J. Brozinick

发表

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.

G. Dohm, J. Brozinick, B. Roberts, 2003, Diabetes.

Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle.

S. Cushman, J. Brozinick, D. Dean, 1998, American journal of physiology. Endocrinology and metabolism.

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle*

M. Birnbaum, J. Brozinick, 1998, The Journal of Biological Chemistry.

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.

M. Birnbaum, K. Hoehn, J. Brozinick, 2007, Cell metabolism.

Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans.

B. Bergman, J. Brozinick, L. Perreault, 2015, American journal of physiology. Endocrinology and metabolism.

Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

B. Bergman, J. Brozinick, L. Perreault, 2016, Diabetologia.

Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans.

R. Eckel, B. Bergman, J. Brozinick, 2018, American journal of physiology. Endocrinology and metabolism.

Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans.

B. Bergman, A. D’Alessandro, J. Brozinick, 2016, Journal of applied physiology.

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Scott B. Crown, S. Kajimura, M. A. Moseley, 2021, Nature Communications.

Excess Membrane Cholesterol is an Early Contributing Reversible Aspect of Skeletal Muscle Insulin Resistance in C57BL/6NJ Mice Fed a Western-Style High-Fat Diet.

J. S. Elmendorf, J. Brozinick, Brian A. Grice, 2019, American journal of physiology. Endocrinology and metabolism.

Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport.

J. S. Elmendorf, J. Brozinick, K. Spisak, 2006, American journal of physiology. Cell physiology.

Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues*

A. Strawbridge, J. S. Elmendorf, J. Brozinick, 2004, Journal of Biological Chemistry.

GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure.

T. Reynolds, S. Cushman, J. Brozinick, 2001, Diabetes.

Insulin resistance of obese Zucker rats exercise trained at two different intensities.

J. Ivy, J. Brozinick, C. Torgan, 1991, The American journal of physiology.

Cytoskeletal regulation of skeletal muscle glucose uptake 1 The actin-related p 41 ARC subunit contributes to p 21-activated kinase-1 ( PAK 1 ) – mediated glucose uptake into skeletal muscle cells

J. S. Elmendorf, J. Brozinick, V. Salunkhe, 2017 .

J. S. Elmendorf, J. Brozinick, V. Salunkhe, 2017, The Journal of Biological Chemistry.

Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution

B. Bergman, A. D’Alessandro, J. Brozinick, 2021, Obesity.

Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase.

J. Weidner, J. Brozinick, V. Reynolds, 2016, Journal of medicinal chemistry.

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.

P. Scherer, J. Brozinick, W. Holland, 2013, Cell metabolism.

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle.

M. Bucan, M. Birnbaum, O. Valladares, 2001, Molecular cell.

AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.

Nolan J. Hoffman, J. S. Elmendorf, J. Brozinick, 2012, Endocrinology.

Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance.

J. S. Elmendorf, J. Brozinick, A. M. McCarthy, 2008, Molecular endocrinology.

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.

B. Kemp, S. Fiering, L. Goodyear, 2007, American journal of physiology. Endocrinology and metabolism.

Biomarkers of Ectopic Fat Deposition: The Next Frontier in Serum Lipidomics.

B. Bergman, J. Brozinick, L. Perreault, 2016, The Journal of clinical endocrinology and metabolism.

Nonesterified Fatty Acids: The Multi-Ethnic Study of Atherosclerosis n-3 Fatty Acids Attenuate the Risk of Diabetes Associated With Elevated Serum

M. Febbraio, L. Steffen, A. Klip, 2015 .

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

Sean J. Humphrey, David E. James, J. Burchfield, 2022, bioRxiv.

Nucleotides Released From Palmitate-Challenged Muscle Cells Through Pannexin-3 Attract Monocytes

A. Klip, J. Brozinick, P. Bilan, 2014, Diabetes.

Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis.

J. Lockwood, J. Andrews, K. Kikly, 2013, American journal of physiology. Endocrinology and metabolism.

"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action.

J. S. Elmendorf, J. Brozinick, Bradley A Berkemeier, 2007, Current diabetes reviews.

The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity

M. Birnbaum, P. Scherer, J. Brozinick, 2016 .

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity

M. Verhage, A. Groffen, J. Brozinick, 2012, Diabetes.

Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic mice.

C. Wilson, J. Ivy, S. Cushman, 1996, The Biochemical journal.

Short-term exercise enhances insulin-stimulated GLUT-4 translocation and glucose transport in adipose cells.

T. Reynolds, S. Cushman, M. Zarnowski, 1998, Journal of applied physiology.

Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats.

R. Miller, J. Ivy, J. Brozinick, 1991, The American journal of clinical nutrition.

Substrate utilization during acute exercise in obese Zucker rats.

J. Ivy, J. Brozinick, M. Willems, 1990, Journal of applied physiology.

A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia.

J. Brozinick, E. Hawkins, W. Bensch, 2005, Molecular endocrinology.

Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells[S]

A. Klip, J. Zierath, J. Brozinick, 2018, Journal of Lipid Research.

MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk

W. Geldenhuys, P. Scherer, J. Brozinick, 2016, Diabetes.

Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.

A. R. Miller, J. Brozinick, C. Montrose‐Rafizadeh, 2006, Bioorganic & medicinal chemistry letters.

Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training.

T. Reynolds, S. Cushman, J. Brozinick, 2000, Journal of applied physiology.

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen.

T. Reynolds, S. Cushman, J. Brozinick, 1998, The American journal of physiology.

Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen.

T. Reynolds, S. Cushman, J. Brozinick, 1998, American journal of physiology. Endocrinology and metabolism.

Effects of exercise training on glucose transport and cell surface GLUT-4 in isolated rat epitrochlearis muscle.

T. Reynolds, S. Cushman, J. Brozinick, 1997, The American journal of physiology.

Muscle glucose transport, GLUT-4 content, and degree of exercise training in obese Zucker rats.

J. Ivy, J. Brozinick, B. Yaspelkis, 1992, The American journal of physiology.

Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat.

J. Ivy, J. Brozinick, G. Etgen, 1992, Journal of applied physiology.

Skeletal muscle glucose transport in obese Zucker rats after exercise training.

J. Ivy, J. Brozinick, C. Torgan, 1989, Journal of applied physiology.

GLUCOSE UPTAKE IN INSULIN RESISTANT MUSCLE OF OBESE ZUCKER RATS IS FULLY ACTIVATED BY CONTRACTION: 527

J. Ivy, J. Brozinick, G. Etgen, 1992 .

1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.

T. Reynolds, S. Cushman, J. Brozinick, 1999, The Biochemical journal.

Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats.

J. Ivy, J. Brozinick, G. Etgen, 1993, The American journal of physiology.

Effects of fasting and training on pyruvate dehydrogenase activation during exercise.

G. Dohm, J. Brozinick, V. Patel, 1988, The International journal of biochemistry.

Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat.

J. Ivy, J. Brozinick, G. Etgen, 1994, The American journal of physiology.

Effects of exercise training on skeletal muscle glucose uptake and transport.

J. Ivy, J. Brozinick, G. Etgen, 1993, The American journal of physiology.

Effects of exercise training on muscle GLUT4 protein content and translocation in obese Zucker rats

J. Brozinick, G. Etgen, B. Yaspelkis, 2002 .

Exercise training and clenbuterol reduce insulin resistance of obese Zucker rats.

J. Ivy, J. Brozinick, R. Wilcox, 1993, The American journal of physiology.

The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle.

J. Ivy, J. Brozinick, G. Etgen, 1994, The Biochemical journal.

Muscle glycogen storage after different amounts of carbohydrate ingestion.

J. Ivy, J. Brozinick, M. Reed, 1988, Journal of applied physiology.

Muscle glycogen storage postexercise: effect of mode of carbohydrate administration.

J. Ivy, J. Brozinick, M. Reed, 1989, Journal of applied physiology.

Muscle morphological and biochemical adaptations to training in obese Zucker rats.

J. Ivy, J. Brozinick, C. Torgan, 1989, Journal of applied physiology.

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice[S]

J. Zierath, L. Mannerås-Holm, J. Brozinick, 2017, Journal of Lipid Research.

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

V. Pirro, O. Ilkayeva, C. Newgard, 2022, Molecular metabolism.

Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro

B. Bergman, J. Brozinick, S. Zarini, 2022, Journal of lipid research.

Muscle glucose uptake of obese Zucker rats trained at two different intensities.

J. Ivy, J. Brozinick, M. Willems, 1991, Journal of applied physiology.

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

R. Campbell, P. Iversen, M. Clay, 2004, Journal of medicinal chemistry.

The development of potent and selective bisarylmaleimide GSK3 inhibitors.

R. Campbell, B. Anderson, T. Engler, 2005, Bioorganic & medicinal chemistry letters.

Calorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle.

S. Cushman, J. Brozinick, D. Dean, 1998, American Journal of Physiology.

Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice

J. Zierath, A. Krook, J. Brozinick, 2019, Diabetes.

Nucleotides released from palmitate-activated murine macrophages attract neutrophils

A. Klip, J. Brozinick, P. Bilan, 2020, The Journal of Biological Chemistry.

FGF-21 as a novel metabolic regulator.

J. Gromada, G. Sandusky, F. Mehrbod, 2005, The Journal of clinical investigation.

In Vivo Assay Guidelines

S. Iturria, P. Iversen, Hui-Rong Qian, 2004 .

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models.

K. Ogilvie, J. Brozinick, G. Etgen, 2002, Diabetes.

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

M. Birnbaum, P. Scherer, J. Brozinick, 2011, Nature Medicine.

Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57BL/6J mice fed a western‐style high‐fat diet

J. S. Elmendorf, J. Brozinick, L. Tackett, 2017, Physiological reports.

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

Scott B. Crown, W. Kraus, O. Ilkayeva, 2020, Cell reports.

A Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with a Unique in Vitro Profile and Potent Glucose and Lipid Effects in Rodent Models of Type 2 Diabetes and Dyslipidemia

Joseph T. Brozinick, Alan M. Warshawsky, J. Brozinick, 2005 .

A Predominant Role of Acyl-CoA:monoacylglycerol Acyltransferase-2 in Dietary Fat Absorption Implicated by Tissue Distribution, Subcellular Localization, and Up-regulation by High Fat Diet*

J. Brozinick, Yuguang Shi, Jingsong Cao, 2004, Journal of Biological Chemistry.

Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet

J. Brozinick, K. Grove, E. Hawkins, 2012, International Journal of Obesity.

Metabolic and anthropometric factors related to skeletal muscle UCP3 gene expression in healthy human adults.

J. Hill, J. Brozinick, J. Dahl, 2002, American journal of physiology. Endocrinology and metabolism.

The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis

J. Brozinick, A. Adams, R. Samms, 2019, Molecular metabolism.

Measurement of contraction-stimulated GLUT-4 translocation in isolated skeletal muscle.

J. Brozinick, 2003, Methods in molecular medicine.

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

David E. James, B. Bergman, N. Turner, 2023, bioRxiv.

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.

J. Brozinick, C. Montrose‐Rafizadeh, C. Lamas, 2005, Bioorganic & medicinal chemistry letters.

An Early, Reversible Cholesterolgenic Etiology of Diet-Induced Insulin Resistance.

J. S. Elmendorf, J. Brozinick, K. Habegger, 2023, Molecular metabolism.

Interaction of aerobic exercise training and clenbuterol: effects on insulin-resistant muscle.

J. Ivy, J. Brozinick, G. Etgen, 1993, Journal of applied physiology.

Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice.

C. Wilson, T. Reynolds, S. Cushman, 1997, The Biochemical journal.

Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.

V. Devanarayan, J. Brozinick, C. Montrose‐Rafizadeh, 2006, Bioorganic & medicinal chemistry letters.

Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance (Molecular Endocrinology (2008) 22, (937-950) DOI: 10.1210/me.2007-0410)

J. S. Elmendorf, J. Brozinick, A. M. McCarthy, 2010 .

Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity‐induced insulin resistance

J. Zierath, J. Lanner, J. Brozinick, 2021, Journal of cachexia, sarcopenia and muscle.

epitrochlearis muscle after exercise training Transient enhancement of GLUT-4 levels in rat

Samuel W. Cushman, Thomas H. Reynolds, Lisa M. Larkin, 2013 .