J. Cortés

发表

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.

A. D. Buss, S. Gaisser, P. Leadlay, 2000, Chemistry & biology.

A novel LysR‐type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin

J. Zakrzewska‐Czerwińska, P. Koch, J. Cortés, 2020, Engineering in life sciences.

Analysis of a gene cluster from S. longisporoflavus potentially involved in tetronasin biosynthesis.

P. Leadlay, J. Cortés, J. Staunton, 1993, Biochemical Society transactions.

Purification and characterization of a 2-oxoglutarate-linked ATP-independent deacetoxycephalosporin C synthase of Streptomyces lactamdurans.

J. Martín, J. Cortés, J. Castro, 1987, Journal of general microbiology.

A mutant generated by expression of an engineered DEBS 1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid

P. Leadlay, J. Cortés, J. Staunton, 1995 .

Polyketide synthesis in vitro on a modular polyketide synthase.

P. Leadlay, J. Cortés, J. Staunton, 1995, Chemistry & biology.

An efficient blue-white screening system for markerless deletions and stable integrations in Streptomyces chromosomes based on the blue pigment indigoidine biosynthetic gene bpsA

J. Cortés, D. Homerova, J. Kormanec, 2018, Applied Microbiology and Biotechnology.

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

B. Rudd, M. Dawson, J. Cortés, 2009, Molecular microbiology.

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

I. Chopra, B. Rudd, M. Dawson, 2009, Chemistry & biology.

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

P. Leadlay, S. Haydock, J. Cortés, 1992, European journal of biochemistry.

Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis

P. Leadlay, R. Hale, N. Dhillon, 1989, Molecular microbiology.

Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea

S. Gaisser, P. Leadlay, N. Dhillon, 1998, Molecular and General Genetics MGG.

Analysis of seven genes from the eryAI –eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea

S. Gaisser, P. Leadlay, J. Cortés, 1997, Molecular and General Genetics MGG.

Cloning and partial characterization of the putative rifamycin biosynthetic gene cluster from the actinomycete Amycolatopsis mediterranei DSM 46095.

P. Leadlay, R. Lal, J. Cortés, 2001, Microbiological research.

Organization of the biosynthetic genes encoding deoxyactagardine B (DAB), a new lantibiotic produced by Actinoplanes liguriae NCIMB41362

M. Dawson, J. Cortés, S. Boakes, 2010, The Journal of Antibiotics.

Lantibiotics and Similar Peptides Produced by and Active on Gram-Positives: Discovery, Development and Perspectives

J. Cortés, 2014 .

Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase

James Staunton, P. Leadlay, P. Long, 2002, Molecular microbiology.

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.

P. Leadlay, J. Cortés, J. Staunton, 1995, Science.

An improved HPLC assay of the substrate and products of the isopenicillin N synthase

J. Martín, J. Cortés, B. Meesschaert, 1987 .

Engineering of complex polyketide biosynthesis — insights from sequencing of the monensin biosynthetic gene cluster

P. Leadlay, P. Long, J. Cortés, 2001, Journal of Industrial Microbiology and Biotechnology.

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

P. Leadlay, S. Haydock, J. Cortés, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Conversion of phenylacetyl‐cysteinyl‐valine in vitro into penicillin G by isopenicillin N synthase of Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1986 .

Glucose regulation of cephamycin biosynthesis in Streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin C synthase.

J. Martín, J. Cortés, J. Castro, 1986, Journal of general microbiology.

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

P. Leadlay, S. Haydock, J. Cortés, 1990, Nature.

High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio Technologies

J. Zakrzewska‐Czerwińska, P. Koch, J. Cortés, 2016, Genome Announcements.

Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P

J. Cortés, C. Méndez, C. Olano, 2017, Front. Microbiol..

Cloning, characterization, and heterologous expression of the Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-hand calcium-binding protein

P. Leadlay, R. Hale, J. Cortés, 1989, Journal of bacteriology.

Construction of new vectors for high-level expression in actinomycetes.

S. Gaisser, P. Leadlay, C. Rowe, 1998, Gene.

An efficient blue-white screening system for markerless deletions and stable integrations in Streptomyces chromosomes based on the blue pigment indigoidine biosynthetic gene bpsA

J. Cortés, D. Homerova, J. Kormanec, 2018, Applied Microbiology and Biotechnology.

Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains

J. Cortés, D. Homerova, J. Kormanec, 2017, Applied Microbiology and Biotechnology.

An efficient system for stable markerless integration of large biosynthetic gene clusters into Streptomyces chromosomes

J. Cortés, D. Homerova, J. Kormanec, 2021, Applied Microbiology and Biotechnology.

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

Guido Sauter, James Staunton, P. Leadlay, 2008, Chembiochem : a European journal of chemical biology.

A hybrid modular polyketide synthase obtained by domain swapping.

P. Leadlay, J. Cortés, J. Staunton, 1996, Chemistry & biology.

Engineering broader specificity into an antibiotic-producing polyketide synthase.

B Wilkinson, P. Leadlay, B. Wilkinson, 1998, Science.

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

P. Leadlay, B. Wilkinson, J. Cortés, 1999, Chemistry & biology.

Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea ‡

B. Wilkinson, G. Foster, B. Rudd, 2002, Molecular microbiology.

Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters.

P. Leadlay, A. Slusarczyk, J. Cortés, 2010, Chemistry & biology.

Active-site residue, domain and module swaps in modular polyketide synthases

J. Staunton, Barrie Wilkinson, R. Lill, 2003, Journal of Industrial Microbiology and Biotechnology.

Chapter 22. Whole-cell generation of lantibiotic variants.

M. Dawson, J. Cortés, A. Appleyard, 2009, Methods in enzymology.

Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A

J. Zakrzewska‐Czerwińska, P. Koch, J. Cortés, 2021, Angewandte Chemie.

Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase.

P. Leadlay, J. Cortés, J. Staunton, 2002, Biochemistry.

Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.

P. Leadlay, B. Rudd, J. Cortés, 1999, Chemistry & biology.

Generation of an actagardine A variant library through saturation mutagenesis

M. Dawson, J. Cortés, S. Boakes, 2012, Applied Microbiology and Biotechnology.

A New Modular Polyketide Synthase in the Erythromycin Producer Saccharopolyspora erythraea

P. Leadlay, B. Rudd, I. Böhm, 2005, Journal of Molecular Microbiology and Biotechnology.

Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea

P. Leadlay, S. Haydock, J. Cortés, 1998, Molecular and General Genetics MGG.

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

P. Leadlay, S. Haydock, N. Dhillon, 1991, Molecular and General Genetics MGG.

Regulation of α-aminoadipyl-cysteinyl-valine, isopenicillin N synthetase, isopenicillin N isomerase and deacetoxycephalosporin C synthetase by nitrogen sources in Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1985, Applied Microbiology and Biotechnology.

Generation of an actagardine A variant library through saturation mutagenesis

M. Dawson, J. Cortés, S. Boakes, 2012, Applied Microbiology and Biotechnology.

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

P. Leadlay, J. Cortés, J. Staunton, 2008, Chembiochem : a European journal of chemical biology.

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.

P. Leadlay, I. Böhm, J. Cortés, 1998, Chemistry & biology.