Stephen A. Smith

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Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase.

M. Coghlan, K. Macaulay, É. Hajduch, 2003, European journal of biochemistry.

Resistin is expressed in human macrophages and directly regulated by PPARγ activators

Joanna D. Holbrook, Paul R. Murdock, P. Murdock, 2003 .

Specific purine N7-nitrogens are critical for high affinity binding by the trp repressor

Stephen A. Smith, L. McLaughlin, S. B. Rajur, 1994, Nature Structural Biology.

4-Bromomethyl-2-chlorooxazole––a versatile oxazole cross-coupling unit for the synthesis of 2,4-disubstituted oxazoles

Richard J. K. Taylor, G. L. Young, Stephen A. Smith, 2004 .

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Martin D. Brand, Mark Skehel, Sohaila Rastan, 2000, Nature.

Normalization of skeletal muscle glycogen synthesis and glycolysis in rosiglitazone-treated Zucker fatty rats: an in vivo nuclear magnetic resonance study.

S. Sarkar, Stephen A. Smith, H. Davis, 2002, Diabetes.

Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080

N. Morgan, Stephen A. Smith, M. Stillings, 1993, British journal of pharmacology.

Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro.

J. Holder, Stephen A. Smith, A. Green, 2002, Diabetes.

Repeat Treatment of Obese Mice With BRL 49653, a New Potent Insulin Sensitizer, Enhances Insulin Action in White Adipocytes: Association With Increased Insulin Binding and Cell-Surface GLUT4 as Measured by Photoaffinity Labeling

J. Holder, Stephen A. Smith, M. Cawthorne, 1995, Diabetes.

Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.

J. Holder, Stephen A. Smith, N. Patel, 2003, Diabetes.

Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes.

Stephen A. Smith, A. Barnett, P. Clark, 2003, The Journal of clinical endocrinology and metabolism.

Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators.

P. Murdock, J. Holbrook, Stephen A. Smith, 2003, Biochemical and biophysical research communications.

Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.

J. Hayes, Stephen A. Smith, I. Jowsey, 2003, Biochemical and biophysical research communications.

PPARγ Is Not a Critical Mediator of Primary Monocyte Differentiation or Foam Cell Formation

S. J. Newman, J. Clapham, Stephen A. Smith, 2002 .

Expression and functional activity of PPAR c in pancreatic b cells 1

N. Morgan, Stephen A. Smith, S. McBain, 2004 .

Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate

N. Morgan, Stephen A. Smith, M. Tadayyon, 2006, Apoptosis.

The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Hung‐Yuan Cheng, Stephen A. Smith, I. Stansfield, 2002, Bioorganic & medicinal chemistry letters.

2-[(substituted)phenyl]-5-[1-(2-phenylazacycloheptyl)methyl]-1H-pyrroles with high affinity and selectivity for the dopamine D3 receptor

G. Riley, Stephen A. Smith, Christopher N. Johnson, 1997 .

Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor : N-benzyl modifications

G. Riley, Stephen A. Smith, Christopher N. Johnson, 1997 .

N-(SUBSTITUTED-PHENYL) PIPERAZINES : ANTAGONISTS WITH HIGH BINDING AND FUNCTIONAL SELECTIVITY FOR DOPAMINE D4 RECEPTORS

G. Riley, Stephen A. Smith, G. Stemp, 1996 .

Probing the Interface of the trp Repressor–Operator Complex Using Operator Sequences Containing Isosteric Base-Pair Analogues☆

Stephen A. Smith, L. McLaughlin, 1999 .

The Discovery of SB-435495: A Potent, Orally Active Inhibitor of Lipoprotein-Associated Phospholipase A2 for Evaluation in Man.

Stephen A. Smith, 2003 .

Insulin Secretagogues with an Imidazoline Structure Inhibit Arginine-Induced Glucagon Secretion from Isolated Rat Islets of Langerhans

N. Morgan, Stephen A. Smith, M. Mourtada, 1997 .

Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.

H. Boyd, Stephen A. Smith, I. Stansfield, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and anti-arthritic activity of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines

P. Wyman, Stephen A. Smith, E. Karran, 1993 .

A [3 + 3] annelation approach to tetrahydropyridines.

Stephen A. Smith, J. P. Harrity, Lisa C. Pattenden, 2006, Organic letters.

Development of a [3+3] approach to tetrahydropyridines and its application in indolizidine alkaloid synthesis

H. Adams, Stephen A. Smith, J. P. Harrity, 2008 .

7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic Acids and 7-Benzoyl-2,3- dihydrobenzo[b]thiophene-3-carboxylic Acids as Analgesic Agents.

P. Wyman, Stephen A. Smith, R. Markwell, 1986 .

Synthesis of 2-hydroxy-3-methylcyclopent-2-enone from methyl acrylate

Stephen A. Smith, R. Cookson, 1980 .

A formal total synthesis of (+)-apicularen A: base-induced conversion of apicularen-derived intermediates into salicylihalamide-like products.

Stephen A. Smith, R. Taylor, S. A. Swain, 2003, Organic & biomolecular chemistry.

Carbohydrate-based routes to salicylate natural products: formal total synthesis of (+)-apicularen A from d-glucal

Stephen A. Smith, R. Taylor, S. A. Swain, 2001 .

Unsaturated enamides via organometallic addition to isocyanates: the synthesis of Lansamide-I, Lansiumamides A–C and SB-204900

Stephen A. Smith, R. Taylor, Ian Stefanuti, 2000 .

The identification of a novel renin inhibitor of equivalent efficacy following oral or intravenous administration.

P. Ham, Stephen A. Smith, R. Buckingham, 1994 .

Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues.

P. Murdock, J. Hayes, Stephen A. Smith, 2003, Prostaglandins & other lipid mediators.

Reduction of intramyocellular lipid following short-term rosiglitazone treatment in Zucker fatty rats: an in vivo nuclear magnetic resonance study.

S. Sarkar, Stephen A. Smith, B. Jucker, 2003, Metabolism: clinical and experimental.

The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macrophages*

H. Vosper, C. Wolf, Stephen A. Smith, 2001, The Journal of Biological Chemistry.

Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

I. Pass, C. Downes, Stephen A. Smith, 2001, Current Biology.

Homologous recombination prevents methylation-induced toxicity in Escherichia coli

M. Marinus, B. Engelward, Stephen A. Smith, 2006, Nucleic acids research.

Rosiglitazone Protects against Ischemia/Reperfusion-Induced Leukocyte Adhesion in the Zucker Diabetic Fatty Rat

Z. Ao, D. Johns, S. Douglas, 2005, Journal of Pharmacology and Experimental Therapeutics.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Insulin-Mediated Upregulation of the Renin Angiotensin System in Human Subcutaneous Adipocytes Is Reduced by Rosiglitazone

S. Coppack, Stephen A. Smith, P. McTernan, 2005, Circulation.

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

Hung‐Yuan Cheng, Stephen A. Smith, I. Stansfield, 2003, Bioorganic & medicinal chemistry letters.

Mono‐unsaturated fatty acids protect against β‐cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure

N. Morgan, Stephen A. Smith, M. Tadayyon, 2004, FEBS letters.

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

J. Holder, M. Coghlan, J. Clapham, 2004, Metabolism: clinical and experimental.

Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets

N. Morgan, Stephen A. Smith, S. Smith, 1999, British journal of pharmacology.

Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion

N. Morgan, Stephen A. Smith, V. Piercy, 1997, British journal of pharmacology.

Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non‐adrenoceptor idazoxan binding sites

N. Morgan, Stephen A. Smith, A. C. Loweth, 1993, British journal of pharmacology.

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

S. O’Rahilly, M. Lazar, J. Holder, 1997, The Journal of clinical investigation.

Expression and functional activity of PPARγ in pancreatic β cells

N. Morgan, Stephen A. Smith, S. McBain, 2004, British journal of pharmacology.

Lipoprotein-associated PLA2 inhibition--a novel, non-lipid lowering strategy for atherosclerosis therapy.

D. Tew, Stephen A. Smith, S. Smith, 2001, Farmaco.

[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.

Stephen A. Smith, M. Cawthorne, S. Smith, 1994, Journal of medicinal chemistry.

Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.

P. Murdock, J. Hayes, Stephen A. Smith, 2001, The Biochemical journal.

Synergistic Activation of UCP-3 Expression in Cultured Fetal Rat Brown Adipocytes by PPARα and PPARγ Ligands

J. Clapham, Stephen A. Smith, T. Teruel, 2000 .

Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model.

Michael R. Braden, Stephen A. Smith, R. Bridges, 2013, Bioorganic & medicinal chemistry letters.

Microwave Accelerated Synthesis of Isoxazole Hydrazide Inhibitors (IV) of the System x(C-) Transporter: Initial Homology Model.

Michael R. Braden, Stephen A. Smith, R. Bridges, 2014 .