D. Stepp

发表

Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone

M. Tremblay, K. Muta, M. Ali, 2009, Circulation research.

A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats.

A. Dorrance, D. Stepp, D. Pollock, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Obesity Increases Blood Pressure, Cerebral Vascular Remodeling, and Severity of Stroke in the Zucker Rat

J. Mintz, D. Stepp, Jessica M. Osmond, 2009, Hypertension.

Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels.

R. D. Rudic, S. Barman, D. Fulton, 2012, American journal of physiology. Heart and circulatory physiology.

Obesity augments vasoconstrictor reactivity to angiotensin II in the renal circulation of the Zucker rat.

J. Mintz, D. Stepp, Clark D. Hair, 2007, American journal of physiology. Heart and circulatory physiology.

SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

R. D. Rudic, D. Fulton, D. Stepp, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins

Yunchao Su, R. D. Rudic, S. Barman, 2018, Front. Immunol..

Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease

J. A. Thompson, E. J. Belin de Chantemèle, J. Mintz, 2017, Circulation research.

Increasing Muscle Mass Improves Vascular Function in Obese (db/db) Mice

Yunchao Su, J. Mintz, Christina Salet, 2014, Journal of the American Heart Association.

Increased Muscle Mass Protects Against Hypertension and Renal Injury in Obesity

J. Mintz, D. Fulton, D. Stepp, 2018, Journal of the American Heart Association.

Atherogenic Activity caused by Excess Membrane Cholesterol in Arterial Smooth Muscle: Role of Calcium Channels

D. Rock, D. Stepp, R. Mason, 1993 .

Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats.

J. Pollock, D. Stepp, J. Imig, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

In vivo location and mechanism of EDHF-mediated vasodilation in canine coronary microcirculation.

D. Stepp, W. Chilian, Y. Nishikawa, 1999, American journal of physiology. Heart and circulatory physiology.

Low-flow vascular remodeling in the metabolic syndrome X.

D. Stepp, D. Pollock, J. Frisbee, 2004, American journal of physiology. Heart and circulatory physiology.

Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis.

R. Gansevoort, D. Fulton, D. Stepp, 2016, Journal of the American Society of Nephrology : JASN.

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones.

F. Chen, D. Fulton, D. Stepp, 2015, Free radical biology & medicine.

Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90.

B. Kemp, D. Fulton, M. Marrero, 2004, American journal of physiology. Heart and circulatory physiology.

Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ.

K. Pritchard, D. Stepp, J. Ou, 2002, American journal of physiology. Heart and circulatory physiology.

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis.

Yunchao Su, S. Barman, Jiliang Zhou, 2019, American journal of physiology. Lung cellular and molecular physiology.

Obesity induced-insulin resistance causes endothelial dysfunction without reducing the vascular response to hindlimb ischemia

E. J. Belin de Chantemèle, J. Mintz, D. Stepp, 2009, Basic Research in Cardiology.

Alterations in basal and serotonin-stimulated calcium permeability and vasoconstriction in atherosclerotic aorta.

D. Stepp, T. Tulenko, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus

N. Hay, M. Ushio-Fukai, A. Makino, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Obesity Induces Disruption of Microvascular Endothelial Circadian Rhythm

J. Mintz, D. Fulton, D. Stepp, 2022, Frontiers in Physiology.

Increasing Peripheral Insulin Sensitivity by Protein Tyrosine Phosphatase 1B Deletion Improves Control of Blood Pressure in Obesity

M. Tremblay, J. Mintz, D. Fulton, 2012, Hypertension.

Reduced constrictor reactivity balances impaired vasodilation in the mesenteric circulation of the obese Zucker rat.

D. Stepp, Olga P Romanko, Olga P. Romanko, 2005, American journal of physiology. Heart and circulatory physiology.

Angiotensin II–Induced Insulin Resistance and Protein Tyrosine Phosphatases

M. Marrero, D. Stepp, D. Stern, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Functional characteristics of the coronary microcirculation

D. Stepp, W. Chilian, D. Merkus, 1999, Herz.

In vivo role of heme oxygenase in ischemic coronary vasodilation.

D. Stepp, W. Chilian, D. Merkus, 2004, American journal of physiology. Heart and circulatory physiology.

Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats.

D. Stepp, K. Maier, J. Frisbee, 2002, American journal of physiology. Heart and circulatory physiology.

Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo.

D. Stepp, W. Chilian, Y. Nishikawa, 2000, American journal of physiology. Heart and circulatory physiology.

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

R. D. Rudic, D. Fulton, M. Marrero, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease

D. Stepp, N. Weintraub, T. Chatterjee, 2014, Adipocyte.

Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: roles of Protein Tyrosine Phosphatase-1B.

Pimonrat Ketsawatsomkron, D. Fulton, M. Marrero, 2010, Vascular pharmacology.

PTP1B in Obesity-Related Cardiovascular Function

Pimonrat Ketsawatsomkron, D. Stepp, E. B. Chantemèle, 2013 .

Origins of Hypertension in Obesity: Plain Vanilla(oid) or Multiple Flavors?

D. Stepp, D. Fulton, 2020, Circulation.

Pin1 Prolyl Isomerase Regulates Endothelial Nitric Oxide Synthase

J. Mintz, D. Fulton, D. Stepp, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Pin 1 Prolyl Isomerase Regulates Endothelial Nitric Oxide Synthase

J. Mintz, D. Fulton, D. Stepp, 2011 .

Regulation of NADPH Oxidase 5 by Protein Kinase C Isoforms

D. Fulton, D. Stepp, R. Lucas, 2014, PloS one.

The LncRNA Carmn is a Critical Regulator for Gastrointestinal Smooth Muscle Contractile Function and Motility

Meixiang Xiang, Xiangqin He, K. Dong, 2022, bioRxiv.

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

Yunchao Su, G. Kéri, S. Barman, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation.

M. A. Moseley, S. Black, D. Fulton, 2012, Free radical biology & medicine.

Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension.

Yunchao Su, S. Barman, Feng Chen, 2018, American journal of respiratory and critical care medicine.

Structural Remodeling in the Limb Circulation: Impact of Obesity and Diabetes

D. Stepp, E. B. D. de Chantemèle, E. B. D. de Chantemele, 2007, Microcirculation.

Origins of vascular disease: is fat where it's at?

D. Stepp, 2010, Journal of applied physiology.

Adenosine preconditions against endothelin-induced constriction of coronary arterioles.

D. Stepp, W. Chilian, D. Merkus, 2000, American journal of physiology. Heart and circulatory physiology.

In vivo location and mechanism of EDHF-mediated vasodilation in canine coronary microcirculation.

D. Stepp, W. Chilian, Y. Nishikawa, 1999, The American journal of physiology.

Increased Superoxide and eNOS Uncoupling in Blood Vessels of Bmal1-KO mice

S. Black, D. Fulton, D. Stepp, 2012 .

Does the coronary microcirculation play a role in heart failure ?

D. Stepp, W. Chilian, C. Wright, 2004 .

Nf1 Heterozygous Mice Recapitulate the Anthropometric and Metabolic Features of Human Neurofibromatosis Type 1.

J. Mintz, D. Stepp, N. Weintraub, 2020, Translational research : the journal of laboratory and clinical medicine.

Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.

D. Stepp, B. Hammock, J. Newman, 2004, Obesity research.

R-00018-2004-R 2 Decreased Epoxygenase and Increased Epoxide Hydrolase Expression in the Mesenteric Artery of Obese Zucker Rats

J. Pollock, D. Stepp, J. Imig, 2004 .

Impairment of sympathetic baroreceptor reflexes in obese Zucker rats.

D. Stepp, A. Schreihofer, D. Mandel, 2007, American journal of physiology. Heart and circulatory physiology.

Reduced plasma volume and mesenteric vascular reactivity in obese Zucker rats.

D. Stepp, Clark D. Hair, A. Schreihofer, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Nitric oxide limits coronary vasoconstriction by a shear stress-dependent mechanism.

D. Stepp, W. Chilian, D. Merkus, 2001, American journal of physiology. Heart and circulatory physiology.

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction

Yunchao Su, F. Chen, S. Barman, 2022, Frontiers in Immunology.

Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals

D. Stepp, N. Weintraub, Anson M. Blanks, 2022, Physiological reports.

Quantitative relation between interstitial adenosine concentration and coronary blood flow.

E. Feigl, D. Stepp, K. Kroll, 1996, Circulation research.

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity

Ha Won Kim, D. Fulton, D. Stepp, 2017, The Journal of Biological Chemistry.

Exaggerated Cardiovascular Stress Responses and Impaired β-Adrenergic–Mediated Pressor Recovery in Obese Zucker Rats

J. Mintz, D. Stepp, A. Schreihofer, 2006, Hypertension.

High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries.

D. Stepp, J. Lombard, J. Frisbee, 2002, American journal of physiology. Heart and circulatory physiology.

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E

Ha Won Kim, D. Stepp, N. Weintraub, 2019, The Journal of Biological Chemistry.

Protein kinase N2 connects blood flow with NO production in a double AKT.

D. Fulton, D. Stepp, 2021, The Journal of clinical investigation.

Opposing Actions of Heat Shock Protein 90 and 70 Regulate Nicotinamide Adenine Dinucleotide Phosphate Oxidase Stability and Reactive Oxygen Species Production

J. Catravas, D. Fulton, D. Stepp, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation.

E. J. Belin de Chantemèle, D. Stepp, Eric J. Belin de Chantemèle, 2012, Journal of molecular and cellular cardiology.

miRNA-93 Inhibits GLUT4 and Is Overexpressed in Adipose Tissue of Polycystic Ovary Syndrome Patients and Women With Insulin Resistance

D. Stepp, R. Azziz, L. Layman, 2013, Diabetes.

Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding

Ha Won Kim, James G. Wilson, J. Mintz, 2018, Molecular and Cellular Endocrinology.

Impact of Nox5 Polymorphisms on Basal and Stimulus-Dependent ROS Generation

D. Fulton, D. Stepp, Feng Chen, 2014, PloS one.

Vascular Disease in Mice With a Dysfunctional Circadian Clock

G. Reed, R. D. Rudic, D. Fulton, 2009, Circulation.

Preventing increased blood pressure in the obese Zucker rat improves severity of stroke.

J. Mintz, D. Stepp, J. Osmond, 2010, American journal of physiology. Heart and circulatory physiology.

Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase*

K. Pritchard, W. Sessa, D. Stepp, 2001, The Journal of Biological Chemistry.

Circadian Clock Control of Nox4 and Reactive Oxygen Species in the Vasculature

R. D. Rudic, D. Fulton, D. Stepp, 2013, PloS one.

Influence of serum cholesterol on atherogenesis and intimal hyperplasia after angioplasty: inhibition by amlodipine.

D. Stepp, R. Mason, K. Boesze-Battaglia, 2005, American journal of physiology. Heart and circulatory physiology.

Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice

R. D. Rudic, S. Black, D. Fulton, 2012, Circulation research.

Diabetes-induced vascular dysfunction involves arginase I.

S. Cederbaum, D. Stepp, M. Romero, 2012, American journal of physiology. Heart and circulatory physiology.

Fructose Feeding Increases Insulin Resistance but Not Blood Pressure in Sprague-Dawley Rats

D. Stepp, D. Pollock, A. Elmarakby, 2005, Hypertension.

Vascular effects of deletion of melanocortin-4 receptors in rats

J. Mintz, D. Stepp, E. B. D. de Chantemèle, 2013, Physiological reports.

Whole body vibration elicits differential immune and metabolic responses in obese and normal weight individuals

M. Tucker, D. Stepp, Anson M. Blanks, 2019, Brain, Behavior, & Immunity - Health.

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II–Dependent Hypertension in Mice

R. D. Rudic, D. Fulton, D. Stepp, 2016, Hypertension.

Effect of myostatin deletion on cardiac and microvascular function

J. Mintz, D. Fulton, D. Stepp, 2017, Physiological reports.

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Ha Won Kim, D. Stepp, N. Weintraub, 2018, Laboratory Investigation.

Anea et al eNOS Uncoupling , Superoxide , and the Circadian Clock 1159 Chronic Treatment With BH 4

R. D. Rudic, S. Black, D. Fulton, 2012 .

Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1.

A. Dorrance, D. Stepp, A. Ergul, 2005, Diabetes.

Obesity and the Bidirectional Risk of Cancer and Cardiovascular Diseases in African Americans: Disparity vs. Ancestry

S. Coughlin, N. Desai, D. Stepp, 2021, Frontiers in Cardiovascular Medicine.

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension.

F. Chen, S. Barman, Jiliang Zhou, 2016, Free radical biology & medicine.

Impact of Obesity on Coronary Microvascular Function in the Zucker Rat

J. Mintz, D. Stepp, Rajan Prakash, 2006, Microcirculation.

IMPACT OF OBESITY AND INSULIN RESISTANCE ON VASOMOTOR TONE: NITRIC OXIDE AND BEYOND

D. Stepp, 2006, Clinical and experimental pharmacology & physiology.

Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats.

D. Stepp, J. Frisbee, 2001, American journal of physiology. Heart and circulatory physiology.

Regulation of shear stress in the canine coronary microcirculation.

D. Stepp, W. Chilian, Y. Nishikawa, 1999, Circulation.

Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats.

D. Stepp, J. Frisbee, 2002, American journal of physiology. Heart and circulatory physiology.

Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation.

R. D. Rudic, D. Fulton, D. Stepp, 2010, American journal of physiology. Heart and circulatory physiology.

Perivascular adipose tissue promotes vascular dysfunction in murine lupus

E. J. Belin de Chantemèle, J. Mintz, D. Stepp, 2023, Frontiers in Immunology.

Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.

D. Stepp, Chaodong Wu, Z. Bagi, 2019, The Journal of endocrinology.

Insulin Resistance Impairs Endothelial Function but not Adrenergic Reactivity or Vascular Structure in Fructose‐fed Rats

J. Mintz, D. Stepp, M. Ali, 2009, Microcirculation.

Angiotensin II-induced signaling pathways in diabetes.

M. Marrero, D. Stepp, D. Stern, 2005, Current diabetes reviews.

Impact of Leptin-Mediated Sympatho-Activation on Cardiovascular Function in Obese Mice

E. J. Belin de Chantemèle, J. Mintz, D. Stepp, 2011, Hypertension.

Matrix Metalloproteinase 2 and 9 Dysfunction Underlie Vascular Stiffness in Circadian Clock Mutant Mice

R. D. Rudic, D. Stepp, J. Sullivan, 2010, Arteriosclerosis, thrombosis, and vascular biology.

The biological clock enhancer nobiletin ameliorates steatosis in obesity by restoring aberrant hepatic circadian rhythm.

J. Mintz, D. Fulton, D. Stepp, 2022, American journal of physiology. Gastrointestinal and liver physiology.

Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species

R. D. Rudic, D. Fulton, D. Stepp, 2016, PloS one.

Obesity Alters the Peripheral Circadian Clock in the Aorta and Microcirculation

J. Mintz, D. Fulton, D. Stepp, 2015, Microcirculation.

Adenosine kinetics in canine coronary circulation.

D. Stepp, K. Kroll, K Kroll, 1996, The American journal of physiology.

OBESITY INDUCED RENAL OXIDATIVE STRESS CONTRIBUTES TO RENAL INJURY IN SALT‐SENSITIVE HYPERTENSION

D. Stepp, J. Imig, S. Knight, 2009, Clinical and experimental pharmacology & physiology.

Protein tyrosine phosphatase 1B (PTP1B): a major regulator of leptin‐mediated control of cardiovascular function

E. Inscho, B. Lilly, K. Muta, 2009, Circulation.

Disruption of endothelial Pfkfb3 ameliorates diet-induced murine insulin resistance.

D. Fulton, D. Stepp, Y. Huo, 2021, The Journal of endocrinology.

Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1

J. Mintz, D. Stepp, M. Brands, 2023, bioRxiv.

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II–Dependent Hypertension in Mice

D. Stepp, L. Cassis, Z. Bagi, 2016, Hypertension.

Vascular Disease in Mice With a Dysfunctional Circadian Clock

D. Fulton, D. Stepp, G. Simkins, 2009, Circulation.

Pressor recovery after acute stress is impaired in high fructose‐fed Lean Zucker rats

J. Mintz, D. Fulton, D. Stepp, 2016, Physiological reports.

Protein Tyrosine Phosphatase 1B, a Major Regulator of Leptin-Mediated Control of Cardiovascular Function

K. Muta, J. Mintz, D. Fulton, 2009, Circulation.

Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones.

F. Chen, D. Fulton, D. Stepp, 2015, Free radical biology & medicine.