT4 to the Membrane in Fat Bodies of Transgenic Drosophila melanogaster

L. Pick, J. Zimmerberg, S. Cushman, 2013, PloS one.

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

S. Cushman, L. J. Wardzala, L. Wardzala, 1980, The Journal of biological chemistry.

Insulin-regulated trafficking of dual-labeled glucose transporter 4 in primary rat adipose cells.

D. Malide, K. Dawson, S. Cushman, 2001, Biochemical and biophysical research communications.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF.

C. Hinck, S. Cushman, H. Al-Hasani, 2005, Biochemical and biophysical research communications.

Summary Activity , phosphorylation state and subcellular distribution of GLUT 4-targeted Akt 2 in rat adipose cells

U. Smith, S. Cushman, H. Al-Hasani, 2003 .

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

I. Simpson, S. Cushman, G. Holman, 1990, The Journal of biological chemistry.

Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

A. Butte, M. Quon, S. Taylor, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin‐responsive cells

S. Cushman, G. Holman, 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.

Morphological effects of wortmannin on the endosomal system and GLUT4-containing compartments in rat adipose cells.

D. Malide, S. Cushman, Samuel W. Cushman, 1997, Journal of cell science.

Endocytosis of the Glucose Transporter GLUT4 Is Mediated by the GTPase Dynamin*

C. Hinck, S. Cushman, H. Al-Hasani, 1998, The Journal of Biological Chemistry.

Tankyrase 1 and Tankyrase 2 Are Essential but Redundant for Mouse Embryonic Development

L. Tessarollo, S. Cushman, R. Hodes, 2008, PloS one.

GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure.

T. Reynolds, S. Cushman, J. Brozinick, 2001, Diabetes.

SUMMARY Demonstration of insulin-responsive trafficking of GLUT 4 and vpTR in fibroblasts

A. Racz, M. Lampson, S. Cushman, 2000 .

Cell-associated fatty acid levels and energy-requiring processes in mouse adipocytes.

S. Cushman, J. Heindel, B. Jeanrenaud, 1974, The American journal of physiology.

In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans1

C. Lamendola, T. McLaughlin, S. Cushman, 2015, Journal of Lipid Research.

Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats.

E. Horton, M. Hirshman, S. Cushman, 1985, The Journal of clinical investigation.

Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.

S. Cushman, L. J. Wardzala, L. Salans, 1978, The Journal of biological chemistry.

BMI and waist circumference cut-offs for corresponding levels of insulin sensitivity in a Middle Eastern immigrant versus a native Swedish population – the MEDIM population based study

S. Cushman, K. Stenkula, K. Brismar, 2016, BMC Public Health.

Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.

J. Flier, B. Kahn, S. Cushman, 1989, The Journal of clinical investigation.

Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size.

E. A. Sims, G. Bray, E. Horton, 1974, The Journal of clinical investigation.

Insulin-stimulated glucose transport in rat adipose cells. Modulation of transporter intrinsic activity by isoproterenol and adenosine.

H. Joost, I. Simpson, S. Cushman, 1986, The Journal of biological chemistry.

Alterations in glucose metabolism and its stimulation by insulin in isolated adipose cells during the development of genetic obesity in the Zucker fatty rat.

S. Cushman, M. Zarnowski, A. Franzusoff, 1978, Metabolism: clinical and experimental.

Mechanism for markedly hyperresponsive insulin-stimulated glucose transport activity in adipose cells from insulin-treated streptozotocin diabetic rats. Evidence for increased glucose transporter intrinsic activity.

B. Kahn, S. Cushman, 1987, The Journal of biological chemistry.

Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance.

D. Bernlohr, S. Cushman, Xiaoli Chen, 2007, American journal of physiology. Endocrinology and metabolism.

Insulin Regulates Fusion of GLUT4 Vesicles Independent of Exo70-mediated Tethering*

J. Zimmerberg, S. Cushman, K. Stenkula, 2009, Journal of Biological Chemistry.

Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools.

L. Lo Leggio, L. Leggio, S. Cushman, 1994, The Journal of biological chemistry.

Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine.

S. Vannucci, I. Simpson, S. Satoh, 1992, The Biochemical journal.

Insulin stimulates both leptin secretion and production by rat white adipose tissue.

V. Barr, D. Malide, S. Taylor, 1997, Endocrinology.

Quantitative proteomic analysis of the secretory proteins from rat adipose cells using a 2D liquid chromatography-MS/MS approach.

L. Pannell, S. Cushman, S. Hess, 2005, Journal of proteome research.

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes

G. Shulman, S. Caprio, R. Kursawe, 2013, Diabetes.

A Possible Mechanism of Insulin Resistance in the Rat Adipose Cell with High-Fat/Low-Carbohydrate Feeding: Depletion of Intracellular Glucose Transport Systems

I. Simpson, S. Cushman, E. Karnieli, 1982, Diabetes.

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice.

C. Wilson, J. Ivy, S. Cushman, 1996, The Biochemical journal.

Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

Richard T. Lee, G. Shulman, P. Patwari, 2010, Diabetes.

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.

A. Butte, M. Quon, G. Sesti, 1994, The Journal of biological chemistry.

Adipose tissue macrophages impair preadipocyte differentiation in humans

T. McLaughlin, E. Engleman, H. Rivas, 2017, PloS one.

A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems.

I. Simpson, S. Cushman, E. Karnieli, 1981, The Journal of clinical investigation.

Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity.

I. Simpson, B. Kahn, S. Cushman, 1988, The Journal of clinical investigation.

Role of SNARE's in the GLUT4 Translocation Response to Insulin in Adipose Cells and Muscle

S. Cushman, J. St-Denis, 1998, Journal of basic and clinical physiology and pharmacology.

Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats.

H. Lodish, J. Flier, B. Kahn, 1989, The Journal of clinical investigation.

Short-term exercise enhances insulin-stimulated GLUT-4 translocation and glucose transport in adipose cells.

T. Reynolds, S. Cushman, M. Zarnowski, 1998, Journal of applied physiology.

Effects of fluorescein isothiocyanate on insulin actions in rat adipocytes.

I. Simpson, S. Cushman, Y. Sumida, 1992, Archives of biochemistry and biophysics.

Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins.

I. Simpson, S. Cushman, C. Londos, 1992, Cellular signalling.

Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus

B. Kahn, S. Cushman, 1989 .

Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool.

E. Horton, B. Kahn, S. Cushman, 1987, Journal of Clinical Investigation.

Chapter 11 Regulation of Glucose Transporter and Hormone Receptor Cycling by Insulin in the Rat Adipose Cell

I. Simpson, S. Cushman, 1985 .

Mechanism of insulin's stimulatory action on glucose transport in the isolated rat adipose cell.

S. Cushman, U. Smith, E. Karnieli, 1985, Society of General Physiologists series.

Hexose Transport Regulation by Insulin in the Isolated Rat Adipose Cell

I. Simpson, S. Cushman, 1985 .

Insulin-induced Internalization of the Insulin Receptor in the Isolated Rat Adipose Cell: Detection of Both Major Receptor Subunits Following Their Biosynthetic Labeling in Culture

I. Simpson, S. Cushman, J. A. Hedo, 1984, Diabetes.

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions.

I. Simpson, S. Cushman, E. Karnieli, 1983, Biochimica et biophysica acta.

Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat.

I. Simpson, S. Cushman, E. Karnieli, 1982, The Journal of clinical investigation.

Cell-associated nonesterified fatty acid levels and their alteration during lipolysis in the isolated mouse adipose cell.

S. Cushman, J. Heindel, B. Jeanrenaud, 1973, Journal of lipid research.

A biological activity of the A-chain of insulin and the inactivity of a synthetic analogue containing an intact intrachain disulfide bridge.

S. Cushman, A. Marglin, 1967, Biochemical and biophysical research communications.

DEPLETION OF INTRACELLULAR GLUCOSE TRANSPORT SYSTEMS

I. Simpson, S. Cushman, E. Karnieli, 2022 .

Biochemical and functional heterogeneity of rat adipocyte glucose transporters.

J. Olefsky, I. Simpson, S. Cushman, 1986, The Journal of biological chemistry.

Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin.

S. Cushman, M. Zarnowski, M. Omatsu-Kanbe, 1996, The Biochemical journal.

Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters.

S. Satoh, Y. Minokoshi, S. Cushman, 1998, The Biochemical journal.

Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells.

S. Cushman, L. Salans, 1978, Journal of lipid research.

Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes.

U. Smith, S. Cushman, B. Gustafson, 2003, Biochemical and biophysical research communications.

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.

R. Russell, Ji Li, L. Young, 2004, American journal of physiology. Endocrinology and metabolism.

Body Composition, Adipocyte Size, Free Fatty Acid Concentration, and Glucose Tolerance in Children of Diabetic Pregnancies

B. Howard, P. Bennett, G. Reaven, 1986, Diabetes.

Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women

P. Tsao, T. McLaughlin, C. Lamendola, 2009, Obesity surgery.

Disrupted erythropoietin signaling promotes obesity and alters hypothalamus proopiomelanocortin production

O. Gavrilova, Masayuki Yamamoto, S. Cushman, 2011, Nature communications.

Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane.

M. Rechler, I. Simpson, S. Cushman, 1984, The Journal of biological chemistry.

Effects of dietary composition on glucose metabolism in rat adipose cells.

S. Cushman, J. Foley, L. J. Wardzala, 1981, The American journal of physiology.

Glucose transport in isolated rat adipocytes with measurements of L-arabinose uptake.

S. Cushman, J. Foley, L. Salans, 1978, The American journal of physiology.

Intracellular glucose concentration in small and large rat adipose cells.

S. Cushman, J. Foley, L. Salans, 1980, The American journal of physiology.

Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training.

T. Reynolds, S. Cushman, J. Brozinick, 2000, Journal of applied physiology.

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen.

T. Reynolds, S. Cushman, J. Brozinick, 1998, The American journal of physiology.

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen.

T. Reynolds, S. Cushman, J. Brozinick, 1998, American journal of physiology. Endocrinology and metabolism.

Effects of exercise training on glucose transport and cell surface GLUT-4 in isolated rat epitrochlearis muscle.

T. Reynolds, S. Cushman, J. Brozinick, 1997, The American journal of physiology.

Glucose transporter localization in rat skeletal muscle

C. Wilson, G. Dohm, S. Cushman, 1994, FEBS letters.

Development of an intracellular pool of glucose transporters in 3T3-L1 cells.

S. Cushman, G. Holman, Jing Yang, 1992, The Journal of biological chemistry.

Cell Biology of Insulin's Stimulatory Action on Glucose Transport and Its Perturbation in Altered Metabolic States

B. Kahn, S. Cushman, 1986, Annals of the New York Academy of Sciences.

Inhibition of internalization of glucose transporters and IGF-II receptors. Mechanism of action of MHC class I-derived peptides which augment the insulin response in rat adipose cells.

S. Satoh, S. Cushman, G. Holman, 1993, The Journal of biological chemistry.

Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter.

T. J. Wheeler, I. Simpson, S. Cushman, 1982, Biochemical and biophysical research communications.

Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin.

I. Simpson, S. Cushman, J. A. Hedo, 1983, The Journal of biological chemistry.

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

Samuel W. Cushman, Arthur Sherman, Sonia Caprio, 2010, Diabetes.

1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.

T. Reynolds, S. Cushman, J. Brozinick, 1999, The Biochemical journal.

Low density lipoprotein receptors in rat adipose cells: subcellular localization and regulation by insulin.

I. Simpson, S. Cushman, F. Kraemer, 1994, Journal of lipid research.

Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface.

C. Wilson, J. Ivy, S. Cushman, 1997, The American journal of physiology.

Role of Insulin Receptor Substrate-1 and pp60 in the Regulation of Insulin-induced Glucose Transport and GLUT4 Translocation in Primary Adipocytes*

Y. Yazaki, T. Kadowaki, T. Yamauchi, 1997, The Journal of Biological Chemistry.

Evidence for the regulatory role of lipocalin 2 in high-fat diet-induced adipose tissue remodeling in male mice.

M. Bazuine, S. Cushman, Xiaoli Chen, 2013, Endocrinology.

Thyroid hormone increases the partitioning of glucose transporters to the plasma membrane in ARL 15 cells.

C. Wilson, S. Cushman, S. Weinstein, 1995, The American journal of physiology.

Hormonal regulation of mammalian glucose transport.

I. Simpson, S. Cushman, 1986, Annual review of biochemistry.

Hypertrophy-driven adipocyte death overwhelms recruitment under prolonged weight gain.

V. Periwal, Juen Guo, K. Hall, 2010, Biophysical journal.

Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states.

B. Kahn, S. Cushman, 1985, Diabetes/metabolism reviews.

Identification and characterization of the rat adipocyte glucose transporter by photoaffinity crosslinking

I. Simpson, S. Cushman, R. Horuk, 1983, FEBS letters.

Insulin-induced translocation of intracellular glucose transporters in the isolated rat adipose cell.

T. J. Wheeler, I. Simpson, S. Cushman, 1984, Federation proceedings.

Proposed mechanism of insulin-resistant glucose transport in the isolated guinea pig adipocyte. Small intracellular pool of glucose transporters.

S. Cushman, R. Horuk, L. J. Wardzala, 1983, The Journal of biological chemistry.

Differential Effects of Thiazolidinediones on Adipocyte Growth and Recruitment in Zucker Fatty Rats

V. Periwal, S. Cushman, Jennifer MacKellar, 2009, PloS one.

Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.

S. Cushman, M. Bennett, G. Holman, 1996, The Biochemical journal.

Insulinomimetic effect on glucose transport by epidermal growth factor when combined with a major histocompatibility complex class I-derived peptide.

S. Satoh, S. Cushman, S. Ziebe, 1993, The Journal of biological chemistry.

Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells.

A. Schürmann, H. Joost, S. Cushman, 2001, The Biochemical journal.

Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin.

E. Eisenberg, L. Greene, S. Cushman, 2001, Journal of cell science.

Activity and phosphorylation state of glucose transporters in plasma membranes from insulin-, isoproterenol-, and phorbol ester-treated rat adipose cells.

H. Joost, I. Simpson, S. Cushman, 1987, The Journal of biological chemistry.

Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat.

C. Wilson, J. Ivy, S. Cushman, 1996, The American journal of physiology.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

Analysis of GLUT4 Distribution in Whole Skeletal Muscle Fibers: Identification of Distinct Storage Compartments That Are Recruited by Insulin and Muscle Contractions

E. Ralston, S. Cushman, T. Ploug, 1998, The Journal of cell biology.

Insulin stimulation of glucose transport activity in rat skeletal muscle: increase in cell surface GLUT4 as assessed by photolabelling.

C. Wilson, S. Cushman, 1994, The Biochemical journal.

Adipose cell size-function relationships: insulin binding and degradation.

S. Cushman, L. Salans, D. Noda, 1981, The American journal of physiology.

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

S. Cushman, 1970, The Journal of cell biology.

Do adipocytes contain high affinity sulfonylurea receptors.

B. Kahn, S. Cushman, Z. Luo, 1994, Endocrinology.

Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle.

S. Cushman, J. Brozinick, D. Dean, 1998, American Journal of Physiology.

A common variant in the patatin‐like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

Hongyu Zhao, G. Shulman, S. Caprio, 2010, Hepatology.

Single injections of apoA-I acutely improve in vivo glucose tolerance in insulin-resistant mice

O. Göransson, S. Cushman, K. Stenkula, 2014, Diabetologia.

Phosphorylation state of the GLUT4 isoform of the glucose transporter in subfractions of the rat adipose cell: effects of insulin, adenosine, and isoproterenol.

I. Simpson, A. Greenberg, S. Cushman, 1991, Proceedings of the National Academy of Sciences of the United States of America.

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

S. Cushman, 1970, The Journal of cell biology.

GLUT 1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1

F. Ruscetti, S. Cushman, S. Jacobson, 2007 .

GLUT1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1

F. Ruscetti, S. Cushman, S. Jacobson, 2006, Journal of Virology.

Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Use Different Receptor Complexes To Enter T Cells

F. Ruscetti, D. Bertolette, S. Cushman, 2006, Journal of Virology.

Adipose cell hypertrophy precedes the appearance of small adipocytes by 3 days in C57BL/6 mouse upon changing to a high fat diet

V. Periwal, S. Cushman, K. Stenkula, 2016, Adipocyte.

GLUT 1 Is Not The Primary Binding Receptor But Is Associated With Cell-Cell Transmission Of HTLV-1

F. Ruscetti, S. Cushman, S. Jacobson, 2006 .

Comparison of body weight and adipose tissue in male C57BI/6J mice fed diets with and withouttrans fatty acids

S. Cushman, J. Sampugna, S. Atal, 1994, Lipids.

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

Junghyo Jo, Oksana Gavrilova, Stephanie Pack, 2009, PLoS Comput. Biol..

Qualitative and quantitative comparison of glucose transport activity and glucose transporter concentration in plasma membranes from basal and insulin-stimulated rat adipose cells.

H. Joost, S. Cushman, S W Cushman, 1988, The Biochemical journal.

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

I. Simpson, S. Cushman, M. Zarnowski, 1981, The Journal of biological chemistry.

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation

E. Sausville, S. Cushman, M. Zarnowski, 2004, Clinical Cancer Research.

Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients

A. Sherman, U. Smith, S. Cushman, 2014, Adipocyte.

Evidence of impaired adipogenesis in insulin resistance.

Maia M. Jack, M. Cam, U. Smith, 2004, Biochemical and biophysical research communications.

Guardian of corpulence: a hypothesis on p53 signaling in the fat cell

M. Bazuine, S. Cushman, K. Stenkula, 2009, Clinical lipidology.

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

T. McLaughlin, S. Cushman, Colleen M Craig, 2016, Diabetes.

Standard Isolation of Primary Adipose Cells from Mouse Epididymal Fat Pads Induces Inflammatory Mediators and Down-regulates Adipocyte Genes*

H. Lodish, H. Ruan, S. Cushman, 2003, Journal of Biological Chemistry.

Using Pre-existing Microarray Datasets to Increase Experimental Power: Application to Insulin Resistance

Russ B. Altman, Margaret C. Cam, Samuel W. Cushman, 2010, PLoS Comput. Biol..

Insulin Regulates Glut4 Confinement in Plasma Membrane Clusters in Adipose Cells

J. Zimmerberg, S. Cushman, K. Stenkula, 2013, PloS one.

Roles of the N- and C-termini of GLUT4 in endocytosis.

K. Dawson, C. Hinck, S. Cushman, 2002, Journal of cell science.

Overexpression of the glucose transporter GLUT4 in adipose cells interferes with insulin‐stimulated translocation

S. Cushman, H. Al-Hasani, D. Yver, 1999, FEBS letters.

Roles of the Nand C-termini of GLUT 4 in endocytosis

K. Dawson, C. Hinck, S. Cushman, 2022 .

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*

G. Shulman, M. White, G. Cooney, 2002, The Journal of Biological Chemistry.

Dexamethasone inhibits insulin-stimulated recruitment of GLUT4 to the cell surface in rat skeletal muscle.

C. Wilson, S. Cushman, S. Weinstein, 1998, Metabolism: clinical and experimental.

Mathematical Models of Adipose Tissue Dynamics

Junghyo Jo, Samuel W. Cushman, Vipul Periwal, 2013 .

GLUT4 trafficking in insulin-stimulated rat adipose cells: evidence that heterotrimeric GTP-binding proteins regulate the fusion of docked GLUT4-containing vesicles.

S. Cushman, C. Ferrara, 1999, The Biochemical journal.

Insulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.

J. Zimmerberg, S. Cushman, K. Stenkula, 2010, Cell metabolism.

Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin

D. Malide, S. Cushman, N. Dwyer, 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells.

M. Quon, S. Taylor, A. Kazlauskas, 1996, Biochemical and biophysical research communications.

Intact glucose uptake despite deteriorating signaling in adipocytes with high-fat feeding.

V. Periwal, P. Storm, P. Vikman, 2018, Journal of molecular endocrinology.

The Size of Large Adipose Cells Is a Predictor of Insulin Resistance in First‐Degree Relatives of Type 2 Diabetic Patients

A. Sherman, U. Smith, S. Cushman, 2012, Obesity.

Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients.

S. Cushman, L. Salans, R. Weismann, 1973, The Journal of clinical investigation.

Characterization of the stimulatory action of insulin on insulin-like growth factor II binding to rat adipose cells. Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters.

I. Simpson, S. Cushman, K. Appell, 1988, The Journal of biological chemistry.

Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal

S. Cushman, K. Stenkula, Joan Domingo-Espín, 2016, Diabetes.

Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues.

I. Simpson, S. Cushman, P. Lönnroth, 1988, The Journal of biological chemistry.

Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts.

M. Lampson, S. Cushman, T. McGraw, 2000, Journal of cell science.

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

R. DeFronzo, G. Shulman, L. Rossetti, 1991, The Journal of clinical investigation.

Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580.

S. Cushman, G. Holman, Jing Yang, 2005, Endocrinology.

Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.

A. Schürmann, S. Cushman, H. Al-Hasani, 2006, Biochemical and biophysical research communications.

Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents.

I. Simpson, S. Cushman, C. Londos, 1987, The Journal of biological chemistry.

Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats

P. Tsao, A. Sherman, T. McLaughlin, 2010, Diabetes & vascular disease research.

Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice.

O. Gavrilova, J. Zimmerberg, S. Cushman, 2012, American journal of physiology. Endocrinology and metabolism.

Glucose deprivation and hexose transporter polypeptides of murine fibroblasts.

M. Birnbaum, O. Rosen, S. Cushman, 1986, The Journal of biological chemistry.

The export of major histocompatibility complex class I molecules from the endoplasmic reticulum of rat brown adipose cells is acutely stimulated by insulin.

J. Yewdell, J. Bennink, D. Malide, 2001, Molecular biology of the cell.

Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells

Samuel W. Cushman, J. Zimmerberg, S. Cushman, 2005, The Journal of cell biology.

Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells.

J. Slot, D. Malide, G. Ramm, 2000, Journal of cell science.

Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets.

S. Satoh, S. Cushman, N. Udaka, 1996, Tissue & cell.

Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome

E. Stener-Victorin, S. Cushman, K. Stenkula, 2017, Molecular and Cellular Endocrinology.

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.

M. Quon, S. Vannucci, I. Simpson, 1993, The Journal of biological chemistry.

Proteomic characterization of thiazolidinedione regulation of obese adipose secretome in Zucker obese rats

S. Cushman, S. Hess, Xiaoli Chen, 2009, Proteomics. Clinical applications.

Role of protein kinase C in the regulation of glucose transport in the rat adipose cell. Translocation of glucose transporters without stimulation of glucose transport activity.

I. Simpson, S. Cushman, C. Londos, 1991, The Journal of biological chemistry.

Human Adipose Cells In Vitro Are Either Refractory or Responsive to Insulin, Reflecting Host Metabolic State

P. Blank, J. Zimmerberg, S. Cushman, 2015, PloS one.

Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells

J. Zimmerberg, S. Cushman, K. Stenkula, 2013, Diabetes.

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

S. Cushman, S., M. Rizack, 1970, The Journal of cell biology.

Mechanism of insulin-resistance in the adipose cell in the aging-rat model of obesity.

I. Simpson, S. Cushman, E. Karnieli, 1981, Biochemical Society transactions.

Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice.

C. Wilson, T. Reynolds, S. Cushman, 1997, The Biochemical journal.

Absence of an early effect of glucocorticoids on nonesterified fatty acid accumulation in isolated rat thymus cells.

S. Cushman, A. Munck, L. Zyskowski, 1979, Journal of steroid biochemistry.

Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat

V. Periwal, S. Cushman, Jennifer MacKellar, 2010, PloS one.

Unique subcellular distribution of five annexins in resting and insulin-stimulated rat adipose cells.

H. Pollard, S. Cushman, M. Guerre-Millo, 1996, Biochemical and biophysical research communications.

Subcellular distribution and phosphorylation state of insulin receptors from insulin- and isoproterenol-treated rat adipose cells.

H. Joost, I. Simpson, S. Cushman, 1991, Cellular signalling.

Two birds with one stone: novel glucokinase activator stimulates glucose-induced pancreatic insulin secretion and augments hepatic glucose metabolism.

M. Tschöp, S. Cushman, H. Al-Hasani, 2003, Molecular interventions.

Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis

A. Sherman, P. Tsao, T. McLaughlin, 2007, Diabetologia.

Rab 3D in rat adipose cells and its overexpression in genetic obesity (Zucker fatty rat).

H. Lodish, S. Cushman, G. Baldini, 1997, Biochemical Journal.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

Summary Activity , phosphorylation state and subcellular distribution of GLUT 4-targeted Akt 2 in rat adipose cells

U. Smith, S. Cushman, H. Al-Hasani, 2022 .

Subcellular trafficking of GLUT4 in insulin target cells

S. Cushman, G. Holman, 1996 .

The effects of insulin on the level and activity of the GLUT4 present in human adipose cells

S. Cushman, G. Gould, G. Holman, 1995, Diabetologia.

Acute effects of cycloheximide on the translocation of glucose transporters in rat adipose cells.

S. Cushman, T. L. Jones, 1989, The Journal of biological chemistry.

Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells

D. Malide, S. Cushman, S. Keller, 1997, FEBS letters.

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

S. Cushman, M. Rizack, Samuel W. Cushman, 1970, The Journal of cell biology.

Characterisation of insulin-resistant phenotype of cultured rat primary adipose cells

S. Cushman, L. Ma, I. Lisinski, 2007, Diabetologia.

epitrochlearis muscle after exercise training Transient enhancement of GLUT-4 levels in rat

Samuel W. Cushman, Thomas H. Reynolds, Lisa M. Larkin, 2013 .

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*

G. Shulman, M. White, G. Cooney, 2002, The Journal of Biological Chemistry.

Insulin controls the spatial distribution of GLUT4 on the cell surface through regulation of its postfusion dispersal.

J. Zimmerberg, S. Cushman, V. Lizunov, 2010, Cell metabolism.

Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Use Different Receptor Complexes To Enter T Cells

F. Ruscetti, D. Bertolette, S. Cushman, 2006, Journal of Virology.

Comparison of body weight and adipose tissue in male C57Bl/6J mice fed diets with and without trans fatty acids.

S. Cushman, M. Zarnowski, J. Sampugna, 1994, Lipids.

A common variant in the patatin‐like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

Hongyu Zhao, G. Shulman, S. Caprio, 2010, Hepatology.

SNAP-23 participates in SNARE complex assembly in rat adipose cells.

J. Cabaniols, S. Cushman, P. Roche, 1999, The Biochemical journal.

Insulin stimulates hormone‐sensitive cyclic GMP‐inhibited cyclic nucleotide phosphodiesterase in rat brown adipose cells

V. Manganiello, S. Cushman, M. Taira, 1995, FEBS letters.