C. Sigmund

C. Sigmund, F. Faraci, K. Lamping, 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization

F. Quelle, C. Sigmund, Chien-Wei Lin, 2022, JCI insight.

Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle.

Christopher J. Pelham, C. Sigmund, H. Keen, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Cerebral Vascular Dysfunction Mediated by Superoxide in Hyperhomocysteinemic Mice

T. Bottiglieri, C. Sigmund, F. Faraci, 2004, Stroke.

Genetic basis of hypertension: revisiting angiotensinogen.

C. Sigmund, M. E. Dickson, Matthew E. Dickson, 2006, Hypertension.

ACE, ACE inhibitors, and other JNK.

C. Sigmund, M. Ryan, 2004, Circulation research.

Nuclear localization of angiotensinogen in astrocytes.

C. Sigmund, Xuebo Liu, Xiaoji Zhang, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice.

A. Mark, D. Morgan, C. Sigmund, 1999, Journal of hypertension.

Increased Superoxide and Vascular Dysfunction in CuZnSOD-Deficient Mice

C. Sigmund, F. Faraci, L. Didion, 2002, Circulation research.

Renal Thrombotic Microangiopathy in a Genetic Model of Hypertension in Mice

C. Sigmund, D. Heistad, S. Sethi, 2006, Experimental biology and medicine.

Antibiotic Resistance Mutations in Escherichia Coli Ribosomal RNA Genes and their Uses

C. Sigmund, E. A. Morgan, S. T. Gregory, 1988 .

Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli.

C. Sigmund, E. A. Morgan, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Nucleic Acids Research Antibiotic resitce mutations in 16S and 23S ribosomal RNA genes of Escherichia coli

C. Sigmund, E. A. Morgan, M. Ettayebi, 2022 .

Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice.

N. Maeda, C. Sigmund, D. Heistad, 1999, American journal of physiology. Heart and circulatory physiology.

Transgenic animals in the study of blood pressure regulation and hypertension.

C. Sigmund, G. Yang, J. Robillard, 1995, The American journal of physiology.

Transgenic Animals as Tools in Hypertension Research

C. Sigmund, J. Lang, N. L. Sinclair, 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Structure, Expression, and Regulation of the Murine Renin Genes

C. Sigmund, K. Gross, 1991, Hypertension.

Smooth Muscle Peroxisome Proliferator–Activated Receptor &ggr; Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo

R. Starke, D. Hasan, N. Chalouhi, 2015, Hypertension.

Genetic Interference With Endothelial PPAR-&ggr; (Peroxisome Proliferator–Activated Receptor-&ggr;) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1–7

C. Sigmund, F. Faraci, Chunyan Hu, 2017, Hypertension.

Endothelial Dysfunction and Blood Pressure Variability in Selected Inbred Mouse Strains

D. Davis, C. Sigmund, F. Faraci, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial PPAR&ggr; (Peroxisome Proliferator–Activated Receptor-&ggr;) Is Essential for Preventing Endothelial Dysfunction With Aging

C. Sigmund, F. Faraci, Ying Li, 2018, Hypertension.

Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.

C. Kane, J. Ingelfinger, Y. Rustum, 1990, The Journal of biological chemistry.

The earliest metanephric arteriolar progenitors and their role in kidney vascular development.

C. Sigmund, Minghong Li, R. A. Gomez, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

D. Davis, C. Sigmund, H. Keen, 2002, Physiological genomics.

Genetic Evidence That Lethality in Angiotensinogen-deficient Mice Is Due to Loss of Systemic but Not Renal Angiotensinogen*

D. Stec, C. Sigmund, Yueming Ding, 2001, The Journal of Biological Chemistry.

Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

J. Stokes, R. Weiss, C. Sigmund, 2008, American journal of physiology. Renal physiology.

Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-κB Activation in Human Endothelial Cells

C. Sigmund, Xuebo Liu, N. Weintraub, 2004, Circulation.

E 47 , and SREBP-1 c Fat Factors Controlling Adiponectin Expression

K. Rahmouni, C. Sigmund, 2008 .

Fat Factors Controlling Adiponectin Expression

K. Rahmouni, C. Sigmund, 2008 .

Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression.

K. Rahmouni, C. Sigmund, 2008, Circulation research.

Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism

L. Ponto, D. Morgan, K. Rahmouni, 2017, Hypertension.

Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin.

G. Pierce, C. Sigmund, K. Gibson-Corley, 2018, American journal of physiology. Regulatory, integrative and comparative physiology.

lipogenesis from glucose without altering glucose uptake ' ' rosiglitazone enhances rat brown adipose tissue agonist γ : focus on ' ' The PPAR brown vs . white adipose differentially regulates energy substrate handling in γ PPAR

C. Sigmund, J. Grobe, M. Ryan, 2014 .

Editorial Focus: PPAR (cid:1) differentially regulates energy substrate handling in brown vs. white adipose : focus on “The PPAR (cid:1) agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake”

C. Sigmund, J. Grobe, M. Ryan, 2009 .

PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake".

C. Sigmund, J. Grobe, M. Ryan, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin".

C. Sigmund, K. Gross, R. A. Gomez, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Twists and turns in the search for the elusive renin processing enzyme . Editorial Focus on “ Cathepsin B is not the processing enzyme for mouse prorenin ”

C. Sigmund, K. Gross, R. A. Gomez, 2010 .

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.

M. Cassell, K. Rahmouni, D. Guo, 2016, Endocrinology.

Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II–Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function

M. Chapleau, R. Weiss, D. Morgan, 2015, Journal of the American Heart Association.

Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice.

C. Sigmund, K. Gross, C. Kane, 1992, Circulation research.

PPAR&ggr; Agonist Rosiglitazone Improves Vascular Function and Lowers Blood Pressure in Hypertensive Transgenic Mice

S. Mathur, C. Sigmund, F. Faraci, 2004, Hypertension.

Differential Control of Calcium Homeostasis and Vascular Reactivity by Ca2+/Calmodulin-Dependent Kinase II

Mark E. Anderson, R. Weiss, Pimonrat Ketsawatsomkron, 2013, Hypertension.

Increased Renin Production in Mice With Deletion of Peroxisome Proliferator-Activated Receptor-&ggr; in Juxtaglomerular Cells

C. Sigmund, M. L. Sequeira López, R. A. Gomez, 2010, Hypertension.

Recent Advances in Hypertension

A. Kwitek, C. Sigmund, J. Grobe, 2021, Hypertension.

Ablation of the Leptin Receptor in the Hypothalamic Arcuate Nucleus Abrogates Leptin-Induced Sympathetic Activation

A. Mark, M. Cassell, D. Morgan, 2011, Circulation research.

Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent.

M. Cassell, Pimonrat Ketsawatsomkron, D. Davis, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity.

A. Mark, K. Rahmouni, C. Sigmund, 2004, American journal of physiology. Endocrinology and metabolism.

Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance.

K. Rahmouni, D. Guo, C. Sigmund, 2016, Physiological genomics.

Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism.

C. Sigmund, G. Deng, J. Grobe, 2017, Physiological genomics.

Genetic Interference With Peroxisome Proliferator–Activated Receptor &ggr; in Smooth Muscle Enhances Myogenic Tone in the Cerebrovasculature via A Rho Kinase–Dependent Mechanism

Pimonrat Ketsawatsomkron, C. Sigmund, F. Faraci, 2015, Hypertension.

Role of CaMKII in Ang-II-dependent small artery remodeling.

Pimonrat Ketsawatsomkron, C. Sigmund, K. Lamping, 2016, Vascular pharmacology.

Endothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet

W. D. de Lange, C. Sigmund, F. Faraci, 2008, Circulation research.

Gamma Causes Cerebral Vascular Dysfunction in Response to a High-fat Diet Endothelium-specific Interference with Peroxisome Proliferator Activated Receptor Endothelium-specific Interference with Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a Hi

W. D. de Lange, C. Sigmund, F. Faraci, 2008 .

Failure to Vasodilate in Response to Salt Loading Blunts Renal Blood Flow and Causes Salt-Sensitive Hypertension.

R. Weiss, J. McCormick, D. Morgan, 2020, Cardiovascular research.

Hypertension-Causing Mutation in Peroxisome Proliferator–Activated Receptor &ggr; Impairs Nuclear Export of Nuclear Factor-&kgr;B p65 in Vascular Smooth Muscle

F. Quelle, K. Rahmouni, D. Guo, 2017, Hypertension.

Role of Vascular Smooth Muscle PPARγ in Regulating AT1 Receptor Signaling and Angiotensin II-Dependent Hypertension

D. Davis, C. Sigmund, J. Grobe, 2014, PloS one.

A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system.

C. Sigmund, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Lipid Deposition , and Fibrosis in Aortic Valves and Aorta

R. Brooks, R. Weiss, C. Sigmund, 2022 .

Local Production of Angiotensinogen

K. Rahmouni, C. Sigmund, 2005 .

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

A. Mark, K. Rahmouni, C. Sigmund, 2009, Diabetes.

Lower Blood Pressure in Floxed Angiotensinogen Mice After Adenoviral Delivery of Cre-Recombinase

D. Stec, C. Sigmund, H. Keen, 2002, Hypertension.

Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.

C. Sigmund, J. Gallagher, W. Held, 1994, Cancer research.

Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma

Pimonrat Ketsawatsomkron, C. Sigmund, 2015, Current opinion in nephrology and hypertension.

PPARγ: no SirT, no service.

F. Quelle, C. Sigmund, 2013, Circulation research.

Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension

R. Santos, C. Sigmund, C. Halabi, 2010, Circulation research.

Molecular Mechanisms Regulating Vascular Tone by PPAR γ

Pimonrat Ketsawatsomkron, C. Sigmund, 2015 .

A Second Chance for a PPAR (cid:1) Targeted Therapy? Ligand

C. Sigmund, A. Norris, 2011 .

Expression of the DBA/2J Ren‐2 gene in the adrenal gland of transgenic mice.

J. Mullins, C. Sigmund, K. Gross, 1989, The EMBO journal.

The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system

M. Cassell, T. Gray, C. Sigmund, 1999, Brain Research.

Endothelial Dysfunction and Elevation of S-Adenosylhomocysteine in Cystathionine &bgr;-Synthase–Deficient Mice

N. Maeda, T. Bottiglieri, C. Sigmund, 2001, Circulation research.

The −20 and −217 Promoter Variants Dominate Differential Angiotensinogen Haplotype Regulation in Angiotensinogen-Expressing Cells

Biophysics, K. Rahmouni, C. Sigmund, 2007, Hypertension.

Glia- and Neuron-specific Expression of the Renin-Angiotensin System in Brain Alters Blood Pressure, Water Intake, and Salt Preference*

M. Cassell, C. Sigmund, S. Morimoto, 2002, The Journal of Biological Chemistry.

The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.

A. Mark, D. Thedens, W. D. de Lange, 2010, Cell metabolism.

Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice

C. Sigmund, J. Grobe, Ko‐ting Lu, 2021, bioRxiv.

Renin-Angiotensin System Physiological Insights from Genetic Manipulation of the

C. Sigmund, 2016 .

Transgenic mice for studies of the renin-angiotensin system in hypertension.

C. Sigmund, K. Sakai, H. Keen, 2004, Acta physiologica Scandinavica.

The Renin-angiotensin System in Hypertension: a Review of Studies Using Transgenic Animals the Renin-angiotensin System

C. Sigmund, J. Lavoie, Lavoie Jl, 2022 .

Physiological insights from genetic manipulation of the renin-angiotensin system.

D. Stec, C. Sigmund, 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Chorionic enhancer is dispensable for regulated expression of the human renin gene.

Xiyou Zhou, C. Sigmund, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

RESEARCH Integrative Cardiovascular Physiology and Pathophysiology Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system

C. Sigmund, Yumei Feng, S. Earley, 2018 .

Local production of angiotensin II in the subfornical organ causes elevated drinking.

M. Cassell, C. Sigmund, K. Sakai, 2007, The Journal of clinical investigation.

Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice.

M. Cassell, D. Davis, C. Sigmund, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Angiotensinogen Driven by the Glial Fibrillary Acidic Protein Promoter Elevated Blood Pressure in Transgenic Mice With Brain-Specific Expression of Human

M. Cassell, C. Sigmund, A. Johnson, 2001 .

Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite.

M. Cassell, C. Sigmund, S. Morimoto, 2002, Physiological genomics.

Angiotensin mutant mice: A focus on the brain renin-angiotensin system

C. Sigmund, S. Morimoto, 2002, Neuropeptides.

Regulation of renin expression and blood pressure by vitamin D(3).

C. Sigmund, 2002, The Journal of clinical investigation.

Vascular versus tubular renin: role in kidney development.

C. Sigmund, Minghong Li, R. A. Gomez, 2015, American Journal of Physiology. Regulatory Integrative and Comparative Physiology.

Hypertension-Causing Mutations in Cullin3 Impair RhoA Ubiquitination and Augment Association with Substrate Adaptors

Stella-Rita C. Ibeawuchi, F. Quelle, C. Sigmund, 2015 .

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products

L. Maquat, C. Sigmund, K. Gross, 1992, Molecular and cellular biology.

Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.

N. Maeda, C. Sigmund, D. Heistad, 1998, American journal of physiology. Heart and circulatory physiology.

Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.

N. Maeda, C. Sigmund, D. Heistad, 1998, The American journal of physiology.

Inactivation of NADPH oxidase organizer 1 Results in Severe Imbalance

C. Sigmund, J. Baltrusaitis, Richard J. H. Smith, 2006, Current Biology.

Human renin 5'-flanking DNA to nucleotide-2750.

David L. Smith, B. Morris, C. Sigmund, 1995, DNA sequence : the journal of DNA sequencing and mapping.

Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury

Fei Wang, D. Kohan, C. Sigmund, 2016, PloS one.

Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake.

M. Cassell, D. Davis, C. Sigmund, 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

Endothelial PPAR-&ggr; Protects Against Vascular Thrombosis by Downregulating P-Selectin Expression

A. Chauhan, Pimonrat Ketsawatsomkron, C. Sigmund, 2015, Arteriosclerosis, thrombosis, and vascular biology.

ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation

C. Sigmund, J. Grobe, J. Segar, 2022, Hypertension.

Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression*

C. Sigmund, K. Gross, C. Kane, 2001, The Journal of Biological Chemistry.

Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line.

C. Sigmund, G. Yang, J. Kern, 1995, Hypertension.

Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons

C. Sigmund, J. Grobe, Erin E Duffy, 2022, Frontiers in Synaptic Neuroscience.

Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase

M. Cassell, C. Sigmund, A. A. Spector, 2009, Brain Research.

Mn-SOD-deficient mice Selective cerebral vascular dysfunction in

C. Sobey, C. Sigmund, F. Faraci, 2015 .

Oxidative Stress through Activation of NAD(P)H Oxidase in Hypertensive Mice with Spontaneous Intracranial Hemorrhage

Saul Wilson, C. Sigmund, D. Heistad, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

mouseangiotensinogen using gene targeting in the Physiological significance of two common haplotypes of

A. Kwitek, S. Khuder, S. Fiering, 2015 .

Estrogen Receptor &agr; Is Required for Maintaining Baseline Renin Expression

C. Sigmund, R. A. Gomez, M. L. Sequeira-Lopez, 2016, Hypertension.

Is Peroxisome Proliferator-Activated Receptor-γ a New “Pal” of Renin?

C. Sigmund, Hana A. Itani, H. Keen, 2007 .

Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells.

C. Sigmund, Xuebo Liu, Q. Shi, 2006, Endocrinology.

Retinoic Acid-mediated Activation of the MouseRenin Enhancer*

C. Sigmund, K. Gross, Q. Shi, 2001, The Journal of Biological Chemistry.

Role of Proximal Promoter Elements in Regulation of Renin Gene Transcription*

J. Fabian, C. Sigmund, K. Gross, 1996, The Journal of Biological Chemistry.

Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II–Induced Organ Damage

D. Morgan, K. Rahmouni, C. Sigmund, 2020, Hypertension.

Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice.

J. Mullins, J. Fabian, C. Sigmund, 1990, Biochemical and biophysical research communications.

Expression of murine renin genes during fetal development.

C. Sigmund, K. Gross, R. McGowan, 1990, Molecular endocrinology.

An androgen-inducible proximal tubule-specific Cre recombinase transgenic model.

Xiyou Zhou, D. Davis, C. Sigmund, 2008, American journal of physiology. Renal physiology.

mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II.

K. Muta, D. Morgan, K. Rahmouni, 2016, Endocrinology.

Downregulation of renin gene expression by interleukin-1.

C. Sigmund, K. Gross, C. Kane, 1997, Hypertension.

Vasopressin: the missing link for preeclampsia?

G. Pierce, E. Devor, C. Sigmund, 2015, American journal of physiology. Regulatory, integrative and comparative physiology.

EB 2015 Water and Electrolyte Homeostasis Section Data Diuresis Reviews Vasopressin : the missing link for preeclampsia ?

G. Pierce, E. Devor, C. Sigmund, 2015 .

allelescauses noncell-specific deletion of floxed Germ line activation of the Tie2 and SMMHC

E. Radaelli, J. Haigh, C. Sigmund, 2012 .

Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice.

H. Jacob, J. Ingelfinger, C. Sigmund, 1991, The American journal of physiology.

Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system.

C. Sigmund, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.

C. Sigmund, J. Grobe, Di Xu, 2008, Physiology.

Adjacent Expression of Renin and Angiotensinogen in the Rostral Ventrolateral Medulla Using a Dual-Reporter Transgenic Model

M. Cassell, C. Sigmund, K. Gross, 2004, Hypertension.

Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model.

M. Cassell, C. Sigmund, K. Gross, 2004, Physiological genomics.

Effects of Escherichia coli Nus A protein on transcription termination in vitro are not increased or decreased by DNA sequences sufficient for antitermination in vivo.

C. Sigmund, E. A. Morgan, 1988, Biochemistry.

Evidence Supporting a Functional Role for Intracellular Renin in the Brain

C. Sigmund, Xuebo Liu, A. Johnson, 2006, Hypertension.

Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension

A. Mark, M. Cassell, H. Stauss, 2013, Hypertension.

Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice

D. Davis, C. Sigmund, Xuebo Liu, 2011, Hypertension.

Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen.

C. Sigmund, F. Faraci, G. Baumbach, 2002, American journal of physiology. Heart and circulatory physiology.

Allele-Specific Expression of Angiotensinogen in Human Subcutaneous Adipose Tissue

A. Kwitek, C. Sigmund, Xuebo Liu, 2013, Hypertension.

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice

C. Sigmund, G. Deng, K. Gibson-Corley, 2022, Hypertension.

Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants.

C. Sigmund, J. Grobe, 2014, Hypertension.

Summary of tissues exhibiting primary expression of renin mRNAa

J. Fabian, C. Sigmund, K. Gross, 2003 .

Cre-Recombinase Lower Blood Pressure in Floxed Angiotensinogen Mice After Adenoviral Delivery of

D. Stec, C. Sigmund, H. Keen, 2002 .

Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney.

C. Sigmund, 2001, American journal of hypertension.

Mice heterozygous for β-ENaC deletion have defective potassium excretion

J. Stokes, C. Sigmund, R. Sigmund, 2006 .

Pregnant mice lacking indoleamine 2,3‐dioxygenase exhibit preeclampsia phenotypes

E. Devor, Pimonrat Ketsawatsomkron, D. Davis, 2015, Physiological reports.

A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells.

C. Sigmund, J. Sun, K. Gross, 1994, Kidney international.

How Is the Brain Renin-Angiotensin System Regulated?

C. Sigmund, P. Nakagawa, 2017, Hypertension.

Brain Endoplasmic Reticulum Stress Mechanistically Distinguishes the Saline-Intake and Hypertensive Response to Deoxycorticosterone Acetate–Salt

M. Cassell, C. Sigmund, J. Grobe, 2015, Hypertension.

Expression and regulation of the renin gene.

J. Fabian, C. Sigmund, K. Gross, 1992, Trends in cardiovascular medicine.

Cerebral vascular effects of angiotensin II: New insights from genetic models

C. Sigmund, F. Faraci, K. Lamping, 2005 .

Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice.

J. Laragh, C. Sigmund, K. Gross, 1998, Circulation research.

Appropriate Tissue- and Cell-specific Expression of a Single Copy Human Angiotensinogen Transgene Specifically Targeted Upstream of the HPRT Locus by Homologous Recombination*

C. Sigmund, B. Yang, R. Williamson, 2000, The Journal of Biological Chemistry.

Collecting duct renin regulates potassium homeostasis in mice

C. Sigmund, N. Ramkumar, Yantin Chen, 2022, Acta physiologica.

Cardiovascular Consequences of Genetic Variation at −6/235 in Human Angiotensinogen Using “Humanized” Gene-Targeted Mice

D. Davis, C. Sigmund, J. Grobe, 2010, Hypertension.

A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.

C. Sigmund, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension : focus on “ A haplotype of human angiotensinogen gene containing 217 A increases blood pressure in transgenic mice compared with 217

C. Sigmund, 2008 .

Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice.

C. Sigmund, Y. Ding, 2001, American journal of physiology. Renal physiology.

Regulation of human renin mRNA expression and protein release in transgenic mice.

C. Sigmund, S. B. Smith, M. W. Thompson, 1996, Hypertension.

Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1).

C. Sigmund, K. Gross, J. Lang, 1995, Endocrinology.

No Brain Renin-Angiotensin System: Déjà vu All Over Again?

C. Sigmund, D. Diz, M. Chappell, 2017, Hypertension.

Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.

M. Cassell, C. Sigmund, Xuebo Liu, 2017, American journal of physiology. Regulatory, integrative and comparative physiology.

Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension

M. Cassell, D. Morgan, K. Rahmouni, 2016, Hypertension.

Neurons : Fact , Hypothesis , or Fantasy An Intracellular Renin-Angiotensin System in

C. Sigmund, J. Grobe, Di Xu, 2008 .

Using a Dual-Reporter Transgenic Model Adjacent Expression of Renin and Angiotensinogen in the Rostral Ventrolateral Medulla

M. Cassell, C. Sigmund, K. Gross, 2004 .

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation.

C. Sigmund, P. Sinn, 2000, Physiological genomics.

Identiﬁcation of three human renin mRNA isoforms from alternative tissue-speciﬁc transcriptional initiation

C. Sigmund, P. Sinn, 2000 .

Developmental expression of human angiotensinogen in transgenic mice.

C. Sigmund, Gongyu Yang, 1998, American journal of physiology. Renal physiology.

Functional expression of the human angiotensinogen gene in transgenic mice.

C. Sigmund, G. Yang, J. Robillard, 1994, The Journal of biological chemistry.

Renin Promoter SV40 T‐Antigen Transgenic Mouse A Model of Primary Renal Vascular Hyperplasia

H. Jacob, C. Sigmund, V. Dzau, 1991, Hypertension.

C. Sigmund, J. Lavoie, 2022 .

Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

John A Wemmie, Curt D Sigmund, M. Welsh, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Endothelial and Vascular Muscle PPAR&ggr; in Arterial Pressure Regulation: Lessons From Genetic Interference and Deficiency

C. Sigmund, 2010, Hypertension.

Angiotensin II–Induced Vascular Dysfunction Is Mediated by the AT1A Receptor in Mice

S. Mathur, C. Sigmund, F. Faraci, 2004, Hypertension.

Angiotensin II – Induced Vascular Dysfunction Is Mediated by the AT 1 A Receptor in Mice

S. Mathur, C. Sigmund, F. Faraci, 2004 .

Vascular biology in genetically altered mice : smaller vessels, bigger insight.

C. Sigmund, F. Faraci, F M Faraci, 1999, Circulation research.

Differential expression of angiotensin receptor 1A and 1B in mouse.

C. Sigmund, G. Aguilera, K. Gross, 1994, The American journal of physiology.

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure.

D. Davis, C. Sigmund, J. Grobe, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?*

Pimonrat Ketsawatsomkron, C. Sigmund, F. Faraci, 2010, The Journal of Biological Chemistry.

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.

G. Booz, C. Sigmund, S. Eguchi, 2018, Physiological reviews.

Activity of Protein Kinase C-&agr; Within the Subfornical Organ Is Necessary for Fluid Intake in Response to Brain Angiotensin

M. Cassell, C. Sigmund, J. Grobe, 2014, Hypertension.

Role of Peroxisome Proliferator–Activated Receptor-&ggr; in Vascular Muscle in the Cerebral Circulation

Pimonrat Ketsawatsomkron, C. Sigmund, F. Faraci, 2014, Hypertension.

Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.

W. D. de Lange, C. Sigmund, F. Faraci, 2008, Cell metabolism.

Structure of Cerebral Arterioles in Cystathionine &bgr;-Synthase-Deficient Mice

T. Bottiglieri, C. Sigmund, S. Lentz, 2002, Circulation research.

Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture.

G. Bishop, C. Sigmund, M. Munroe, 2004, Immunity.

Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice.

C. Sigmund, Xiaoji Zhang, R. Nistala, 2004, Physiological genomics.

PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium.

F. Quelle, C. Sigmund, Addison W. Woll, 2017, Physiological genomics.

PPARγ Regulation in Hypertension and Metabolic Syndrome

C. Sigmund, Chunyan Hu, Masashi Mukohda, 2015, Current Hypertension Reports.

Role of the Peroxisome Proliferator Activated Receptors in Hypertension

C. Sigmund, Jing Wu, Shi Fang, 2021, Circulation research.

Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation.

S. Oparil, W. Cushman, L. Appel, 2020, Hypertension.

PPARγ and RhoBTB1 in hypertension.

C. Sigmund, Shi Fang, 2019, Current opinion in nephrology and hypertension.

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.

Stella-Rita C. Ibeawuchi, F. Quelle, D. Guo, 2019, The Journal of clinical investigation.

Interference With Endothelial PPAR (Peroxisome Proliferator–Activated Receptor)-&ggr; Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation

C. Sigmund, Xuebo Liu, A. Nair, 2018, Hypertension.

Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin.

Stella-Rita C. Ibeawuchi, F. Quelle, D. Davis, 2017, JCI insight.

Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction.

D. Davis, C. Sigmund, F. Faraci, 2016, Physiological genomics.

Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator–Activated Receptor-&ggr; Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate–Salt Hypertension

Pimonrat Ketsawatsomkron, D. Davis, C. Sigmund, 2016, Hypertension.

Interference With Peroxisome Proliferator-Activated Receptor-&ggr; in Vascular Smooth Muscle Causes Baroreflex Impairment and Autonomic Dysfunction

D. Mohapatra, M. Cassell, D. Morgan, 2014, Hypertension.

PPAR γ Regulates Resistance Vessel Tone Through a Mechanism Involving RGS 5-Mediated Control of Protein Kinase C and BKCa Channel Activity

Xuebo Liu, Pimonrat Ketsawatsomkron, C. Sigmund, 2022 .

Peroxisome proliferator-activated receptor-γ protects against vascular aging.

C. Sigmund, F. Faraci, Y. Chu, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

A second chance for a PPARγ targeted therapy?

C. Sigmund, A. Norris, 2012, Circulation research.

Peroxisome Proliferator-Activated Receptor-β and its Agonists in Hypertension and Atherosclerosis

C. Sigmund, C. Halabi, 2005 .

Gene expression profiling of potential PPARγ target genes in mouse aorta

T. Casavant, T. Scheetz, S. Mathur, 2004 .

Differential requirement for SLP-76 domains in T cell development and function.

B. Freedman, G. Koretzky, C. Sigmund, 2001, Immunity.

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.

A. Mark, D. Morgan, K. Rahmouni, 2012, American journal of physiology. Heart and circulatory physiology.

Untraditional methods for targeting the kidney in transgenic mice.

C. Sigmund, H. Keen, J. Lavoie, 2003, American journal of physiology. Renal physiology.

Use of transgenic and knockout strategies in mice.

C. Sigmund, M. Ryan, 2002, Seminars in nephrology.

Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice.

D. Stec, C. Sigmund, S. Morimoto, 2001, BioTechniques.

Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity

A. Kwitek, K. Knudtson, K. Rahmouni, 2020, Hypertension.

Targeting brain AT1 receptors by RNA interference.

C. Sigmund, R. Davisson, 2006, Hypertension.

Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.

C. Sigmund, J. Engelhardt, M. Filali, 2004, American journal of physiology. Lung cellular and molecular physiology.

Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice.

C. Sigmund, G. Yang, G. Yang, 1998, Hypertension.

Are Dispensable in Transgenic Mice Regulatory Elements Required for Human Angiotensinogen Expression in HepG 2 Cells

C. Sigmund, Gongyu Yang, 1998 .

The microRNA-processing enzyme dicer maintains juxtaglomerular cells.

B. Harfe, C. Sigmund, O. Carretero, 2010, Journal of the American Society of Nephrology : JASN.

Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein Vivo *

B. Davidson, D. Stec, C. Sigmund, 1999, The Journal of Biological Chemistry.

Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome.

V. Sheffield, E. Stone, K. Rahmouni, 2005, Human molecular genetics.

Allele-specific expression of the murine Ren-1 genes.

J. Mullins, J. Fabian, C. Sigmund, 1989, The Journal of biological chemistry.

The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes.

M. Cassell, C. Sigmund, G. Yang, 1998, Circulation research.

Containing Both the Human Renin and Human Angiotensinogen Transgenes The Brain Renin-Angiotensin System Contributes to the Hypertension in Mice

M. Cassell, C. Sigmund, A. Johnson, 1998 .

The Brain Renin-Angiotensin System in Transgenic Mice Carrying a Highly Regulated Human Renin Transgene

M. Cassell, C. Sigmund, S. Morimoto, 2002, Circulation research.

Elevated Blood Pressure in Transgenic Mice With Brain-Specific Expression of Human Angiotensinogen Driven by the Glial Fibrillary Acidic Protein Promoter

Curt D. Sigmund, Martin D. Cassell, M. Cassell, 2001, Circulation research.

A colorful view of the brain renin–angiotensin system

C. Sigmund, J. Grobe, 2020, Hypertension Research.

The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation

C. Sigmund, J. Grobe, Javier A. Gomez, 2020, Current Hypertension Reports.

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin.

A. Mark, D. Morgan, K. Rahmouni, 2004, The Journal of clinical investigation.

Genetic Ablation of Angiotensinogen in the Subfornical Organ of the Brain Prevents the Central Angiotensinergic Pressor Response

C. Sigmund, K. Sakai, E. Lazartigues, 2006, Circulation research.

Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase.

D. Stec, C. Sigmund, 2001, Methods in molecular medicine.

Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus.

Xiyou Zhou, C. Sigmund, Xuebo Liu, 2008, American journal of physiology. Renal physiology.

Molecular evidence of tissue renin-angiotensin systems: A focus on the brain

C. Sigmund, K. Sakai, 2005, Current hypertension reports.

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

M. Goodheart, Y. Chai, C. Sigmund, 2007, Developmental biology.

Nus A protein affects transcriptional pausing and termination in vitro by binding to different sites on the transcription complex.

C. Sigmund, E. A. Morgan, 1988, Biochemistry.

Highly Regulated Cell Type-restricted Expression of Human Renin in Mice Containing 140- or 160-Kilobase Pair P1 Phage Artificial Chromosome Transgenes*

D. Davis, C. Sigmund, P. Sinn, 1999, The Journal of Biological Chemistry.

JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter.

C. Sigmund, P. Sinn, Xiaoji Zhang, 1999, American journal of physiology. Renal physiology.

Transgenic animal models as tools for studying renal developmental physiology

C. Sigmund, R. Davisson, 1996, Pediatric Nephrology.

Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli.

C. Sigmund, E. A. Morgan, M. Ettayebi, 1984, Nucleic acids research.

Insulin resistance in HIV protease inhibitor-associated diabetes.

K. Yarasheski, P. Cryer, P. Halban, 1999, Journal of acquired immune deficiency syndromes.

Modifiable Gene Expression in Mice: Kidney-Specific Deletion of a Target Gene via the Cre-loxP System

D. Stec, C. Sigmund, 1998, Nephron Experimental Nephrology.

Understanding hypertension through genetic manipulation in mice.

C. Sigmund, B. Cvetkovic, 2000, Kidney international.

Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension.

D. Stec, C. Sigmund, R. Davisson, 1998, Trends in cardiovascular medicine.

Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells.

C. Sigmund, K. Gross, C. Jones, 1997, Circulation research.

Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.

C. Sigmund, J. Robillard, B. Granwehr, 1996, The Journal of clinical investigation.

Species-specific differences in positive and negative regulatory elements in the renin gene enhancer.

C. Sigmund, K. Gross, T. A. Black, 1999, Circulation research.

Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways

C. Sigmund, K. D. Lake-Bruse, Kristy D. Lake-Bruse, 2000, Current hypertension reports.

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.

Stella-Rita C. Ibeawuchi, F. Quelle, D. Davis, 2016, JCI insight.

Abnormal Coronary Function in Mice Deficient in α1H T-type Ca2+ Channels

Chien-Chang Chen, Rita Barresi, Sarah K. England, 2003, Science.

RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.

J. Ingelfinger, P. Hamet, Shao-Ling Zhang, 2006, Kidney international.

Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule.

C. Sigmund, J. Lavoie, K. D. Lake-Bruse, 2004, American journal of physiology. Renal physiology.

Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice.

H. Kobori, L. Navar, C. Sigmund, 2007, American journal of physiology. Renal physiology.

Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents

A. Kwitek, J. Kirby, C. Sigmund, 2022, Frontiers in Physiology.

Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice.

D. Stec, C. Sigmund, Y. Ding, 1999, Physiological genomics.

Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli

C. Sigmund, E. A. Morgan, L. G. Mark, 1983, Journal of bacteriology.

Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice.

C. Sigmund, J. Lin, Q Wang, 2000, Circulation research.

Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels.

Chien-Chang Chen, Curt D Sigmund, Rita Barresi, 2003, Science.

β-Arrestin-Biased Agonist Targeting the Brain AT1R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension.

S. Karnik, C. Sigmund, G. Deng, 2020, Hypertension.

Preservation of Intracellular Renin Expression Is Insufficient to Compensate for Genetic Loss of Secreted Renin

C. Sigmund, J. Grobe, Baoli Yang, 2009, Hypertension.

Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat

C. Sigmund, Y. Chu, W. Talman, 2012, The Journal of physiology.

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.

F. Quelle, J. McCormick, J. Singer, 2019, JCI insight.

Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or Agouti-related peptide.

Matthew J. Potthoff, C. Sigmund, G. Deng, 2020, American journal of physiology. Regulatory, integrative and comparative physiology.

Pioglitazone Attenuates Valvular Calcification Induced by Hypercholesterolemia

R. Brooks, R. Weiss, C. Sigmund, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Pioglitazone and Valvular / Vascular Calcification 525 Comparison of Gene Expression in Aortas Versus Aortic Valves

R. Brooks, R. Weiss, C. Sigmund, 2013 .

Transactivation of the Human Renin Promoter by the Cyclic AMP/Protein Kinase A Pathway Is Mediated by Both cAMP-responsive Element Binding Protein-1 (CREB)-dependent and CREB-independent Mechanisms in Calu-6 Cells*

B. Morris, C. Sigmund, L. Ying, 1997, The Journal of Biological Chemistry.

Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells.

B. Morris, C. Sigmund, L. Ying, 1996, The American journal of physiology.

Gene expression profiling of potential PPARgamma target genes in mouse aorta.

A. Beyer, T. Casavant, T. Scheetz, 2004, Physiological genomics.

Angiotensinogen Modulates Renal Vasculature Growth

C. Sigmund, P. Corvol, E. Larger, 2006, Hypertension.

Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle*

J. Pessin, C. Sigmund, Ahmir H. Khan, 2001, The Journal of Biological Chemistry.

Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice.

N. Maeda, C. Sigmund, D. Heistad, 1999, The American journal of physiology.

Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.

G. Pierce, R. Weiss, Matthew J. Potthoff, 2018, JCI insight.

Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals.

Josephine C. Adams, C. Sigmund, B. Yates, 2018, American journal of physiology. Regulatory, integrative and comparative physiology.

Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice

M. Chapleau, K. Knudtson, R. Brooks, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.

W. D. de Lange, C. Sigmund, C. Halabi, 2008, Physiological genomics.

metabolismaffect renal renin, baseline arterial pressure, or Neuron- or glial-specific ablation of secreted renin does

M. Cassell, D. Davis, C. Sigmund, 2015 .

Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.

M. Cassell, D. Davis, C. Sigmund, 2011, Physiological genomics.

Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure.

L. Navar, J. Cook, R. Re, 2010, American journal of physiology. Heart and circulatory physiology.

Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.

H. S. Kim, C. Sigmund, J. Krege, 1997, The Journal of clinical investigation.

Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension.

D. Kohan, C. Sigmund, A. Hoek, 2014, American journal of physiology. Renal physiology.

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor.

Matthew J. Potthoff, D. Morgan, K. Rahmouni, 2016, Cell reports.

Metabolic rate regulation by the renin–angiotensin system: brain vs. body

K. Rahmouni, C. Sigmund, Xuebo Liu, 2012, Pflügers Archiv - European Journal of Physiology.

Metabolic rate regulation by the renin–angiotensin system: brain vs. body

K. Rahmouni, C. Sigmund, Xuebo Liu, 2012, Pflügers Archiv - European Journal of Physiology.

Viewpoint: are studies in genetically altered mice out of control?

C. Sigmund, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Biosynthesis of renin in mouse kidney tumor As4.1 cells.

C. Sigmund, K. Gross, R. Swank, 1997, European journal of biochemistry.

Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort

G. Pierce, C. Sigmund, M. Santillan, 2020, Hypertension.

Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli.

C. Sigmund, E. A. Morgan, M. Ettayebi, 1988, Methods in enzymology.

Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension

A. Kwitek, C. Sigmund, G. Deng, 2023, Frontiers in Cellular Neuroscience.

Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects upon intake behaviors and energy homeostasis in C57BL/6J mice.

C. Sigmund, J. Grobe, J. Segar, 2022, American journal of physiology. Regulatory, integrative and comparative physiology.

Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent upon sodium and non-sodium components of diet.

A. Kwitek, A. Kriegel, C. Sigmund, 2022, American journal of physiology. Regulatory, integrative and comparative physiology.

Gene trapping uncovers gender‐specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression

D. Davis, C. Sigmund, Xuebo Liu, 2011, Hypertension.

Studies on the regulation of renin genes using transgenic mice.

J. Mullins, C. Sigmund, K. Gross, 1988, Clinical and experimental hypertension. Part A, Theory and practice.

Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.

Curt D Sigmund, Eric B Kmiec, E. Kmiec, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR−/− mice

D. Meyerholz, M. Welsh, C. Sigmund, 2011, Proceedings of the National Academy of Sciences.

Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites

S. Reddy, Rongsong Li, T. Hsiai, 2023, bioRxiv.

NF-Y Antagonizes Renin Enhancer Function by Blocking Stimulatory Transcription Factors

C. Sigmund, K. Gross, Q. Shi, 2001, Hypertension.

Expression of the human renin gene in transgenic mice throughout ontogeny

C. Sigmund, 1993, Pediatric Nephrology.

Major approaches for generating and analyzing transgenic mice. An overview.

C. Sigmund, C D Sigmund, 1993, Hypertension.

Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue.

C. Sigmund, K. Gross, 1990, Biochemical and biophysical research communications.

Expression of murine renin genes in subcutaneous connective tissue.

J. Mullins, C. Sigmund, K. Gross, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Microarray analysis of models of hypertension

C. Sigmund, H. Keen, 2006 .

Structural biology: On stress and pressure

C. Sigmund, 2010, Nature.

Functional characterization of polymorphisms in the kidney enhancer of the human renin gene.

C. Sigmund, Xuebo Liu, J. Pratt, 2007, Endocrinology.

From molecules to medicine: a future cure for preeclampsia?

C. Sigmund, M. Santillan, D. Santillan, 2009, Drug news & perspectives.

Abstract 10: Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice in vivo

R. Starke, D. Hasan, N. Chalouhi, 2016 .

The Kidney Androgen-regulated Protein Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice*

D. Hardy, C. Sigmund, R. Davisson, 1997, The Journal of Biological Chemistry.

EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

C. Sigmund, M. Schwartzman, J. Grobe, 2021, Hypertension.

Under Pressure: A Baroreceptor Mechanism in the Renal Renin Cell Controlling Renin.

C. Sigmund, P. Nakagawa, 2021, Circulation research.

Genetic manipulation of the renin-angiotensin system in the kidney.

C. Sigmund, 2001, Acta physiologica Scandinavica.

Ganglionic Action of Angiotensin Contributes to Sympathetic Activity in Renin-Angiotensinogen Transgenic Mice

F. Abboud, M. Chapleau, C. Sigmund, 2004, Hypertension.

HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression.

C. Sigmund, M. Ryan, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin.

C. Sigmund, J. Engelhardt, M. Filali, 2004, The Journal of investigative dermatology.

Interleukin-1 (cid:1) Attenuates Renin Gene Expression Via a Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase and Signal Transducer and Activator of Transcription 3-Dependent Mechanism in As4.1 Cells

C. Sigmund, Xuebo Liu, Q. Shi, 2022 .

Developmental expression of human angiotensinogen in transgenic mice

C. Sigmund, G. Yang, Gongyu Yang, 1998 .

PPAR&ggr; Regulates Resistance Vessel Tone Through a Mechanism Involving RGS5-Mediated Control of Protein Kinase C and BKCa Channel Activity

Pimonrat Ketsawatsomkron, C. Sigmund, Xuebo Liu, 2012, Circulation research.

Bioinformatic Analysis of Gene Sets Regulated by Ligand-Activated and Dominant-Negative Peroxisome Proliferator–Activated Receptor &ggr; in Mouse Aorta

T. Casavant, N. Maeda, W. D. de Lange, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice

A. Kwitek, G. Pierce, E. Devor, 2019, Hypertension.

Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data.

Thomas L. Casavant, Jinlu Cai, Henry L. Keen, 2012, Journal of integrative bioinformatics.

Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data

Jinlu Cai, Henry L Keen, Curt D Sigmund, 2012, J. Integr. Bioinform..

Preservation of Intracellular Renin Expression Is Insufficient to Compensate for Genetic Loss of Secreted Renin

C. Sigmund, J. Grobe, Baoli Yang, 2009, HYPERTENSION.

Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity

D. Atasoy, C. Sigmund, G. Deng, 2023, Cell reports.

Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system.

C. Sigmund, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Pivotal Role of Local Ang-II Production in the Subfornical Organ on Water Intake: 2

L. Navar, M. Cassell, C. Sigmund, 2005 .

Gene expression profiling of potential PPARγ target genes in mouse aorta

T. Casavant, T. Scheetz, S. Mathur, 2004 .

Ghrelin Inhibits Proinflammatory Responses and Nuclear Factor-κB Activation in Human Endothelial Cells

C. Sigmund, Xuebo Liu, N. Weintraub, 2004, Circulation.

The microRNA-processing enzyme dicer maintains juxtaglomerular cells.

B. Harfe, C. Sigmund, O. Carretero, 2010, Journal of the American Society of Nephrology : JASN.

Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II

C. Sigmund, H. Keen, 2001, Hypertension.

CALL FOR PAPERS Integrative and Translational Physiology: Inflammation and Immunity in Organ System Physiology Dominant negative PPAR promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle

C. Sigmund, H. Keen, S. Lentz, 2013 .