T. Haruta

发表

Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.

H. Ishihara, T. Sasaoka, H. Hori, 1999, Biochemical and biophysical research communications.

Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.

H. Ishihara, T. Sasaoka, T. Wada, 1999, Endocrinology.

Association of the Insulin Receptor with Phospholipase C-γ (PLCγ) in 3T3-L1 Adipocytes Suggests a Role for PLCγ in Metabolic Signaling by Insulin*

P. Vollenweider, J. Olefsky, N. Webster, 1998, The Journal of Biological Chemistry.

Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.

T. Imamura, T. Sasaoka, T. Haruta, 1997, Biochemical and biophysical research communications.

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Diabetes.

SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes

H. Ishihara, T. Sasaoka, H. Hori, 2001, Diabetologia.

Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity

T. Asano, M. Funaki, W. Ogawa, 2001, Molecular and Cellular Biology.

Insulin-like growth factor I receptors on erythrocytes in NIDDM.

T. Haruta, M. Kobayashi, Y. Takata, 1989, Diabetes research and clinical practice.

[A case of familial insulin resistance due to type A insulin receptor disorder].

K. Egawa, T. Haruta, M. Kobayashi, 1993, Nihon Naibunpi Gakkai zasshi.

Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome*

T. Imamura, H. Ishihara, T. Sasaoka, 1998, The Journal of Biological Chemistry.

Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.

T. Haruta, I. Usui, M. Ishiki, 2007, Endocrinology.

Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes*

A. Klippel, J. Olefsky, L. Williams, 1996, The Journal of Biological Chemistry.

Interleukin-1α inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes

T. Sasaoka, T. Haruta, I. Usui, 2006 .

Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling Pathway (*)

J. Olefsky, D. Rose, M. Mueckler, 1995, The Journal of Biological Chemistry.

Junko Kawahara , Signals and Metabolic Signals of Insulin Substrate 1 and Integrates Nutritional Redistribution of Insulin Receptor Regulates Insulin Signaling via Subcellular Mammalian Target of Rapamycin Pathway

T. Haruta, I. Usui, Masashi Kobayashi, 2001 .

Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis1.

H. Ishihara, T. Sasaoka, H. Hori, 1999, Endocrinology.

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis.

H. Ishihara, T. Sasaoka, H. Hori, 1999, Endocrinology.

The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Metabolism: clinical and experimental.

Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.

P. Vollenweider, J. Olefsky, D. Rose, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

J. Olefsky, Prem M. Sharma, K. Egawa, 2000, Molecular endocrinology.

Translocation of IRS-1 to Cytosol Attenuates Insulin-Stimulated Glucose Transport without Affecting PI3-Kinase Activity

K. Tobe, T. Haruta, I. Usui, 2010 .

Signal transduction pathways leading to insulin-induced early gene induction.

J. Olefsky, A. Saltiel, B. Jhun, 1995, Biochemistry.

Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.

H. Ishihara, T. Sasaoka, H. Hori, 2001, Endocrinology.

Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation.

P. Vollenweider, J. Olefsky, D. Rose, 1998, Endocrinology.

Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

T. Sasaoka, T. Haruta, I. Usui, 2006, Molecular endocrinology.

Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.

T. Sasaoka, T. Haruta, M. Kobayashi, 2000, Biochemical and biophysical research communications.

Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.

H. Ishihara, T. Sasaoka, T. Wada, 1998, Biochemical and biophysical research communications.

Co-expression of mutant and normal human insulin receptors in COS 7 cells.

H. Maegawa, A. Kashiwagi, K. Egawa, 1993, Biochimica et biophysica acta.

Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.

P. Vollenweider, J. Olefsky, N. Webster, 1998, The Journal of biological chemistry.

Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

T. Sasaoka, T. Haruta, Y. Takata, 2001 .

Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Diabetes.

Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression

T. Haruta, I. Usui, Masashi Kobayashi, 2007, Diabetes.

Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin

T. Haruta, I. Usui, Masashi Kobayashi, 2001, Molecular and Cellular Biology.

The Functional Role of CrkII in Actin Cytoskeleton Organization and Mitogenesis*

J. Olefsky, A. Saltiel, D. Rose, 1999, The Journal of Biological Chemistry.

Ala1048→Asp Mutation in the Kinase Domain of Insulin Receptor Causes Defective Kinase Activity and Insulin Resistance

T. Imamura, H. Maegawa, K. Egawa, 1993, Diabetes.

A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

T. Imamura, K. Egawa, T. Sasaoka, 1993, Diabetologia.

Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.

T. Imamura, H. Ishihara, T. Sasaoka, 1996, Biochemical and biophysical research communications.

The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.

P. Vollenweider, Y. Le Marchand-Brustel, J. Olefsky, 1997, Endocrinology.

Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.

Isao Usui, T. Haruta, I. Usui, 2005, Biochemical and biophysical research communications.

Amplification and analysis of promoter region of insulin receptor gene in a patient with leprechaunism associated with severe insulin resistance.

T. Imamura, K. Egawa, T. Haruta, 1995, Metabolism: clinical and experimental.

Differential Effects of Palmitate on Glucose Uptake in Rat-1 Fibroblasts and 3T3-L1 Adipocytes

H. Ishihara, T. Sasaoka, T. Wada, 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Potential Role of Gab1 and Phospholipase C-γ in Osmotic Shock-Induced Glucose Uptake in 3T3-L1 Adipocytes

T. Sasaoka, T. Haruta, M. Kobayashi, 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.

T. Imamura, T. Sasaoka, T. Haruta, 1994, The Journal of biological chemistry.

Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes.

T. Haruta, I. Usui, M. Ishiki, 2008, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.