Hsien-yu Wang

发表

G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation

E. Shumay, S. Gavi, Hsien-yu Wang, 2006, Trends in Endocrinology & Metabolism.

Insulin Stimulates Phosphorylation of the β2-Adrenergic Receptor by the Insulin Receptor, Creating a Potent Feedback Inhibitor of Its Tyrosine Kinase*

Hsien-yu Wang, C. Malbon, S. Doronin, 2002, The Journal of Biological Chemistry.

Expression of Constitutively Activated Giα2 in Vivo Ameliorates Streptozotocin-induced Diabetes*

Hsien-yu Wang, C. Malbon, Xi-Long Zheng, 1998, The Journal of Biological Chemistry.

G Proteins Regulating Insulin Action and Obesity

P. Galvin-Parton, Hsien-yu Wang, C. Malbon, 1998 .

Conditional, tissue-specific expression of Q205L Gαi2 in vivo mimics insulin action

Hsien-yu Wang, C. Malbon, J. Guo, 1997, Journal of Molecular Medicine.

Structure-function analysis of Frizzleds.

Hsien-yu Wang, C. Malbon, Tong Liu, 2006, Cellular signalling.

Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer.

Hsien-yu Wang, C. Malbon, Zhiyong Cheng, 2003, Cancer letters.

Rapid Publication Hyperexpression of Mitogen-activated Protein Kinase in Human Breast Cancer

G. Nuovo, Hsien-yu Wang, C. Malbon, 2013 .

Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells.

E. Shumay, S. Gavi, Hsien-yu Wang, 2005, Biochemical and biophysical research communications.

The Intracellular Loop 2 F328S Frizzled-4 Mutation Implicated in Familial Exudative Vitreoretinopathy Impairs Dishevelled Recruitment

Hsien-yu Wang, C. Malbon, Shujuan Gao, 2015, Journal of molecular signaling.

Site-directed anti-peptide antibodies define the topography of the beta-adrenergic receptor.

Hong Wang, Hsien-yu Wang, C. Malbon, 1989, The Journal of biological chemistry.

Regulation of AKAP-Membrane Interactions by Calcium*

E. Shumay, Hsien-yu Wang, C. Malbon, 2006, Journal of Biological Chemistry.

Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells

Ujunwa C. Okoye, Hsien-yu Wang, C. Malbon, 2008, Journal of molecular signaling.

Insulin-like growth factor-I provokes functional antagonism and internalization of β1-Adrenergic receptors

E. Shumay, S. Gavi, Hsien-yu Wang, 2007 .

Lysophosphatidic Acid Regulates Trafficking of β2-Adrenergic Receptors

E. Shumay, Hsien-yu Wang, C. Malbon, 2007, Journal of Biological Chemistry.

Inositol Pentakisphosphate Mediates Wnt/β-Catenin Signaling*

Hsien-yu Wang, Yuan Gao, 2007, Journal of Biological Chemistry.

Casein Kinase 2 Is Activated and Essential for Wnt/β-Catenin Signaling*

Hsien-yu Wang, Yuan Gao, 2006, Journal of Biological Chemistry.

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA: Attenuation of glucocorticoid-induced up-regulation of β-adrenergic receptors

Hsien-yu Wang, C. Malbon, J. Hadcock, 1989 .

Signaling of Rat Frizzled-2 Through Phosphodiesterase and Cyclic GMP

R. Moon, Xunxian Liu, Hsien-yu Wang, 2002, Science.

Gαi2 Enhances in VivoActivation of and Insulin Signaling to GLUT4*

Hsien-yu Wang, C. Malbon, Xiaosong Song, 2001, The Journal of Biological Chemistry.

Trafficking of β2-adrenergic receptors: insulin and β-agonists regulate internalization by distinct cytoskeletal pathways

E. Shumay, S. Gavi, Hsien-yu Wang, 2004, Journal of Cell Science.

pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation.

E. Shumay, Hsien-yu Wang, C. Malbon, 2002, Molecular biology of the cell.

Targeted expression of activated Q227L Gαs in vivo

Hsien-yu Wang, C. Malbon, X. Huang, 2002 .

Probing the stoichiometry of β2-adrenergic receptor phosphorylation by targeted mass spectrometry

Hsien-yu Wang, C. Malbon, Shujuan Gao, 2014, Journal of molecular signaling.

“Shaping” of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor

Hsien-yu Wang, C. Malbon, S. S. Koçer, 2012, Journal of molecular signaling.

AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold

Hsien-yu Wang, C. Malbon, J. Tao, 2010, Journal of molecular signaling.

Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation

Hsien-yu Wang, C. Malbon, Shujuan Gao, 2016, Journal of molecular signaling.

Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells.

Hsien-yu Wang, C. Malbon, Hong Li, 2004, Molecular pharmacology.

Mitogen-activated Protein Kinase p38 Regulates the Wnt/Cyclic GMP/Ca2+ Non-canonical Pathway*

Li Ma, Hsien-yu Wang, 2007, Journal of Biological Chemistry.

G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.

Hsien-yu Wang, C. Malbon, Yi-Nan Lee, 2004, The Journal of biological chemistry.

Activation of the β-Catenin/Lef-Tcf Pathway Is Obligate for Formation of Primitive Endoderm by Mouse F9 Totipotent Teratocarcinoma Cells in Response to Retinoic Acid*

Hsien-yu Wang, C. Malbon, Tong Liu, 2002, The Journal of Biological Chemistry.

Gαi2 Enhances Insulin Signaling via Suppression of Protein-tyrosine Phosphatase 1B*

Hsien-yu Wang, C. Malbon, J. Tao, 2001, The Journal of Biological Chemistry.

Expression of Gα13 (Q226L) Induces P19 Stem Cells to Primitive Endoderm via MEKK1, 2, or 4*

Hsien-yu Wang, C. Malbon, J. Kanungo, 2002, The Journal of Biological Chemistry.

Repression of Adipogenesis by Adenylyl Cyclase Stimulatory G-protein α Subunit Is Expressed within Region 146-220*

Xunxian Liu, G. Johnson, Hsien-yu Wang, 1996, The Journal of Biological Chemistry.

Antisense oligodeoxynucleotides to Gs protein α-subunit sequence accelerate differentiation of fibroblasts to adipocytes

Hsien-yu Wang, C. Malbon, D. C. Watkins, 1992, Nature.

Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulin.

E. Shumay, Hsien-yu Wang, C. Malbon, 2002, The Journal of biological chemistry.

Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking

E. Shumay, Hsien-yu Wang, C. Malbon, 2006, Journal of molecular signaling.

WNT-frizzled signaling via cyclic GMP.

Hsien-yu Wang, 2004, Frontiers in bioscience : a journal and virtual library.

The Frizzled-1/β2-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor

Xi-Ping Huang, Hsien-yu Wang, C. Malbon, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling.

Hsien-yu Wang, Yuan Gao, 2006, The Journal of biological chemistry.

[20]In vivo analysis of signaling elements via targeted, inducible antisense RNA

P. Galvin-Parton, Hsien-yu Wang, C. Malbon, 1996 .

[1] G proteins controlling differentiation, growth, and development: Analysis by antisense RNA/DNA technology

Hsien-yu Wang, C. Malbon, C. Moxham, 1996 .

Wnt Signaling, Ca2+, and Cyclic GMP: Visualizing Frizzled Functions

Hsien-yu Wang, C. Malbon, Hsien-yu Wang, 2003, Science.

G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf Pathway

R. Moon, Xunxian Liu, Hsien-yu Wang, 2001, Science.

The Scaffold Protein Gravin (cAMP-dependent Protein Kinase-anchoring Protein 250) Binds the β2-Adrenergic Receptor via the Receptor Cytoplasmic Arg-329 to Leu-413 Domain and Provides a Mobile Scaffold during Desensitization*

E. Shumay, Hsien-yu Wang, C. Malbon, 2001, The Journal of Biological Chemistry.

Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization*

Hsien-yu Wang, C. Malbon, F. Lin, 2000, The Journal of Biological Chemistry.

Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin*

John D. Scott, Hsien-yu Wang, C. Malbon, 1999, The Journal of Biological Chemistry.

Insulin Stimulates Sequestration of β-Adrenergic Receptors and Enhanced Association of β-Adrenergic Receptors with Grb2 via Tyrosine 350*

Hsien-yu Wang, C. Malbon, V. Karoor, 1998, The Journal of Biological Chemistry.

Akt Mediates Sequestration of the β2-Adrenergic Receptor in Response to Insulin*

E. Shumay, Hsien-yu Wang, C. Malbon, 2002, The Journal of Biological Chemistry.

Insulin Stimulates Tyrosine Phosphorylation and Inactivation of Protein-tyrosine Phosphatase 1B in Vivo *

Hsien-yu Wang, C. Malbon, C C Malbon, 2001, The Journal of Biological Chemistry.

Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin

Hsien-yu Wang, C. Malbon, N. Yokoyama, 2012, Journal of molecular signaling.

Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes

Hsien-yu Wang, C. Malbon, N. Yokoyama, 2010, Journal of Cell Science.

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.

Hsien-yu Wang, Yuan Gao, Yi-Nan Lee, 2008, Cellular signalling.

Activation of Rat Frizzled-1 Promotes Wnt Signaling and Differentiation of Mouse F9 Teratocarcinoma Cells via Pathways That Require Gαq and Gαo Function*

R. Moon, Xunxian Liu, Hsien-yu Wang, 1999, The Journal of Biological Chemistry.

MEKK4 Mediates Differentiation in Response to Retinoic Acid via Activation of c-Jun N-terminal Kinase in Rat Embryonal Carcinoma P19 Cells*

Hsien-yu Wang, C. Malbon, H. Wang, 2000, The Journal of Biological Chemistry.

The 15-amino acid motif of the C terminus of the beta2-adrenergic receptor is sufficient to confer insulin-stimulated counterregulation to the beta1-adrenergic receptor.

E. Shumay, S. Gavi, Hsien-yu Wang, 2005, Endocrinology.

Inducible, tissue-specific suppression of heterotrimeric G protein α subunits in vivo

Hsien-yu Wang, C. Malbon, X. Huang, 2002 .

Targeted, regulatable expression of activated heterotrimeric G protein alpha subunits in transgenic mice.

Xi-Ping Huang, Hsien-yu Wang, C. Malbon, 2002, Methods in enzymology.

c-Src Tyrosine Kinase Binds the β2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2, and Mediates Agonist-induced Receptor Desensitization*

E. Shumay, Hsien-yu Wang, C. Malbon, 2001, The Journal of Biological Chemistry.

Ku80 is required but not sufficient for Galpha13-mediated endodermal differentiation in P19 embryonic carcinoma cells.

Hsien-yu Wang, C. Malbon, J. Kanungo, 2004, Biochemical and biophysical research communications.

Gsα Repression of Adipogenesis via Syk*

Hsien-yu Wang, C. Malbon, 1999, The Journal of Biological Chemistry.

Identification of Amino Acid Residues of Gsα Critical to Repression of Adipogenesis*

Xunxian Liu, Hsien-yu Wang, C. Malbon, 1998, The Journal of Biological Chemistry.

Temporal Activation of Ca2+-Calmodulin-sensitive Protein Kinase Type II Is Obligate for Adipogenesis*

M. Goligorsky, Hsien-yu Wang, C. Malbon, 1997, The Journal of Biological Chemistry.

Probing receptor structure/function with chimeric G-protein-coupled receptors.

S. Gavi, Hsien-yu Wang, C. Malbon, 2004, Molecular pharmacology.

AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes.

Hsien-yu Wang, C. Malbon, J. Tao, 2004, The Biochemical journal.

Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via β-adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor*

Hsien-yu Wang, C. Malbon, Sergey Doronin, 2000, The Journal of Biological Chemistry.

Dishevelled: a mobile scaffold catalyzing development.

Hsien-yu Wang, C. Malbon, 2006, Current Topics in Developmental Biology.

Suppression of Cyclic GMP-dependent Protein Kinase Is Essential to the Wnt/cGMP/Ca2+ Pathway*

Li Ma, Hsien-yu Wang, 2006, Journal of Biological Chemistry.

G-Protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin).

E. Shumay, Hsien-yu Wang, C. Malbon, 2006, European journal of cell biology.

AKAP12 and AKAP5 form higher-order hetero-oligomers

Hsien-yu Wang, C. Malbon, Shujuan Gao, 2011, Journal of molecular signaling.

AKAP5 and AKAP12 Form Homo-oligomers

Hsien-yu Wang, C. Malbon, Shujuan Gao, 2011, Journal of molecular signaling.

Src Docks to A-kinase Anchoring Protein Gravin, Regulating β2-Adrenergic Receptor Resensitization and Recycling*

Hsien-yu Wang, C. Malbon, J. Tao, 2007, Journal of Biological Chemistry.

Protein kinase A regulates AKAP250 (gravin) scaffold binding to the β2‐adrenergic receptor

Hsien-yu Wang, C. Malbon, J. Tao, 2003, The EMBO journal.

Dvl3 translocates IPMK to the cell membrane in response to Wnt.

Ying Wang, Hsien-yu Wang, 2012, Cellular signalling.

Probing the physical nature and composition of signalsomes

Hsien-yu Wang, C. Malbon, 2011, Journal of molecular signaling.

Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling

Ying Wang, Li Ma, Hsien-yu Wang, 2010, Journal of molecular signaling.

Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization.

E. Shumay, Hsien-yu Wang, C. Malbon, 2007, The Journal of biological chemistry.

Conditional, Tissue-specific Expression of Q205L Gαi2 in Vivo Mimics Insulin Activation of c-Jun N-terminal Kinase and p38 Kinase*

Hsien-yu Wang, C. Malbon, H. Wang, 1998, The Journal of Biological Chemistry.

Gene profiling of transgenic mice with targeted expression of activated heterotrimeric G protein alpha subunits using DNA microarray.

Xi-Ping Huang, Hsien-yu Wang, J. Tao, 2002, Methods in enzymology.

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

G. Nuovo, Hsien-yu Wang, C. Malbon, 1997, The Journal of clinical investigation.

G-protein mRNA levels during adipocyte differentiation.

Hsien-yu Wang, C. Malbon, H. Wang, 1989, Biochemical and biophysical research communications.

PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development.

Hsien-yu Wang, C. Malbon, H. Wang, 2004, Biochemical Society transactions.

Inositol pentakisphosphate mediates Wnt/beta-catenin signaling.

Hsien-yu Wang, Yuan Gao, 2007, The Journal of biological chemistry.

Probing Receptor Structure/Function with Chimeric G-Protein-Coupled Receptors

S. Gavi, Hsien-yu Wang, C. Malbon, 2004 .

Probing receptor structure/function with chimeric G-protein-coupled receptors.

S. Gavi, Hsien-yu Wang, C. Malbon, 2004, Molecular pharmacology.

Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.

R. Moon, Hsien-yu Wang, C. Malbon, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Gα13 Signals via p115RhoGEF Cascades Regulating JNK1 and Primitive Endoderm Formation*

Hsien-yu Wang, C. Malbon, Yi-Nan Lee, 2004, Journal of Biological Chemistry.

Dishevelled C‐terminus: prolyl and histidinyl motifs

Hsien-yu Wang, C. Malbon, H. Wang, 2012, Acta physiologica.

AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signalling.

E. Shumay, Hsien-yu Wang, C. Malbon, 2004, Biochemical Society transactions.