J. Whitehead

发表

Natural variants of human p85α phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity

S. O’Rahilly, G. Panayotou, R. Stein, 2000, Diabetologia.

Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.

S. O’Rahilly, K. Baynes, M. Soos, 1998, The Journal of clinical investigation.

Congenital leptin deficiency is associated with severe early-onset obesity in humans

S. O’Rahilly, N. Wareham, J. Hurst, 1997, Nature.

Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications.

J. Whitehead, J. Prins, Alun Jones, 2006, Molecular endocrinology.

Adiponectin--it's all about the modifications.

J. Whitehead, F. Simpson, Fiona Simpson, 2010, The international journal of biochemistry & cell biology.

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats

D. Fairlie, J. Whitehead, J. Prins, 2012, Diabetes.

Fibroblast growth factor 1: a key regulator of human adipogenesis.

F. Newell, J. Whitehead, J. Prins, 2004, Diabetes.

Adipose tissue from pregnant women with and without gestational diabetes mellitus: insulin-sensitive but resistant to hyperosomolarity.

J. Whitehead, J. Prins, A. Russell, 2005, American journal of obstetrics and gynecology.

Glucose uptake and insulin action in human adipose tissue—influence of BMI, anatomical depot and body fat distribution

J. Hay, J. Whitehead, A. Russell, 2002, International Journal of Obesity.

Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats.

P. J. Armstrong, J. Whitehead, J. Morton, 2011, General and comparative endocrinology.

Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling.

S. O’Rahilly, M. Soos, J. Whitehead, 2006, American journal of physiology. Endocrinology and metabolism.

Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects*

S. O’Rahilly, K. Siddle, J. Tavaré, 1997, The Journal of Biological Chemistry.

Diabetes: New conductors for the peroxisome proliferator-activated receptor γ (PPARγ) orchestra.

J. Whitehead, 2011, The international journal of biochemistry & cell biology.

Truncated Human Leptin (Δ133) Associated with Extreme Obesity Undergoes Proteasomal Degradation after Defective Intracellular Transport.

Barbara J. Reaves, S. O’Rahilly, J. Whitehead, 1999, Endocrinology.

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

M. Febbraio, J. Whitehead, D. Henstridge, 2017, Scientific Reports.

TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue — influence of BMI and adipose distribution

L. Haupt, J. Whitehead, J. Prins, 2006, Diabetes & vascular disease research.

Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation.

G. Cooney, A. Xu, K. Hoehn, 2010, Molecular endocrinology.

The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity.

D. James, G. Ramm, J. Molero, 2006, The international journal of biochemistry & cell biology.

Nocodazole Inhibits Insulin-stimulated Glucose Transport in 3T3-L1 Adipocytes via a Microtubule-independent Mechanism*

D. James, J. Molero, J. Whitehead, 2001, The Journal of Biological Chemistry.

Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

J. Whitehead, J. Prins, J. Barry, 2009, Molecular and Cellular Endocrinology.

Ascending dose‐controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women

T. Hughes, J. Whitehead, J. Proietto, 2013, Obesity.

Identification of carboxypeptidase X (CPX)‐1 as a positive regulator of adipogenesis

J. Whitehead, J. Prins, Jingjing He, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein.

J. Whitehead, Yu-Hee Kim, H. M. O'Neill, 2015, Biochemical and biophysical research communications.

Olanzapine Treatment is Associated with Reduced High Molecular Weight Adiponectin in Serum: A Potential Mechanism for Olanzapine-induced Insulin Resistance in Patients with Schizophrenia

F. Newell, B. Mowry, J. Whitehead, 2006, Journal of clinical psychopharmacology.

Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle.

S. O’Rahilly, M. Soos, J. Whitehead, 2000, The Biochemical journal.

Overexpression of the Adiponectin Receptor AdipoR1 in Rat Skeletal Muscle Amplifies Local Insulin Sensitivity

N. Turner, G. Cooney, E. Kraegen, 2012, Endocrinology.

Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.

S. O’Rahilly, K. Siddle, A. Krook, 1998, Diabetes.

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

J. Whitehead, J. Prins, H. Thomas, 2014, Nature Medicine.

Arachidonic Acid Stimulates Glucose Uptake in 3T3-L1 Adipocytes by Increasing GLUT1 and GLUT4 Levels at the Plasma Membrane

S. O’Rahilly, J. Whitehead, J. Prins, 2001, The Journal of Biological Chemistry.

Distinct adiponectin profiles might contribute to differences in susceptibility to type 2 diabetes in dogs and humans.

J. Whitehead, J. Morton, L. Fleeman, 2011, Domestic animal endocrinology.

Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC‐1 in dermal fibroblasts from patients with syndromes of severe insulin resistance

S. O’Rahilly, J. Whitehead, K. Dib, 1997, Clinical endocrinology.

Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks

J. Whitehead, S. Keshvari, 2015, Molecular and Cellular Endocrinology.

ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling.

J. Whitehead, F. Simpson, Hayley K Charlton, 2010, Biochemical and biophysical research communications.

Effects of Delayed Sample Processing on Determination of Total and High Molecular Weight (HMW) Adiponectin in Serum and Plasma: A Pilot Study

M. Reeves, J. Whitehead, G. Dimeski, 2016 .

Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 – Adiponectin axis

J. Whitehead, Jingjing He, J. Barclay, 2014, Molecular and Cellular Endocrinology.

Induction of Heme-oxygenase-1 ( HO-1 ) does not enhance 1 adiponectin production in human adipocytes : Evidence against a 2 direct HO-1 – adiponectin axis 3 4 Short title : Evidence against a direct HO-1 – adiponectin axis 5 6

J. Whitehead, Jingjing He, J. Barclay, 2015 .

Genetic variants of insulin receptor substrate‐1 (IRS‐1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS‐1

S. O’Rahilly, I. Barroso, M. Soos, 2002, Diabetic medicine : a journal of the British Diabetic Association.

Molecular mechanisms of inherited insulin resistance.

S. O’Rahilly, A. Krook, K. Baynes, 1997, QJM : monthly journal of the Association of Physicians.

A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes

F. Newell, J. Whitehead, J. Prins, 2011, Molecular and Cellular Endocrinology.

Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity.

F. Newell, J. Molero, J. Whitehead, 2009, Biochemical and biophysical research communications.

Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes

J. Whitehead, J. Prins, I. Hickman, 2007, Diabetes, obesity & metabolism.

The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity

A. Shulkes, J. Whitehead, J. Proietto, 2012, Diabetes.

Glucose uptake and insulin-signaling in human adipose tissue in pregnancy

J. Whitehead, J. Prins, A. Russell, 2003 .

Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.

S. O’Rahilly, P. Shepherd, M. Soos, 2001, Archives of biochemistry and biophysics.

Multiple Molecular Mechanisms of Insulin Receptor Dysfunction in a Patient With Donohue Syndrome

S. O’Rahilly, V. Tasic, M. Kocova, 1998, Diabetes.

Riboflavin deficiency and iron absorption in adult Gambian men.

J. Whitehead, S. Fairweather-Tait, H. Powers, 1992, Annals of nutrition & metabolism.

The Role of Ca2+ in Insulin-stimulated Glucose Transport in 3T3-L1 Cells*

D. James, S. Clark, J. Molero, 2001, The Journal of Biological Chemistry.

Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes

T. Herbert, J. Whitehead, Jingjing He, 2022, Molecular and Cellular Endocrinology.

The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?

J. Whitehead, J. Prins, O. Wright, 2013, Canadian journal of physiology and pharmacology.

IRS‐1 Regulation in Health and Disease

J. Whitehead, C. Schmitz‐Peiffer, 2003, IUBMB life.

Ectodermal‐Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3‐E1 Osteoblast Mineralization and Gene Expression

S. Barry, T. Gonda, J. Whitehead, 2017, Journal of cellular biochemistry.

Ectodermal-neural cortex 1 isoforms have contrasting effects on MC 3 T 3E 1 osteoblast mineralization and gene expression † Running title : ENC 1 isoform effects on MC 3 T 3 differentiation

S. Barry, T. Gonda, J. Whitehead, 2016 .

Development of an enzyme-linked immunosorbent assay for thrombospondin-1 and comparison of human plasma and serum concentrations

W. Inder, J. Whitehead, J. Barclay, 2016, Annals of clinical biochemistry.

Different Characteristics and Nucleotide Binding Properties of Inosine Monophosphate Dehydrogenase (IMPDH) Isoforms

R. Parton, J. Whitehead, V. Oorschot, 2012, PloS one.

Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.

J. Whitehead, Alun Jones, N. Barnett, 2008, The international journal of biochemistry & cell biology.

Resveratrol does not benefit patients with nonalcoholic fatty liver disease.

K. Klein, G. Cowin, J. Coombes, 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Differences in Signaling Properties of the Cytoplasmic Domains of the Insulin Receptor and Insulin-like Growth Factor Receptor in 3T3-L1 Adipocytes*

B. Ursø, S. O’Rahilly, K. Siddle, 1999, The Journal of Biological Chemistry.

Characterization of the transcriptional and functional effects of fibroblast growth factor‐1 on human preadipocyte differentiation

J. Whitehead, H. Tornqvist, J. Prins, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential Signaling to Glycogen Synthesis by the Intracellular Domain of the Insulin versus the Insulin-like Growth Factor-1 Receptor

S. O’Rahilly, K. Siddle, J. Tavaré, 1997, The Journal of Biological Chemistry.

Signalling through the insulin receptor.

B. Ursø, D. James, S. Clark, 2000, Current opinion in cell biology.

Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes.

F. Newell, J. Whitehead, J. Prins, 2009, American journal of physiology. Endocrinology and metabolism.

Structure, signalling and physiologic role of adiponectin-dietary and exercise- related variations.

J. Whitehead, I. Hickman, Ingrid J. Hickman, 2012, Current medicinal chemistry.

A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

David W. Johnson, C. Hawley, K. Campbell, 2014, BMC Nephrology.

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

F. Newell, N. Turner, J. Whitehead, 2011, Diabetes.

GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?

J. Whitehead, M. Taing, F. J. Rose, 2014, Drug design, development and therapy.

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

J. Reiling, J. Whitehead, D. Crawford, 2018, Cellular and molecular gastroenterology and hepatology.

Insulin and Oleate Promote Translocation of Inosine‐5′ Monophosphate Dehydrogenase to Lipid Bodies

David E. James, F. Collart, L. Connolly, 2004, Traffic.

Thrombospondin-1 is a glucocorticoid responsive protein in humans.

W. Inder, C. Thompson, J. Whitehead, 2016, European journal of endocrinology.

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

D. Fairlie, J. Whitehead, J. Prins, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface.

R. Parton, J. Whitehead, Yu-Hee Kim, 2013, Biochemical and biophysical research communications.

The Feasibility of an Exercise Intervention in Males at Risk of Oesophageal Adenocarcinoma: A Randomized Controlled Trial

D. Whiteman, J. Paratz, M. Reeves, 2015, PloS one.

GLUT4 – At the Cross Roads Between Membrane Trafficking and Signal Transduction

D. James, J. Whitehead, F. Simpson, 2001, Traffic.

influence of BMI and adipose distribution − − tissue TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose

L. Haupt, J. Whitehead, J. Prins, 2006 .

Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) – a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity

A. Perkins, Gongshe Yang, J. Greenfield, 2016, Growth factors.

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

J. Whitehead, W. Sanchez, S. McGee, 2013, British Journal of Cancer.

The Role of Ca in Insulin-stimulated Glucose Transport in 3T3-L1 Cells*

D. James, S. Clark, J. Molero, 2001 .

The Role of Ca 2 1 in Insulin-stimulated Glucose Transport in 3 T 3L 1 Cells *

D. James, S. Clark, J. Molero, 2001 .

High Molecular Weight Adiponectin Correlates with Insulin Sensitivity in Patients with Hepatitis C Genotype 3, But Not Genotype 1 Infection

J. Whitehead, J. Prins, I. Hickman, 2005, The American Journal of Gastroenterology.

A Pilot Randomised Study of the Metabolic and Histological Effects of Exercise in Non-alcoholic Steatohepatitis

Amalia Gastaldelli, Ingrid J. Hickman, Graeme A. Macdonald, 2013 .

An observational study evaluating the efficacy of microfragmented adipose tissue in the treatment of osteoarthritis.

J. Whitehead, A. Yewlett, Frankie Fan, 2022, Regenerative medicine.

Adiponectin – a key adipokine in the metabolic syndrome

J. Whitehead, J. Prins, I. Hickman, 2006, Diabetes, obesity & metabolism.

P-32: TrkC/insulin receptor and TrkC/IGF-1 receptor chimaeras: Tools for the examination of differential signalling to mitogenic and metabolic events by the intracellular domains of the insulin and IGF-1 receptors

S. O’Rahilly, K. Siddle, J. Tavaré, 2009 .

S. O’Rahilly, J. Whitehead, J. Prins, 2000, International Journal of Obesity.

Synergistic effects of ascorbic acid and thiazolidinedione on secretion of high molecular weight adiponectin from human adipocytes

J. Whitehead, A. A. Richards, J. Webster, 2010, Diabetes, obesity & metabolism.

Scurvy and stroke: is there an association?

J. Whitehead, F. J. Rose, 2011, Medical Journal of Australia.

Glucose Transport in 3T3-L1 Cells in Insulin-stimulated 2+ The Role of Ca

D. James, S. Clark, J. Molero, 2014 .

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

J. Whitehead, J. Prins, H. Thomas, 2014, Nature Medicine.

Chelation of organoarsenate with dimercaptosuccinic acid.

J. Whitehead, T. Hale, S. Shum, 1995, Veterinary and human toxicology.

Thrombospondin-1 is a glucocorticoid responsive protein in humans.

W. Inder, C. Thompson, J. Whitehead, 2016, European journal of endocrinology.