W. Busby

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Insulin-like Growth Factor-I-stimulated Insulin Receptor Substrate-1 Negatively Regulates Src Homology 2 Domain-containing Protein-tyrosine Phosphatase Substrate-1 Function in Vascular Smooth Muscle Cells*

Y. Radhakrishnan, L. Maile, D. Clemmons, 2010, The Journal of Biological Chemistry.

Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth.

T. Nam, D. Clemmons, W. Busby, 2000, Endocrinology.

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet

G. Koch, D. Clemmons, W. Busby, 2015, PloS one.

Role of insulin-like growth factor binding proteins in the control of IGF actions.

T. Nam, D. Clemmons, W. Busby, 1995, Progress in growth factor research.

Purification and characterization of a peptidyl glycine monooxygenase from porcine pituitary.

C. Miller, W. Busby, R. Bateman, 1986, Endocrinology.

Glycosaminoglycans inhibit degradation of insulin-like growth factor-binding protein-5.

A. Arai, D. Clemmons, W. Busby, 1994, Endocrinology.

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I

D. Clemmons, W. Busby, J. I. Jones, 1993, The Journal of cell biology.

An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs.

L. Maile, D. Clemmons, W. Busby, 2017, Atherosclerosis.

A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation.

P. Rotwein, D. Clemmons, W. Busby, 1993, The Journal of biological chemistry.

Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.

D. Clemmons, W. Busby, J. I. Jones, 1993, The Journal of biological chemistry.

Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I.

D. Clemmons, W. Busby, C. Rees, 1998, Molecular biology of the cell.

A Protease-Resistant Form of Insulin-Like Growth Factor (IGF) Binding Protein 4 Inhibits IGF-1 Actions* * These studies were supported by Grant HL-56850 from the National Institutes of Health.

D. Clemmons, W. Busby, C. Rees, 1998, Endocrinology.

Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.

D. Clemmons, W. Busby, C. Rees, 1997, The Journal of clinical investigation.

Identification of the Extracellular Matrix Binding Sites for Insulin-like Growth Factor-binding Protein 5*

D. Clemmons, W. Busby, J. Clarke, 1996, The Journal of Biological Chemistry.

Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin.

D. Clemmons, W. Busby, B. Zheng, 1998, Endocrinology.

Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation

Y. Radhakrishnan, L. Maile, D. Clemmons, 2010 .

Role of Insulin‐like Growth Factor Binding Proteins in Modifying IGF Actions a

D. Clemmons, W. Busby, J. I. Jones, 1993, Annals of the New York Academy of Sciences.

Biochemical and functional analysis of a conserved IGF-binding protein isolated from rainbow trout (Oncorhynchus mykiss) hepatoma cells.

W. Busby, P. Swanson, C. Duan, 2001, The Journal of endocrinology.

Substitutions for Hydrophobic Amino Acids in the N-terminal Domains of IGFBP-3 and -5 Markedly Reduce IGF-I Binding and Alter Their Biologic Actions*

D. Clemmons, W. Busby, U. Andag, 2000, The Journal of Biological Chemistry.

Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.

D. Clemmons, W. Busby, F. Sverdrup, 2009, Osteoarthritis and cartilage.

Blocking ligand occupancy of the αVβ3 integrin inhibits the development of nephropathy in diabetic pigs.

L. Maile, D. Clemmons, W. Busby, 2014, Endocrinology.

Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children.

T. Nam, D. Clemmons, W. Busby, 1993, The Journal of clinical endocrinology and metabolism.

Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

D. Clemmons, W. Busby, D. Klapper, 1988, The Journal of biological chemistry.

Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells.

D. Clemmons, W. Busby, A. Gockerman, 1995, Endocrinology.

Blocking αVβ3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats

L. Maile, D. Clemmons, W. Busby, 2014, Journal of diabetes research.

Human fibroblasts secrete a serine protease that cleaves insulin-like growth factor-binding protein-5.

T. Nam, D. Clemmons, W. Busby, 1994, Endocrinology.

Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.

D. Clemmons, R. McCusker, W. Busby, 1992, The Journal of biological chemistry.

Competition for binding to insulin-like growth factor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs.

D. Clemmons, W. Busby, M. Bayne, 1992, Endocrinology.

An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.

W. Busby, J. Kizer, J. Humm, 1987, The Journal of biological chemistry.

Modulation of integrin antagonist signaling by ligand binding of the heparin‐binding domain of vitronectin to the αVβ3 integrin

Umadevi Veluvolu, L. Maile, Ariel W. Aday, 2008, Journal of cellular biochemistry.

Insulin-like growth factor-i signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the β3-subunit of αVβ3

L. Maile, B. Capps, D. Clemmons, 2006 .

Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis.

R. Altman, D. Howell, D. Clemmons, 2002, Arthritis and rheumatism.

Insulin-like growth factor (IGF) binding to cell monolayers is directly modulated by the addition of IGF-binding proteins.

M. Dehoff, D. Clemmons, R. McCusker, 1991, Endocrinology.

A Monoclonal Antibody Against αVβ3 Integrin Inhibits Development of Atherosclerotic Lesions in Diabetic Pigs

Umadevi Veluvolu, L. Maile, D. Clemmons, 2010, Science Translational Medicine.

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.

D. Clemmons, W. Busby, T. Arai, 1994, The Journal of biological chemistry.

Studies of substrate requirements, kinetic properties, and competive inhibitors of the enzymes catabolizing TRH in rat brain

W. Busby, J. Kizer, W. Youngblood, 1982, Brain Research.

Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects.

D. Clemmons, W. Busby, D. K. Snyder, 1991, The Journal of clinical endocrinology and metabolism.

Regulation of Vascular Smooth Muscle Cell Responses to Insulin-like Growth Factor (IGF)-I by Local IGF-binding Proteins*

D. Clemmons, W. Busby, C. Duan, 2003, Journal of Biological Chemistry.

Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I.

T. Nam, D. Clemmons, W. Busby, 1997, Endocrinology.

Three distinct forms of insulin-like growth factor binding proteins are released by decidual cells in culture.

S. Handwerger, D. Clemmons, W. Busby, 1990, Endocrinology.

The Complement Component C1s Is the Protease That Accounts for Cleavage of Insulin-like Growth Factor-binding Protein-5 in Fibroblast Medium*

T. Nam, D. Clemmons, W. Busby, 2000, The Journal of Biological Chemistry.

THE ROLE OF INSULIN-LIKE GROWTH FACTOR I IN THE REGULATION OF GROWTH

M. Dehoff, D. Clemmons, R. McCusker, 1987 .

The heparin binding domain of vitronectin is the region that is required to enhance insulin-like growth factor-I signaling.

L. Maile, B. Capps, D. Clemmons, 2006, Molecular endocrinology.

Insulin-Like Growth Factor-I Signaling in Smooth Muscle Cells Is Regulated by Ligand Binding to the 177 CYDMKTTC 184 Sequence of the (cid:1) 3-Subunit of (cid:2) V (cid:1) 3

L. Maile, B. Capps, D. Clemmons, 2006 .

The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins.

D. Clemmons, W. Busby, R. Collier, 1991, Endocrinology.

Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart.

M. Boes, D. Clemmons, W. Busby, 1990, Endocrinology.

Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix.

D. Clemmons, W. Busby, T. Arai, 1996, Endocrinology.

Purified preparations of the amniotic fluid-derived insulin-like growth factor-binding protein contain multimeric forms that are biologically active.

D. Clemmons, W. Busby, M. Binoux, 1989, Endocrinology.

Insulin differentially alters transcapillary movement of intravascular IGFBP-1, IGFBP-2 and endothelial cell IGF-binding proteins in the rat heart.

M. Boes, D. Clemmons, W. Busby, 1990, Endocrinology.

Modifications of insulin-like growth factor binding proteins and their role in controlling IGF actions.

T. Nam, D. Clemmons, W. Busby, 1998, Endocrine journal.

Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3.

L. Maile, B. Capps, D. Clemmons, 2006, Molecular endocrinology.

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the a5I31 integrin by means of its Arg-Gly-Asp sequence

G. Wright, D. Clemmons, W. Busby, 2005 .

Radioimmunoassay of a 26,000-dalton plasma insulin-like growth factor-binding protein: control by nutritional variables.

D. Clemmons, W. Busby, D. K. Snyder, 1988, The Journal of clinical endocrinology and metabolism.

Differential regulation of insulin-like growth factor binding protein secretion from human decidual cells by IGF-I, insulin, and relaxin.

S. Handwerger, D. Clemmons, W. Busby, 1990, The Journal of clinical investigation.

Structure and evolution of artiodactyla haptoglobins.

W. Busby, J. C. Travis, 1978, Comparative biochemistry and physiology. B, Comparative biochemistry.

Control of insulin-like growth factor binding protein-5 protease synthesis and secretion by human fibroblasts and porcine aortic smooth muscle cells.

D. Clemmons, W. Busby, A. Moralez, 2003, Endocrinology.

Insulin‐like growth factor binding protein‐5 (IGFBP‐5) interacts with thrombospondin‐1 to induce negative regulatory effects on IGF‐I actions

L. Maile, D. Clemmons, W. Busby, 2005, Journal of cellular physiology.

A rapid, sensitive assay for glycine-directed amidating enzymes

W. Busby, R. Bateman, J. Kizer, 1985, Journal of Neuroscience Methods.

Nonenzymatic peptide alpha-amidation. Implications for a novel enzyme mechanism.

W. Busby, R. Bateman, J. Kizer, 1985, The Journal of biological chemistry.

Protease-resistant insulin-like growth factor (IGF)-binding protein-4 inhibits IGF-I actions and neointimal expansion in a porcine model of neointimal hyperplasia.

D. Clemmons, W. Busby, T. Nichols, 2007, Endocrinology.

Human IGFBP-1 is phosphorylated on 3 serine residues: effects of site-directed mutagenesis of the major phosphoserine.

D. Clemmons, W. Busby, J. I. Jones, 1993, Growth regulation.

Cloning, characterization, and expression of a human insulin-like growth factor binding protein.

M. T. Brewer, R. Thompson, D. Clemmons, 1988, Biochemical and biophysical research communications.

CHOLINE ACETYLTRANSFERASE ACTIVITY IN LARGE VENTRAL SPINAL NEURONS

W. Busby, D. Mcilwain, D. Weil, 1977, Journal of neurochemistry.

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

D. Clemmons, W. Busby, J. I. Jones, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and sequence determination of bovine insulin‐like growth factor binding protein‐2 (IGFBP‐2): Comparison of its structral and functional properties with IGFBP‐1

D. Clemmons, R. McCusker, W. Busby, 1992, Journal of cellular biochemistry.

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

D. Clemmons, W. Busby, R. Elgin, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Tissue Transglutaminase Facilitates the Polymerization of Insulin-like Growth Factor-binding Protein-1 (IGFBP-1) and Leads to Loss of IGFBP-1's Ability to Inhibit Insulin-like Growth Factor-I-stimulated Protein Synthesis*

D. Clemmons, W. Busby, J. Clarke, 2001, The Journal of Biological Chemistry.

Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1.

D. Clemmons, W. Busby, R. Jyung, 1994, Surgery.

Adiponectin lowers glucose production by increasing SOGA.

I. Rusyn, R. Tisch, B. Medoff, 2010, The American journal of pathology.

Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone).

W. Busby, J. Kizer, W. Youngblood, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Bovine serum albumin—GABA-His-Pro-NH2: An immunogen for production of higher affinity antisera for TRH

W. Busby, J. Kizer, W. Youngblood, 1983, Journal of Neuroscience Methods.

Role of the integrin αVβ3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress

L. Maile, D. Clemmons, Y. Ling, 2007 .

Aldosterone enhances IGF-I-mediated signaling and biological function in vascular smooth muscle cells.

Y. Radhakrishnan, L. Maile, D. Clemmons, 2010, Endocrinology.

Characterization and determination of the relative abundance of two types of insulin-like growth factor binding protein-5 proteases that are secreted by human fibroblasts.

T. Nam, D. Clemmons, W. Busby, 1996, Endocrinology.

Identification of Compounds That Inhibit IGF-I Signaling in Hyperglycemia

Umadevi Veluvolu, L. Maile, B. Capps, 2010, Experimental diabetes research.

Evaluation of the developmental and nutritional changes in porcine insulin-like growth factor-binding protein-1 and -2 serum levels by immunoassay.

D. Clemmons, R. McCusker, W. Busby, 1991, Endocrinology.

Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress.

L. Maile, D. Clemmons, Y. Ling, 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

A review of the methods used for the measurement of thyrotropin-releasing hormone (TRH)

W. Busby, J. Kizer, J. Humm, 1981, Journal of Neuroscience Methods.

Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

D. Clemmons, W. Busby, D. Klapper, 1988, The Journal of biological chemistry.

Recombinant, nonglycosylated human insulin-like growth factor-binding protein-3 (IGFBP-3) is degraded preferentially after administration to type II diabetics, resulting in increased endogenous glycosylated IGFBP-3.

D. Clemmons, W. Busby, M. Sleevi, 2005, The Journal of clinical endocrinology and metabolism.